scholarly journals Immune targeted therapies for COVID-19 Infection: A Promising Outlook

2020 ◽  
Author(s):  
Bahareh Forouzani-Haghighi ◽  
Alireza Rezvani ◽  
Afsaneh Vazin
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Checkpoint Inhibitors ◽  
The Elderly ◽  
World Health ◽  
Laboratory Findings ◽  
System A ◽  
Disease Prognosis ◽  
Health Organization

In December 2019, the coronavirus disease-19 (COVID-19) outbreak emerged in Wuhan, China. On March 11, 2020, the WHO (World Health Organization) officially declared it a pandemic. Reports indicated that the associated mortality of the infection is quite higher in the elderly, patients with specific comorbidities (like diabetes mellitus), and generally the ones with a compromised immune system. A cohort study of 452 patients with laboratory-confirmed COVID-19 in Wuhan, China, reported a dysregulated immune response in these patients. As a result of this suppressed immune response, the increase of neutrophil to lymphocyte ratio (NLR), T lymphopenia, and decrease of CD4+ T cells was considered as common laboratory findings, especially in severe cases. On the other hand, there is also clear evidence of T cell exhaustion in severely ill patients. So, the immune system seems to play an important role in disease prognosis and pathogenesis. This study aims to review the evidence on the immune response dysregulation in COVID-19 infection and the potential role of immunoregulatory treatments such as immune checkpoint inhibitors, interferons, and CD200 inhibitors in altering disease prognosis, especially in critically ill patients.

scholarly journals Breast Cancer Immunotherapy: An Update

2018 ◽  
Vol 12 ◽  
pp. 117822341877480 ◽  
Author(s):  
Issam Makhoul ◽  
Mohammad Atiq ◽  
Ahmed Alwbari ◽  
Thomas Kieber-Emmons
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Monoclonal Antibodies ◽  
Immune System ◽  
Cancer Vaccines ◽  
Checkpoint Inhibitors ◽  
Cancer Surveillance ◽  
Cancer Disease ◽  
Immune Attack

The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community’s interest in extending the benefits to all cancers including breast cancer. The first section of this article reviews the biological foundations of the immune response to different subtypes of breast cancer and the ways cancer may overcome the immune attack leading to cancer disease. The second section is dedicated to the actual immune treatments including breast cancer vaccines, checkpoint inhibitors, monoclonal antibodies, and the “unconventional” immune role of chemotherapy.

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

scholarly journals Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 With a Focus on Physical Tissue Barrier Integrity

2020 ◽  
Vol 7 ◽  
Author(s):  
José João Name ◽  
Ana Carolina Remondi Souza ◽  
Andrea Rodrigues Vasconcelos ◽  
Pietra Sacramento Prado ◽  
Carolina Parga Martins Pereira
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Viral Infections ◽  
Adequate Intake ◽  
High Demand ◽  
Comprehensive Overview ◽  
Disease Prognosis ◽  
Mucous Membranes ◽  
And Function

Some nutrients play key roles in maintaining the integrity and function of the immune system, presenting synergistic actions in steps determinant for the immune response. Among these elements, zinc and vitamins C and D stand out for having immunomodulatory functions and for playing roles in preserving physical tissue barriers. Considering the COVID-19 pandemic, nutrients that can optimize the immune system to prevent or lower the risk of severe progression and prognosis of this viral infection become relevant. Thus, the present review aims to provide a comprehensive overview of the roles of zinc and vitamins C and D in the immune response to viral infections, focusing on the synergistic action of these nutrients in the maintenance of physical tissue barriers, such as the skin and mucous membranes. The evidence found in the literature shows that deficiency of one or more of these three elements compromises the immune response, making an individual more vulnerable to viral infections and to a worse disease prognosis. Thus, during the COVID-19 pandemic, the adequate intake of zinc and vitamins C and D may represent a promising pharmacological tool due to the high demand for these nutrients in the case of contact with the virus and onset of the inflammatory process. Ongoing clinical trials will help to clarify the role of these nutrients for COVID-19 management.

scholarly journals Influence of advanced age on postoperative outcomes and total loss following breast reconstruction: a critical assessment of 560 cases

