scholarly journals Sustained impact of subcutaneous immunotherapy among patients with allergic rhinitis who experienced treatment delay due to the COVID-19 pandemic: A multicenter, two-arm, real-world study

2021 ◽  
Author(s):  
SUIZI ZHOU ◽  
Yibin Liu ◽  
Jianrong Xue ◽  
Juan Tang ◽  
Qingqing Yu ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Depression Scale ◽  
Treatment Delay ◽  
Psychological Status ◽  
Subcutaneous Immunotherapy ◽  
Self Rating ◽  
Medication Score ◽  
Delayed Group ◽  
One Year ◽  
The Impact

Background: The aim of this study is to investigate the impact of COVID-19 related treatment delay on subcutaneous immunotherapy (SCIT) efficacy in patients with allergic rhinitis (AR). Methods: The study was performed in 643 patients with SCIT appointments between February 1 and May 31, 2020. The clinical assessment, performed at baseline (V0) and one year later (V1), included visual analogue scale (VAS); daily symptom score (dSS); daily medication score (dMS); combined symptom and medication scores (CSMS); quality of life (QoL); self-rating anxiety scale (SAS); and self-rating depression scale (SDS) for each patient. Results: At V0, 249 patients were treated on schedule, and 394 were delayed (7 ± 4.68 weeks). Among them, 319 patients (105 on schedule, and 214 delayed) also completed the assessments at V1, with the absence of 25.39% patients due to completion of SCIT, and 25.35% patients were withdrawal. The results of all assessments were within the normal range for all patients at V0 and V1, with the exception of a slightly higher SDS score (56.13) at V0. In the SCIT delayed group. there was a significant positive correlation between the length (weeks) of the delay and SDS score, and this was significantly higher in patients with poor control of nasal symptoms. Conclusions: This study showed the long-term efficacy of SCIT for AR patients, including those who have had to delay normal therapy due to the COVID-19 outbreak. The psychological status of SCIT patients in response to lockdown of hospital services during this critical period should be considered.

scholarly journals Comparison of Prevalence and Risk Factors of PTSS Between Chinese Patients With Depression and Non-depressed Controls During COVID-19 Outbreak

2022 ◽  
Vol 12 ◽  
Author(s):  
Min Peng ◽  
Xinran Song ◽  
Luyu Liu ◽  
Weifeng Zhao ◽  
Pingmei Lai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Traumatic Event ◽  
Linear Regression Analysis ◽  
Depression Scale ◽  
Psychological Status ◽  
Chinese Patients ◽  
Depressed Patients ◽  
Self Rating ◽  
Depressed Group ◽  
The Impact

Background: COVID-19 pandemic is a traumatic event all over the world, and may lead to post-traumatic stress symptom (PTSS) in different population who are under the threat of novel corona virus. Therefore, the aim of our study was to compare the prevalence and risk factors of PTSS between Chinese patients with depression and non-depressed controls during the COVID-19 outbreak.Methods: 437 depressed patients and 2,940 non-depressed controls were enrolled in this cross-sectional study between February 14 and May 9, 2020.The Impact of Events Scale-Revised (IES-R), Zung Self-Rating Depression Scale (SDS), Zung Self-Rating Anxiety Scale (SAS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the psychological status of all the participants.Results: The prevalence of PTSS (IES-R ≥ 33) in depressed patients (45.08%) was higher than that in non-depressed controls (5.31%). Patients with depression were 16 times more likely to suffer from PTSS than those without depression. Correlation analyses showed that the IES-R total score was positively correlated with SDS, SAS, and PSQI scores in both depressed and non-depressed groups (Bonferroni corrected all p < 0.001). Multiple linear regression analysis showed that SAS score, and PSQI score were independently associated with IES-R total score in both depression and non-depression groups. In depressed patients, education level and duration of media exposure to COVID-19 were positively associated with PTSS, while in the non-depressed group, subjects who were married, in the 31–50 year group or with higher SDS score were more likely to develop PTSS.Conclusions: These results indicate that the prevalence rate of PTSS in patients with depression is very higher than that in subjects without depression. PTSS are associated with a number of socio-demographic and clinical variables.

