scholarly journals Antitoxic, Antifungal and Phytochemical Analysis of Medicinal Compounds of Guiera senegalensis Leaves

2020 ◽  
Vol 10 (2) ◽  
pp. 148-152
Author(s):  
Z.M. Anka ◽  
Vijender Singh ◽  
S.N. Gimba ◽  
Gunjan Singh
Keyword(s):  
Antifungal Activity ◽  
Phytochemical Analysis ◽  
Desert Area ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Chemical Substances ◽  
Western Africa ◽  
Traditional Medicinal Plants ◽  
The World ◽  
Guiera Senegalensis

Millions of people in the world depend on traditional medicinal plants for treatment of many diseases.  They have curative properties due to presence of various complex chemical substances of different composition, which are found as secondary plant metabolites in one or more parts of these plants. These plant metabolites according to their composition are grouped as flavonoids, tannins, alkaloids, saponins etc. Guiera senegalensis(Gs), which grows in abundance in semi-desert area of Western Africa such as Nigeria, has been used for treating specific diseases and wounds. The study is carried out to investigate the phytochemical analysis, toxicity, and the antifungal activity of Gs leaves extract. Keywords: Guiera senegalensis, Antifungal activity, Brine shrimp, toxicity, phytochemical analysis;

scholarly journals Bioactive Plant Compounds in Coffee Charcoal (Coffeae carbo) Extract Inhibit Cytokine Release from Activated Human THP-1 Macrophages

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4263 ◽  
Author(s):  
Weber ◽  
Hammoud Mahdi ◽  
Jankuhn ◽  
Lipowicz ◽  
Vissiennon
Keyword(s):  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Inflammatory Diseases ◽  
Cytokine Signaling ◽  
Phytochemical Analysis ◽  
Inhibitory Effects ◽  
Plant Metabolites ◽  
Electron Microscopic ◽  
Secondary Plant Metabolites ◽  
Secondary Plant

The herbal preparation coffee charcoal is produced by over-roasting and milling green dried Coffea arabica L. seeds, and has a long-standing tradition in the treatment of inflammatory and gastrointestinal disorders. Its therapeutic properties are commonly attributed to adsorptive and astringent effects. This insufficiently explains its mode of action, especially when used in the treatment of inflammatory diseases in lower dosages. Our investigations aimed to identify bioactive secondary plant metabolites affecting cytokine-signaling. Thus, a phytochemical analysis of coffee charcoal extract was conducted using HPLC and LC/MS. Trigonelline, neochlorogenic acid, chlorogenic acid, caffeine, cryptochlorogenic acid, feruloylquinic acid isomers, and a caffeoylquinolacton were identified in the extract. Subsequently, the effects of coffee charcoal extract, chlorogenic acid isomers, their metabolite caffeic acid, caffeine, and trigonelline on cytokine (TNF, IL-6, MCP-1) release from LPS-challenged human THP-1 macrophages were examined to evaluate anti-inflammatory activity. Coffee charcoal showed concentration-dependent mild-to-medium inhibitory effects. The chlorogenic acid isomers and caffeic acid inhibited the TNF release, with cryptochlorogenic acid exerting the most distinct effects, as well as decreasing the release of IL-6 and MCP-1. In addition, scanning electron microscopic images provided an impression of the particle constitution, indicating a larger particle size and less structured surface of coffee charcoal in comparison to activated charcoal. In conclusion, our findings underline that beyond adsorptive effects, coffee charcoal exhibits pharmacological properties, which derive from a spectrum of secondary plant metabolites and support the therapeutic use in inflammatory diseases. Chlorogenic acids, particularly cryptochlorogenic acid, appear as pivotal bioactive compounds.

Revisiting the antiviral efficacy of terpenoids: Plausible adjunct therapeutics for novel SARS-CoV-2?

2021 ◽  
Vol 21 ◽  
Author(s):  
Afza Ahmad ◽  
Rohit Kumar Tiwari ◽  
Irfan Ahmad Ansari
Keyword(s):  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Scientific Literature ◽  
Bioactive Constituents ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Chemical Structures ◽  
Antiviral Efficacy ◽  
The World ◽  
History Of

: Presently the world is witnessing most devastating pandemic in the history of mankind caused due to Severe Acute Respiratory Syndrome or SARS-CoV-2. This dreaded pandemic is responsible for escalated mortality rate across the globe and thus is the worst catastrophes in the history of mankind. Since its outbreak, substantial scientific explorations focusing on formulation of novel therapeutical and/or adjunct intervention against the disease are continuously in pipeline. However, till date no effective therapy has been approved and hence the present alarming situation urges the necessity of exploring novel, safe and efficient interventional strategies. Functionally, terpenoids are a class of secondary plant metabolites having multi facet chemical structures and are categorically documented to be the largest reservoir of bioactive constituents, predominant in nature. Intriguingly, very little is scientifically explored or reviewed in regards with the anti-CoV-2 attributes of terpenoids. The present article thus aims to revisit the antiviral efficacy of terpenoids by reviewing the current scientific literature and thereby provide an opinion on the plausibility of exploring them as potential therapeutical intervention to deal with ongoing CoV-2 pandemic.

