scholarly journals Efektivitas Ekstrak Buah Merah (Pandanus conoideus De Vriese) Asal Kabupaten Poso Sebagai Alternatif Penurun Kadar Gula Darah

2017 ◽  
Vol 5 (4) ◽  
pp. 185
Author(s):  
Anang Wahid M. D. Diah ◽  
Ni Kadek Ana Diani ◽  
Minarni Rama Jura
Keyword(s):  
Free Radicals ◽  
Blood Sugar ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Fruit Extract ◽  
Control Data ◽  
Significance Level ◽  
The Third ◽  
Sugar Levels

Bioactive compounds contained in red fruit (pandanus conoideus De Vriese) among others are flavonoids and tannins. The compounds are classified as very powerful antioxidants and can inhibit free radicals. This study aimed to determine the effective concentration of the red fruit extract from Poso as an alternative for lowering blood sugar levels. The separatin method used was boiling. The animals test were 15 male of mice (Mmus musculus) induced by ethylene diamine tetra acetic (EDTA). The mice were divided randomly into 5 groups with different treatments. The first, the second, and the third treatments were given red fruit extract each with a concentration of 10%, 20% and 30%. The fourth treatment was given glibenclamide suspension as a positive control, and the fifth treatments was given Na-CMC as a negative control. Data were analyzed using a statistical analysis of variance (Anova) test followed by Duncan test. The results showed that the preclinical test of red fruit extract reduced blood sugar levels of mice, and the most effective concentration was 20% as much as 68% (w/v) with significance level a = 0.05.

scholarly journals Efek Ekstrak Buah Kelor (Moringa oleifera) Terhadap Penurunan Kadar Gula Darah Mencit (Mus musculus)

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Ida Ayu Pitriya ◽  
Nurdin Rahman ◽  
Sri Mulyani Sabang
Keyword(s):  
Blood Sugar ◽  
Moringa Oleifera ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Fruit Extract ◽  
Control Data ◽  
The Third ◽  
Lower Blood ◽  
Sugar Levels

The plant could be potential as a traditional medicine, relatively safe, and inexpensive, that is of Moringa (moringa oleifera) fruit, which contains compounds those can lower blood sugar levels. The purpose of this study was to investigate the effect of Moringa fruit extracts on decreasing blood sugar levels of mice and to determine the most effective concentration of the extract. The separation method used was maceration. The animals test used were 15 male mice induced by EDTA. Mice were divided into 5 groups with different treatments. The first, the second, and the third treatments were given moringa extracts each with a concentration of 10, 20, and 40%. The fourth treatment was given glibenclamide suspension as a positive control, and the fifth treatment was given Na-CMC as a negative control. Data were analyzed using a statistical analysis of variance (ANOVA) test followed by Duncan test. The results showed that Moringa fruit extract lowered blood sugar levels of mice. The means decrease of blood sugar levels for each treatments were 49.67 mg/dL for the first, 58.33 mg/dL for the second, 70.33 mg/dL for the third, 66.67 mg/dL for the fourth, and 10.00 mg/dL for the fifth, . This study concluded that the Moringa fruit extract decreased blood sugar levels of mice with the most effective concentration of 10% and α = 0.05.

scholarly journals Pengaruh Ekstrak Tanaman Putri Malu (Mimosa pudica Linn) Terhadap Penurunan Kadar Glukosa Darah Pada Mencit (Mus musculus)

2017 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Kasmudin Mustapa ◽  
Amalia Rizky ◽  
Minarni Rama Jura
Keyword(s):  
Blood Sugar ◽  
Plant Extract ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Mimosa Pudica ◽  
Group Vi ◽  
Test Analysis ◽  
Group I ◽  
Sugar Levels

The research aim is to determine the effect of mimosa plant (mimosa pudica Linn) to reduce blood sugar levels in mice and determining the effective concentration of mimosa plant extracts as an alternative to decrease blood sugar levels. The extract is produced by the infusion method. The animal test used is male mice with amount 18 mice that induced by EDTA (ethylene diamine tetraacetic acid). Mice are divided into 6 groups randomly with different treatment. The group I, II, III and IV were given the mimosa plant extract with a concentration of 10, 20, 30, and 40% (w/v) respectively while group V is given glibenclamide suspension as positive control (+) and group VI is given Na-CMC 1% as negative control (-). Data were analyzed using the statistical test analysis of variance (ANOVA) and then followed by Duncan test. The results showed that the mimosa plant extract contains flavonoids, alkaloids, and tannins. In preclinical testing of mimosa plant extract proven to reduce blood sugar levels in mice and the most effective concentration is a concentration of 20% (w/v) with significantly α = 0.05.

