scholarly journals Prospective selected biomarkers in COVID-19 diagnosis and treatment

2021 ◽  
Author(s):  
Tahani Tabassum ◽  
Ahsab Rahman ◽  
Yusha Araf ◽  
Md A Ullah ◽  
Mohammad J Hosen
Keyword(s):  
Early Diagnosis ◽  
Risk Groups ◽  
Viral Pathogenesis ◽  
Health Concern ◽  
Effective Strategy ◽  
Proper Treatment ◽  
Pulmonary Infections ◽  
Disease Prognosis ◽  
Proper Diagnosis

COVID-19 has become a global health concern, due to the high transmissible nature of its causal agent and lack of proper treatment. Early diagnosis and nonspecific medical supports of the patients appeared to be effective strategy so far to combat the pandemic caused by COVID-19 outbreak. Biomarkers can play pivotal roles in timely and proper diagnosis of COVID-19 patients, as well as for distinguishing them from other pulmonary infections. Besides, biomarkers can help in reducing the rate of mortality and evaluating viral pathogenesis with disease prognosis. This article intends to provide a broader overview of the roles and uses of different biomarkers in the early diagnosis of COVID-19, as well as in the classification of COVID-19 patients into multiple risk groups.

Foregut Cysts in Infants and Children

1982 ◽  
Vol 91 (6) ◽  
pp. 622-627 ◽  
Author(s):  
Seymour R. Cohen ◽  
Kenneth A. Geller ◽  
Jeffrey W. Birns ◽  
Jerome W. Thompson ◽  
Bert W. Meyer ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Early Diagnosis ◽  
Tracheobronchial Tree ◽  
Disease Entity ◽  
Pathologic Findings ◽  
Life Threatening ◽  
Proper Diagnosis ◽  
Cervical Area ◽  
In Infants And Children

The charts of 15 patients with foregut cysts were reviewed. The lesions were intrathoracic in 14 patients and in the cervical area in one child. The importance of early diagnosis and surgical management is stressed. In untreated infants with foregut cysts, severe progressive and life-threatening airway obstruction may develop. Since the symptoms of this congenital lesion may simulate other more common diseases of the tracheobronchial tree and esophagus, the physician should become familiar with this disease entity so that proper diagnosis and surgical treatment will not be delayed. The study includes symptomatology, methods of diagnosis, pathologic findings and classification of the cysts.

TRACHEAL AND BRONCHIAL ADENOMAS IN CHILDHOOD

PEDIATRICS ◽  
1961 ◽  
Vol 28 (3) ◽  
pp. 394-398
Author(s):  
Wilson Weisel ◽  
Derward Lepley
Keyword(s):  
Early Diagnosis ◽  
Respiratory Tract ◽  
Lung Tissue ◽  
Correct Diagnosis ◽  
Surgical Excision ◽  
Proper Treatment ◽  
Pulmonary Infections ◽  
Case Histories ◽  
Made In

Case histories of three patients are reported, in whom adenomas of the respiratory tract produced dangerous prolonged morbidity in children before correct diagnosis was made. In all children with ususual wheezing disorders or recurrent pulmonary infections, the possible diagnosis of adenoma should be entertained. The proper treatment of adenomas of the respiratory tract in children is surgical excision of the tumor and of the permanently damaged lung tissue. Early diagnosis will reduce the incidence of pulmonary destruction and the possibility of metastasis.

ANALYSIS OF PLANT FRAGARIA XANANASSA DISEASE DIAGNOSES USING PRODUCTION RULES BASE ON EXPERT SYSTEM

2020 ◽  
Vol 16 (1) ◽  
pp. 25-32
Author(s):  
Basiroh Basiroh ◽  
Wiji Lestari
Keyword(s):  
Expert System ◽  
Early Diagnosis ◽  
General Public ◽  
Insect Pests ◽  
Fruit Rot ◽  
Proper Treatment ◽  
Harvest Time ◽  
Production Rules

Errors that occur in solving problems in strawberry plants (Fragaria Xananassa) such as the presence of leaf patches, fruit rot, perforated leaves, and insect pests can be the cause of not maximum in harvest time. The farmers and the general public who planted strawberry (Fragaria Xananassa) need to know the proper treatment of diseases and pests so that future yields as expected. Therefore, it takes an application as a solution in the delivery of information related to the problems that are often encountered in strawberry plants (Fragaria Xananassa). Methods of production rules can be used to diagnose the disease strawberry (Fragaria Xananassa) based on signs or symptoms that occur in the parts of plants and strawberry, the results of diagnosis using this method are the same as we do Consultation on experts.  The purpose of this study was to determine the early diagnosis of disease in strawberry plants (Fragaria Xananassa) based on signs or symptoms that occur in the plant and fruit parts. The results of the analysis of this study showed that the validation of disease and symptom data in strawberry plants (Fragaria Xananassa) reached 99%, meaning that between the data of symptoms and disease understudy the accuracy was guaranteed with the experts.