scholarly journals Metabolomics Reveals Process of Allergic Rhinitis Patients with Single- and Double-Species Mite Subcutaneous Immunotherapy

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 613
Author(s):  
Peiyan Zheng ◽  
Guanyu Yan ◽  
Yida Zhang ◽  
Huimin Huang ◽  
Wenting Luo ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Arachidonic Acid ◽  
Allergic Diseases ◽  
Subcutaneous Immunotherapy ◽  
Therapeutic Effects ◽  
Life Questionnaire ◽  
Potential Biomarker ◽  
Significant Difference ◽  
Acid Pathway ◽  
One Year

Allergen immunotherapy (AIT) is the only treatment that can change the course of allergic diseases. However, there has not been any research on metabolic reactions in relation to AIT with single or mixed allergens. In this study, patients with allergic rhinitis caused by Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) were treated with single-mite (Der p) and double-mite (Der p:Der f = 1:1) subcutaneous immunotherapy (SCIT), respectively. To compare the efficacy and the dynamic changes of inflammation-related single- and double-species mite subcutaneous immunotherapy (SM-SCIT and DM-SCIT), we performed visual analogue scale (VAS) score, rhinoconjunctivitis quality of life questionnaire (RQLQ) score and serum metabolomics in allergic rhinitis patients during SCIT. VAS and RQLQ score showed no significant difference in efficacy between the two treatments. A total of 57 metabolites were identified, among which downstream metabolites (5(S)-HETE (Hydroxyeicosatetraenoic acid), 8(S)-HETE, 11(S)-HETE, 15(S)-HETE and 11-hydro TXB2) in the ω-6-related arachidonic acid and linoleic acid pathway showed significant differences after approximately one year of treatment in SM-SCIT or DM-SCIT, and the changes of the above serum metabolic components were correlated with the magnitude of RQLQ improvement, respectively. Notably, 11(S)-HETE decreased more with SM-SCIT, and thus it could be used as a potential biomarker to distinguish the two treatment schemes. Both SM-SCIT and DM-SCIT have therapeutic effects on patients with allergic rhinitis, but there is no significant difference in efficacy between them. The reduction of inflammation-related metabolites proved the therapeutic effect, and potential biomarkers (arachidonic acid and its downstream metabolites) may distinguish the options of SCIT.

scholarly journals Hubungan Faktor Demografi Dan Dukungan Sosial Dengan Depresi Pascasalin

2018 ◽  
Vol 11 (2) ◽  
Author(s):  
Nurfatimah Nurfatimah ◽  
Cristina Entoh
Keyword(s):  
Social Support ◽  
Postnatal Depression ◽  
Economic Status ◽  
Depression Scale ◽  
Dominant Factor ◽  
Research Subjects ◽  
Cross Sectional ◽  
One Year ◽  
The Impact ◽  
The Relationship

Postnatal depression is a mental disorder after the birth of her child and can last up to one year. Maternal postnatal mood disorder not an easy matter. The impact can be devastating life of the mother and her child. Currently there are many women who experienced postnatal depression but has not been detected. The purpose of this study was to analyze the relationship between demographic factors and social support in postnatal depression in The Working Area Of Puskesmas Kayamanya.The design of this research is cross sectional. Research subjects were followed for 56 respondents ranging from childbirth to 7 days postnatal. The samples was chosen by using consequtive sampling. The instruments used in this research are the Edinburgh Postnatal Depression Scale (EPDS) and standard social support questionnaire. The results reveal that the age is not significantly associated with depression postnatal (p = 0.514) and education (p = 0.154); but it is significantly parity (p = 0.012); economic status (p = 0.030), social support include the family (p = 0.035); friends (p = 0.017); and midwives (p = 0.005). The multivariate analysis reveals that midwifes support (wald=4,236; p= 0,04) is the dominant factor causing postnatal depression.

