scholarly journals Investigation the levels of endotoxin and 8-OHdG in sera of patients with H.pyloripositive peptic ulcer

2021 ◽  
Author(s):  
Nihayet Bayraktar ◽  
İslim Guler ◽  
Ismail Koyuncu ◽  
Mehmet Bayraktar
Keyword(s):  
Peptic Ulcer ◽  
Public Health Problem ◽  
The Body ◽  
Serum Samples ◽  
Important Public Health Problem ◽  
Damage Level ◽  
Significant Difference ◽  
Infected Cells ◽  
Antigen Tests ◽  
H Pylori

Background and aim: Peptic ulcer is considered an important public health problem and generally associated with complicated conditions such as bleeding and perforation. The aim of this study is to reflect the rate of oxidative damage in the body among patients with H. pylori positive peptic ulcer by measuring serum 8-hydroxy-2p-deoxyguanosine (8-OHdG) and its association with the level of bacterial endotoxin. Methods Patients applied to Harran University Gastroenterology Outpatient Clinic with dyspeptic complaints were enrolled in this study. According to gastrointestinal endoscopy findings, 43 patients with H.pylori positive peptiv ulcer patients and 43 healthy volunteers were included in this study. H.pylori diagnosis was detemined by H.pylori urea breath and stool antigen tests. Serum 8-OHdG and endotoxins were measued by ELISA. Results A total of 43 patients with peptic ulcer (13 females 30 males), 43 healthy individuals (16 females 27 males) ages (18- 70) years in the study. In biopsies taken endoscopically; Hp severity was mild in 19 patients (43.9%), moderate in 21 patients (48.5%), and severe in 3 patients (7.6%). 8-OHdG which has the potential to mark DNA damage level in serum samples of patients with H.pylori positive peptic ulcer, was compared with the healthy and patient group. It was observed that there was a statistically significant difference (p <0.01). In addition, a weak correlation was found between OHdG and endotoxin. Conclusion: Reactive oxygen species (ROS) produced due to increased endotoxin as a result of H. pylıori infection can attack nucleic acid in infected cells resulting in an increased in serum 8-OHdG level. H.pylori and its endotoxin had a significant in peptic ulcer pathogensis.

scholarly journals Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyedeh Amineh Hojati ◽  
Sara Kokabpeyk ◽  
Salma Yaghoubi ◽  
Farahnaz Joukar ◽  
Mehrnaz Asgharnezhad ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Epigastric Pain ◽  
Tap Water ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Common Symptom ◽  
Pathological Findings ◽  
Significant Difference ◽  
H Pylori

Abstract Background Helicobacter pylori (H. pylori) infection is the most important risk factor for gastritis and peptic ulcer. However, factors other than H. pylori are involved in its pathogenesis. In the current study, we aimed to compare the clinical manifestations and endoscopic and histopathological findings of patients with and without H. pylori infection. Methods In this cross-sectional study, 233 patients with dyspepsia, referred for endoscopy, were examined regarding the presence of H. pylori infection. During an endoscopic exam, 5 biopsy specimens were taken from the stomach. The criteria for the presence of H. pylori infection was the presence and identification of bacteria in pathology. Two groups of H. pylori-positive and H. pylori-negative patients were compared regarding their demographic, endoscopic, and pathological findings. Results Of 233 patients, 154 (66.1%) were non-smokers, 201 (86.3%) were not alcohol users, and 153 (65.7%) used tap water. The most common symptom, reported in 157 (67.4%) patients, was epigastric pain. There was a significant difference between patients with and without H. pylori infection in terms of the educational status, occupational status, family history of gastrointestinal cancer, and some gastrointestinal symptoms. Also, there was a significant relationship between the endoscopic and pathological findings of patients with H. pylori. Conclusions The results of the present study revealed that H. pylori infection was not associated with sex, alcohol consumption, or non-steroidal anti-inflammatory drug use. The role of H. pylori in the pathophysiology of peptic ulcer was clarified. Also, there was a significant difference in the endoscopic and pathological findings of patients with H. pylori.

scholarly journals Estudio Descriptivo: Variación del Índice de Tiempo de Aceleración/Tiempo de Eyección Sistólico del Tronco de la Arteria Pulmonar por Efecto de Maduración Pulmonar con Corticoides en Fetos Prematuros. Clínica Humanitaria. Cuenca – Ecuador, 2016