PROSPECTS OF ARTIFICIAL INTELLIGENCE IN CARRYING OUT THE ONCOLOGICAL COMPONENT OF MEDICAL EXAMINATION OF THE POPULATION

2019 ◽  
Vol 65 (2) ◽  
pp. 234-237
Author(s):  
Vyacheslav Cherenkov ◽  
A. Petrov ◽  
I. Gulkov ◽  
A. Kostyukov
Keyword(s):  
Artificial Intelligence ◽  
Early Diagnosis ◽  
Mass Screening ◽  
Malignant Tumors ◽  
Risk Groups ◽  
Modern World ◽  
Pilot Program ◽  
Urgent Problem ◽  
Gender And Age ◽  
Group Version

Diagnosis of malignant tumors is an urgent problem of the modern world. Early diagnosis depends on General practitioners. The doctor should conduct a systematic examination of the patient regularly, taking into account the risk groups, gender and age. With mass screening, signs of dysplasia or an early focus, developing cancer can «slip away» [1]. Optimization of analysis and examination algorithms is required, which is not always possible for one person. Positive application of the digital program with elements of imaging in Oncology, we were able to create such a class of tasks for the preliminary subjective-objective survey of patients in three versions: with a widescreen screen and consoles for patients (group version up to 15 or more patients), interactive (touch) and tablet. The results of the survey are sent through the accepted channels to the doctor with recommendations for further examination, and the patient is given a coupon. The pilot program showed that the system of such robotic technologies in the future can replace the oncologist in its development to artificial intelligence at the stage of the primary link.

scholarly journals Preventing corneal blindness caused by keratitis using artificial intelligence

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhongwen Li ◽  
Jiewei Jiang ◽  
Kuan Chen ◽  
Qianqian Chen ◽  
Qinxiang Zheng ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Vision Loss ◽  
Learning System ◽  
Automated Classification ◽  
Slit Lamp ◽  
Resource Limited ◽  
The World ◽  
Different Types ◽  
Corneal Blindness

AbstractKeratitis is the main cause of corneal blindness worldwide. Most vision loss caused by keratitis can be avoidable via early detection and treatment. The diagnosis of keratitis often requires skilled ophthalmologists. However, the world is short of ophthalmologists, especially in resource-limited settings, making the early diagnosis of keratitis challenging. Here, we develop a deep learning system for the automated classification of keratitis, other cornea abnormalities, and normal cornea based on 6,567 slit-lamp images. Our system exhibits remarkable performance in cornea images captured by the different types of digital slit lamp cameras and a smartphone with the super macro mode (all AUCs>0.96). The comparable sensitivity and specificity in keratitis detection are observed between the system and experienced cornea specialists. Our system has the potential to be applied to both digital slit lamp cameras and smartphones to promote the early diagnosis and treatment of keratitis, preventing the corneal blindness caused by keratitis.

scholarly journals Epidemiological factors associated with recent HIV infection among newly-diagnosed cases in Singapore, 2013–2017

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Wei Ang ◽  
Carmen Low ◽  
Chen Seong Wong ◽  
Irving Charles Boudville ◽  
Matthias Paul Han Sim Toh ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Hiv Infection ◽  
Hiv Transmission ◽  
Risk Groups ◽  
Newly Diagnosed ◽  
Hiv Diagnosis ◽  
Factors Associated ◽  
Epidemiological Factors ◽  
Voluntary Testing ◽  
Recent Hiv Infection

