Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG

In recent decades, probiotic products have been increasingly used to prevent certain gastro-intestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters.

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Extracellular Vesicles of Mesenchymal Stem Cells: Therapeutic Properties Discovered with Extraordinary SuccessOK

Biomedicines ◽

10.3390/biomedicines9060667 ◽

2021 ◽

Vol 9 (6) ◽

pp. 667

Author(s):

Gabriella Racchetti ◽

Jacopo Meldolesi

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Immune Responses ◽

Extracellular Vesicles ◽

Immune Regulation ◽

Great Increase ◽

The Body ◽

Cell Aging ◽

Therapeutic Effects ◽

Therapeutic Properties

Mesenchymal stem cells (MSCs), the cells distributed in the stromas of the body, are known for various properties including replication, the potential of various differentiations, the immune-related processes including inflammation. About two decades ago, these cells were shown to play relevant roles in the therapy of numerous diseases, dependent on their immune regulation and their release of cytokines and growth factors, with ensuing activation of favorable enzymes and processes. Such discovery induced great increase of their investigation. Soon thereafter, however, it became clear that therapeutic actions of MSCs are risky, accompanied by serious drawbacks and defects. MSC therapy has been therefore reduced to a few diseases, replaced for the others by their extracellular vesicles, the MSC-EVs. The latter vesicles recapitulate most therapeutic actions of MSCs, with equal or even better efficacies and without the serious drawbacks of the parent cells. In addition, MSC-EVs are characterized by many advantages, among which are their heterogeneities dependent on the stromas of origin, the alleviation of cell aging, the regulation of immune responses and inflammation. Here we illustrate the MSC-EV therapeutic effects, largely mediated by specific miRNAs, covering various diseases and pathological processes occurring in the bones, heart and vessels, kidney, and brain. MSC-EVs operate also on the development of cancers and on COVID-19, where they alleviate the organ lesions induced by the virus. Therapy by MSC-EVs can be improved by combination of their innate potential to engineering processes inducing precise targeting and transfer of drugs. The unique properties of MSC-EVs explain their intense studies, carried out with extraordinary success. Although not yet developed to clinical practice, the perspectives for proximal future are encouraging.

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Therapeutic nanomedicine surmounts the limitations of pharmacotherapy

Open Medicine ◽

10.1515/med-2017-0041 ◽

2017 ◽

Vol 12 (1) ◽

pp. 271-287 ◽

Cited By ~ 2

Author(s):

Arome Odiba ◽

Victoria Ottah ◽

Comfort Ottah ◽

Ogechukwu Anunobi ◽

Chimere Ukegbu ◽

...

Keyword(s):

Cytotoxic Effect ◽

Unique Property ◽

The Body ◽

Regulatory Agencies ◽

Therapeutic Effects ◽

Genetic Therapy ◽

Target Drug Delivery ◽

Target Drug ◽

And Control ◽

Manipulation And Control

AbstractScience always strives to find an improved way of doing things and nanoscience is one such approach. Nanomaterials are suitable for pharmaceutical applications mostly because of their size which facilitates absorption, distribution, metabolism and excretion of the nanoparticles. Whether labile or insoluble nanoparticles, their cytotoxic effect on malignant cells has moved the use of nanomedicine into focus. Since nanomedicine can be described as the science and technology of diagnosing, treating and preventing diseases towards ultimately improving human health, a lot of nanotechnology options have received approval by various regulatory agencies. Nanodrugs also have been discovered to be more precise in targeting the desired site, hence maximizing the therapeutic effects, while minimizing side-effects on the rest of the body. This unique property and more has made nanomedicine popular in therapeutic medicine employing nanotechnology in genetic therapy, drug encapsulation, enzyme manipulation and control, tissue engineering, target drug delivery, pharmacogenomics, stem cell and cloning, and even virus-based hybrids. This review highlights nanoproducts that are in development and have gained approval through one clinical trial stage or the other.

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Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis in mice

Molecular Medicine Reports ◽

10.3892/mmr.2018.9612 ◽

2018 ◽

Cited By ~ 2

Author(s):

Huan Zhou ◽

Hui‑Jing Zhang ◽

Lin Guan ◽

Yi‑Ning Zhang ◽

Yue Li ◽

...