2018 ◽  
Vol 45 (2) ◽  
Author(s):  
WALTER KOITI MATSUMOTO ◽  
ALEXANDRE MENDONÇA MUNHOZ ◽  
ALBERTO OKADA ◽  
EDUARDO MONTAG ◽  
EDUARDO GUSTAVO ARRUDA ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Breast Reconstruction ◽  
The Elderly ◽  
Advanced Age ◽  
World Health ◽  
Elderly Age ◽  
Significant Difference ◽  
Health Organization

ABSTRACT Objective: to evaluate the role of age in the risk of postoperative complications in patients submitted to unilateral breast reconstruction after mastectomy, with emphasis on total reconstruction loss. Methods: we conducted a retrospective study of patients submitted to breast reconstruction, whose variables included: oncological and reconstruction data, postoperative complications, including loss of reconstruction and complications of surgical wound. We divided the patients into two groups, according to the classification of the Brazilian National Elderly Policy and the Statute of the Elderly: young (age <60 years) and elderly (60 years or more). We also grouped them according to the World Health Organization classification: young people (age <44 years), middle age (45-59 years); elderly (age 60-89 years) and extreme advanced age (90 years or older). We applied the surgical risk classification of the American Society of Anesthesiologists to investigate the role of the preoperative physical state as a possible predictor of complications. Results: of the 560 patients operated on, 94 (16.8%) were 60 years of age or older. We observed a local complication rate of 49.8%, the majority being self-limited. The incidences of necrosis, infection and dehiscence were 15.5%, 10.9% and 9.3%, respectively. Patients older than 60 years presented a chance of complication 1.606 times greater than the younger ones. Forty-five (8%) patients had loss of the reconstruction; there was no statistically significant difference in the mean age of the patients who presented this result or not (p=0.321). Conclusion: in selected patients, breast reconstruction can be considered safe; most documented complications were limited and could be treated conservatively.

scholarly journals Immunosenescence and the Susceptibility of the Elderly to Coronavirus Disease 2019 (COVID-19)

2020 ◽  
Vol 40 (3) ◽  
pp. 182-191
Author(s):  
Widya Wasityastuti ◽  
Andika Dhamarjati ◽  
Siswanto Siswanto
Keyword(s):  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
Literature Review ◽  
The Elderly ◽  
World Health ◽  
New Disease ◽  
Risk Of Infection ◽  
The World ◽  
Long Time ◽  
Health Organization

A new disease caused by a newly-found coronavirus, known as Coronavirus Disease 2019 (COVID-19), has been declared as a pandemic by World Health Organization (WHO). This new disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak started in late December of 2019 and it did not take a long time until it spread to more than 200 countries in the world with over 4 million confirmed cases to date. The number keeps skyrocketing as day passes, followed by the increasing number of fatalities. Among all of the infected patients, elderly is one of the vulnerable populations. Studies reported that the risk of infection is doubled in older people. This infection-susceptible characteristic may be due to the weak immune system, therefore they lack the capabilities to fight the infection. The deterioration of immune system in elderly is known as immunosenescence. The aim of this literature review is to understand the effect of immunosenescence in the immunopathogenesis and susceptibility of elderly who are exposed to COVID-19 infection. (J Respir Indo. 2020; 40(3): 182-91)

scholarly journals The role of Astana primary health care declaration for development of primary health care at postsoviet countryes

2019 ◽  
Vol 23 (3) ◽  
pp. 13-18
Author(s):  
Nurlan N. Brimkulov ◽  
Damilya S. Nugmanova
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Rural Areas ◽  
World Health ◽  
Negative Consequences ◽  
Health Care Reforms ◽  
System A ◽  
Primary Health ◽  
Health Organization

The article presents the goals, principles and results of the implementation of the Almaty Declaration of the World Health Organization (WHO) on primary health care (PHC) of 1978; the background and main provisions of the Astana Declaration of WHO on PHC 2018. The article presents the stages of PHC development in the USSR, which was characterized by the widespread introduction of narrow specialists at the primary level of health care, which subsequently had certain negative consequences. In a number of post-Soviet countries, the principles of General medical practice (family medicine) were implemented in health care reform, but some provisions of the Alma-Ata Declaration were introduced with distortions. This has led to a lack of effective functioning of the PHC system, a shortage of General practitioners, especially in rural areas. The implementation of the main principles of the new Astana Declaration will be important for the effective implementation of health care reforms in all post-Soviet countries.