scholarly journals UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 44-53
Author(s):  
Andri Priyoherianto ◽  
◽  
Panji Ratih Suci ◽  
Putri Rizki Cahya Fatimah ◽  
Atik Nur Wijayanti
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Water Hyacinth ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Normal Limits ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

scholarly journals Increased Plasma GLP-1 Levels after Resistant Starch Type 3 From Cassava Starch (Manihot Esculanta Crantz) Diet on Diabetic Rat

2018 ◽  
Vol 4 (2) ◽  
pp. 116
Author(s):  
Elly Nurus Sakinah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Resistant Starch ◽  
Nutritional Therapy ◽  
Positive Control ◽  
Cassava Starch ◽  
Negative Control ◽  
Diabetic Rat ◽  
Sugar Levels ◽  
Type 3

Diabetes mellitus (DM) occur when human body is unable to produce enough insulin and/or unable to use insulin effectively, resulting in an increase of blood sugar levels (hyperglycemia). Indonesia  has  ranks  fourth  after  United  States,  China  and  India  in  the  prevalence  of  DM. Controling blood sugar and insulin levels can be done through the stimulation effect of Glucagon- like peptide-1 (GLP-1). The goal of this study was to determine the effects of resistant starch type 3 (RS3) from cassava starch in increasing plasma GLP-1 levels. This reasearch use male mouse (Ratttus novergicus) as a diabetic model by providing a high-fat diet (HFD) for one mounth than combine with intraoperitonel injection of low dose streptozotocin (STZ). The mouse then grouped into 4 groups randomly (1) normal or negative control, (2) cassava starch diet, (3) RS3 diet, (4) positive control. Blood sugar levels were measured before and after STZ injection to determine the diabetic conditions (blood sugar > 200 mg /dL). After 4 weeks of dietary administration blood sugar  and  plasma  GLP-1  levels  were  examined  using  ELISA.  Statistical  analysis  showed decreased in blood sugar levels and increased in plasma GLP-1 levels after one mounth of RS3 diet. This research shows that RS3 from cassava starch has a potential role as a nutritional therapy on diabetes mellitus condition. Keywords: Resistant starch type 3, cassava starch, GLP-1, Blood Sugar, Diabetes Mellitus

scholarly journals EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN RAMBUSA (Passiflora foetida L.) PADA MENCIT (Mus musculus) DENGAN INDUKSI GLUKOSA

2015 ◽  
Vol 1 (2) ◽  
pp. 99-104
Author(s):  
Khildah Khaerati ◽  
Ihwan Ihwan ◽  
Musdalifah S Maya
Keyword(s):  
Blood Sugar ◽  
Leaf Extract ◽  
Drug Research ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Antidiabetic Drug ◽  
Passiflora Foetida ◽  
Sugar Levels

Passiflora foetida leaves used by the society for generations as a natural antidiabetic drug research aims to test the effectiveness of the leaf extract of Passiflora foetida with variations of a dose of 250 mg / kg, 500 mg / kg, and 750 mg / kg in lowering blood sugar levels in mice. Passiflora foetida leaves were extracted by sokhletasi method with 70% ethanol, the extract was tested on 15 mice, the test animals were randomized into 5 groups consist of negative control group given 0.5% Na-CMC, positive control group was given glibenclamide 0, 65 mg / kg, and the treatment group were given the leaf extract of Passiflorafoetida with variations of each dose of 250 mg / kg, 500 mg / kg, 750 mg / kg. To increase blood sugar levels in mice induced glucose 50%. Measurement of blood sugar levels in mice were performed using an easy touch glucometer and blood is taken via the lateral tail vein. The results showed that the percentage of blood sugar levels drop to a negative control is 13.1%, for a dose of 250 mg / kg body weight of 29.52%, for a dose of 500 mg / kg was 38.79%, to dosis750 mg / kg was 49, 21%, and 48.1% for the positive control. The results showed that the leaf extract of Passiflorafoetida at a dose of 750 mg / kg is most effective as an antidiabetic

scholarly journals Pengaruh Pemberian Ekstrak Buah Kelor (Moringa oleifera) Terhadap Penurunan Kadar Kolestrol Pada Darah Hewan Mencit (Mus musculus)

2017 ◽  
Vol 6 (1) ◽  
pp. 15
Author(s):  
Eva Zulviana ◽  
Nurdin Rahman ◽  
Supriadi Supriadi
Keyword(s):  
Moringa Oleifera ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Blood Cholesterol ◽  
Fruit Extract ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Lower Blood Cholesterol ◽  
Lower Blood

