scholarly journals UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 44-53
Author(s):  
Andri Priyoherianto ◽  
◽  
Panji Ratih Suci ◽  
Putri Rizki Cahya Fatimah ◽  
Atik Nur Wijayanti
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Water Hyacinth ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Normal Limits ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

scholarly journals In Vivo Activities and In Silico Study of Jackfruit Seeds (Artocarpus heterophyllus Lam.) on the Reduction of Blood Sugar Levels of Gestational Diabetes Rate Induced by Streptozotocin

2019 ◽  
Vol 7 (22) ◽  
pp. 3819-3826
Author(s):  
Dwitiyanti Dwitiyanti ◽  
Rizky Arcinthya Rachmania ◽  
Kriana Efendi ◽  
Riri Septiani ◽  
Pahlevi Jihadudin
Keyword(s):  
Molecular Docking ◽  
Blood Glucose ◽  
Virtual Screening ◽  
Blood Sugar ◽  
Positive Control ◽  
Artocarpus Heterophyllus ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
In Silico Study ◽  
Sugar Levels

BACKGROUND: Jackfruit Seeds (Artocarpus heterophyllus L.) are plants that are thought to be able to reduce blood sugar levels. AIM: The purpose of this study was to prove the activity of jackfruit seeds in reducing blood glucose levels in gestational diabetic rats induced by streptozotocin and in silico study virtual screening through molecular docking to find out the compounds in jackfruit seeds that have interaction with sulfonylurea receptors. METHODS: The animals used in this study were Sprague Dawley strain pregnant female rats which were divided into six groups, namely the normal control group, negative control, positive control, various dose groups (100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW). After the rat was pregnant, the rats were induced first with streptozotocin so that the rats had hyperglycemia. Blood glucose levels were measured on the 14th day after treatment. The data obtained were statistically tested by one-way ANOVA test followed by the HSD Tukey test. Virtual screening was done using PLANTS 1.2 software. RESULTS: The results showed that all groups of ethanol extract 70% of jackfruit seeds could reduce blood glucose levels. The biggest decrease in blood glucose levels occurred at dose 3 with a dose of 400 mg/kg BW which was 61.73%, comparable to positive control glibenclamide. The results of virtual screening with molecular docking showed that betacarotene epoxide compounds have better affinity than glibenclamide as a comparative compound. CONCLUSION: It can be concluded that jackfruit seeds beta-carotene epoxide has the potential to reduce blood sugar levels by inducing insulin secretion.

scholarly journals Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)

WARTA FARMASI ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 43-52
Author(s):  
Muhammad Azdar Setiawan ◽  
Muhammad Syaiful Saehu ◽  
Kartini Kartini
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose ◽  
Albizia Saman

ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosin 150 mg/kgBB secara Intraperitonial. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: Ekstrak dosis 25 mg/kgBB, 50 mg/kgBB, 100  mg/kgBB, sebagai kontrol positif Glibenclamid 5 mg dan kontrol negatif suspensi Na.CMC 0,5%. Data yang diperoleh dianalisis dengan uji ANOVA. Hasil analisa statistik menunjukan pada konsentrasi ekstrak 100 mg/kgBB memberikan efek yang optimum dengan perlakuan kontrol positif Glibenklamid.  Kata Kunci  : Ekstrak Daun Trembesi, Antidiabetik.  ABSTRACT Trembesi leaf (Albizia saman (Jacq.) Merr) is one of the efficacious plants to reduce blood glucose levels where the chemical content has the potential to reduce blood glucose levels, among others, flavonoids that work by stimulating beta cells of the island langerhans, so that insulin secretion is increased. It aims to determine the antidiabetic effect of trembesi leaf extract (Albizia saman (Jacq.) Merr) in mice (Mus musculus). This research method is an experimental study in which as many as 20 mice were made diabetic using Streptozotosin 150 mg / kgBW intraperitonially. Then divided into 5 treatment groups, namely: Extract dose 25 mg / kg body weight, 50 mg / kg body weight, 100 mg / kg body weight, as positive control Glibenclamid 5 mg and negative control suspension Na.CMC 0.5%. The data obtained were analyzed by ANOVA test. The results of statistical analysis showed that the extract concentration of 100 mg / kgBB gave the optimum effect with the positive control of Glibenclamide. Keywords: Trembesi Leaf Extract, Antidiabetic.