2018 ◽  
Vol 10 (2) ◽  
pp. 93-97
Author(s):  
Angélica del Rosario Murillo Aguirre ◽  
Mariana Eulalia Gaybor Guillén
Keyword(s):  
Pulmonary Arteries ◽  
Public Health Problem ◽  
Infant Mortality Rate ◽  
Ejection Time ◽  
Lung Maturation ◽  
Important Public Health Problem ◽  
Convenience Sample ◽  
Acceleration Time ◽  
Significant Difference ◽  
Before And After

BACKGROUND: Premature birth represents an important public health problem worldwide and especially in developing countries. In Ecuador (2014), the infant mortality rate reached 8.35 deaths per 1 000 births and their main causes were newborns respiratory distress and gestation period short-term disorders. METHODS: This is an observational longitudinal descriptive research; it was performed in a convenience sample that included 26 singlet on pregnant women between 24 and 34 weeks of gestation. They also were on risk of preterm delivery and had indication of lung maturation with corticosteroids. Information of the fetal pulmonary arteries flow was collected to determine the effect of corticosteroids in pulmonary maturation. RESULTS: Mean age was 25.64 years and had an average gestation of 31.2 weeks. Most common diseases were preterm labor threat (72 %) and premature rupture of membranes (13.9 %). There was a statistically significant difference between the values of Acceleration Time / Ejection Time indexes before and after lung maturation (0.272 ms vs. 0.310 ms respectively; P < 0.0001). CONCLUSIONS: Comparison of Acceleration Time / Ejection Time indexes from the trunk of the pulmonary arteries before and after lung maturation evidenced an important significant difference. The findings suggest that pulmonary maturation with corticosteroids is effective to improve the pulmonary arteries flow of preterm fetus.

scholarly journals Immunomodulatory Effect of H. Pylori CagA Genotype and Gastric Hormones On Gastric Versus Inflammatory Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders

2016 ◽  
Vol 4 (3) ◽  
pp. 364-373
Author(s):  
Ali Ibrahim Ali Al-Ezzy
Keyword(s):  
Gene Expression ◽  
Lamina Propria ◽  
Gastric Gland ◽  
Inflammatory Cells ◽  
Serum Samples ◽  
Pepsinogen I ◽  
Significant Difference ◽  
H Pylori ◽  
Demographic Distribution ◽  
Gastroduodenal Disorders

AIM: To evaluate the Immunomodulatory effects of CagA expression; pepsinogen I, II & gastrin-17 on PMNs and lymphocytes Fas expression in inflammatory and gastric cells; demographic distribution of Fas molecule in gastric tissue and inflammatory cells.METHODS: Gastroduodenal biopsies were taken from 80 patients for histopathology and H. pylori diagnosis. Serum samples were used for evaluation of pepsinogen I (PGI); (PGII); gastrin-17 (G-17).RESULTS: Significant difference (p < 0.001) in lymphocytes & PMNs Fas expression; epithelial & lamina propria Fas localization among H. pylori associated gastric disorders. No correlation between grade of lymphocytes & PMNs Fas expression in gastric epithelia; lamina propria and types of gastric disorder. Significant difference (p < 0.001) in total gastric Fas expression, epithelial Fas; lamina propria and gastric gland Fas expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Total gastric Fas expression has significant correlation with CagA, PGII levels. Gastric epithelial and gastric lamina propria Fas expression have significant correlation with CagA, PGI; PGII levels. Significant difference (p < 0.001) was found in lymphocytes & PMNs Fas expression; epithelial & lamina propria localization of lymphocytes & PMNs Fas expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Lymphocytes Fas expression have correlation with PGI, PGII, PGI/PGII. PMNs Fas expression have correlation with PGI, PGII.CONCLUSION: Fas gene expression and localization on gastric and inflammatory cells affected directly by H. pylori CagA and indirectly by gastric hormones. This contributes to progression of various gastric disorders according to severity of CagA induced gastric pathology and gastric hormones disturbance throughout the course of infection and disease.

