scholarly journals Nghên cứu giảm đắng nước bưởi thanh trùng bằng chế phẩm enzyme biocitrus

2021 ◽  
Vol 57 (6) ◽  
pp. 160-168
Author(s):  
Quang Bình Hoàng ◽  
Thị Ny Trần ◽  
Tiến Đạt Huỳnh ◽  
Trung Thiên Lê
Keyword(s):  
Vitamin C ◽  
C 50

Bưởi có nhiều hợp chất có lợi cho sức khỏe như vitamin C, polyphenol. Nước bưởi sau thanh trùng thường có vị đắng khó chịu. Nghiên cứu này được thực hiện nhằm đánh giá khả năng cải thiện vị đắng của nước bưởi sau thanh trùng bằng phương pháp thủy phân với chế phẩm enzyme Biocitrus. Các yếu tố như pH (pH tự nhiên (3,5-3,6), 4,5, 5,5 và 6,5), nhiệt độ thủy phân (nhiệt độ phòng (29 – 31°C), 40°C, 50°C và 60°C) và thời gian thủy phân (0,5, 1,0, 2,0 và 3,0 giờ) lần lượt được thực hiện. Các hợp chất như naringin, polyphenol và vitamin C trong nước bưởi được định lượng bằng máy đo quang phổ UV-VIS, bên cạnh đó vị đắng của nước bưởi cũng được đánh giá cảm quan bằng phép thử cho điểm. Kết quả cho thấy thủy phân dịch bưởi tại nhiệt độ 60°C, pH môi trường 4,5 và thời gian thủy phân trong 2 giờ cho nước bưởi sau thanh trùng có vị đắng giảm so với nước bưởi không xử lý. Nước bưởi xử lý enzyme sau thanh trùng có hàm lượng naringin thấp hơn 2 lần so với nước bưởi không xử lý, giữa hai sản phẩm khác biệt về hàm lượng polyphenol và vitamin C. Enzyme Biocitrus có nhiều triển vọng trong ứng dụng giảm đắng của nước bưởi thanh trùng.

scholarly journals High-dose vitamin C infusion for the treatment of critically ill COVID-19

2020 ◽  
Author(s):  
Jing Zhang ◽  
Xin Rao ◽  
Yiming Li ◽  
Yuan Zhu ◽  
Fang Liu ◽  
...  
Keyword(s):  
Placebo Group ◽  
Vitamin C ◽  
Critically Ill ◽  
Day Treatment ◽  
Invasive Mechanical Ventilation ◽  
Controlled Clinical Trial ◽  
High Dose ◽  
C 50 ◽  
Intravenous Vitamin ◽  
High Dose Vitamin

Abstract BackgroundNo specific medication has been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe COVID-19.MethodsThis randomized, controlled clinical trial was performed at 3 hospitals in Hubei, China. Patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the ICU were randomly assigned in as 1:1 ratio to either the high-dose intravenous vitamin C (HDIVC) or the placebo. HDIVC group received 12 g of vitamin C/50 ml every 12 hours for 7 days at a rate of 12 ml/hour, and the placebo group received bacteriostatic water for injection in the same way. The primary outcome was invasive mechanical ventilation-free days in 28 days(IMVFD28). Secondary outcomes were 28-day mortality, organ failure, and inflammation progression.ResultsFifty-four critical COVID-19 patients were ultimately recruited. There was no difference in IMVFD28 between two groups. During the 7-day treatment period, patients in the HDIVC group had a steady rise in the PaO2/FiO2 (day 7: 229 vs. 151 mmHg, 95% CI 33 to 122, P = 0.01). Patients with SOFA scores ≥ 3 in the HDIVC group exhibited a significant reduction in 28-day mortality (P = 0.05) in univariate survival analysis. IL-6 in the VC group was lower than that in the placebo group (19.42 vs. 158.00; 95% CI -301.72 to -29.79; P = 0.04) on day 7.ConclusionThe addition of HDIVC may provide a protective clinical effect without any adverse events in critically ill patients with COVID-19.Clinicaltrial.gov identifer: NCT04264533

Intake of nutrient supplements affects multiplication ofLeishmania donovaniin hamsters

