scholarly journals Risk factors for syphilis infection in the South Backa blood donor population

2011 ◽  
Vol 139 (3-4) ◽  
pp. 192-196
Author(s):  
Sanja Bogdanovic ◽  
Nevenka Bujandric ◽  
Radmila Jovanovic
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Blood Donor ◽  
Blood Donors ◽  
Syphilis Infection ◽  
Donor Population ◽  
Syphilis Screening ◽  
Safe Blood ◽  
First Time

Introduction. Syphilis is one of infectious diseases that can be transmitted by blood transfusion. Determining the frequency of syphilis among blood donors and the relevant risk factors is an important aspect of safe blood transfusion. Objective. To determine the frequency and the trend of syphilis infection among blood donors in South Backa Region, to classify the confirmed infection and to describe demographic characteristics of seropositive blood donors and their risk factors. Methods. This retrospective study analyzed results of routine EIA syphilis screening and blood donor data from South Backa Region between 2004 and 2008. Results. Thirteen out of 153,431 tested blood units were confirmed as syphilis-infected. The study found that the overall frequency of infection was 8.47 per 100,000 blood donations, with a trend increase of 2.4%; there was a statistically significant (p<0.001) higher frequency among first-time blood donors (51.93/100,000) than regular ones (2.84/100 000). The highest prevalence was noted in donors aged over 45 years. All cases were classified as past syphilis infections. Post-donation interviews revealed exposure risk in 69.23% of the donors. Conclusion. A higher frequency of past infections detected in older donors is probably due to a higher prevalence and incidence of syphilis in the past. Further continual epidemiologic follow-up of syphilis in blood donors is crucial in obtaining safe blood.

scholarly journals A Systematic Review of Transfusion Transmissible Infections Among Blood Donors and Associated Safety Challenges in Pakistan

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 26-28
Author(s):  
Hamid Ehsan ◽  
Ahsan Wahab ◽  
Muhammad Ammar Shafqat ◽  
Muhammad Khawar Sana ◽  
Farhan Khalid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Transfusion ◽  
Blood Donor ◽  
Blood Donors ◽  
Blood Donation ◽  
Blood Donations ◽  
High Prevalence ◽  
Blood Banks ◽  
Donor Population

Introduction: The blood transfusion (BT) system in Pakistan is fragmented, demand-driven, and depends on weakly regulated transfusion practices. This is primarily a big problem in smaller cities and remote rural areas. Pakistan has one of the highest hepatitis B virus (HBV) and hepatitis C virus (HCV) prevalence worldwide, estimated around 5 & 10 million cases, respectively. There is a considerable risk that transfusion-transmissible infections (TTIs) may have contributed to the current epidemic of HBV & HCV, affecting 7.4 % of the general population, and potential risk of HIV transmission in the country. In this systematic review, we aim to identify the prevalence of TTIs among the blood donor population and associated safety challenges. Method & Material: We conducted a systematic literature search to identify studies related to TTIs and transfusion safety in Pakistan from January 1, 2010, to January 31, 2020. A search was conducted using PubMed and PakMedinet.com (largest medical database of Pakistan); initial search retrieved 981 articles, 166 met the inclusion criteria, and after review by two independent reviewers, 33 articles met the final criteria for qualitative synthesis. Results: Analysis of 33 studies showed the seroprevalence of HBV of 2.04 % (0.81% to 4.22%), HCV of 2.44% (1.29 % to 10%), HIV of 0.038% (0% to 0.18%), syphilis of 1.1% (0.11-3.01%) and malaria of 0.11% (0.05-1.20). The rate of coinfections among blood donors varied from 0.0099% to 0.35 %. The highest number of coinfections were HCV & syphilis, followed by HCV & HBV infections. The rate of TTIs was dependent on the number of donors, donor types (replacement vs. voluntary), screening techniques used, number, and type of TTIs tested. There was a lack of universal screening for common TTIs. Syphilis and malaria were tested only 38 % & 46 % of all the blood donations. The studies with a high number of replacement donors (RDs) noted a high prevalence of TTIs of 2.5 % to 12 % compared to the studies with a high number of voluntary non-remunerated donations (VNRDs) reported TTIs rates of 1.57% to 6.2 %. There was a significant difference in the prevalence of HBV & HCV in VNRDs (0.48%) compared to RDs (4.15%). The rate of VNRDs was 0.10 % to 13%. The majority of blood donations were from male donors, representing more than 70 % of all donations. The female donations varied from 0.03% to 15 % in government/public blood banks than 29 % in private sector blood banks. The HBV & HCV infections and anemia were the most common causes of blood donation deferral. The 69.5 % of donors who tested positive for TTIs in a study reported previous blood donations. The educational status of donors noted to have an association with knowledge about the risk of TTIs. Odds of having limited knowledge about TTIs (OR: 4.04, CI: 1.567-10.435, p&lt;0.01) were greater if donors had a secondary level of education compared to those with tertiary education. 48 % of blood donors did not know about the risk of TTIs through blood transfusion. There was notification of only about 54.25 % of all donors, who tested positive for any TTIs. This was mainly due to a lack of standardized reporting and follow up systems. Conclusion: This systemic review shows a high prevalence of TTIs, especially HBV, HCV & syphilis in the blood donor population. There is a high dependency on RDs, with minimal use of healthy voluntary blood donation practices, inadequate screening of high-risk donors, repeated collections of the blood from RDs, poor quality of screening methods, and limited knowledge of donors about their health. There is a lack of widespread standardized testing and follow up of patients who tested positive on initial testing. Large prospective multicenter clinical trials are required for a better understanding of the TTIs by testing and creating a follow-up system for both blood donors and recipients. Disclosures Anwer: Incyte, Seattle Genetics, Acetylon Pharmaceuticals, AbbVie Pharma, Astellas Pharma, Celegene, Millennium Pharmaceuticals.:Honoraria, Research Funding, Speakers Bureau.