scholarly journals Evaluation of Diarrhea in Patients with COVID-19

2021 ◽  
Author(s):  
Şenol Comoglu ◽  
Sinan Öztürk ◽  
Aydın Kant ◽  
Mustafa Arslan ◽  
Hanife Nur Karakoc ◽  
...  
Keyword(s):  
Public Health Problem ◽  
The Elderly ◽  
World Health ◽  
Shortness Of Breath ◽  
Comorbid Disease ◽  
Laboratory Findings ◽  
Medical Centers ◽  
The World ◽  
Normal Defecation ◽  
Health Organization

Background/Aims:The COVID-19 disease, which was declared epidemic by the World Health Organization (WHO), is a global emergency public health problem. Patients with extrapulmonary symptoms are the group of patients who should be considered for person-to-person transmission in the community. In our study, it was aimed to investigate the characteristics of patients with COVID-19-related diarrhea symptoms. Materials and Methods:The study was conducted retrospectively in COVID-19 rtRT-PCR-positive patients in five medical centers. 3 or more loose/liquid stools per day or increased number of defecations compared to normal defecation were defined as diarrhea. The patients were analyzed in two groups as those with and without diarrhea. Results:1086 patients were included in the study. 78 (7.2%) of the patients had diarrhea. Diarrhea was watery in 54 (69.2%) patients while with blood and mucus in 18 (23.1%) patients. Diarrhea continued for an average of 5.2±1.6 (2-11) days. The clinical and laboratory findings of patients with diarrhea were more serious than those without diarrhea. Diarrhea is more common in the elderly and people with comorbid disease, and patients with diarrhea had higher CMI score and CRP and higher complaints of fever, cough, shortness of breath, myalgia and fatigue. Conclusions:The presence of diarrhea should indicate a suspected COVID-19 infection and suggest testing for early diagnosis of the disease. It should be kept in mind that the course of the disease may be more severe in these patients and precautions should also be taken in terms of fecal transmission during discharge.

Community Organizing among the Elderly Poor in the United States: A Case Study

1992 ◽  
Vol 22 (2) ◽  
pp. 303-316 ◽  
Author(s):  
Meredith Minkler
Keyword(s):  
Low Income ◽  
Community Organizing ◽  
Community Organization ◽  
The Elderly ◽  
The United States ◽  
World Health ◽  
Definition Of ◽  
Health Organization

This case study demonstrates the role of community organizing as a vehicle for enhancing individual and community-level empowerment. Building on social support theory, Freire's “education for critical consciousness,” and the principles and strategies of community organization practice, the 12-year-old Tenderloin Senior Organizing Project reflects the World Health Organization definition of health promotion as a means of helping individuals and communities to take increasing control over the factors influencing their health. Through the Project, low-income elders have successfully identified and addressed shared problems in such areas as crime and safety, undernutrition, and tenants rights. They further have developed ongoing tenants' associations and other community-based organizations that have provided continuity over time and contributed to the development of a “competent community.” Problems in areas such as funding, evaluation, and volunteer burnout are discussed, as are the potentials for project replication in other settings.

scholarly journals Significance of Immune System to Fight COVID-19 and its Co-relation with Physical Exercise and Nutrition

2021 ◽  
pp. 224-228
Author(s):  
Nisha Bharti ◽  
Neha Bhatt ◽  
Swarupa Chakole
Keyword(s):  
Immune System ◽  
World Health ◽  
World Knowledge ◽  
Global Epidemic ◽  
Time To Build ◽  
The World ◽  
Consistent Manner ◽  
Global Movement ◽  
Health Organization

The proliferation of covid-19 has caused extensive damage worldwide and brought global movement into a state of complete stagnation. By the year 2019, another type of infection came into the world knowledge that followed its origins in the bats of Wuhan, China. Coronavirus was declared a global epidemic by the World Health Organization and thinks that the Earth  is fighting the inevitable danger posed by humans. As we may be aware that this infection  is a new phenomenon, so no vaccines or drugs are available for treatment and the medication currently being used gives our body time to build up its defenses against COVID-19.  Immune system is a combination of different organs and cells where each person performs   their function in a consistent manner to protect the host from any non-particulate matter for example infections, microbes, growths, parasites, etc. Our body needs a large   variety of micro (such as sugar, protein,fats) add to the synthesis of different types of safe cells. In this article, I have tried to explain the role of the immune system in the fight  against covid-19 virus and how exercise and proper diet can help build strong immune systems.