Larvicidal Activity of Secondary Plant Metabolites in Aedes aegypti Control: An Overview of the Previous 6 Years

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986289
Author(s):  
Aline Camargo Jesus de Souza Wuillda ◽  
Roberto Carlos Campos Martins ◽  
Fernanda das Neves Costa
Keyword(s):  
Aedes Aegypti ◽  
Mechanisms Of Action ◽  
World Population ◽  
Plant Metabolites ◽  
Resistance Development ◽  
Natural Sources ◽  
Secondary Plant Metabolites ◽  
Structure Activity ◽  
The World ◽  
Continuous Application

Aedes aegypti is the main transmitter of several arboviruses, mainly dengue. It occurs, recently, in more than 100 countries and majority of the world population lives in areas of mosquito incidence, marking its control relevant and necessary. Presently, the main form of vector control is the use of synthetic insecticides; however, its continuous application has led to inefficiency due to resistance development. Based on this fact, the insecticides from natural sources appear as a friendly alternative for man and the environment. This study provides an overview of the larvicidal compounds isolated from plant extracts while controlling A. aegypti, in the previous 6 years (2013-2018), and aims to impart more knowledge regarding the described metabolites and to encourage the search for new bioactive compounds. In addition, the proposals for mechanisms of action and structure-activity relationships that may justify the larvicidal potential are also discussed.

scholarly journals Diversity Analysis of Arabidopsis thaliana (L.) Heynh Ecotypes for Glucosinolates in Shoots and Seeds

HortScience ◽  
2011 ◽  
Vol 46 (7) ◽  
pp. 968-974 ◽  
Author(s):  
Dilip R. Panthee ◽  
Dean A. Kopsell ◽  
Carl E. Sams
Keyword(s):  
Arabidopsis Thaliana ◽  
Genetic Variation ◽  
Dry Weight ◽  
Geographic Area ◽  
Genotypic Differences ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
The World ◽  
Large Geographical Region ◽  
Total Seed

Glucosinolates (GS) are important secondary plant metabolites present in several plant species, including Arabidopsis thaliana (L.) Heynh. Although genotypic differences among a limited number of samples from a limited geographical range have been reported, there have been few studies exploring the variation from a wider genetic base. The objective of this study was to explore the genetic variation for GS in A. thaliana collected throughout the world. We screened 58 A. thaliana ecotypes collected from the geographic area of lat. 15° N to lat. 59° N and long. 137° E to long. 123° W. Elevation in these areas ranged from sea level to over 480 m. We believe that this study has covered a large geographical region and captured most of the available genetic variation in A. thaliana for GS. There was no geographical trend in A. thaliana shoot or seed tissue for GS concentration. Total shoot GS ranged from 1.1 to 52.8 μmol·g−1 dry weight (DW), averaging 9.3 μmol·g−1 DW among all ecotypes. Total seed GS ranged from 1.6 to 41.8 μmol·g−1 DW with an average of 16.8 μmol·g−1 DW among all ecotypes. Low and high GS-accumulating A. thaliana ecotypes identified in this study may provide a basis for further genetic analysis for GS metabolism. Information provided may also prove useful for improving concentrations of nutritionally beneficial GS in vegetable Brassicas.

Preliminary Phytochemical Analysis and Wound Healing Activity from the Leaves of Cocculus hirsutus Diels

2009 ◽  
Vol 2 (3) ◽  
pp. 675-678 ◽  
Author(s):  
Panda Bikash Ranjan ◽  
Mohanta S.R ◽  
Sii S. ◽  
Das G. K.
Keyword(s):  
Wound Healing ◽  
Petroleum Ether ◽  
Methanol Extract ◽  
Traditional Healers ◽  
Phytochemical Analysis ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Scientific Support ◽  
Cocculus Hirsutus ◽  
Wound Healing Activity

In qualitative phytochemical analysis of petroleum ether, chloroform and methanol extracts of the leaves of Cocculus hirsutus Diels, the important secondary plant metabolites detected are Carbohydrates, Steroids, Glycosides, Tannins, Saponins and Flavonoids. The methanol extract and fresh leaves juice are subjected to wound healing activity in incision and excision wound models taking Soframycin sulphate as standard. The results revealed that the methanol extract ointment 10%w/w has highest wound healing potency among the test groups and is comparable with the standard and thus the results offer a scientific support to the treatment of traditional healers of this region.