scholarly journals How Dialysis Patients Cope with a Curfew? A Comparison of Psychological Status between Hemodialysis and Peritoneal Dialysis Patients During the COVID-19 Pandemic

2021 ◽  
pp. 1-6
Author(s):  
Cebrail Karaca ◽  
Necmi Eren ◽  
Mevlut Tamer Dincer ◽  
Senol Turan ◽  
Hatice Kubra Karaca ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Social Isolation ◽  
Depression Scale ◽  
Psychological Status ◽  
Daily Routine ◽  
Dialysis Patients ◽  
Event Scale ◽  
The Social ◽  
The Impact ◽  
Isolation Period

<b><i>Introduction:</i></b> There are many differences between hemodialysis (HD) and peritoneal dialysis (PD) treatments, including their impact on the psychological status of the patients. In this study, our aim was to compare the psychological statuses of HD and PD patients during the social isolation period due to the COVID-19 pandemic. <b><i>Methods:</i></b> We conducted this cross-sectional study on adult HD and PD patients when the curfew measures were in effect. We used an electronic form composed of 3 sections to collect data. In the first section, we collected data on the demographics and clinical and laboratory parameters of the patients. The second and third sections consisted of the Hospital Anxiety and Depression Scale (HADS) and the Impact of Event Scale-Revised (IES-R) questionnaires, respectively. <b><i>Results:</i></b> The HD (<i>n</i> = 116) and PD (<i>n</i> = 130) groups were similar regarding age and sex, and they had similar HADS anxiety scores. HADS depression scores were higher in PD patients (<i>p</i> = 0.052). IES-R scores were significantly higher in PD patients in comparison to HD patients (<i>p</i> = 0.001). Frequencies of abnormal HADS-anxiety (<i>p</i> = 0.035) and severe psychological impact (<i>p</i> = 0.001) were significantly higher in PD patients. <b><i>Discussion/Conclusion:</i></b> During the social isolation period due to the COVID-19 pandemic, HD patients had better mood profiles than PD patients. A more stable daily routine, an uninterrupted face-to-face contact with health-care workers, and social support among patients in the in-center dialysis environment might be the cause of the favorable mood status. PD patients might need additional psychological support during those periods.

scholarly journals Effect of Postoperative Specific Immunotherapy Combined with Nasal Irrigation on Chronic Rhinosinusitis with Allergic Rhinitis

2021 ◽  
Author(s):  
Jia Li ◽  
Houyong Kang ◽  
Suling Hong ◽  
Yang Shen
Keyword(s):  
Allergic Rhinitis ◽  
Chronic Rhinosinusitis ◽  
Eosinophil Cationic Protein ◽  
Sinus Surgery ◽  
Postoperative Treatment ◽  
Subcutaneous Immunotherapy ◽  
Expression Levels ◽  
Nasal Irrigation ◽  
Group A ◽  
One Year

Patients with chronic rhinosinusitis (CRS) and allergic rhinitis (AR) (CRSwAR) have a more severe condition with a higher rate of recurrence after endoscopic sinus surgery (ESS). This study aimed to explore the effect of specific subcutaneous immunotherapy (SCIT) and nasal irrigation on CRSwAR after ESS. Sixty-four patients who were diagnosed as CRSwAR and received ESS were enrolled and divided into groups A, B, and C to receive different postoperative treatment strategies (conventional medication, medication with nasal irrigation, and medication with nasal irrigation and SCIT), and their prognosis was evaluated by scoring, electron microscopy, and inflammatory factors. One year after ESS, the recurrence rate of group C was significantly reduced; and the scoring from baseline was significantly different among the three groups, which of group C were the best. The epithelium arrangement, cilia morphology, and inflammation of nasal mucosa in each group were better than those in the preoperative state; and those in group C were the best. After one year, the expression levels of eosinophil cationic protein (ECP), interleukin (IL)-8, and IL-17 in group B were lower than those of group A; and the expression levels of ECP, IL-8, IL-25, IL-33, IL-17 in group C were lower than those in group A. SCIT combined with nasal irrigation can improve the patients' symptoms and quality of life, promote the epithelialization of the mucosa in the surgical cavity, regulate the local immune response of the nasal cavity; thus improve the prognosis of patients with ESS after 1 year.