Keyword(s):

Experimental Colitis ◽

Saccharomyces Boulardii ◽

Therapeutic Effects

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Inert gas-exchange theory using an electric analogue

Journal of Applied Physiology ◽

10.1152/jappl.1964.19.6.1193 ◽

1964 ◽

Vol 19 (6) ◽

pp. 1193-1198 ◽

Cited By ~ 11

Author(s):

W. W. Mapleson

Keyword(s):

Alveolar Ventilation ◽

The Body ◽

Exchange Theory ◽

Inert Gases ◽

Inert Gas ◽

Respiratory Pattern ◽

Whole Body ◽

High Solubility ◽

Systematic Analysis ◽

Inhaled Anesthetics

When an inert gas of moderate or high solubility in blood is inhaled, the rate at which the alveolar concentration rises toward the inspired concentration increases as the inspired concentration is increased. The only previous systematic analysis of whole-body uptake of inert gases to allow for this effect was restricted to a single, artificial, respiratory pattern and the numerical calculations had to be made on a digital computer. This paper develops the theory for a range of respiratory patterns and shows how the computations may be made on a slightly modified form of a simple electric analogue. It is shown that the rate of saturation of the body increases less markedly with inspired concentration if the inspired alveolar ventilation, rather than the expired alveolar ventilation, is kept constant during the saturation process. Conversely, washout is more rapid with a constant inspired ventilation than with a constant expired ventilation. The theory is extended to show how the uptake of one inert gas may substantially affect the uptake of another, administered simultaneously. uptake, distribution and elimination; induction; recovery; drugs; inhaled anesthetics; nitrous oxide; diethyl ether; halothane; computers; ventilation; concentration effect; alveolar ventilation Submitted on February 13, 1964

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Olanzapine-high potency antipsychotic drug inducing significant weight gain: A case report

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0806284m ◽

2008 ◽

Vol 136 (5-6) ◽

pp. 284-288 ◽

Cited By ~ 1

Author(s):

Nadja Maric ◽

Dragana Josifovic-Kostic ◽

Olivera Vukovic ◽

Dubravka Britvic ◽

Miroslava Jasovic-Gasic

Keyword(s):

Weight Gain ◽

Psychotic Disorders ◽

Vascular Diseases ◽

Initial Response ◽

Young Female ◽

The Body ◽

Average Weight ◽

Therapeutic Effects ◽

Significant Weight Gain ◽

High Level

INTRODUCTION Olanzapine is a second generation antipsychotic (SGA) with a high level of therapeutic effectiveness in schizophrenia and other psychotic disorders. Along with the positive therapeutic effects, an increase of the body weight frequently occurs. According to the literature, the average weight gain is about 6-7 kg during several months of treatment. This could be valued as a moderate weight increase. CASE OUTLINE This article presents a case of a young female with schizophrenia, without clinical improvement with several antipsychotics (clozapine, risperidone, haloperidol) and with the occurrence of significant neurological side effects. The treatment started with olanzapine (baseline) was associated with good initial response (PANSS reduction 20% in the first two weeks) and the improvement was maintained further on (PANSS reduction 50% after 16 weeks). Significant increase (20 kg, 40%) in weight appeared during the following 16 weeks (BMI at baseline 17.9 kg/m2; BMI 16 weeks later 25.1 kg/m2). CONCLUSION High effectiveness of olanzapine in schizophrenia symptoms reduction was accompanied by a significant weight gain. However, this drug leads to impaired glucoregulation, dyslipidaemia etc. It also increases the risk of diabetes and cardio-vascular diseases, i.e. the main causes of mortality in schizophrenia after a suicide. Therefore, clinicians are suggested to focus on possible predictors of weight gain during olanzapine therapy, and act accordingly in order to prevent serious health consequences.

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The reconstitution of African women's spiritualities in the context of the Amazwi Abesifazane (Voices of Women) project in KwaZulu-Natal (1998-2005)

10.51415/10321/454 ◽

2006 ◽

Author(s):

◽

Bernice Stott

Keyword(s):