scholarly journals UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH

2019 ◽  
Vol 2 (1) ◽  
pp. 24-28
Author(s):  
Herviani Sari ◽  
Vera Estefania Kaban ◽  
Friska Raulina Situmorang ◽  
Firdaus Fahdi
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
High Dose ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels

Purpose: To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide. Method: This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg/kgMB, group 3 single roselle extract dose 130 mg/kgMB, group 4 single meniran leaf extract dose 200 mg/kgMB, group 5 combination of meniran leaf extract dose of 100 mg/kgMB and rosella extract dose of 65 mg/kgMB, group 6 combination of meniran leaf extract dose of 200 mg/kgMB and rosella extract dose of 130 mg/kgMB, and group 7 meniran leaf extract combination dose 400 mg/kgMB and rosella extract dose 195 mg/kgMB. Result: The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella gave a significant effect compared to the negative control group did not have a significant effect in reducing blood glucose levels. Conclusion: Single meniran extract and high-dose combination extract are more effective than glibenclamide.

UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) pada TIKUS JANTAN PUTIH SEBAGAI HEWAN PERCOBAAN

2019 ◽  
Vol 2 (1) ◽  
pp. 19-23
Author(s):  
Herviani Sari ◽  
Vera Estefania Kaban ◽  
Friska Raulina Situmorang ◽  
Firdaus Fahdi
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
High Dose ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels

Background : Diabetes mellitus (DM) is a chronic disease caused by the body's inability to produce the hormone insulin or due to ineffective use of insulin production. Diabetes has become a global problem, DM prevalence of 4.6%, estimated in 2000 amounted to 5.6 million. One of the plants that can reduce blood glucose levels is meniran and rosella which are found in Indonesia. Objective : To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide.Method : This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg / kgBB, group 3 single roselle extract dose 130 mg / kgBB, group 4 single meniran leaf extract dose 200 mg / kgBB, group 5 combination of meniran leaf extract dose of 100 mg / kgBB and rosella extract dose of 65 mg / kgBB, group 6 combination of meniran leaf extract dose of 200 mg / kgBB and rosella extract dose of 130 mg / kgBB, and group 7 meniran leaf extract combination dose 400 mg / kgBB and rosella extract dose 195 mg / kgBB. Result : The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella where p <0.05 gave a significant effect compared to the negative control group p> 0.05 did not have a significant effect in reducing blood glucose levels. Conclusion : Single meniran extract and high-dose combination extract are more effective than glibenclamide.

scholarly journals Ingredients of Active Compounds and Anti-Diabetic Test of Water Extract of Lannea coromandelica (Houtt) Merr. On Wistar Rats

2021 ◽  
pp. 116-122
Author(s):  
Nona Rahmaida Puetri ◽  
Rita Marleta Dewi ◽  
Sahrul ◽  
Yasir ◽  
Munawir Annasri
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Descriptive Analysis ◽  
Water Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lannea Coromandelica ◽  
Sugar Levels

Leaves of Lannea coromandelica (Houtt.) Merr. is one of the plants found in Aceh. This study aims to determine the effect of giving water extract of Lannea coromandellica (Houtt.) Merr. against STZ-induced blood sugar levels of wistar rats. The experimental study used a sample of 25 male and 15 female Wistar rats. This research is experimental with a sample of 25 male and 15 female of Wistar rats. The treatments were given, namely negative control (aquades), positive control (metformin), 50 mg EALC, 100 mg EALC, and 150 mg EALC. The data obtained will be analyzed by using the Kruskal Wallis test to obtain the effectiveness of the treatment and also a descriptive analysis for the average reduction in blood glucose levels. Macro and histological observations were also carried out on the liver and pancreas. The results obtained from the Kruskal Wallis test results showed that there was no effect of EALC on changes in the decrease in blood glucose levels of wistar rats for 14 days of treatment. Observation of the macro organs showed pancreas had a changes. While the histological observations pancreas and liver showed changes. The results of this study indicate that the effectiveness of EALC is not proven to have an effect, this is presumably because the extract concentration is too small so it is not enough to work optimally. Phytochemical test shows that EALC contains flavonoids, steroids, phenolics, tannins, saponins and alkaloids.