Parasitology ◽  
2004 ◽  
Vol 129 (6) ◽  
pp. 685-691 ◽  
Author(s):  
RAVENDRA GARG ◽  
NIRPENDRA SINGH ◽  
ANURADHA DUBE
Keyword(s):  
Vitamin C ◽  
Leishmania Donovani ◽  
Supportive Therapy ◽  
Leishmania Infection ◽  
Nutrient Supplements ◽  
Antileishmanial Drug ◽  
Parasite Multiplication ◽  
Prophylactic Use ◽  
C 50

The role of the essential nutrients, vitamins A,B (complex), C and E and iron, as prophylactic as well as supportive therapy in experimental visceral leishmaniasis (VL), was studied in hamsters. Prophylactic administration of vitamin C (50, 100 and 250 mg/kg) from day15 to day 0 (15 doses) significantly reduced the intake ofLeishmania donovaniin hamsters but had no therapeutic effect. In contrast, vitamins A,B complex and E and iron, whether used prophylactically or therapeutically, promoted parasite multiplication. The efficacy of sodium stibogluconate, a reference antileishmanial drug, was appreciably improved in animals administered prophylactically with vitamin C. However, supplementation of vitamin C during established infections resulted in reduced drug action. The results show that the prophylactic use of vitamin C may prevent the onset of leishmania infection and cautions against the indiscriminate use of nutrient supplements such as vitamin A, B complex, and E and iron in VL endemic areas.

Vitamin C ameliorates fluoride-induced embryotoxicity in pregnant rats

2001 ◽  
Vol 20 (12) ◽  
pp. 619-623 ◽  
Author(s):  
R J Verma ◽  
D M Guna Sherlin
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Vitamin C ◽  
Oral Administration ◽  
Olive Oil ◽  
Feed Consumption ◽  
Uterine Weight ◽  
Pregnant Rats ◽  
Total Percentage ◽  
C 50

Oral administration of sodium fluoride (40 mg/kg body weight) from day 6 to 19 of gestation caused, as compared to control, significant reductions in body weight, feed consumption, absolute uterine weight and number of implantations. Significantly higher incidence of skeletal (wavy ribs, 14th rib, <6 sternal centre, dumbell-shaped second and fifth sternebrae, incomplete ossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were also observed in NaF-treated dams than that of control. Oral administration of vitamin C (50 mg/kg body weight) and vitamin E (2 mg/0.2 ml olive oil/animal/day) from day 6 to 19 of gestation along with NaF significantly ameliorates NaF-induced reductions in body weight, feed consumption, absolute uterine weight (only with vitamin E treatment) and number of implantations. As compared with NaF-treated alone, the total percentage of skeletal and visceral abnormalities were significantly lowered in fluoride plus vitamin C-treated animals. Vitamin E was less effective. These findings suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryotoxicity in rats.

scholarly journals Efek Pemberian Vitamin C terhadap Mikroskopis Ginjal Tikus Wistar yang Terpapar Plumbum Asetat

2017 ◽  
Vol 6 (2) ◽  
pp. 417
Author(s):  
Zaki Farhan ◽  
M. Setia Budi ◽  
Elmatris Syamsir
Keyword(s):  
Vitamin C ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
C 50

Plumbum merupakan salah satu logam berat yang terkandung dalam bahan bakar kendaraan bermotor. Plumbum diekskresikan melalui ginjal sehingga dalam jangka waktu yang lama akan menyebabkan kerusakan sel epitel tubulus proksimal. Vitamin C merupakan salah satu senyawa yang bersifat antioksidan yang dapat melindungi efek radikal bebas yang ditimbulkan oleh plumbum. Tujuan penelitian ini adalah menentukan efek pemberian vitamin C terhadap mikroskopis ginjal tikus Wistar yang terpapar plumbum asetat. Penelitian ini merupakan studi eksperimental post test only control group design. Subjek penelitian adalah 24 ekor tikus Wistar jantan yang dibagi menjadi empat kelompok, yaitu K- tanpa perlakuan, K+ dengan pemberian Pb asetat 50 mg/kgbb/hari, P1 dengan pemberian Pb asetat dan vitamin C 50 mg/kgbb/hari, dan P2 dengan pemberian Pb asetat dan vitamin C 75 mg/kgbb/hari. Masing- masing kelompok terdiri dari enam ekor tikus dengan perlakuan selama empat minggu. Hasil penelitian menunjukkan bahwa terjadi kerusakan tubulus proksimal ginjal yang berbeda secara bermakna pada kelompok K+, P1, P2 dibandingkan dengan kelompok K- serta perbedaan yang bermakna pada kelompok P1, P2 terhadap kelompok K+ (p < 0,05). Terdapat efek pemberian vitamin C terhadap mikroskopis ginjal tikus Wistar terhadap paparan  plumbum asetat dengan dosis 50 mg/kgbb/hari. Simpulan hasil penelitian ini adalah terjadi perubahan mikroskopis ginjal tikus Wistar yang terpapar plumbum asetat dengan dosis 50 mg/kgbb/hari.