AbstractBackgroundEarly diagnosis is crucial in securing optimal outcomes in the HIV care cascade. Recent HIV infection (RHI) serves as an indicator of early detection in the course of HIV infection. Surveillance of RHI is important in uncovering at-risk groups in which HIV transmission is ongoing. The study objectives are to estimate the proportion of RHI among persons newly-diagnosed in 2013–2017, and to elucidate epidemiological factors associated with RHI in Singapore.MethodsAs part of the National HIV Molecular Surveillance Programme, residual plasma samples of treatment-naïve HIV-1 positive individuals were tested using the biotinylated peptide-capture enzyme immunoassay with a cutoff of normalized optical density ≤ 0.8 for evidence of RHI. A recent infection testing algorithm was applied for the classification of RHI. We identified risk factors associated with RHI using logistic regression analyses.ResultsA total of 701 newly-diagnosed HIV-infected persons were included in the study. The median age at HIV diagnosis was 38 years (interquartile range, 28–51). The majority were men (94.2%), and sexual route was the predominant mode of HIV transmission (98.3%). Overall, 133/701 (19.0, 95% confidence interval [CI] 16.2–22.0%) were classified as RHI. The proportions of RHI in 2015 (31.1%) and 2017 (31.0%) were significantly higher than in 2014 (11.2%). A significantly higher proportion of men having sex with men (23.4, 95% CI 19.6–27.6%) had RHI compared with heterosexual men (11.1, 95% CI 7.6–15.9%). Independent factors associated with RHI were: age 15–24 years (adjusted odds ratio [aOR] 4.18, 95% CI 1.69–10.31) compared with ≥55 years; HIV diagnosis in 2015 (aOR 2.36, 95% CI 1.25–4.46) and 2017 (aOR 2.52, 95% CI 1.32–4.80) compared with 2013–2014; detection via voluntary testing (aOR 1.91, 95% CI 1.07–3.43) compared with medical care; and self-reported history of HIV test(s) prior to diagnosis (aOR 1.72, 95% CI 1.06–2.81).ConclusionAlthough there appears to be an increasing trend towards early diagnosis, persons with RHI remain a minority in Singapore. The strong associations observed between modifiable behaviors (voluntary testing and HIV testing history) and RHI highlight the importance of increasing the accessibility to HIV testing for at-risk groups.

scholarly journals Classification of cesarean section through Robson criteria: an emerging concept to audit the increasing cesarean section rate

2018 ◽  
Vol 7 (11) ◽  
pp. 4674
Author(s):  
Anita Kant ◽  
Shweta Mendiratta
Keyword(s):  
Cesarean Section ◽  
Sedentary Lifestyle ◽  
Health Concern ◽  
Vaginal Birth After Cesarean ◽  
Public Health Concern ◽  
Cesarean Deliveries ◽  
Poor Tolerance ◽  
Group 5 ◽  
The Cost

Background: There has been an increase in rate of cesarean section over last five decades. This is a matter of international public health concern as it increases the cesarean section related maternal morbidity. The aim of the present study was to audit the increasing rate of caesarean section.Methods: In the present study, all cases delivered by cesarean section during the period of six months were recorded and classified according to Robson's 10 group classification system. This was an attempt to see which clinically relevant groups contributed most to the cesarean deliveries.Results: There was a trend of increased percentage of cesarean section in group 5 and 2 respectively in present study. Increasingly sedentary lifestyle and poor tolerance to pain are adding to cesarean delivery on maternal request.Conclusions: We should judiciously make use of vaginal birth after cesarean section but not at the cost of maternal or fetal health. Standardization of indication of cesarean deliveries, regular audits and definite protocols in                                                                                                                                                                                                                                                                                                                                 hospital will aid in curbing the rate of cesarean deliveries in hospitals.

scholarly journals A57 THE USE AND INTERPRETATION OF HLA-DQ2/DQ8 GENOTYPING BY PEDIATRIC GASTROENTEROLOGISTS

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 14-15
Author(s):  
B Moreau ◽  
E Robidoux
Keyword(s):  
Risk Groups ◽  
Risk Classification ◽  
Low Risk ◽  
Risk Alleles ◽  
Seronegative Patient ◽  
Espghan Guidelines ◽  
Recent Classification ◽  
American Society ◽  
Hla Dq2

Abstract Background A recent classification of high and low risk alleles associated with celiac disease (CD) shows that the presence of a single allele (DQA1*05 or DQB1*02; coding together for HLA-DQ2), without a positive genotype (HLA-DQ2 and or HLA-DQ8), represents a risk of developing the disease. Aims The aim of this study is to evaluate the use and interpretation of the HLA-DQ2/DQ8 genotyping by pediatric gastroenterologists, as there is no study on the matter and the latest guidelines do not address this risk classification. Methods A web-based survey was sent by email to all NASPGHAN (North American society of pediatric gastroenterolgy, hepatology and nutrition) members. Results Results 294 pediatric gastroenterologists sent a complete survey. 86,1% use the HLA-DQ2/DQ8 genotyping according mainly to the NASPGHAN and ESPGHAN guidelines. The main indications considered were to exclude CD in a patient on a gluten-free diet with a resolution of his symptoms and in a seronegative patient with equivocal biopsies. A minority would consider the genotyping for screening high risk groups or for making a diagnosis in children with high specific CD antibodies and strong clinical suspicion without performing biopsies, as suggested by the ESPGHAN guidelines. The alleles associated with CD are not well known, but 76,7% the participants are aware of the risk classification. While only 62,8% have access to the complete genotype, 47,8% consider it useful. Nevertheless, 82,6% would still want to know the presence of a low risk allele. Conclusions The risk classification of alleles related to CD warrants a modification of the genotyping result with access to the alleles and an adaptation of the guidelines. Funding Agencies None

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