scholarly journals PENGARUH PEMBERIAN EKSTRAK DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) YANG DIINDUKSI ALLOXAN

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Febbyola S. Moniaga
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Wistar Rat ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Annona Muricata ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

Abstract: People sure that Soursop leaves (A.muricata L.) has a lot of advantage for health, one example is to reduced blood glucose levels. The objectives of this research were to study the effectiveness of administration of soursop leaves extract (A.muricata L.) on blood glucose levels of wistar rat (R.norvegicus) induced by alloxan. The subjects in these research were male wistar rat with total of 18 samples divided into 6 groups as follows negative control group and 5 hyperglycemic groups induced by alloxan with dose 110 mg/kg bodyweight of rat. Hyperglycemic rats administered by soursop leaves extract dosing 1000 mg, 2000 mg, and 5000 mg/kg bodyweight of rat, positive control groups administered by novomix flexpen, and the last one only administered by alloxan. Data taken from measurement of blood sugar on first day, second day, and third day on minutes 0,30,60,90, and 120. The result showed reduction of alloxan-induced wistar rat’s blood sugar levels on administration of soursop leaves extract. Keyword: Annona Muricata L, Soursop leaves, Blood sugar levels, Alloxan.       Abstrak: Daun sirsak (A.muricata L.) diyakini masyarakat memiliki banyak manfaat bagi kesehatan salah satunya menurunkan kadar gula darah. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak daun sirsak (A.muricata L.) terhadap kadar gula darah tikus Wistar (R.norvegicus) yang diinduksi alloxan. Subjek penelitian berupa tikus Wistar jantan berjumlah 18 ekor yang dibagi dalam 6 kelompok, kelompok kontrol negatif dan 5 kelompok tikus Wistar hiperglikemik akibat pemberian alloxan dengan dosis 110 mg/kg berat badan tikus. Tikus hiperglikemik diberi ekstrak daun sirsak dosis 1000, 2000, dan 5000 mg/kg BB tikus,  kelompok kontrol positif yang diberi novomix flexpen, dan 1 kelompok hanya diberi alloxan. Data diperoleh dari pemeriksaan kadar gula darah pada semua kelompok tikus Wistar pada hari pertama, hari kedua , hari ketiga pada menit ke-0 ,30, 60, 90, dan menit ke-120. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirsak mempunyai efek terhadap penurunan kadar gula darah tikus Wistar yang telah diinduksi alloxan. Kata kunci: Annona Muricata L., Daun Sirsak, Kadar Gula Darah, Alloxan.

scholarly journals Ekstrak Daun Asam Jawa (Tamarindus Indica L.) Sebagai Antidiabetes

2017 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Olfiana T. Lahamado ◽  
Sri Mulyani Sabang ◽  
Kasmudin Mustapa
Keyword(s):  
Blood Glucose ◽  
Positive Control ◽  
Negative Control ◽  
Tamarindus Indica ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Infusion Method ◽  
Ethylene Diamine Tetra Acetate ◽  
Sugar Levels

One of the plant that is widely used as a medicinal plant is the leaves of tamarind (tamarindus indica L). This study aims to determine the effectiveness of anti-diabetic of tamarind (tamarindus indica L.) extract in lowering blood glucose levels in mice animals test. The experiment was performed using tamarind leaves extracted through infusion method. The animals test were 15 male mice induced by ethylene diamine tetra acetate (EDTA). Mice were divided randomly into 5 groups with different treatments. Treatments I, II and III were given tamarind leaves extracts for each with a concentration of 10%, 20% and 40%. Treatment IV was given glibenclamide suspense as a positive control (+), and the treatment V was given Na-CMC 1% as a negative control (-). Based on the analysis of variance statistical calculations tamarind leaves extracts can lower blood glucose levels on mice test. Furthermore, the significant difference was tested to check the concentration effect. The results on animals test with a significant level of 5% showed that the tamarind leaves extract of 40% or Treatment III affected on decreasing blood sugar levels on mice.