scholarly journals Efek Pemberian Vitamin C terhadap Mikroskopis Ginjal Tikus Wistar yang Terpapar Plumbum Asetat

2017 ◽  
Vol 6 (2) ◽  
pp. 417
Author(s):  
Zaki Farhan ◽  
M. Setia Budi ◽  
Elmatris Syamsir
Keyword(s):  
Vitamin C ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
C 50

Plumbum merupakan salah satu logam berat yang terkandung dalam bahan bakar kendaraan bermotor. Plumbum diekskresikan melalui ginjal sehingga dalam jangka waktu yang lama akan menyebabkan kerusakan sel epitel tubulus proksimal. Vitamin C merupakan salah satu senyawa yang bersifat antioksidan yang dapat melindungi efek radikal bebas yang ditimbulkan oleh plumbum. Tujuan penelitian ini adalah menentukan efek pemberian vitamin C terhadap mikroskopis ginjal tikus Wistar yang terpapar plumbum asetat. Penelitian ini merupakan studi eksperimental post test only control group design. Subjek penelitian adalah 24 ekor tikus Wistar jantan yang dibagi menjadi empat kelompok, yaitu K- tanpa perlakuan, K+ dengan pemberian Pb asetat 50 mg/kgbb/hari, P1 dengan pemberian Pb asetat dan vitamin C 50 mg/kgbb/hari, dan P2 dengan pemberian Pb asetat dan vitamin C 75 mg/kgbb/hari. Masing- masing kelompok terdiri dari enam ekor tikus dengan perlakuan selama empat minggu. Hasil penelitian menunjukkan bahwa terjadi kerusakan tubulus proksimal ginjal yang berbeda secara bermakna pada kelompok K+, P1, P2 dibandingkan dengan kelompok K- serta perbedaan yang bermakna pada kelompok P1, P2 terhadap kelompok K+ (p < 0,05). Terdapat efek pemberian vitamin C terhadap mikroskopis ginjal tikus Wistar terhadap paparan  plumbum asetat dengan dosis 50 mg/kgbb/hari. Simpulan hasil penelitian ini adalah terjadi perubahan mikroskopis ginjal tikus Wistar yang terpapar plumbum asetat dengan dosis 50 mg/kgbb/hari.

scholarly journals PENGARUH VITAMIN C PADA PAKAN BUATAN TERHADAP PERTUMBUHAN DAN KELANGSUNGAN HIDUP BENIH IKAN TENGADAK (Barbonymus Schwanenfeldii)

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Rachimi . ◽  
Hambali . ◽  
Sunarto .
Keyword(s):  
Vitamin C ◽  
C 50

