scholarly journals Dr Genetic Association of Angiotensin Converting Enzyme I/D Gene Polymorphisms with Breast Cancer

2020 ◽  
Vol 1 (4) ◽  
Author(s):  
Annum Ishfaq ◽  
Ejaz Ali ◽  
Warda Fatima ◽  
Nageen Hussain
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphisms ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional ◽  
Pakistani Population ◽  
Ace Gene ◽  
Alu Insertion ◽  
Enzyme I

Breast cancer presents a serious public health risk in both developed and developing countries. The ACE gene, which is located in chromosome 17q23, has many polymorphisms. The most commonly studied is a 287 bp Alu insertion/deletion (I/D) polymorphism in intron 16 that accounts for 50% of the variability in circulating ACE levels. The main aim of this study is to find out the association of ACE gene with breast cancer in Pakistani population. Experimental and cross-sectional. A total of 186 samples were collected. Of the 186, 93 were taken as healthy controls and 93 were the female patients suffering from breast cancer. First DNA was isolated and then further genotypes II, ID and DD were identified by Nested PCR. Chi-square (χ2) test was applied to check the association level between ACE I/D polymorphism and breast cancer. The DD genotype showed (76) 81.7% and ID showed (17) 18.2% whereas II was not found (0) 0% in breast cancer patients. In controls, the frequency of DD is (80) 86%, ID (13) 13.9% and (0) 0 percent for II genotype. It is concluded that there is no significant association of ACE I/D polymorphisms with the breast cancer (p < 0.05) in Pakistani population.

scholarly journals Assessment of Estradiol, Progesterone and Lipid Profile among Breast Cancer Patients in Ethiopia: Hospital-based Comparative Cross-Sectional Study

2021 ◽  
Author(s):  
Etagegn Tadesse ◽  
Daniel Seifu ◽  
Menakath Menon ◽  
Wondmagegnehu Tigeneh ◽  
Teka Obsa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Sectional Study ◽  
Serum Progesterone ◽  
Cross Sectional ◽  
Progesterone Metabolism

Abstract Background Breast cancer is the most often diagnosed type of cancer and the leading cause of death worldwide. Estrogen, also known as estradiol, influences progesterone metabolism and modifies lipid metabolism. Thus, steroid hormone and lipid profile levels for breast cancer patients must be evaluated. However, this has yet to be explored and used for therapy in Ethiopia. As a result, the present study at Tikur Anbessa Specialized Hospital attempted to assess serum estrogen, progesterone, and lipid profile levels in breast cancer patients and healthy controls. Methods A hospital-based comparative cross-sectional study was conducted on a total of 80 participants (40 newly diagnosed breast cancer patients and 40 healthy control females). A convenient sampling method was used to recruit the study participants. Steroid hormones and lipid profile were determined using immunoassays and an enzymatic colorimetric technique, respectively. SPSS version 20.0 was used for statistical analysis, and p-values of 0.05 were considered statistically significant. Results When compared to healthy controls, the mean serum progesterone, TC, and HDL-C levels in breast cancer patients were considerably lower, while estradiol, TG, and LDL-C levels were insignificantly higher. Conclusions Breast cancer may be to blame for changes in progesterone, estradiol, and lipid profile levels, which can lead to secondary problems.

scholarly journals LDL-c as a predictor of hormonal status and determining factor for therapy of breast cancer patients

2021 ◽  
Vol 2 (2) ◽  
pp. 023-031
Author(s):  
Reynard Budy Setiawan ◽  
Desak Gede Agung Suprabawati ◽  
Jusak Nugraha
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Density Lipoprotein ◽  
P Value ◽  
Hormonal Status ◽  
Breast Cancer Patients ◽  
Characteristic Analysis ◽  
Chi Square ◽  
Cross Sectional