scholarly journals Urgensi Revisi Undang-Undang tentang Kesejahteraan Lanjut Usia

2020 ◽  
Vol 11 (1) ◽  
pp. 43-55
Author(s):  
Lukman Nul Hakim
Keyword(s):  
World Health Organization ◽  
Old Age ◽  
The Elderly ◽  
Scientific Study ◽  
World Health ◽  
Active Ageing ◽  
The World ◽  
The Law ◽  
Health Organization

At present we are witnessing an increasing population of the world's elderly. The World Health Organization (WHO) calls this phenomenon as humanity’s greatest triumph. Indonesia is one of the countries with the most elderly population in the world. The WHO predicts that in 2025 Indonesia will occupy the fifth position with the highest percentage of elderly people in the world. This article tries to answer what is the latest scientific study of the elderly? What should be the category limit old age in Indonesia? Is the revision of the Law Number 13 of 1998 concerning Elderly Welfare (the Elderly Act) is urgent to do? Finally, what is the role of the Indonesian Parliament on this issue? The researcher uses a qualitative method with a combination of interview techniques and literature studies. This article tries to answer what is the latest scientific study of the elderly? What should be the category limit old age in Indonesia? Is the revision of the Law Number 13 of 1998 concerning Elderly Welfare (the Elderly Act) is urgent to do? Finally, what is the role of the Indonesian Parliament on this issue? So if there is an elderly bonus, the burden on productive people will be heavier. Gerontologists introduce the concept of active aging as a solution. A concept that invites us to see the elderly not as burdens but people with economic and social potential. A solutive, comprehensive and implementative policy that is supported by implementers at the central, regional, and community level will make the bonus of the elderly a blessing. Therefore, the revision of Law No. 13 of 1998 on Elderly Welfare is urgently called for, with several important things that must be included, namely the principle of humanity, the rights of the elderly, elderly data collection, and economic protection for the elderly.AbstrakSaat ini kita sedang menyaksikan meningkatnya populasi lanjut usia (lansia) di dunia. World Health Organization (WHO) menyebut fenomena ini sebagai kemenangan terbesar umat manusia. Indonesia merupakan salah satu negara yang mempunyai populasi lansia terbanyak di dunia. WHO memprediksi bahwa pada tahun 2025 Indonesia akan menempati posisi kelima negara dengan persentase lansia tertinggi di dunia. Artikel ini mencoba menjawab bagaimanakah kajian ilmiah terkini tentang lansia? Berapakah sebaiknya batasan kategori usia lansia di Indonesia? Apakah revisi Undang-Undang Nomor 13 Tahun 1998 tentang Kesejahteraan Lanjut Usia (UU Lansia) mendesak untuk dilakukan? Terakhir, bagaimana peran DPR RI mengenai isu ini? Peneliti menggunakan metode penelitian kualitatif, yaitu dengan kombinasi teknik wawancara dengan pakar dan kajian literatur. Berdasarkan perhitungan dependency ratio oleh BPS, pada tahun 2020 ini 100 orang usia produktif menanggung beban 48 orang non-produktif, sehingga jika terjadi bonus lansia maka beban orang produktif akan semakin berat. Para ahli gerontologi memperkenalkan konsep active ageing sebagai solusi. Sebuah konsep yang mengajak kita memandang lansia bukan sebagai beban melainkan orang-orang yang potensial secara ekonomi dan sosial. Sebuah kebijakan yang solutif, komprehensif dan implementatif yang didukung oleh para pelaksana di tingkat pusat, daerah, dan unsur masyarakat akan menjadikan bonus lansia sebagai berkah. Karena itu revisi UU Lansia mendesak dilakukan, dengan beberapa hal penting yang harus dimasukkan, yaitu prinsip kelanjutusiaan, hak-hak lansia, pendataan lansia, dan proteksi ekonomi bagi lansia.

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