scholarly journals Omalizumab: Pharmacological Properties, Primary Therapeutic Effect Mechanisms and Adverse Effects

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Ozdemir Oner
Keyword(s):  
Adverse Effects ◽  
Therapeutic Effect ◽  
Pharmacological Properties

Dithranol creams for psoriasis

1979 ◽  
Vol 17 (14) ◽  
pp. 53-54
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
Normal Skin ◽  
Inactive Compound ◽  
Topical Corticosteroids

Dithranol is a valuable agent in the treatment of chronic discoid psoriasis. Properly used it can clear the lesions in most patients without any of the adverse effects of the strong topical corticosteroids.1 Dithranol inactivates various enzymes, binds with DNA, and inhibits mitosis, but the basis for the therapeutic effect is not fully understood.2 The main drawbacks of dithranol preparations, which often make patients reluctant to treat themselves, are dose-related irritancy, especially affecting normal skin, and staining of skin, clothing and bedclothes. To reduce the spread to normal skin, dithranol is usually applied accurately to psoriatic plaques in a stiff base (Zinc and Salicylic Acid Paste BPC). The salicylic acid in this preparation appears to prevent oxidation of the dithranol to an inactive compound.2

Nanomedicine

2015 ◽  
pp. 64-89
Author(s):  
Roy Gaurab ◽  
Shetti Dattatrya ◽  
Yadav Amit ◽  
Kundu Gopal C
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
21St Century ◽  
Delivery Systems ◽  
Imaging Agents ◽  
Life Threatening

Nanomedicine, an offshoot of nanotechnology, is considered as one of the most promising technologies of the 21st century. Due to their minute size, nanomedicines can easily target difficult-to-reach sites with improved solubility and bioavailability and reduced adverse effects. They also act as versatile delivery systems, carrying both chemotherapeutics and imaging agents to targeted sites. Hence, nanomedicine can be used to achieve the same therapeutic effect at smaller doses than their conventional counterparts and can offer impressive resolutions for various life-threatening diseases. Although certain issues have been raised about the potential toxicities of nanomaterials, it is anticipated that the advances in nanomedicine will furnish clarifications to many of modern medicine's unsolved problems. This chapter aims to provide a comprehensive and contemporary survey of various nanomedicine products along with the major risks and side effects associated with the nanoparticles.

Double-Blind Trial of Aminophylline in Status Asthmaticus

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 642-646
Author(s):  
William E. Pierson ◽  
C. Warren Bierman ◽  
Stanley J. Stamm ◽  
Paul P. VanArsdel
Keyword(s):  
Adverse Effects ◽  
Therapeutic Effect ◽  
Status Asthmaticus ◽  
Controlled Trial ◽  
Hospitalized Children ◽  
Double Blind Trial ◽  
Ventilatory Function ◽  
Double Blind ◽  
Medical Supervision ◽  
Blind Trial

Significant improvement in ventilatory function without observable adverse effects has been demonstrated by this double-blind controlled trial of intravenous aminophylline in status asthmaticus. Aminophylline appears to have a beneficial therapeutic effect when given in addition to other accepted medications in appropriate dosage and under careful medical supervision to hospitalized children with status asthmaticus.

Pilot Open-Label Study of Alprazolam (U-31,889) in Anxious Alcoholic Out-Patients

1977 ◽  
Vol 5 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Louis F Fabre ◽  
Allison Gainey ◽  
Sherrie Kemple
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
Analysis Of Variance ◽  
Marked Improvement ◽  
Study Analysis ◽  
Open Label ◽  
Open Label Study ◽  
Label Study

Twenty out-patients suffering from anxiety and tension after withdrawal from alcohol were treated for 28 days with alprazolam. Three patients dropped out for intercurrent events, and 2 dropped out for recurrent drinking. Of the 15 patients completing the study, analysis of variance showed significant improvement in all Physician's Ratings as well as all patient self-ratings. At the 28th day, 93% of the patients rated moderate to marked improvement on the Physician's Global Impression and Therapeutic Effect, and 93% self rated at least a little better. Side-effects were generally mild and inconsequential. No adverse effects attributable to alprazolam were noted on laboratory evaluations, EKG's, or ophthalmologic examinations.

scholarly journals Nanomedicine

2017 ◽  
pp. 1258-1285
Author(s):  
Roy Gaurab ◽  
Shetti Dattatrya ◽  
Yadav Amit ◽  
Kundu Gopal C
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
21St Century ◽  
Delivery Systems ◽  
Imaging Agents ◽  
Life Threatening

Nanomedicine, an offshoot of nanotechnology, is considered as one of the most promising technologies of the 21st century. Due to their minute size, nanomedicines can easily target difficult-to-reach sites with improved solubility and bioavailability and reduced adverse effects. They also act as versatile delivery systems, carrying both chemotherapeutics and imaging agents to targeted sites. Hence, nanomedicine can be used to achieve the same therapeutic effect at smaller doses than their conventional counterparts and can offer impressive resolutions for various life-threatening diseases. Although certain issues have been raised about the potential toxicities of nanomaterials, it is anticipated that the advances in nanomedicine will furnish clarifications to many of modern medicine's unsolved problems. This chapter aims to provide a comprehensive and contemporary survey of various nanomedicine products along with the major risks and side effects associated with the nanoparticles.

scholarly journals Analgesic combinations as a strategy for pain relief and isobolographic analysis