Background: Immunohistochemical testing is important in determining clinical diagnosis and therapy, and is useful as a prognostic and predictive factor, but it is not easy to do and is not always available. Breast cancer patient with higher low-density-lipoprotein cholesterol [LDL-c]. level tends to have larger tumor size, higher grade, higher proliferation rate, positive Human Epidermal growth factor Receptor-2 (HER2-neu) and occasionally come at late stage. High LDL-c receptors are found on the surface of breast cancer cells, where cancer cells will take up cholesterol in serum, and a metabolite of 27-hydroxycholesterol cholesterol will affect Estrogen Receptor-α. Methods: Analytical observational study by cross sectional method, during July 2020 – November 2020, at Oncology Clinic Dr. Soetomo Hospital Surabaya with a total sample size of 42. The data obtained were analyzed using the SPSS version 23.0 program, regression test and Chi-Square were performed for characteristic analysis and Chi-Square Fischer’s Exact Test were performed for correlation test between lipid profiles with hormonal status. Results: The mean value of LDL-c was 117.88 ± 33.89 mg/dL. In the analysis of the correlation between LDL-c and hormonal status, it was found that the majority of patients who had positive hormonal status had LDL-c levels of ≤160 mg/dL with p value = 0.049. ROC analysis shown LDL-c cut-off point of 132 mg/dL, p value = 0.034 (OR 5.031, 95% CI 1.159-21.848), sensitivity 46.7% and specificity 83.35%. Conclusion: There is a statistically significant relationship between LDL-c levels and hormonal status with the cut-off point of 132 mg/dL. The increase in LDL-c in serum increases the tendency of negative hormonal status, therefore LDL-c levels can be considerate in determining the therapy for breast cancer patients.

scholarly journals HUBUNGAN KEMOTERAPI DAN ASUPAN ENERGI DENGAN STATUS GIZI PASIEN KANKER PAYUDARA STADIUM II DAN III DI RSUP FATMAWATI JAKARTA PADA TAHUN 2018-2019 Relationship of Chemotherapy and Energy Intake with Nutritional Status of Breast Cancer Patients Stage II-III at Fatmawati General Hospital in 2018–2019

2020 ◽  
Vol 15 (2) ◽  
pp. 110
Author(s):  
Alfat Hidayat ◽  
Luh Eka Purwani ◽  
Nunuk Nugrohowati
Keyword(s):  
Breast Cancer ◽  
Nutritional Status ◽  
Cancer Patients ◽  
General Hospital ◽  
Energy Intake ◽  
Sampling Technique ◽  
Stage Ii ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

Breast cancer is the highest cause of death in women around the world. Common problems that arise in breast cancer patients is nutritional problems. The purpose of this study was to determine the relationship between chemotherapy, energy intake and nutritional status of stage II and III breast cancer patients at Fatmawati General Hospital in 2018-2019. The type of study was observational analytic with cross-sectional design on 34 breast cancer patients at Fatmawati General Hospital. The sample used purposive sampling technique by choosing patients who accomplish inclusion criterias including patients with compos mentis state, stage II and III, aged between 25–64 years old, have been taken chemotherapy without complication, outpatient, and agreed to be participant in this study. The exclusion criteria were patients with undernutrition before chemotherapy, received radiation and hormonal therapy, patients with severe infectious diseases (TBC and HIV/AIDS) and chronic diseases. The taken datas including nutritional status measured by Body Mass Index (BMI); chemotherapy status gained from medical record; and energy intake assessed by 3×24 hours food recall. The Chi-Square test showed there was no relationship between chemotherapy and nutritional status of breast cancer patients (p=1.000). However, there was a relationship between energy intake and nutritional status of breast cancer patients (p<0.05) with CI 95%, OR = 65.000 (4.905-861.448) which means that the patients with the intake of energy defi cit have 65 times bigger risk for malnutrition. The conclusion from this study is, there was a relationship between the energy intake with nutritional status of stage II and III breast cancer patients at Fatmawati General Hospital.

scholarly journals HUBUNGAN PENGETAHUAN DENGAN PEMERIKSAAN PAYUDARA SENDIRI (SADARI) SEBAGAI DETEKSI DINI KANKER PAYUDARA PADA MAHASISWA DIII KEBIDANAN STIKES MURNI TEGUH

2019 ◽  
Vol 1 (2) ◽  
pp. 44-49
Author(s):  
Laurena Ginting
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional ◽  
Breast Self Examination ◽  
A Value ◽  
Chi Square Test ◽  
Cross Sectional Design ◽  
Self Examination

