scholarly journals Phyto-pharmacological and safety reports of Khaya senegalensis (Desr) A Juss (Meliaceae), an important multifunctional tropical forest plant

2021 ◽  
Vol 01 (01) ◽  
pp. 28-43
Author(s):  
Dauda Muhammed ◽  
Ovaiyoza Blessing Adaaja ◽  
Iyaji Godwin Otiwa ◽  
Yuyu Ezekiel Zaman ◽  
Olayinka Ezekiel Oloyede
Keyword(s):  
Therapeutic Agent ◽  
Plant Metabolites ◽  
Detailed Report ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Secondary Plant Metabolites ◽  
Chemical Substances ◽  
Complex Chemical ◽  
The Family ◽  
Khaya Senegalensis

Medicinal plants have curative properties due to the presence of various complex chemical substances of different compositions, which are found as secondary plant metabolites in one or more parts of these plants. Khaya senegalensis (Desr) A Juss is a popular medicinal plant among the Nupes and Yorubas in Nigeria. It belongs to the family Meliaceae (mahogany) and has been reported by several works for its usefulness in the treatment of various diseases. The plant has been studied for its various pharmacological activities like antioxidant, antibacterial, antifungal, antiprotozoal, anticancer, hypoglycemic, and antiparasitic properties. A scrutiny of the literature reveals some notable pharmacological activities of the plant. The phytochemistry and pharmacology of this plant necessitate a comprehensive review of its prospects as an important therapeutic agent for the management of numerous diseases commonly affecting humans. The present review provides a detailed report of the phytochemical, pharmacological, and toxicological properties carried out on this plant and also throws light on its therapeutic prospects

scholarly journals Antitoxic, Antifungal and Phytochemical Analysis of Medicinal Compounds of Guiera senegalensis Leaves

2020 ◽  
Vol 10 (2) ◽  
pp. 148-152
Author(s):  
Z.M. Anka ◽  
Vijender Singh ◽  
S.N. Gimba ◽  
Gunjan Singh
Keyword(s):  
Antifungal Activity ◽  
Phytochemical Analysis ◽  
Desert Area ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Chemical Substances ◽  
Western Africa ◽  
Traditional Medicinal Plants ◽  
The World ◽  
Guiera Senegalensis

Millions of people in the world depend on traditional medicinal plants for treatment of many diseases.  They have curative properties due to presence of various complex chemical substances of different composition, which are found as secondary plant metabolites in one or more parts of these plants. These plant metabolites according to their composition are grouped as flavonoids, tannins, alkaloids, saponins etc. Guiera senegalensis(Gs), which grows in abundance in semi-desert area of Western Africa such as Nigeria, has been used for treating specific diseases and wounds. The study is carried out to investigate the phytochemical analysis, toxicity, and the antifungal activity of Gs leaves extract. Keywords: Guiera senegalensis, Antifungal activity, Brine shrimp, toxicity, phytochemical analysis;

scholarly journals Isolation and seasonal variation of fruticin in fruits of false indigo-bush (Amorpha fruticosa L. Fabaceae) from Serbia

2020 ◽  
pp. 52-56
Author(s):  
Stevan Samardžić ◽  
Aleksandra Tucović ◽  
Danilo Stojanović ◽  
Zoran Maksimović
Keyword(s):  
Optimal Time ◽  
Plant Metabolites ◽  
Pharmacological Activities ◽  
Secondary Plant Metabolites ◽  
Amorpha Fruticosa ◽  
External Standard Method ◽  
Partial Evaporation ◽  
Optimal Period ◽  
External Standard ◽  
Time Of Collection

Fruticin (amorphin) is a constituent of the fruit of the false indigo-bush (Amorpha fruticosa L.), which belongs to the class of rotenoid glycosides, and shows several interesting pharmacological activities. The aim of this study was to isolate and chemically characterize this natural product, as well as to determine the optimal period of the year for A. fruticosa fruits collection. Fruticin was obtained by re-crystallization of the precipitate that formed after partial evaporation of the extract, prepared by 3fold extraction of powdered plant material by chloroform - ethanol (1:1, v/v). The structure of the final product was determined by various techniques of instrumental analysis (NMR, UV and MS), and confirmed by comparing the obtained spectra with corresponding data in available literature. The content of fruticin in A. fruticosa fruit was determined by LC-DAD-MS, using the external standard method based on the constructed calibration curve. Limits of detection (LOD) and quantification (LOQ) were also determined. A substantial increase in fruticin content was observed during the ripening period (>50 %). It has also been established that the optimal time for fruit collection is mid-December. Obtained results indicate that the content of fruticin in the A. fruticosa fruit is highly dependable on the time of collection. Since the biosynthesis of secondary plant metabolites is influenced not only by the time of collection, but by numerous other factors as well, additional studies are needed to define, with greater certainty, the conditions that are necessary for design of prospective efficient and sustainable production process.

scholarly journals Rotula aquatica. Lour-A Review on Medicinal uses Phytochemistry and Pharmacological actions