This study aimed to identify bioactive compounds of moringa (moringa oleifera) extracts and determine the effective concentration on lowering blood cholesterol levels of mice. The animals used were 15 male mice induced by propylthiouracil and fat food diet. The mice were divided randomly into 5 groups with different treatment groups. The first, the second, and the third treatments were given moringa extracts each with a concentration of 10, 20% and 40%. The fourth treatment group was given food fat diet and propiltiorasil as a positive control, and the fifth treatment was given standard food and distilled water as a negative control. Data were analyzed using a statistical analysis of variance (ANOVA) test followed by Duncan test. The results showed that moringa fruit extract contains alkaloids, saponins, flavonoids, and tannins. Moringa fruit extract can lower blood cholesterol levels of mice with the most effective concentration of 10%.

Improved cellular immunity and increased insulin in streptozotosin-induced mice using ethanol coriander (Coriandrum sativum) extract

2021 ◽  
pp. 3689-3694
Author(s):  
Dahliatul Qosimah ◽  
Sri Widyarti ◽  
MAG Beltran ◽  
Muhaimin Rifa’i
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Gastric Tube ◽  
Fat Metabolism ◽  
Relative Number ◽  
Positive Control ◽  
Negative Control ◽  
Coriandrum Sativum ◽  
Treatment Groups ◽  
Sugar Levels

An increase in blood sugar levels is an indication of diabetes mellitus (DM). DM is a metabolic disease characterized by disorders of carbohydrate and fat metabolism due to impaired activity, insulin secretion or both. Alternatively, the body's inability to secrete insulin. The purpose of this study was to determine the effect of coriander extract (Coriandrum sativum) on mice induced by streptozotocin (STZ) on the relative number of CD11b and insulin-IL6 cells. The study used Balb-C strain mice, aged 2.5-3 months, with five (5) treatment groups which were given STZ at a dose of 145mg/kg BW on the 8th day IP (Intraperitoneal) after adaptation for seven days, then add coriander extract with successive doses of 25 (T1), 50 (T2), and 100mg/kg BW (T3), negative control (healthy) (T4) and positive control (STZ) (T5) through the administration of intraperitoneal gastric tube. Blood Glucose is measured on the 13th day. Herbs are given on days 14-28. On the 29th day, the mice. An increase in blood sugar levels is an indication of diabetes mellitus (DM). DM is a metabolic disease characterized by disorders of carbohydrate and fat metabolism due to impaired activity, insulin secretion or both Alternatively, the body's inability to secrete insulin. The purpose of this study was to determine the effect of coriander extract (Coriandrum sativum) on mice induced by streptozotocin (STZ) on the relative number of CD11b and insulin-IL6 cells. The study used Balb-C strain mice, aged 2.5-3 months, with five (5) treatment groups which were given STZ at a dose of 145mg/kg BW on the 8th day IP (Intraperitoneal) after adaptation for seven days, then add coriander extract with successive doses of 25 (T1), 50 (T2), and 100mg/kg BW (T3), negative control (healthy) (T4) and positive control (STZ) (T5) through the administration of intraperitoneal gastric tube. Blood Glucose is measured on the 13th day. Herbs are given on days 14-28. On the 29th day, the mice were sacrificed Furthermore, the pancreas was taken for insulin examination, and the spleen was checked with the relative number of CD11b-IL6 and T CD4 cells using a flow cytometer. Data were quantitatively analyzed using the One Way ANOVA test (p≤0.05). The results showed that doses of coriander in T1 treatment causes an increase in insulin levels, decreased blood sugar levels, weight gain, proliferation and activation of CD4+ T cells, and decrease inflammation (CD11b cell-IL6) on the tissue. This research concludes that extracts of coriander can reduce Hyperglycemia in mice by modulation of cellular immunity and increased levels of insulin

scholarly journals Efek Ekstrak Daun Alpukat (Persea americana Mill.) dalam Menurunkan Kadar Kolesterol Darah pada Mencit (Mus Musculus)

2018 ◽  
Vol 7 (1) ◽  
pp. 11
Author(s):  
Mufida Mufida ◽  
Nurdin Rahman ◽  
Supriadi Supriadi
Keyword(s):  
Mus Musculus ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Persea Americana ◽  
Blood Levels ◽  
Male Mice ◽  
High Fat ◽  
Control Data ◽  
Dietary Food