Penelitian ini bertujuan untuk mengatahui persentase penambahan vitamin C yang optimal dalam formulasipakan buatan untuk mendukung pertumbuhan dan kelangsungan hidup benih ikan tenga dak (Barbonymus schwanenfeldii). Pelaksanaan penelitian ini dilakukan di Laboratorium Budidaya Perairan Fakultas Perikanan dan Ilmu Kelautan Universitas Muhammadiyah Pontianak serta Balai Riset Standarisasi Industri Kota Pontianak. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 3 ulangan dengan persentase penambahan vitamin C antaralain adalah perlakuan A (kontrol), B (Penambahan vitamin C 50%), C (penambahan vitamin C 100%), D (penambahan vitamin C 150%), E (penambahan vitamin C 200%). Parameter yang diamati meliputi Laju pertumbuhan spesifik (SGR), laju konumsi pakan harian (LKPH), jumah konsumsi pakan harian (JKPH), Retensi protein (RP), efesiensi Pakan (EP) Kelangsungan Hidup (SR) dan Pengukuran parameter kualitas air sebagai data penunjang. Hasil penelitian menunjukkan penambahan vitamin C sebanyak 50% menghasilkan nilai tertinggi untuk laju pertumbuhan spesifik sebesar 1,95%, laju konsumsi pakan harian 79,58%, jumlah konsumsi pakan harian 2,35%, retensi protein sebesar 6,78%, efesiensi pakan 2,02%, dan kelangsungan hidup 100% yang tidak berpengaruh  nyata (P<0,05) dengan penambahan vitamin C 50%, 100%, 150%, 200%dan tanpa penambahan tepug maggot (kontrol). Kata kunci : Vitamin C, Pakan, Pertumbuhan, Kelangsungan, Tengadak.

scholarly journals The effect of fertilisation with fermented pig slurry on the quantitative and qualitative parameters of tomatoes (Solanum lycopersicum)

2009 ◽  
Vol 4 (No. 3) ◽  
pp. 116-121 ◽  
Author(s):  
L. Kouřimská ◽  
L. Babička ◽  
K. Václavíková ◽  
D. Miholová ◽  
Z. Pacáková ◽  
...  
Keyword(s):  
Vitamin C ◽  
Significant Influence ◽  
Dry Matter ◽  
Titratable Acidity ◽  
Matter Content ◽  
Dry Matter Content ◽  
Pig Slurry ◽  
Suitable Alternative ◽  
Organic Fertiliser ◽  
C 50

The effect of fertilisation with fermented pig slurry on the quantitative and qualitative parameters of two kinds of tomatoes was assessed by means of pot trials. These trials were carried out between the years 2005 and 2008. Each trial involved four treatments, namely (a) control without fertilisation, (b) fertilisation with mineral fertilisers, (c) 50% nutrients in mineral fertilisers and 50% in fermented pig slurry, and (d) fertilisation with fermented pig slurry only. Besides the yield parameters, the following characteristics were monitored: dry matter content, vitamin C content, titratable acidity, nitrogen compounds, nitrates and selected elements (Pb, Cd, As, Zn and Hg) contents. The fertilisation method showed no statistically significant influence on many parameters (titratable acidity, Hg, As, dry matter, vitamin C and nitrates contents). These results showed that anaerobically fermented pig slurry can be a suitable alternative to the use of mineral fertiliser. They also showed that its use as an organic fertiliser did not impair the hygienic quality and safety of the vegetable products grown, as all tomato samples fulfilled the tested heavy metals and nitrates legislation limits. The fertilisation method showed a statistically significant influence on the yield. Diffe-rences occurred between the organic and mineral methods in the case of Cd, and between non-fertilised and organic methods in the case of Zn. The fertilisation method also significantly influenced N-compounds content in tomatoes. A statistically significant influence of the year was found with all parameters except zinc and vitamin C contents. The influence of cultivar was also found, but only in the case of zinc and dry matter contents.

scholarly journals MENURUNKAN INFLAMASI PASIEN SLE DAN GIZI BURUK DENGAN SUPLEMENTASI MIKRONUTRIEN

2018 ◽  
Vol 1 (1) ◽  
pp. 80-89
Author(s):  
Mia Miranda ◽  
Haerani Rasyid ◽  
Agussalim Bukhari ◽  
Aryanti R. Bamahry
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin C ◽  
Fish Oil ◽  
Olive Oil ◽  
Vitamin D3 ◽  
Lupus Erythematosus ◽  
Vitamin B6 ◽  
Hydrogen Phosphate ◽  
Systemic Lupus ◽  
C 50