Efek Ekstrak Etanol Kulit Petai (Parkia speciosa Hassk) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Verawaty Verawaty ◽  
Dhea Claudia Novel
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels

<p>Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol kulit petai (Parkia speciosa Hassk) terhadap penurunan kadar glukosa darah mencit jantan yang diinduksi aloksan. Hewan percobaan dibagi atas 5 kelompok diantaranya kelompok kontrol negatif, kelompok kontrol positif,dosis I (280 mg/kgBB mencit), dosis II (560 mg/kg BB mencit), dosis III (840 mg/kg BB mencit). Penelitian dilakukan selama 21 hari. Persentase penurunan kadar glukosa darah mencit jantan setelah diberikan ekstrak etanol kulit petai pada hari ke-21 adalah dosis I (77,52 %) lebih besar dibandingkan dengan dosis II (69,5 %) dan dosis III (73,37 %). Data yang diperoleh dianalisis dengan uji Two Way Anova dengan program SPSS 17. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit petai untuk tiga variasi dosis menyatakan perbedaan yang bermakna secara statistik terhadap penurunan kadar glukosa darah mencit jantan.</p><p><em>Petai (Parkia speciosa Hassk) has a compound β-sitosterol and stigmasterol that have efficacy to decreased blood glucose levels. This study aimed to determine the effect of ethanol extract of petai peel for decrease blood glucose levels of male mice induced by alloxan. Experimental animals were divided into 5 groups including negative control group, positive control group, the first dose (280 mg/kg in mice), the second dose (560 mg/kg in mice), the third dose (840 mg/kg in mice). The study was conducted for 21 days. After 21 days, the result found that the percentage of blood glucose levels after the male mice given the ethanol extract of petai peel was, the first dose (77.52%) biger than the second dose (69.5%) and the third dose (73.37%). The data obtained were analyzed by Two Way ANOVA using SPSS 17. The results showed that have signicantly difference between three dose variation of ethanol extract of petai peel in blood glucose levels.</em></p>

scholarly journals Effectiveness of Graptophyllum pictum (L.) Griff leaf extraction on blood glucose level in alloxan-induced Wistar rat

Food Research ◽  
2020 ◽  
Vol 4 (S3) ◽  
pp. 123-126
Author(s):  
A. Leonoreza ◽  
T. Excelinda ◽  
J. Elnitiarta ◽  
H.S. Heri-Nugroho ◽  
M. Hendrianingtyas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Group ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Negative Control ◽  
Normal Group ◽  
Treatment Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes mellitus is a metabolic disease that always increasing in prevalence. Excessive glucose intake and oxidative stress that can lead to damage to the pancreatic cell or insulin resistance, are such factors that influence the occurrence of diabetes mellitus. Graptophyllum pictum (L.) Griff leaf contains active metabolites such as flavonoid which able to decrease free radical levels. This study aimed to prove the effectiveness of Graptophyllum pictum (L.) Griff leaves extract on blood glucose levels in alloxan-induced Wistar rats. In this study, twenty-five male Wistar rats were divided into five groups. On day 0, the negative control and each treatment group injected with 125 mg/kg dose of alloxan and would be checked on 4th day. On the 4th day after the rats had diabetes, normal group (K-1) was given only standard feed, Negative control (K-2) was given only alloxan intraperitoneally on day 0, first treatment group (K-3) was given 50 mg/kg dose of Graptophyllum pictum (L.) Griff, second treatment group (K-4) was given 100 mg/kg dose of the leaf extract, and the third treatment group (K-5) was given the leaf 200 mg/kg dose of the leaf extract. On the 10th day, fasting blood glucose was taken from the rats. Post-test only group design was used to be the experimental design. There were significant differences in the treatment groups (K-3, K-4, and K-5) compared to the negative control group (K-2) after treatment. The mean of blood glucose levels decreased with the increased doses of Graptophyllum pictum (L.) Griff leaf extract treatment. The treatment groups (K-3, K-4, and K-5) were not significant compared to the normal group (K-1).

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