2017 ◽  
Vol 5 (04) ◽  
pp. 04-09
Author(s):  
Baby T. Bency ◽  
K. Remya ◽  
Smitha Rani ◽  
Shebina P. Rasheed ◽  
A. K. Azeem
Keyword(s):  
Clinical Trials ◽  
Medicinal Herb ◽  
Therapeutic Effects ◽  
Preclinical Studies ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
The Family ◽  
Stream Beds ◽  
Anti Inflammatory

Rotula aquatic Lour is an important medicinal herb in Ayurvedic system of medicine. The plant occurs as a small branched shrub that grows characteristically among rocks and trailing over pebbles in stream beds, belonging to the family Boraginaceae and widely distributed throughout India. It is commonly called as Pasanabheda in Ayurveda. As only few studies are done on this plant, the comprehensive review presenting here will summarize regarding its Phytochemical and Pharmacological activities with the help of available and update information. Various studies indicated the antiurolithiatic, hypoglycemic, anti-inflammatory, antibacterial and anthelmintic properties of Rotula aquatica. Although the information are very encouraging and revealed some of the constituents of the plant like polyphenols and tannins as important therapeutically agents. The herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Various traditional claims of the plant are still remain to be validated scientifically. Clinical trials for the reported preclinical studies should be performed urgently to further validate the claims on humans

Therapeutic Potential of Cinnoline Core: A Comprehensive Review

2020 ◽  
Vol 20 (3) ◽  
pp. 196-218
Author(s):  
Rajiv K. Tonk ◽  
Sandhya Bawa ◽  
Deepak Kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Present Review ◽  
Natural Occurrence ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Wide Range ◽  
The Family ◽  
Almost All

Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity through a number of research publications and patents during last few decades. A creative consideration has been rewarded to the synthesis of cinnoline based heterocyclic compounds, mostly due to their wide range of diverse pharmacological activities. The present review covers the principle approaches to the synthesis of cinnoline nucleus and almost all biological properties of 115 cinnoline derivatives reported during the last 65 years from natural and synthetic origin with 140 references.

scholarly journals DURANTA REPENS LINN. (VERBENACEAE): A COMPREHENSIVE REVIEW OF PHARMACOGNOSTIC, ETHNOMEDICINAL, PHARMACOLOGICAL, AND PHYTOCHEMICAL ASPECTS

2018 ◽  
Vol 11 (11) ◽  
pp. 91 ◽  
Author(s):  
Abhijeet V Puri
Keyword(s):  
Therapeutic Potential ◽  
Safety Data ◽  
Future Research ◽  
Pharmacological Activities ◽  
Scientific Publications ◽  
Comprehensive Review ◽  
Published Report ◽  
The Family ◽  
Therapeutic Properties ◽  
Source Of Information

Objective: This review is intended to investigate the published report regarding phytochemical, ethnomedicinal, and pharmacological activities and put forth the therapeutic potential of Duranta repens Linn. (D. repens). It belongs to the family Verbenaceae, one of the therapeutically important plants, broadly distributed all throughout the world. It is commonly referred as golden dewdrop, angel whisper, pigeon berry, or skyflower.Methods: I utilized logical writing and scientific literature regarding D. repens by referring search engine such as Springerlink, ScienceDirect, SciFinder, PubMed, Scopus, Google Scholar, and BioMed Central as well as relevant books, websites, scientific publications, and dissertations as a source of information that provided an up-to-date review. My work on morphology and extraction of various phytochemicals and their evaluation has helped to provide an insightful account of D. repens.Results: Phytochemical profiling of these species revealed the presence of some imperative phytochemicals such as alkaloids, flavonoids, glycosides, phenolics, saponins, steroids, tannins and terpenoids as the basis of its valuable therapeutic properties. The other imperative phytoconstituents which contribute to the therapeutic properties are durantol, repennoside, repenins, and scutellarein. The pharmacological activities exhibited by D. repens as antimicrobial, antioxidant, and insecticide properties are attributed to the presence of valuable bioactive phytoconstituents.Conclusion: Considering these facts, I endeavored to present a comprehensive review enlightening the phytochemistry and pharmacological activities of plant D. repens. Future research can be directed to an extensive investigation about phytochemistry, clinical trials, pharmacokinetics, and acquiring safety data so as to add new dimensions to the therapeutic utilization of D. repens and other Duranta species.

scholarly journals ETHNOPHARMACOLOGICAL STUDIES OF Polypodium vulgare Linn. : A COMPREHENSIVE REVIEW

2018 ◽  
Vol 8 (5) ◽  
pp. 73-76
Author(s):  
Afshan Khan ◽  
Aisha Siddiqui ◽  
M.A Jafri ◽  
Mohd Asif
Keyword(s):  
Medicinal Plant ◽  
Review Paper ◽  
Reducing Sugar ◽  
Organic Substances ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Unani Medicine ◽  
Inorganic Substances ◽  
The Family ◽  
Calcium Magnesium