Kasus kematian kanker di Indonesia menjadi yang tertinggi dengan angka 21,5 pada setiap 100.000, 70% pasien kanker payudara datang ke fasilitas kesehatan dengan keadaan stadium lanjut. Pengenalan penyakit kanker menjadi penting karena dapat menurunkan kasus baru kanker. Sehingga diperlukannya upaya pencegahan deteksi dini untuk mempermudah mengenali faktor risiko dan gejala kanker. Jenis penelitian ini adalah deskriptif analitik dengan desain cross sectional. Populasi dalam penelitian ini adalah seluruh mahasiswi D-III Kebidanan STIKes Murni Teguh yaitu sebanyak 32 orang. Sampel berjumlah 100 orang mahasiswi. Pengambilan sampel dilakukan dengan menggunakan total sampling. Penelitian dianalisa secara univariat dan bivariat dengan uji statistik chi square. Dari hasil uji bivariat menunjukan Hasil uji Chi square dengan bantuan SPSS diperoleh nilai P = 0,001 (P ≤ 0. 005) sehingga dapat dikatakan secara statistik terdapat hubungan antara pengetahuan dengan pemeriksaan payudara sendiri (SADARI) sebagai deteksi dini kanker payudara. Disarankan agar mahasiswi STIKes Murni Teguh meningkatkan Pengetahuan tentang pemeriksaan payudara sendiri (SADARI) dan rutin melakukan pemeriksaan payudara sendiri sesuai dengan waktu dan langkah – langkah pemeriksaan. STIKes Murni Teguh memberikan konseling dan informasi kepada mahasiswa untuk rutin melakukan SADARI.  Cancer death cases in Indonesia are the highest with 21.5 in every 100,000, 70% of breast cancer patients come to health facilities with an advanced stage. The introduction of cancer is important because it can reduce new cases of cancer. So that the need to prevent early detection efforts to facilitate recognizing risk factors and symptoms of cancer. This type of research is descriptive analytic with cross sectional design. The population in this study were all 32 D-III Midwifery students from STIKes Murni Teguh. The sample amounted to 100 female students. Sampling is done using total sampling. The study was analyzed by univariate and bivariate tests with chi square statistics. From the results of the bivariate test, the results of the Chi square test with the help of SPSS obtained a value of P = 0.001 (P ≤ 0. 005) so that it can be said statistically there is a relationship between knowledge with breast self examination (BSE) as early detection of breast cancer. It is recommended that Pure STIKes students firmly increase their knowledge of breast self-examination (BSE) and routinely carry out breast self-examinations according to the time and steps of the examination. STIKes Murni Teguh provides counseling and information to students to routinely conduct BSE.

scholarly journals HUBUNGAN MEKANISME KOPING DENGAN KUALITAS HIDUP PADA PASIEN KANKER PAYUDARA

2018 ◽  
Vol 1 (1) ◽  
pp. 38
Author(s):  
Abdul Wakhid ◽  
Wiwik Nurhikmah ◽  
Rosalina Rosalina
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Sampling Technique ◽  
P Value ◽  
Coping Mechanism ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

THE ROLE OF MENTAL HEALTH CADRES IN THE HANDLING OF MENTAL PATIENTS ABSTRACTPatients with cancer have a very significant increase including breast cancer that causes death. Breast cancer affects the greatest impact on the sufferer, thus affecting the quality of life. Decreased quality of life that is not resolved will inhibit treatment that will cause death. The purpose of this study was to determine the relationship between coping mechanism with quality of life in breast cancer patients. This research design is descriptive correlational with cross sectional approach. The population of this study was breast cancer patients with a sample of 55 respondents using accidental sampling technique and data collection tool using Cancer Coping Questionnaire 21 and WHOQoL-BREF. Data analysis used chi square test. The results showed that the mechanism of coping cancer patients 65.5% adaptive category, quality of life of breast cancer patients bad category 52,7%. There is a relationship of coping mechanism with quality of life in breast cancer patients who underwent chemotherapy with p value 0,048 (α = 0,05). Should the hospital facilitate interaction activities with fellow breast cancer patients in order to share experiences about improving the quality of life. Keywords: Mechanism of Coping, Quality of Life, Breast Cancer Patients

scholarly journals Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatolo

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Aisha Rahmatya ◽  
Daan Khambri ◽  
Henny Mulyani
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Primary Breast Cancer ◽  
Ductal Carcinoma ◽  
Developed Countries ◽  
Clinicopathologic Features ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional ◽  
Histologic Subtypes