scholarly journals Tuberculosis Problem In Dakahlia Governorate, Egypt

2013 ◽  
Vol 10 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Amina Mostafa Abdel Aal ◽  
Noha El-Mashad ◽  
Dalia Magdi
Keyword(s):  
Age Groups ◽  
Public Health Problem ◽  
The Body ◽  
World Health ◽  
Tuberculosis Control ◽  
Important Public Health Problem ◽  
The Past ◽  
Chest Disease ◽  
Low Levels ◽  
Compliance To Treatment

Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. It has been present in humans since antiquity. In the past, tuberculosis has been called consumption, because it seemed to consume people from within, with a bloody cough, fever, pallor, and long relentless wasting. In Egypt, TB constitutes the second most important public health problem after schistosomiasis. Although Egypt has relatively low levels of TB according to data from the World Health of Organization, 2005:66% of TB cases occur among the socially and economically productive age groups of 15 to 54 years. According to Ministry of Health and Population (MOHP), Egypt; tuberculosis control is carried out through 111 chest centers and 39 chest disease hospitals. Treatment failure accounts for 3%–5%of the treatment outcome of new smear positive cases and 13%–17% of retreated cases and this is due to non-compliance to treatment, defi cient health education to the patient, poor patient knowledge regarding the disease and diabetes mellitus as co-morbid. The incidence and prevalence of tuberculosis in Egypt has been declining due to increased efforts of the MOHP. Prevalence dropped from 88/100,000 population in 1990 to 24 in 2008, according to data from WHO. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS; 2013; X(1); 43-49 DOI: http://dx.doi.org/10.3126/saarctb.v10i1.8677

The Role of Gastric Acid in Preventing Foodborne Disease and How Bacteria Overcome Acid Conditions†

2003 ◽  
Vol 66 (7) ◽  
pp. 1292-1303 ◽  
Author(s):  
JAMES L. SMITH
Keyword(s):  
Peptic Ulcer ◽  
Acid Secretion ◽  
Peptic Ulcer Disease ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Gastric Fluid ◽  
The Body ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
H Pylori

The secretion of hydrochloric acid by the stomach plays an important role in protecting the body against pathogens ingested with food or water. A gastric fluid pH of 1 to 2 is deleterious to many microbial pathogens; however, the neutralization of gastric acid by antacids or the inhibition of acid secretion by various drugs may increase the risk of food- or waterborne illnesses. Peptic ulcer disease is often treated by decreasing or eliminating gastric acid secretion, and such treatment blocks the protective antibacterial action of gastric fluid. The majority of peptic ulcer disease cases originate from Helicobacter pylori infections. Treatment of H. pylori–induced peptic ulcers with antibiotics reduces the need for drugs that inhibit gastric acid secretion and thereby diminishes the risk of food- and waterborne illness for peptic ulcer disease patients. Many bacterial pathogens, such as Escherichia coli, Salmonella Typhimurium, and H. pylori, can circumvent the acid conditions of the stomach by developing adaptive mechanisms that allow these bacteria to survive in acid environments. As a consequence, these bacteria can survive acidic stomach conditions and pass into the intestinal tract, where they can induce gastroenteritis.

scholarly journals Prognostic Significance of Ischemia-Modified Albumin Levels in Community-Acquired Pneumonia Cases

2021 ◽  
Author(s):  
Melis Yağdıran ◽  
Ebru Sengul Parlak ◽  
H.Canan Hasanoglu
Keyword(s):  
Intensive Care ◽  
Predictive Value ◽  
Prognostic Significance ◽  
Public Health Problem ◽  
Community Acquired Pneumonia ◽  
High Morbidity ◽  
Important Public Health Problem ◽  
Ischemia Modified Albumin ◽  
Antioxidant Mechanism ◽  
Significant Difference

Background: Community-acquired pneumonia (CAP) is an important public health problem because of its high morbidity, mortality, and health care costs. Many biomarkers have been used to determine the severity and prognosis of pneumonia. Ischemia-modified albumin (IMA) is a marker of the recently used oxidant-antioxidant mechanism and has been found to increase in many inflammatory conditions. Objectives: To investigate the role of the levels of IMA in CAP and to evaluate its relationship with pneumonia severity. Methods: A total of 150 patients with a diagnosis of CAP and 150 healthy individuals were included in the study. IMA levels were evaluated in both groups. The patients with CAP were divided into ambulatory, ward and intensive care groups, and their IMA levels were compared. Results: There was no significant difference between the two groups in terms of age or gender (p > 0.05 for both). No significant difference was observed in the IMA levels of the patient and control groups (p ˃ 0.05). The lowest IMA level was observed in the ambulatory group (p = 0.001). When the patients in the ambulatory and hospitalized (ward and intensive care together) groups were evaluated, the cut-off value of IMA was 77.60 ABSU, sensitivity was 64.9%, specificity was 75.0%, positive predictive value was 89.2%, and negative predictive value was 40.3%. Conclusion: In the management of patients with CAP, IMA seems to be a useful marker for CAP severity and hospitalization decision. Keywords: Community-acquired pneumonia, ischemia-modified albumin, biomarker