South Africa ◽

Narrative Therapy ◽

Well Being ◽

National Archive ◽

The Body ◽

Government Support ◽

African Women ◽

Primary Data ◽

Therapeutic Effects ◽

Kwazulu Natal

This study will investigate and critically evaluate the reconstitution of African women’s spiritualities in the context of the Amazwi Abesifazane project. This project forms part of the endeavours of Create Africa South, a Non Governmental Organisation situated in Durban, KwaZulu-Natal, which was initiated by the artist Andries Botha. It encourages women, post trauma, to ‘re-member’ themselves by creating memory cloths of embroidery and appliqué reflecting on their experiences in pre- and post-apartheid South Africa. This interdisciplinary study theorises that it is an archive that speaks about African women resisting destructive forces and reconstituting their spiritualities through the therapeutic effects of creativity. The study will not include research into the many other activities undertaken by Create Africa South. Rupture is implied in the use of the word ‘reconstitution’. Reconstitution encompasses the act of constituting again the character of the body, mind and spirit as regards health, strength and well-being of the women (McIntosh, 1970:261). In this study, spirituality is defined as the way in which the women in the Amazwi Abesifazane project reflect upon and live out their belief in God. The power of storytelling is examined from the perspectives of narratology, narrative therapy, sewing and orality/literary studies as resources for the women’s reclamation of their lives. Defining feminisms in South Africa is problematised by issues of race, class and culture. In a context of poverty, everyday survivalist strategies are the diverse forms of resistance seen in the Amazwi Abesifazane project. The women’s stories, cloths and interviews are triangulated as primary data. They are examples of the rich art of resistance against despair and are located in a paradigm of hope. In conclusion, I strongly call for government support in declaring the project a national archive. The multidimensional mediums of the Amazwi Abesifazane/ UbuMama projects nurture the women’s creativity and revitalise their spiritualities towards personal and national transformation.

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Role of Stress on Women’s Health: Causes and Prevention

International Journal of Indian Psychology ◽

10.25215/0304.127 ◽

2016 ◽

Vol 3 (4) ◽

Author(s):

Razia Saleem ◽

Shamsul Siddiqui

Keyword(s):

General Condition ◽

Preventive Measures ◽

The Body ◽

Poor Health ◽

Research Attention ◽

Stress Effects ◽

After Hours ◽

The Individual ◽

Intense Research

In recent years, stress has been the focus of intense research attention. Stress is a misfit between the demands of the environment and the individual’s abilities; the imbalance may be corrected, according to the situation, either by adjusting external demands to fit the individual or by strengthening the individual’s ability to cope or both. Everyone is exposed to stress, and a great number of people have experienced the traces of stress. Women are socialized to be the caretakers of others. More women than men have both a career outside the home and continue to try to juggle traditional responsibilities after hours. It has often been shown that women are the worriers and often do not make time to manage their health and take care of themselves. Stress is on the rise for women as they struggle to find a balance between their homes and careers. The recession has caused a greater need for women to work outside of the home to support their families. Health is a general condition of the body or mind with reference to soundness and vigor; it will be reflected by good or poor health. A poor health affects our mind, as a stressed life affects our health. The struggle that women confront each days trying to achieve the standards of being a daughter, women, wife, mother, house, and/ or career keeper puts us in a vulnerable position of presenting stress effects that may affect our health. And there are some preventive measures to cope with stress such as meditation, yoga, quality time etc.

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Optimization of The Electrospinning Process for Preparation of Nanofibers From Poly (Vinyl Alcohol) (PVA) and Chromolaena odorata L. Extrac (COE)

Jurnal Pendidikan Fisika Indonesia ◽

10.15294/jpfi.v16i1.12629 ◽

2020 ◽

Vol 16 (1) ◽

pp. 47-56

Author(s):

I. Sriyanti ◽

L. Marlina ◽

J. Jauhari

Keyword(s):

Wound Dressing ◽

Fiber Diameter ◽

Sem Analysis ◽

Electrospinning Process ◽

The Body ◽

Poly Vinyl Alcohol ◽

Therapeutic Effects ◽

Important Process ◽

Chromolaena Odorata ◽

Solubility In Water

The Cromaloena odorata (COE) contains phenols, flavonoids, tannins, alkaloids, saponins, steroids that possess diverse therapeutic effects. However, COE has poor solubility in water and poor absorbtion in the body. Incorporation of COE in nanofiber system is a promising way to increase CEO solubility. One of the method to produce nanofiber is electrospinning. The electrospinning process there are three of the most important process parameters are applied flowrate, voltage and TCD. In this study we developed optimized condition for electrospinning process of polyvinyl alcohol (PVA)/CEO and their characterization. The Scanning electron microscopy (SEM) analysis showed that modification of flowrate and TCD did not affect the morphology of PVA and COE fiber. However fiber diameter decreased when lower flowrate, higher voltage was applied, and TCD. Fourier Transform Infrared (FTIR) study was conducted to identify possible intermolecular interaction between PVA/COE that has potential application as antimicrobial wound dressing.