Depressive Symptoms before and One Year after Heart Surgery

1987 ◽  
Vol 61 (1) ◽  
pp. 173-174 ◽  
Author(s):  
Guido Magni
Keyword(s):  
Depressive Symptoms ◽  
Heart Surgery ◽  
Depressive Symptomatology ◽  
Depression Scale ◽  
Self Rating ◽  
Clinically Significant ◽  
One Year

For 57 patients undergoing major heart surgery depressive symptoms were assessed before the operation and one year afterwards. The Zung Self-rating Depression Scale was used. Mean depressive scores significantly decreased at the follow-up. However, looking at frequencies instead of mean scores indicated about one-fourth of the sample showed clinically significant depressive symptomatology one year after surgery.

scholarly journals Effects of Dual-Perspective Nursing Intervention Based on Safety and Comfort Needs on Psychological Status and Safety Quality of MRI Patients

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Yan Yu
Keyword(s):  
Safety Management ◽  
Safety Information ◽  
Depression Scale ◽  
Nursing Intervention ◽  
Psychological Status ◽  
Control Group ◽  
Observation Group ◽  
Self Rating ◽  
Dual Perspective

Objective: To investigate the effect of dual-perspective nursing intervention based on safety and comfort needs on the psychological status and safety quality of patients undergoing magnetic resonance imaging (MRI). Methods: A total of 100 patients who received MRI in our hospital from October 2017 to December 2019 were selected and randomly divided into two groups, 50 cases for each group. Routine nursing intervention was performed in the control group, and double-perspective nursing intervention based on safety and comfort needs in addition to routine nursing was performed in the observation group. Psychological status and examination of safety quality were observed and compared between the two groups. Results: The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were lower than those in the control group after intervention. Meanwhile, the scores of early treatment of dangerous conditions, implementation of safety measures, prevention of accidental injuries, communication of safety information, education of safety knowledge, standardized examination and awareness of self-safety management in the observation group were higher than those in the control group after intervention, and the differences were statistically significant (P < 0.05). Conclusion: Dual-perspective nursing intervention based on safety and comfort needs is effective for patients undergoing MRI examination, which can improve the psychological status of patients and improve the quality of examination safety.

Quality of Sleep, Fatigue and Daytime Sleepiness in Migraine—A Controlled Study

Cephalalgia ◽  
2009 ◽  
Vol 29 (6) ◽  
pp. 662-669 ◽  
Author(s):  
S Seidel ◽  
T Hartl ◽  
M Weber ◽  
S Matterey ◽  
A Paul ◽  
...  
Keyword(s):  
Daytime Sleepiness ◽  
Depression Scale ◽  
Study Groups ◽  
The Self ◽  
Controlled Study ◽  
Semistructured Interview ◽  
Quality Of Sleep ◽  
Self Rating ◽  
The Impact

The objective of this study was to evaluate whether the quality of sleep and the degree of fatigue and daytime sleepiness are related to migraine. We investigated 489 subjects comprising 97 patients with eight or more, 77 patients with five to seven and 196 patients with one to four migraine days per month, and 119 migraine-free controls with fewer than six headache days per year. The patients were recruited via articles in newspapers not stressing the subject of the study. All participants underwent a semistructured interview and completed the Pittsburgh Sleep Quality Index (PSQI), the Fatigue Severity Scale (FSS), the Epworth Sleepiness Scale (ESS) and the Self-rating Depression Scale and the Self-rating Anxiety Scale. For statistical analysis we used two way MANOVAs, post hoc univariate two-way ANOVAs and Hochberg's GT2 tests as well as three-way mixed design ANOVAs. The PSQI total score was highest in patients with frequent migraine (5.9 ± 4.3) and lowest in controls (4.3 ± 2.5, P = 0.04). Four subscores of the PSQI showed similar statistically significant differences. The FSS and ESS scores did not differ in the four study groups. Analysing depression and anxiety revealed a significant impact on PSQI, FSS and ESS, but did not demonstrate interactions with migraine, thus suggesting that the impact of migraine is similar in patients without and with psychiatric comorbidity. In conclusion, the quality of sleep is decreased in patients with migraine, whereas fatigue and daytime sleepiness do not differ from healthy controls. The decreased quality of sleep in migraineurs is also a consequence of migraine itself and cannot be explained exclusively by comorbidity with depression or anxiety.