scholarly journals The impact of using BASNEF model on self-control behaviors among Patients with hypertension

2018 ◽  
Vol 3 (3) ◽  
pp. 112
Author(s):  
Moradali Zareipour ◽  
Mousa Ghelichi Ghojogh ◽  
Masoumeh Mahdi-akhgar ◽  
Sarvin Abbasi ◽  
Nooshin Yoshany ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intervention Group ◽  
Public Health Problem ◽  
Developed Countries ◽  
Self Control ◽  
Control Group ◽  
Validity And Reliability ◽  
Important Public Health Problem ◽  
Significant Difference ◽  
The Impact

Background: High blood pressure is the most important public health problem in developed countries. It is one reason for early mortality and risk factors for cardiovascular diseases like stroke and kidney failure. This study aimed to determine the effect of educational intervention based on BASNEF in blood pressure control in 1395.Methods and Materials: This study was a quasi-experimental study on 160 patients in two groups (each n = 80) suffering from hypertension in urban health centers of Urmia. Data collection questionnaire included: demographic questions, knowledge base questions, self-control behaviors questions and structures of  BASNEF model. Validity and reliability were respectively 80% and 79%. Intervention group had taken three 45 minutes sessions using speeches, questions and answers, posters, booklets, pamphlets and whiteboard. Before training, information collected through questionnaires and after training questionnaires were completed again after 3 months. The data were analyzed in SPSS software with chi-square tests, Fisher, independent and paired sample t-test.Results: The average age of case and control group were  99.11 ± 01.56 and 75.12 ± 66.53 years. That there was no statistically significant difference (p=0.1). After intervention average systolic blood pressure significantly decreased in the intervention group from 43.157 to 24.147 mm Hg and diastolic blood pressure significantly decreased from 21.93 to 52.87 mm Hg (P <0.05)Conclusion:  The training program using BASNEF model has provided better results in controlling blood pressure than conventional trainings.

scholarly journals Risk Factors For Recurrence of Peptic Ulcer Disease: A Retrospective Study In Tertiary Care Referral Center

2022 ◽  
Author(s):  
Yaser Alsinnari ◽  
Mohammed S. Alqarni ◽  
Meshari Attar ◽  
Ziad M. Bukhari ◽  
Faisal Baabbad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Recurrence Rate ◽  
Univariate Analysis ◽  
Tertiary Care ◽  
Ulcer Disease ◽  
Significant Difference ◽  
Risk Factors For Recurrence ◽  
H Pylori

Abstract Backgrounds: Peptic ulcer disease (PUD) is a common gastrointestinal tract disease characterized by mucosal damage secondary to pepsin and gastric acid secretion. The aim of this study was to evaluate the five-year recurrence rate for treated patients with PUD and risk factors contributing to PUD relapses.Methods: From 2016 through 2021, all patients with endoscopy-proved PUD were identified by reviewing medical records (Best-Care system). Possible risk factors including smoking, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, alcohol, caffeine, and steroid were analyzed by univariate analysis. Treatment outcomes, 5-year recurrence rate, and mortality rate were assessed.Results: Among 223 patients, there were 187 (83.8%), who diagnosed endoscopy-proved PUD and 36 (16.2%), who diagnosed clinical PUD. Among them, 126 (56.5%) patients were males and the mean age was 62±2 years. The five years recurrence rate of PUD was 30.9%. There was no significant difference in the recurrence rate between the duodenal ulcer (33.3%) and the gastric ulcer (28.8%). By univariate analysis, the use of steroid and NSAID and H. pylori infection were potential risk factors for PUD (P < 0.005). The common complication of PUD was gastrointestinal bleeding (34.1%). Patients who had a complicated PUD were associated with a higher rate of recurrence (45.9%) compared to the uncomplicated PUD (19.2%) (P > 0.05). Conclusion: Our findings demonstrated that the five years recurrence rate of PUD was 30.9%. The use of steroid and NSAID and H. pylori infection were risk factors for recurrence of PUD. PUD places a significant burden on health care systems. Therefore, a multicenter prospective study is needed for effective management to prevent recurrence and complications of PUD.