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Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress

International Journal of Ophthalmology ◽

10.18240/ijo.2021.08.19 ◽

2021 ◽

Vol 14 (8) ◽

pp. 1260-1273

Author(s):

Zi-Yan Cai ◽

◽

Ke Liu ◽

Xuan-Chu Duan ◽

◽

...

Keyword(s):

Oxidative Stress ◽

Vision Loss ◽

Eye Diseases ◽

The Body ◽

Age Related Macular Degeneration ◽

Therapeutic Effects ◽

Related Factor ◽

Classical Pathway ◽

Age Related ◽

Important Relationship

Age-related eye diseases, including cataract, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), are the leading causes of vision loss in the world. Several studies have shown that the occurrence and development of these diseases have an important relationship with oxidative stress in the eye. The Keap1-Nrf2-ARE pathway is a classical pathway that resists oxidative stress and inflammation in the body. This pathway is also active in the development of age-related eye diseases. A variety of drugs have been shown to treat age-related eye diseases through the Keap1-Nrf2-ARE (Kelch-like ECH-Associating protein 1- nuclear factor erythroid 2 related factor 2-antioxidant response element) pathway. This review describes the role of oxidative stress in the development of age-related eye diseases, the function and regulation of the Keap1-Nrf2-ARE pathway, and the therapeutic effects of drugs associated with this pathway on age-related eye diseases.

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Clinical Evaluation of Dental Metal Hazards and Therapeutic Effects of Shortwave Diathermy in Dental Medicine

International Journal of Prosthodontics and Restorative Dentistry ◽

10.5005/jp-journals-10019-1055 ◽

2012 ◽

Vol 2 (3) ◽

pp. 88-95

Author(s):

Chisato Mukai ◽

Tetsuji Nakamoto ◽

Yusuke Kondo ◽

Chihiro Masaki ◽

Atsumi Ohta ◽

...

Keyword(s):

Blood Flow ◽

Thermal Effect ◽

Clinical Evaluation ◽

The Body ◽

Therapeutic Effects ◽

Maxillofacial Region ◽

Doppler Flowmetry ◽

Whole Saliva ◽

Dental Metal ◽

Shortwave Diathermy

ABSTRACT Objective Shortwave diathermy causes increase in temperature from deep inside the body, results in upregulation of metabolism, and has analgesic effects. In this study, we explored the potential application of shortwave diathermy in the maxillofacial region by monitoring internal and external temperature changes, changes in blood flow, and resting saliva secretion under shortwave diathermy for subjects with and without dental metal restorations (MR) to confirm the safety and the limitation of shortwave diathermy for dental medicine. Materials and methods Twenty young healthy subjects were recruited (10 subjects with MR and 10 subjects without MR). Shortwave exposure was achieved with condenser-type probes placed on the bilateral mandibular angles, and the intraoral temperature was monitored. For functional analysis, unstimulated whole saliva before and after exposure was collected. The temperature and blood flow distributions of the exposed areas were then monitored by thermography and twodimensional (2D) laser Doppler flowmetry. Results Shortwave exposure for 20 minutes induced significant temperature increases in all groups (p ≤ 0.05). The subjects reported no discomfort. When subjects without MR held gold or titanium crowns in their mouths, the thermal effect by shortwave diathermy was reduced. Resting saliva upon exposure only increased significantly in metal-free subjects, and amylase concentration was also increased, but the level of the salivary stress biomarker chromogranin A was unchanged. Furthermore, thermography showed that shortwave diathermy significantly increased the surface temperature for cheek skin and the buccal mucosa; however, this increase failed to elevate surface blood flow. Conclusion Shortwave diathermy induces temperature increases in the maxillofacial region. MR did not cause excessive heating, on the contrary, reduce the thermal effect of shortwave radiation. The temperature rise maintains upregulation in salivary function, which could be utilized safely in dental medicine. How to cite this article Mukai C, Nakamoto T, Kondo Y, Masaki C, Ohta A, Hosokawa R. Clinical Evaluation of Dental Metal Hazards and Therapeutic Effects of Shortwave Diathermy in Dental Medicine. Int J Prosthodont Restor Dent 2012;2(3): 88-95.

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