Latar Belakang Lupus eritematosus sistemik (Systemic Lupus Erythematosus)(SLE) merupakan penyakit inflamasi autoimun kronis dengan etiologi yang belum diketahui serta manifestasi klinis. Laporan Kasus Nn.M, Perempuan, 20 Tahun dikonsul dengan bagian penyakit bagian Interna divisi Ginjal Hipertensi untuk evaluasi dan penatalaksanaan gizi serta rawat bersama dengan diagnosis medis Sistemik Lupus Eritematosus dan anoreksia Asupan makan berkurang dialami sejak 2 minggu yang lalu karena tidak ada nafsu makan. Mual ada setiap kali makan, muntah tidak ada, nyeri ulu hati ada, demam tidak ada, riwayat demam ada terutama malam hari, badan lemas,tidak mampu berdiri maupun duduk sendiri, batuk ada sejak 2 minggu, lendir ada. Penurunan berat badan ada ±4 kg dalam 2 minggu(BB dulu 35 kg). Asupan 24 jam 97,5 kkal. Pasien didiagnosis dengan status gizi buruk, status metabolik anemia (Hb 6,2 g/dl), deplesi berat sistem imun (TLC 400/uL), Hipertrigliseridemia 236 mg/dl, risiko refeeding, hipoalbumin berat 2.2 g/dl dan status gastrointestinal fungsional. Penatalaksanaan nutrisi dengan target awal energi 2000 kkal, oleh karena pasien dengan resiko refeeding maka dilakukan penatalaksanaan nutrisi 10-15 kkal/hari selama 3 hari  dengan pemberian thiamin 300 mg/hari serta perbaikan kadar kalium darah. Setelah terlewati 3 hari , nutrisi dinaikkan sesuai toleransi pasien sampai 2500 kkal dengan komposisi protein 2 gr/kg BBI/hari(16%), karbohidrat 60%, lemak 24% melalui oral berupa makanan lunak sesuai toleransi, formula nutrican, jus buah tinggi kalium, madu,  dan olive oil, zink 20 mg/24 jam, Ca hydrogen phosphate 400 mg, Ca laktat 200 mg, Vitamin B6 40 mg, Vitamin C 50 mg, Vitamin D3 200 IU, fish oil(EPA) 2000 mg/24 jam, ekstrak ikan gabus 3 kapsul/8 jam. Setelah 15 hari perawatan, status gizi buruk dengan perbaikan pasien secara klinis(IMT 14,5 kg/m2), hemoglobin 10.7 g/dl, deplesi berat sistem imun (TLC 600/uL), hipoalbumin ringan 3.1 gr/dL. Kesimpulan Dukungan nutrisi optimal dapat membantu untuk mengendalikan inflamasi yang ditemukan akibat penyakit SLE dan komplikasi yang disebabkan efek samping pengobatan.

Teor de Vitamina C em Farinha da Casca, Polpa e Semente de Mamão (Carica papaya) Submetidas a Diferentes Temperaturas de Secagem

UNICIÊNCIAS ◽  
2019 ◽  
Vol 22 (3Esp) ◽  
pp. 43
Author(s):  
Alessandra Cristina Tome ◽  
Bianca Ferreira Augustinha
Keyword(s):  
Vitamin C ◽  
Carica Papaya ◽  
Maturation Stage ◽  
Local Market ◽  
Physical Damage ◽  
Fruit Peel ◽  
Drying Time ◽  
Different Temperatures ◽  
C 50 ◽  
Calcium Iron