Polypodium vulgare Linn. commonly called as Bisfaij is a medicinal plant which is used in various ailments. It is one of the most archaic and essential plant, belonging to the family Polypodiaceae. It contains organic substances such as resin, tannins, steroids, flavonoids, alkaloids, glycosides, protein, reducing sugar and inorganic substances like calcium, magnesium, potassium, sulphur, iron and chloride. It is used in Unani system of medicine for the treatment of sorethroat, stomach-aches, leprosy, melancholia, spleenomegaly, haemorrhoids, rheumatic swelling of the joints etc. Besides this, it has other pharmacological activities too such as antiepileptic, neuro-psychopharmacological, antipyretic, antibiotic, antiviral etc. This review paper discuses the medicinal values of Polypodium vulgare Linn. in Unani medicine as well as its modern pharmacology and gives a new impetus to utilize Bisfaij in various disorders. Keywords: Bisfaij, Polypodium vulgare Linn, Phytopharmacology, Unani Medicine.

A Comprehensive Review on the Therapeutic Versatility of Imidazo [2,1-b]thiazoles

2020 ◽  
Vol 27 (40) ◽  
pp. 6864-6887 ◽  
Author(s):  
Mohd Adil Shareef ◽  
Irfan Khan ◽  
Bathini Nagendra Babu ◽  
Ahmed Kamal
Keyword(s):  
Literature Review ◽  
Medicinal Chemistry ◽  
Therapeutic Agents ◽  
Present Review ◽  
Thiazole Derivatives ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Derivatives Of

Background:: Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents. Objective:: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness. Method:: Thorough literature review of all relevant papers and patents was conducted. Conclusion:: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

Phytochemical and Pharmacological Review on Two Herbs of Baijiangcao: Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss

2020 ◽  
Vol 17 (5) ◽  
pp. 496-517
Author(s):  
Yangcheng Liu ◽  
Wei Liu ◽  
Jiaqi Wang ◽  
Yang Liu ◽  
Changlan Chen ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Volatile Components ◽  
Research Papers ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Scientific Databases ◽  
The Past ◽  
Current State ◽  
Patrinia Scabiosaefolia ◽  
Antiviral Activities

Patrinia scabiosaefolia Fisch. Trev. and Patrinia villosa (Thunb.) Juss, are two species of Patrinia recorded in the Chinese Pharmacopoeia with the same Chinese name “Baijiangcao” and similar therapeutic effect in traditional Chinese medicine. The present article is the first comprehensive review on the chemical composition and pharmacological activities of these herbs. In this review, data on chemical constituents and pharmacological profile of the two herbs are provided. This review discusses all the classes of the 223 compounds (phenylpropanoids, flavonoids, terpenes, saponins and volatile components, etc.) detected in the two herbs providing information on the current state of knowledge of the phytochemicals present in them. In the past three years, our research group has isolated and identified about more than 100 ingredients from the two herbs. Therefore, we published a systematic review of our research papers and studies on the two herbs were carried out using resources such as classic books about Chinese herbal medicine and scientific databases including Pubmed, Web of Science, SciFinder, CNKI. etc. The present review discusses the most thoroughly studied pharmacological activities (antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antitumor and antiviral activities) of the two herbs. This comprehensive review will be informative for scientists searching for new properties of these herbs and will be important and significant for the discovery of bioactive compounds from the two herbs and in complete utilization of Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss.

A Review of Phytochemical and Pharmacological Studies of Inula Species

2020 ◽  
Vol 16 (5) ◽  
pp. 557-567
Author(s):  
Aparoop Das ◽  
Anshul Shakya ◽  
Surajit Kumar Ghosh ◽  
Udaya P. Singh ◽  
Hans R. Bhat
Keyword(s):  
Bacterial Infections ◽  
Chemical Constituents ◽  
Valuable Insight ◽  
Important Ingredient ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
The Family ◽  
Pharmacological Studies ◽  
Perennial Herbs ◽  
Insight Into

Background: Plants of the genus Inula are perennial herbs of the family Asteraceae. This genus includes more than 100 species, widely distributed throughout Europe, Africa and Asia including India. Many of them are indicated in traditional medicine, e.g., in Ayurveda. This review explores chemical constituents, medicinal uses and pharmacological actions of Inula species. Methods: Major databases and research and review articles retrieved through Scopus, Web of Science, and Medline were consulted to obtain information on the pharmacological activities of the genus Inula published from 1994 to 2017. Results: Inula species are used either alone or as an important ingredient of various formulations to cure dysfunctions of the cardiovascular system, respiratory system, urinary system, central nervous system and digestive system, and for the treatment of asthma, diabetes, cancers, skin disorders, hepatic disease, fungal and bacterial infections. A range of phytochemicals including alkaloids, essential and volatile oils, flavonoids, terpenes, and lactones has been isolated from herbs of the genus Inula, which might possibly explain traditional uses of these plants. Conclusion: The present review is focused on chemical constituents, medicinal uses and pharmacological actions of Inula species and provides valuable insight into its medicinal potential.

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