scholarly journals Seroprevalence of anti HCV antibodies among blood donors: a retrospective study from Haryana, India

2017 ◽  
Vol 5 (8) ◽  
pp. 3389
Author(s):  
P. K. Sehgal ◽  
Anubha Garg
Keyword(s):  
Hepatitis C ◽  
Blood Donor ◽  
Blood Donors ◽  
Blood Bank ◽  
Hcv Infection ◽  
North India ◽  
Potential Threat ◽  
Hcv Transmission ◽  
Donor Population ◽  
Safe Blood

Background: HCV is known for its chronicity and leads to cirrhosis in about 10 to 20 per cent of patients and may further progress to hepatocellular carcinoma (HCC). The global seroprevalence of HCV among blood donors varies from 0.4 to 19.2 per cent and the estimated risk for HCV transmission is between 0.10 to 2.33 per million units transfused. ELISA is the most commonly used initial assay for detecting HCV antibodies. The purpose of the present analysis was to monitor the seroprevalence of anti-HCV antibodies in the blood donor population in a hospital based blood bank in north India for a period of 10 years (2007-2016), and to evaluate the trends over the years.Methods: The purpose of the present analysis was to monitor the seroprevalence of anti-HCV antibodies in the blood donor population in a hospital based blood bank in north India for a period of 10 years (2007-2016), and to evaluate the trends over the years.Results: Of the total 340078, 298421 (87.75%) collections were voluntary and 41657 (12.25%) were replacement collections. A prevalence of 0.72% of hepatitis C virus infection was seen among the donors from the period 2007-2016. The trend of hepatitis C prevalence among donors has been fluctuating while ranging from 0.51% to 0.89%.Conclusions: For a safe blood service in our country, where comprehensive laboratory tests are neither possible nor pragmatic, it is best to switch over to 100% voluntary donations, as it is now established that only voluntary non-remunerated regular donation is the safest. Thus, one of our key strategies to enhance blood safety is to focus on motivating non-remunerated blood donors and phasing out even replacement donors. Since, no vaccine is presently available for immunization against HCV infection, transfusion transmitted HCV infection remains a potential threat to the safety of the blood supply.

scholarly journals Analysis of Blood Donor Deferral in a Tertiary Care Hospital

2020 ◽  
Vol 10 (2) ◽  
pp. 373-376
Author(s):  
Farida Parvin ◽  
Daanish Arefin Biswas ◽  
Bepasha Naznin ◽  
Tamanna Afroz ◽  
Mohammad Ali ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Blood Donor ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Medical Officer ◽  
Uncontrolled Hypertension ◽  
Care Hospital ◽  
Safe Blood ◽  
Donor Deferral