This study aimed to determine the effective concentration of avocado leaves extract in lowering cholesterol blood levels in mice (Mus musculus). The animals test were 15 male mice and were induced with propylthiouracil and high-fat dietary food. Mice were divided randomly into 5 groups with different treatments. Treatments I, II and III were given avocado leaves extracts each with a concentration of 10, 20, and 40%, respectively. Treatment IV was given simvastatin suspension as a positive control, and treatment V was given (Na-CMC) 1% as a negative control. Data were analyzed statistically with analysis of variance (ANOVA) test followed by Duncan test. The results showed that avocado leaves extract contained positively of alkaloids, flavonoids, saponins, tannins, and triterpenoid or steroids. Avocado leaves extract lowered cholesterol blood levels in mice with the most effective concentration was 10% (w/v).

scholarly journals Hypoglicemic and Antioxidant Activities in Extracts Star Anise (Illcium Verum Hook.f) on Wistar Rat (Rattus norvegicus) Diabetes

2020 ◽  
Vol 4 (1) ◽  
pp. 34-43
Author(s):  
Anna Maria Dewajanthi ◽  
Agus Limanto ◽  
Clarita Clarita ◽  
Audrey Fidelia
Keyword(s):  
Diabetes Mellitus ◽  
Free Radicals ◽  
Blood Sugar ◽  
Positive Control ◽  
Diabetic Rats ◽  
Male Rats ◽  
Control Group ◽  
Star Anise ◽  
Endogenous Antioxidants ◽  
Sugar Levels

Diabetes mellitus is a disease that is quite common among the people. The causes of diabetes mellitus vary depending on the classification of this group of diseases. If diabetes mellitus is not handLed properly and correctly, there will be chronic hyperglycemia that causes oxidative stress, so patients will complain of some complications from diabetes mellitus that is actually caused by free radicals. Star anise (Illicium Verum) is one of the plants that are often used, one of which is as a spice in food. The star anise  has several compounds, one of which is flavonoid which is as an easily oxidized compound (antioxidant), so it is often used as a traditional medicine to treat many diseases. In several studies in vitro this star anise plant has also been proven to have antioxidant levels such as flavonoids and phenolic which are high enough so that it can be used as a source of exogenous antioxidants that can help endogenous antioxidants such as glutathione (GSH) to reduce free radicals that enter and remain keep body cells in normal condition. The study was carried out experimentally and conducted on rats in diabetes mellitus to see the effect of giving star anise extracts on glucose levels and blood levels of endogenous antioxidants (glutathione). Male rats with 2-3 months of age as many as 24 animals were divided into 6 groups, namely the negative control group (mice only given distilled water), diabetic rats without treatment group (positive control), diabetic rats treated with rootbose (positive control), and diabetic rats by treating the extract of star anise of 50, 100, and 150 mg/kg body weight of rats. This research was conducted for 7 days. GSH levels were measured on days 0 and 7. To analyze the differences in the average data of glucose and GSH, statistics were used. Results of the Wilcoxon test showed that there were significant differences (with p < 0.05) in blood sugar levels between the control group and the diabetic rats treated with star anise extract group. There was a significant decrease in blood sugar levels in diabetic rats given an extract of star anise. The greatest decrease in blood sugar levels occurred in the group of diabetic rats who were given an extract of star anise at 150 mg/kg bw. It is also known that there are difference in GSH levels between the control group and the diabetic rat group with the treatment of extract of star anise, but statistically the difference is not significant. GSH levels increased 0.03 µM/mL by administering an extract of star anise at 50 mg/kg bw.

scholarly journals Reducing the Effects of Blood Sugar Infusion of Melastoma Malabathricum L. in Mus Musculus

2020 ◽  
Vol 1 (1) ◽  
pp. 1-10
Author(s):  
Le Cong Truong
Keyword(s):  
Blood Sugar ◽  
Mus Musculus ◽  
Positive Control ◽  
Negative Control ◽  
Statistical Testing ◽  
Group V ◽  
Melastoma Malabathricum ◽  
Group I ◽  
Significant Difference ◽  
Sugar Levels

This study aims to determine the blood sugar-lowering effect of Melastoma malabathricum L. infusion on Mus musculus. The research design used was an experimental laboratory carried out in the pharmacology laboratory of the Ho Chi Minh City University. This study used 15 male mice which were divided into 5 groups consisting of group I as negative control by giving aquadest, groups II, III, IV were given infusion of Melastoma malabathricum L. respectively 0.1 g/ml, 0.2 g/ml, and 0.4 g/ml, and group V as a positive control with glibenclamide suspension. The results showed that statistical testing using the SPSS program showed a significant difference (p <0.05), which means that senggani leaf infusion had a significant effect on reducing blood sugar levels in mice and the most optimal was 0.4 g/ml infusion.

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