scholarly journals The Mental Well-Being of Frontline Physicians Working in Civil Wars Under Coronavirus Disease 2019 Pandemic Conditions

2021 ◽  
Vol 11 ◽  
Author(s):  
Muhammed Elhadi ◽  
Ahmed Msherghi ◽  
Moutaz Elgzairi ◽  
Ayiman Alhashimi ◽  
Ahmad Bouhuwaish ◽  
...  
Keyword(s):  
Depression Scale ◽  
Maslach Burnout Inventory ◽  
Well Being ◽  
Cross Sectional Study ◽  
Stressful Events ◽  
Psychological Status ◽  
Emergency Physicians ◽  
Cross Sectional ◽  
Frontline Staff ◽  
The Impact

Background and Objective: Emergency medical physicians are regarded as essential frontline staff in combating the coronavirus disease 2019 (COVID-19) pandemic. These health-care workers are faced with significant stressors in addition to the usual stress felt in their regular work. Therefore, this study aimed to examine the prevalence of anxiety, depression, and burnout among emergency physicians on the frontline of the COVID-19 pandemic.Method: Using a cross-sectional study methodology, we surveyed physicians active on April 2020 to study depression and anxiety [using Hospital Anxiety and Depression Scale (HADS)] and burnout [using the Abbreviated Maslach Burnout Inventory (aMBI) scale].Results: A total of 154 emergency physicians completed the survey. We found that about 65.6% of patients were experiencing anxiety (based on a HADS score ≥ 11), and 73.4% were displaying depressive symptoms. For burnout, three subscales indicated that 67.5% endured emotional exhaustion, and 48.1% experienced depersonalization (defined as a score of ≥10 on aMBI). A total of 21.4% of respondents perceived a sense of personal underachievement, defined as a score of &lt;10 via aMBI.Conclusion: Physicians' psychological status is crucial and plays a major role in their well-being, affecting their work satisfaction. Therefore, implementing strategies aimed at decreasing the impact of stressful events is crucial to alleviate the distress experienced by physicians on the frontline of the COVID-19 pandemic.

scholarly journals Real-life effect of a microcrystalline tyrosine adjuvanted mite immunotherapy in patients with allergic rhinitis

Immunotherapy ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Albert Roger ◽  
Alfons Malet ◽  
Victoria Moreno ◽  
Antonio Parra ◽  
Diego Gutiérrez ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Treatment Initiation ◽  
Real Life ◽  
Subcutaneous Immunotherapy ◽  
Serious Adverse Events ◽  
End Points ◽  
Life Study ◽  
Real Life Setting ◽  
Medication Score ◽  
Real Life Study

Aim: Evaluate the effectiveness and safety of immunotherapy with Acarovac Plus® in a 1-year prospective multicentered real-life study. Methods: A total of 118 adults with allergic rhinitis sensitized to Dermatophagoides received subcutaneous immunotherapy with Acarovac Plus. Treatment outcomes were evaluated at baseline, 6 months and 1 year after treatment initiation. Primary end point was the evolution of the combined symptom and medication score. Secondary end points included other effectiveness outcomes and measurement of product tolerability. Results: Acarovac Plus induced significant improvements in primary and secondary end points after 6 months compared with baseline. These differences persisted after 1 year of treatment (p < 0.001; baseline vs 1 year): combined symptom and medication score (1.60 vs 0.79). No serious adverse events were recorded. Conclusion: Acarovac Plus for 1 year was effective and well tolerated in a real-life setting.

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