scholarly journals Phyto-pharmacological and safety reports of Khaya senegalensis (Desr) A Juss (Meliaceae), an important multifunctional tropical forest plant

2021 ◽  
Vol 01 (01) ◽  
pp. 28-43
Author(s):  
Dauda Muhammed ◽  
Ovaiyoza Blessing Adaaja ◽  
Iyaji Godwin Otiwa ◽  
Yuyu Ezekiel Zaman ◽  
Olayinka Ezekiel Oloyede
Keyword(s):  
Therapeutic Agent ◽  
Plant Metabolites ◽  
Detailed Report ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Secondary Plant Metabolites ◽  
Chemical Substances ◽  
Complex Chemical ◽  
The Family ◽  
Khaya Senegalensis

Medicinal plants have curative properties due to the presence of various complex chemical substances of different compositions, which are found as secondary plant metabolites in one or more parts of these plants. Khaya senegalensis (Desr) A Juss is a popular medicinal plant among the Nupes and Yorubas in Nigeria. It belongs to the family Meliaceae (mahogany) and has been reported by several works for its usefulness in the treatment of various diseases. The plant has been studied for its various pharmacological activities like antioxidant, antibacterial, antifungal, antiprotozoal, anticancer, hypoglycemic, and antiparasitic properties. A scrutiny of the literature reveals some notable pharmacological activities of the plant. The phytochemistry and pharmacology of this plant necessitate a comprehensive review of its prospects as an important therapeutic agent for the management of numerous diseases commonly affecting humans. The present review provides a detailed report of the phytochemical, pharmacological, and toxicological properties carried out on this plant and also throws light on its therapeutic prospects

scholarly journals Phytochemical Analysis of Selected Indigenous Medicinal Plants in Quirino Province, Cagayan Valley, Philippines

2021 ◽  
Vol 9 (VII) ◽  
pp. 1382-1386
Author(s):  
Annalene Grace E. Co
Keyword(s):  
Phenolic Compounds ◽  
Medicinal Plants ◽  
Essential Role ◽  
Phytochemical Analysis ◽  
Bioactive Components ◽  
Plant Metabolites ◽  
Indigenous Plants ◽  
Secondary Plant Metabolites ◽  
Ethanolic Extracts

Medicinal plants have bioactive components which are used for curing various human diseases. They also play an essential role in healing. Fresh fruits and leaves of collected plant samples were used following standard solvent extraction protocol and qualitative analysis to detect secondary plant metabolites. The ethanolic extracts of eight indigenous medicinal plants of Quirino Province, Cagayan Valley, Philippines, were subjected to phytochemical analysis. Results confirmed alkaloids, saponins, phytosterols, phenolic compounds, and flavonoids in specific extracts. The inferences of the findings are discussed in light of the role of indigenous plants in the traditional medicinal system.

scholarly journals A Review Bioactive Components of Vigna mungo

2019 ◽  
Vol 9 (4-s) ◽  
pp. 748-754 ◽  
Author(s):  
Jeevan Suresh Dhumal ◽  
Sanjay R Chaudhari ◽  
Macchindra J Chavan
Keyword(s):  
Bioactive Compound ◽  
Relevant Information ◽  
Vigna Mungo ◽  
World Population ◽  
Bioactive Components ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Toxicological Effects ◽  
The World ◽  
Excellent Source

The bioactive compound is secondary plant metabolites eliciting pharmacological or toxicological effects in man and animals. Legumes are a valuable source of proteins and nutrients for the majority of the world population. Vigna mungo is one of the important legume crops extensively cultivated in India and other parts of the world. Pulses and legumes have been gaining interest because they are an excellent source of bioactive compounds. The objective of this present review is to compile all relevant information published regarding bioactive components from the Vigna mungo. Various bioactive components reported in Vigna mungo were found and it includes flavonoids, isoflavonoids, phytoestrogens, phenolic acids, enzymes, fibers, starches, trypsin inhibitors, phytic acid, lectins, saponins, tocopherols, fatty acids and proteins. This review clearly demonstrates that Vigna mungo is rich in bioactive components and these components are located in various organs of the plant.

General principle of primary and secondary plant metabolites: Biogenesis, metabolism, and extraction

2021 ◽  
pp. 3-23
Author(s):  
Charles Oluwaseun Adetunji ◽  
Santwana Palai ◽  
Chika Precious Ekwuabu ◽  
Chukwuebuka Egbuna ◽  
Juliana Bunmi Adetunji ◽  
...  
Keyword(s):  
General Principle ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Secondary Plant
Sign in / Sign up

Export Citation Format

Share Document