Introduction: Selection of proper donor according to stringent selection criteria is the prerequisite for safe blood transfusion practice. It is widely known that a large number of blood donors are deferred for different reasons. Objective: The aim of present study is to evaluate the incidence and different reasons of blood donor deferral in atertiary care hospital. Methodology: This retrospective cross-sectional study was carried out in Transfusion Medicine and Clinical Haematology Department of BIRDEM General Hospital, Dhaka, during the period from July 2016 to June 2017.The blood donor of either sex attending the mentioned department were selected purposively and categorized into four groups according to their age for this study. Donors were selected and deferred by medical officer according to national guideline. Deferred blood donors were recorded in register book and were analyzed retrospectively. Results: In current study, 1152 blood donor (8.8%) were deferred attending for allogeneic blood donation during the study period. Out of 13082 registered blood donor 11961were male (91.43%) and 1121 were female (8.57%) and deferral rate was 2.37 times more in female. Majority of the deferred donors (55.38%) were under the age of 40 where 26.82% were in between 40-49 years and 17.8% were in the range of 50 years and above. Age range of highest deferred donors (32.20%) was between 30-39 years. The number of temporary and permanent deferral were 836 (72.57 %) and 316 (27.43%) respectively. Anaemia (33.01%), underweight (21.53%) and hypotension (17.34%) were the most common reason of temporary deferral. Chronic uncontrolled hypertension (42.4%), donors with medication (16.77%) and asthma (15.18%) was the most common cause of permanent deferral. Conclusion: The deferral rate was low and most of the deferred donors were young adult. Temporary deferred donors were higher than permanent deferred donors. The most common reasons for temporary deferral were anemia, underweight and hypotension. Permanent deferral causes were chronic uncontrolled hypertension, donors on medication for various reason and asthma. Donors should be informed with a clear message on their deferral status. It is important to determine the rate and causes of donor deferral for the safety of blood transfusion and to guide the recruitment efforts for safe blood transfusion and to avoid the permanent loss of blood donors. Northern International Medical College Journal Vol.10 (2) Jan 2019: 373-376

scholarly journals ANALYSIS OF PRE-DONATION DEFERRAL REASONS AMONGST BLOOD DONORS IN VADODARA, GUJARAT.

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Jhalak Patel ◽  
Dr. Milind Dighe ◽  
Dr. Farzana Kothari ◽  
Dr. Rahul Rajvanshi
Keyword(s):  
Blood Transfusion ◽  
Blood Donor ◽  
Health Care Policy ◽  
Blood Donors ◽  
Blood Donation ◽  
Blood Bank ◽  
Age Group ◽  
Donor Pool ◽  
Gender Based ◽  
Safe Blood

Background: Blood transfusion saves lives and improves health, but many patients requiring transfusion do not have timely access to safe blood. Providing safe and adequate blood should be an integral part of every country’s national health care policy and infrastructure. Aim: The main aim of the study was to analyze the reasons for pre-donation deferral amongst blood donors attending our blood bank and outdoor camp organized by our blood bank and to evaluate and categorize the reasons into temporary and permanent deferral. Materials and methods: It is a Record based Retrospective Study conducted in Department of Immunohematology and blood transfusion over a period of two years from July 2015 to July 2017. The reasons of deferral were analyzed after classification into following categories, namely, temporary- permanent deferral, in-house –camp blood donors, gender-based (male -female), and various age group categories. Results: A total of 30,022 prospective blood donors registered for blood donation out of which 2241 blood donors were deferred (7.46%) with low hemoglobin level, medication and hypertension as top three causes. The majority of deferral was seen in 18-25 years of age group which mainly comprises the youth population. The female donors were rejected eight times the male donors. Conclusion: The knowledge of the deferral incidences and their causes in a particular region helps in deciding the magnitude and the direction of the blood donor recruitment efforts. This knowl­edge also helps in calculating the eligible and the potential blood donor pool. Keywords: Blood Donors, Pre-Donation, Deferral, Temporary, Permanent.

scholarly journals Seroprevalence and Risk Factors for Hepatitis B Virus Infection in Adolescent Blood Donors within Selected Counties of Western Kenya