O mamão é um dos mais importantes frutos tropicais atualmente cultivados no país e no mundo, apresentando uma excelente fonte de vitaminas A e C, fósforo, cálcio, ferro e potássio, entre outros.  Apenas a polpa do mamão é geralmente consumida, o restante do fruto, casca e sementes, na maioria das vezes é rejeitado. Esses subprodutos podem ser úteis como elementos para estudos e suas utilizações alternativas, tendo como base as características químicas. Dessa forma, este trabalho foi realizado com o objetivo de avaliar o efeito de diferentes temperaturas de secagem no teor de vitamina C em farinha da casca, polpa e semente de mamão (Carica papaya). Os frutos foram adquiridos no mercado local da cidade de Morrinhos-Go, transportados para o laboratório e selecionados quanto ao estádio de maturação e danos físicos, foi aplicada a lavagem com posterior sanitização. O preparo da farinha foi realizado em diferentes temperaturas, 40 °C, 50 ºC e 60 °C por meio de secagem em estufa com circulação de ar. A determinação de vitamina C foi realizada pelo do método titulométrico com iodato de potássio. Nas amostras com aplicação de secagem a 60 ºC, a degradação da vitamina C foi relativamente maior quando comparadas às amostras secas a 40 ºC, as polpas de mamão secas a 40 ºC apresentaram menores teores de vitamina C, quando comparados aos resultados obtidos na aplicação de temperatura de secagem a 50 ºC, inferindo assim que o tempo e a temperatura de secagem influenciaram na degradação do teor de vitamina C. Palavras chave: Carica papaya. Secagem. Farinha. Vitamina C. AbstractPapaya is one of the most important tropical fruits currently cultivated in the country and in the world, presenting an excellent source of vitamins A and C, phosphorus, calcium, iron and potassium among others and fibers. Only the pulp of papaya is usually consumed, the rest of the fruit, peel and seeds, most of the time it is rejected. Such by-products may be useful as elements for studies and their alternative uses, based on the chemical characteristics. The goal of this study was to evaluate the effect of different drying temperatures on the content of vitamin C in the peel, pulp and seed from papaya (Carica papaya). The fruits were purchased in the local market of the city of Morrinhos-Go, transported to the laboratory and selected for maturation stage and physical damage, washing was applied with subsequent sanitization. Flour preparation was performed at different temperatures, 40 °C, 50 °C and 60 °C by drying in an air circulation oven. The determination of vitamin C was carried out using the titration method with potassium iodate. In the samples with drying application at 60 °C, the vitamin C degradation was relatively higher when compared to the dry samples at 40 ° C, the dried papaya pulps at 40 °C presented lower vitamin C contents when compared to the results obtained in the application of drying temperature at 50 °C, thus inferring that the drying time and temperature influenced the degradation of the vitamin C content. Keywords: Carica papaya. Drying. Flour. Vitamin C.

scholarly journals Effect of Co Enzyme Q10 Alone or in Combination with Vitamin C on Lipopolysaccharide-Induced Brain Injury in Rats

2018 ◽  
Vol 11 (3) ◽  
pp. 1215-1226
Author(s):  
Nabila A. El-Laithy ◽  
Elsayed M.E. Mahdy ◽  
Eman R. Youness ◽  
Nermeen Shafee ◽  
Mohamed S.S. Mowafy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Brain Tissue ◽  
Paraoxonase 1 ◽  
Intraperitoneal Dose ◽  
High Doses ◽  
C 50 ◽  
Histopathological Results ◽  
The Impact

Our was to determine the impact of CoenzymeQ10 (Co Q10) and vitamin C alone or in combination on oxidative stress in brain tissue of rats during endotoxemia induced by single intraperitoneal dose of Lipopolysaccharide (LPS), 500µg/kg. Both CoQ10&vitamin C were given orally to rats with doses (200&100 mg/kg) respectively for 7successive days prior induction of endotoxemia .LPS injected, with Co Q10 with doses (100 &200 mg/kg) &vit. C (50&100 mg/kg).In addition CoQ10 and vitamin C together in doses (100&50 mg/kg) & (200&100 mg/kg) respectively were added to LPS-treated rats. Then euthanized 4 hours later. Histopathological assessment of brain tissue was done. Results: LPS injection induced oxidative stress in brain tissue, resulting in marked increase in malondiadehyde (MDA), nitrite (NO) and Amyloid beta (Aβ), while decreasing reduced glutathione (GSH), paraoxonase-1 (PON1) and brain derived neurotrophic factor (BDNF).CoQ10 and vit.C administration with doses(200&100 mg/ kg) before endotoxemia result in reduction of brain MDA, NO and Aβ, while increasing levels of GSH, PON1 and BDNF compared to controls. The addition of both Co Q10 &vit.C to LPS- treated rats lead to decrease of brain NO, MDA and Aβ, also increase of GSH, PON1 and BDNF. This effect was more obviouswith high doses, this due to the ameliorating effect of both CoQ10 and vit.C on oxidative stress of brain tissue during endotoxemia.This consisted with the histopathological results. Conclusion: this work focuses on the possible role of CoQ10 &vit.C as antioxidants in protecting brain tissue.

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