scholarly journals Prevalence of COVID symptoms, their severity and duration: a gender based analysis

2021 ◽  
Vol 8 (9) ◽  
pp. 4463
Author(s):  
Abhishek Kumar Mishra ◽  
Chhaya Mittal ◽  
Tanveer Bano ◽  
Arun Kumar ◽  
Ganesh Singh ◽  
...  
Keyword(s):  
Attack Rate ◽  
Public Health Problem ◽  
Severity Of Illness ◽  
Simple Random Sampling ◽  
Face Mask ◽  
Cross Sectional Study ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
Significant Difference ◽  
Gender Based

Background: COVID -19 is the most important public health problem of recent time. Approximately (60%) of those infected develop symptoms. Study is needed to assess the prevalence of COVID-19 symptoms, their severity and duration, secondary attack rate and COVID-19 appropriate behaviour for prevention and control of infection. The aim was to assess the prevalence of COVID-19 symptoms, secondary attack rate and COVID-19 appropriate behaviour of infected person.Methods: Present cross sectional study was done among patients who recovered from COVID-19 in Meerut district. After obtaining mobile numbers of patients, they were asked about their experience about pre-COVID, COVID and post-COVID period. Total 100 patients were contacted using simple random sampling and information was collected on predesigned Google form.Results: Out of total respondents 98% developed one or more symptoms. Fever was reported to be most common problem (72%) followed by body ache (62%). Most classified their symptoms as mild and moderate (36% and 43% respectively). There was no statistically significant difference for duration and severity of illness based on gender. While 21% categorized their symptoms as severe and very severe. All 100% patients followed COVID-19 appropriate behaviour post infection frequent hand washing and use of sanitizer being the most common behaviour (79%). Other commonly followed COVID-19 appropriate behaviours were use of face mask (68%), maintaining distance of more than 6 feet (65%).Conclusions: COVID-19 symptoms are common among patients but are usually less severe. Most of the patients are following COVID-19 appropriate behaviour to lessen burden of infection to others. Results also highlight the need of early testing to reduce infection in family members.

scholarly journals Prevalence of rubella antibodies in a non-immunized urban population, São Paulo, Brazil

1994 ◽  
Vol 36 (4) ◽  
pp. 373-376 ◽  
Author(s):  
Vanda A.U.F. Souza ◽  
José Cassio Moraes ◽  
Laura M Sumita ◽  
Maria Claudia C. Camargo ◽  
Maria Cristina D.S. Fink ◽  
...  
Keyword(s):  
Vaccination Campaign ◽  
Public Health Problem ◽  
Sao Paulo ◽  
Mass Vaccination ◽  
São Paulo ◽  
Serum Samples ◽  
Important Public Health Problem ◽  
Rubella Infection ◽  
Cord Serum ◽  
Mass Vaccination Campaign

The prevalence of rubella antibodies was evaluated through a ramdom Seroepidemiological survey in 1400 blood samples of 2-14 year old children and in 329 samples of umbilical cord serum. Rubella IgG antibodies were detected by ELISA, and the sera were collected in 1987, five years before the mass vaccination campaign with measles-mumps-rubella vaccine carried out in the city of São Paulo in 1992. A significant increase in prevalence of rubella infection was observed after 6 years of age, and 77% of the individuals aged from 15 to 19 years had detectable rubella antibodies. However, the seroprevalence rose to 90.5% (171/189) in cord serum samples from children whose mothers were 20 to 29 years old, and reached 95.6% in newborns of mothers who were 30 to 34 years old, indicating that a large number of women are infected during childbearing years. This study confirms that rubella infection represents an important Public Health problem in São Paulo city. The data on the seroprevalence of rubella antibodies before the mass vaccination campaign reflects the baseline immunological status of this population before any intervention and should be used to design an adequate vaccination strategy and to assess the Seroepidemiological impact of this intervention.

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