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hilary O. Awili ◽  
George C. Gitao ◽  
Gerald M. Muchemi
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Hepatitis B Virus ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Health Policies ◽  
Donor Group ◽  
Safety Measures ◽  
B Virus ◽  
Safe Blood

Hepatitis B virus is a widespread public health menace approximated to have infected 257 million people chronically by 2015. Data on the prevalence of HBV is important in formulating public health policies on HBV control like safe blood transfusion. Adolescents aged 15 to 24 years, known to engage in risky activities associated with HBV spread, constitute major blood donors in Kenya. Notwithstanding current blood donation safety measures, HBV still remain hazardous transfusion-transmissible infections in donated blood. This study therefore was to determine the prevalence of HBsAg and related risk factors among this donor group. A cross-sectional study was conducted from April 2019 to August 2019 in Siaya, Kisumu, and Homa Bay counties. One thousand (1000) voluntary blood donors 18 to 25 years old were recruited. A predonation questionnaire was used to record their sociodemographic features and prior risk exposures. Blood samples were initially tested for HBsAg using Murex HBsAg Version 3 (DiaSorin, UK) and positives confirmed using ARCHITECT HBsAg Qualitative Confirmatory assay (Abbott Ireland) as per the manufacturer’s instructions. A result was considered positive if the first and confirmatory tests were all reactive. Generally, the prevalence of HBV was 3.4%, with no significant association between various sociodemographic variables and HBsAg positivity. Nevertheless, scarification and risky sexual behavior were significantly linked to HBV infections (odds ratio OR=8.533, 95%confidence interval CI=3.128‐23.275, p value of 0.001 and OR=5.471, 95%CI=1.925‐15.547, p value of 0.002, respectively). This study revealed a prevalence of 3.4% HBsAg among adolescent blood donors, with perilous sexual behaviors being the most significant risk factor, evidence that sexual contact still plays a major role in transmission of HBV among this donor group despite blood transfusion safety measures put in place. These study findings should therefore be put into consideration while framing health policies to mitigate effects of HBV infection on safe blood transfusion.

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

scholarly journals Cardiovascular family history increases the risk of disease recurrence after a first myocardial infarction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Wahrenberg ◽  
P Magnusson ◽  
R Kuja-Halkola ◽  
H Habel ◽  
K Hambraeus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Family History ◽  
Cardiovascular Events ◽  
Cardiovascular Death ◽  
Funding Source ◽  
History Of ◽  
First Time ◽  
Early Family

Abstract Background Despite recent advances in secondary prevention, recurrent cardiovascular events are common after a myocardial infarction (MI). It has been reported that genetic risk scores may predict the risk of recurrent cardiovascular events. Although patient-derived family history is a composite of both genetic and environmental heritability of atherosclerotic cardiovascular disease (ASCVD), it is an easily accessible information compared to genetically based risk models but the association with recurrent events is unknown. Purpose To evaluate whether a register-verified family history of ASCVD is associated with recurrent cardiovascular events (rASCVD) in patients after a first-time MI. Methods We included patients with a first-time MI during 2005 – 2014, registered in the SWEDEHEART SEPHIA registry and without prior ASCVD. Follow-up was available until Dec 31st, 2018. Data on relatives, diagnoses and prescriptions were extracted from national registers. A family history of ASCVD was defined as a register-verified hospitalisation due to MI, angina with coronary revascularization procedures, stroke or cardiovascular death in any parent. Early history was defined as such an event before the age of 55 years in fathers and 65 years in mothers. The association between family history and a composite outcome including recurrent MI, angina requiring acute revascularization, ischaemic stroke and cardiovascular death during follow-up was studied with Cox proportional hazard regression with time from SEPHIA registry completion as underlying time-scale, adjusted for age with splines, gender and year of SEPHIA registry. Regression models were then further adjusted for hypertension, diabetes, smoking and for a subset of patients, LDL-cholesterol (LDL_C) at time of first event. Results Of 25,615 patients, 2.5% and 32.1% had an early and ever-occurring family history of ASCVD, respectively. Patients with early family history were significantly younger than other patients and were more likely to be current smokers and have a higher LDL-C (Median (IQR) 3.5 (1.1) vs 3.3 (1.1) mmol/L). In total, 3,971 (15.5%) patients experienced the outcome. Early family history of ASCVD was significantly associated with rASCVD (Hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.23–1.87), and the effect was sustained when adjusted for cardiovascular risk factors (HR 1.48, 95% CI 1.20–1.83) and LDL-C (HR 1.35, 95% CI 1.04–1.74). Ever-occurring family history was weakly associated with ASCVD (HR 1.09, 95% CI 1.02 – 1.17) and the association remained unchanged with adjustments for risk factors. Conclusions Early family history of cardiovascular disease is a potent risk factor for recurrent cardiovascular events in a secondary prevention setting, independent of traditional risk factors including LDL-C. This is a novel finding and these patients may potentially benefit from intensified secondary preventive measures after a first-time MI. Funding Acknowledgement Type of funding source: Private grant(s) and/or Sponsorship. Main funding source(s): This work was funded by grants from The Swedish Heart and Lung Association