2015 ◽  
Vol 3 (6) ◽  
Author(s):  
Aracely Evangelina Chávez-Piña ◽  
Arlette Guadalupe Arroyo-Lira
Keyword(s):  
Natural Products ◽  
Pain Management ◽  
Side Effects ◽  
Pain Relief ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
Fixed Ratio ◽  
Opioid Analgesics ◽  
Isobolographic Analysis ◽  
Inflammatory Drugs

Pain is a multidimensional sensory experience that is intrinsically unpleasant and associated with hurting and soreness, it is essentially a sensation. Pain has strong, cognitive and emotional components, it is linked to, or described in terms of suffering. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and opioid analgesics are two of the most common types of drugs used for pain management. However, the use of these analgesics is limited by the presence of significant adverse effects. A useful practice is a combination of two agents with the same therapeutic effect wherein each agent is administered to obtain additive, synergistic or subadditive interaction in a fixed ratio. If the combination resulted in addition or synergism, the doses employed by each agent are reduced, then the side effects are absent; this kind of study is named isobolographic analysis. In this review, the authors summarized previous reports of the combination of NSAIDs with opioids and natural products as an alternative in the pain management.

Concept of Shodhana procedure with special reference to Guggulu Resin (Commiphora Mukul Linn.)

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr.Pramod C. Baragi ◽  
Basavaraj M. S. ◽  
Praveen Simpi ◽  
Bandeppa Sangolge
Keyword(s):  
Special Reference ◽  
Therapeutic Effect ◽  
Pharmacological Properties ◽  
Single Drug ◽  
Commiphora Mukul ◽  
The Media ◽  
Vedic Period ◽  
Pharmaceutical Processes

Ayurveda, the science of life is being practiced by Aryans from Vedic period. In the Vedic period Guggulu was a well-known drug in Indigenous System of Medicine. In Atharvaveda it is mentioned to be used both externally and internally. By just consuming the odour of Guggulu, it reduces many diseases. Many properties of Guggulu are described in our classics. Guggulu is the oleoresin of Commiphora Mukul Linn., a plant that is native to India. Its extracts include compounds known for their hypolipidemic properties, the Z- and E- isomers of guggulsterone and its related guggulsterols. Kalpana is the process through which a substance can be transformed in to the form of medicine according to the need. During preparations of various formulations there are various Samskaras which are to be done for potentiating the drug or the formulation. Among all these pharmaceutical processes Shodhana is one of them. In our text, for a single drug many process of Shodhana in different ways have been mentioned. There are different medias explained in literature for Shodhana of Guggulu. According to the media of purification the quality and pharmacological properties of Guggulu will vary. Depending on the change in properties the therapeutic effect may also vary. The present study includes collection of different concepts regarding Shodana of Guggulu as per various classical references.

scholarly journals Pharmacological Activities of Aminophenoxazinones

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3453
Author(s):  
Jesús G. Zorrilla ◽  
Carlos Rial ◽  
Daniel Cabrera ◽  
José M. G. Molinillo ◽  
Rosa M. Varela ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Natural Products ◽  
Adverse Effects ◽  
Anticancer Drugs ◽  
Plant Species ◽  
Degradation Products ◽  
Database Search ◽  
High Potential ◽  
Pharmacological Properties ◽  
Pharmacological Activities

Aminophenoxazinones are degradation products resulting from the metabolism of different plant species, which comprise a family of natural products well known for their pharmacological activities. This review provides an overview of the pharmacological properties and applications proved by these compounds and their structural derivatives during 2000–2021. The bibliography was selected according to our purpose from the references obtained in a SciFinder database search for the Phx-3 structure (the base molecule of the aminophenoxazinones). Compounds Phx-1 and Phx-3 are among the most studied, especially as anticancer drugs for the treatment of gastric and colon cancer, glioblastoma and melanoma, among others types of relevant cancers. The main information available in the literature about their mechanisms is also described. Similarly, antibacterial, antifungal, antiviral and antiparasitic activities are presented, including species related directly or indirectly to significant diseases. Therefore, we present diverse compounds based on aminophenoxazinones with high potential as drugs, considering their levels of activity and few adverse effects.

Nanocarrier-based activation of necroptotic cell death potentiates cancer immunotherapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Gan-Qing Xia ◽  
Tian-Run Lei ◽  
Teng-Bo Yu ◽  
Pang-Hu Zhou
Keyword(s):  
Cell Death ◽  
Adverse Effects ◽  
Cancer Immunotherapy ◽  
Therapeutic Effect ◽  
Tnf Α ◽  
Effect Of Pd

The injection of liposomes loaded with TNF-α avoids adverse effects and enhances the therapeutic effect of PD-L1 antibody.

On the question of the therapeutic effect of Konvallene in cardiovascular diseases

1937 ◽  
Vol 33 (3) ◽  
pp. 259-263
Author(s):  
N. N. Kovyazin
Keyword(s):  
Cardiovascular Diseases ◽  
Blood Vessels ◽  
Therapeutic Effect ◽  
Pharmacological Properties ◽  
Clinical Observations

In 1853, Waltz discovered two glucosides in a lily of the valley - convallamarin and convallarin. Subsequent experimental and clinical observations showed that the first glucoside is similar in pharmacological properties to the action of digitalin, but was not used due to the inconstancy of its action; the second glucoside, without acting on the heart and blood vessels, irritates the intestines, causing diarrhea.

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