scholarly journals Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 19-24
Author(s):  
O D Damulak ◽  
E D Jatau ◽  
E Ekam ◽  
E Rumji ◽  
R Yakubu ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
High Rate ◽  
Blood Transfusion Service ◽  
First Time

Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the first time voluntarily donated blood. We studied records of blood units collected in a tertiary hospital from donors who scaled pre-donation Rapid diagnostic test (RDT) screening for the human immunodeficiency virus, hepatitis B and hepatitis C viruses and syphilis and rescreened by ELISA techniques at the National Blood Transfusion Service Centre in Jos, along with units from first-time voluntary blood donors. A total of 19562 blood units; 5945 (30.39%) rapid diagnostic tests negative from a linkage hospital and 13617 (69.61%) from first time voluntary donors were screened by ELISA methods for HIV, HBV, HCV, and syphilis. The overall TTIs detected by ELISA was 16.08%, significantly lower among pre-donation rapid screened family replacement blood donors [495(8.32%)] compared to 2651 (19.47%) among first-time voluntary donors; P=0.0001. Fifty-seven (0.96%) HIV, 166 (2.79%) HBV, 137 (2.31%) HCV and 137 (2.31%) syphilis were still detected respectively by ELISA in the pre-screened negative family replacement blood units. The outcome of ELISA screenings of blood collected from first-time volunteer donors were; 143 (1.05%) HIV, 1,486 (10.91%) HBV, 683 (5.02%) HCV, and 339 (2.49%) syphilis. Blood for transfusion should be screened negative at least with ELISA.

Risk Factors and Anti-HBc Reactivity among First Time Blood Donors

Vox Sanguinis ◽  
1997 ◽  
Vol 72 (4) ◽  
pp. 207-210
Author(s):  
J.M. van der Linden ◽  
L.K. Ko ◽  
J. Gorgels ◽  
W. Hop ◽  
D.J. van Rehen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Donors ◽  
First Time

scholarly journals Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

1994 ◽  
Vol 112 (3) ◽  
pp. 595-601 ◽  
Author(s):  
K. R. Neal ◽  
D. A. Jones ◽  
D. Killey ◽  
V. James
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Case Control Study ◽  
Case Control ◽  
Hcv Infection ◽  
History Of ◽  
Control Study

SUMMARYThe introduction of screening for hepatitis C virus (HCV) by the National Blood Transfusion Service identified donors who had acquired HCV infection. We undertook a case-control study amongst blood donors in the Trent Region to determine risks for HCV infection. A total of 74 blood donors confirmed positive for hepatitis C infection and 150 age, sex and donor venue matched controls were included in the study. Fifty-three percent of hepatitis C infected blood donors reported previous use of injected drugs compared to no controls; relative risk (RR) not estimatable (lower limit 95% CI = 20). Other risk factors were a history of: receipt of a blood transfusion or blood products RR = 3·6 (95% CI 1·5–8·3), having been a ‘health care worker’ RR = 2·8 (95% CI 1·1–7·6), tattooing RR = 3·3 (95% CI 1·2–8·7), and an association with having been born abroad RR = 3·2 (95% CI 1·1–9·5). No risk was shown for a history of multiple sexual partners, ear piercing or acupuncture. Injecting drug use explains more than 50% of hepatitis C infections in blood donors, a group who are less likely to have injected drugs than the general population.

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