AbstrakKanker payudara merupakan kanker yang paling sering mengenai perempuan dan menjadi penyebab kematian terbanyak akibat kanker pada perempuan. Angka kejadian kanker payudara bervariasi secara global dimana terjadi peningkatan insiden di negara berkembang tetapi cenderung menurun di negara maju. Gambaran klinikopatologi kanker payudara dapat bervariasi sesuai kelompok usia dan memiliki peran penting dalam faktor prognostik penyakit. Tujuan penelitian ini adalah untuk mengetahui hubungan usia dengan gambaran klinikopatologi kanker payudara. Gambaran klinikopatologi meliputi stadium klinis, subtipe histologi, dan gradasi histologi. Penelitian ini adalah penelitian analitik menggunakan metode cross sectional dengan teknik total sampling. Sampel penelitian yaitu data pasien kanker payudara primer di bagian bedah RSUP Dr. M. Djamil Padang periode Januari 2012 – Desember 2012. Dari 112 penderita kanker payudara primer hanya 46 yang memenuhi kriteria. Sampel penelitian dianalisis dengan uji chi square (p ≤ 0,05). Hasil penelitian ditemukan bahwa sebagian besar penderita berusia ≥ 40 tahun (78,3%) dan <50 tahun (67,4%), datang pada stadium lanjut (69,6%) dengan tipe invasive ductal carcinoma (87%) dan bergradasi rendah (78,3%). Analisis bivariat menunjukkan bahwa tidak terdapat hubungan yang bermakna antara usia dengan gambaran klinikopatologi kanker payudara.Kata kunci: kanker payudara, gambaran klinikopatologi, stadium klinis, subtipe histologi, gradasi histologi AbstractBreast cancer is now become the most common cancer diagnosed in women and the leading cause of deaths from cancer among women. The incidences of the disease vary globally, it has been reported to be increasing in developing countries while slightly down in developed countries. The clinicopathologic features of breast cancer may vary from each age groups and it has an important role as a prognostic factors. The objective of this study was to determine the relationship between age of the breast cancer patients and their clinicopathologic features. The clinicopathologic features i.e. staging, histologic subtypes, and histologic grades. This was an analythical study by using cross sectional method with total sampling technique. Samples were patients with primary breast cancer in Dr. M. Djamil General Hospital period January 2012 – December 2012. From 112 patients with primary breast cancer there were only 46 who fulfilled the criteria. The samples were analyzed by chi square test (p ≤ 0.05). The result of this study has revealed that most of the patients ≥ 40 years of age (78.3%) and < 50 years of age (67.4%), diagnosed in late stage (69.6%) with invasive ductal carcinoma (87%) and low histologic grade (78.3%). Bivariat analyze found that there is no significant relation between age and clinicopathologic features of breast cancer.Keywords: breast cancer, clinicopathologic features, staging, histologic subtypes, histologic grades

scholarly journals Hubungan Kesejahteraan Spiritual dengan Kualitas Hidup pada Pasien Kanker Payudara di Poli Bedah RSUP Dr. M. Djamil Padang

2020 ◽  
Vol 7 (2) ◽  
pp. 118
Author(s):  
Lola Despitasari ◽  
Lenni Sastra ◽  
Fitria Alisa ◽  
Letivia Azro
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
General Hospital ◽  
Poor Quality ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

Di Indonesia peningkatan jumlah kasus baru serta jumlah kematian akibat kanker payudara terus meningkat. Situasi yang dialami pasien kanker payudara menyebabkan permasalahan meliputi perubahan secara fisik, fungsi sosial, psikis maupun spiritual seseorang dan ini mempengaruhi kualitas hidup pasien kanker payudara. Salah satu faktor yang mempengaruhi kualitas hidup pasien kanker payudara adalah kesejahteraan spiritual. Tujuan penelitian untuk mengetahui hubungan kesejahteraan spiritual dengan kualitas hidup pada pasien kanker payudara di Poli Bedah RSUP Dr. M. Djamil Padang. Jenis penelitian analitik dengan desain cross sectional. Populasi pada semua wanita penderita kanker payudara yang datang ke poli bedah RSUP Dr.M.Djamil Padang sebanyak 509 orang dengan jumlah sampel sebanyak 83 orang.Teknik pengambilan sampel dengan accidental sampling. Data di analisa menggunakan uji Chi square. Hasil penelitian 44,6% pasien kanker payudara memiliki kualitas hidup buruk, 53% memiliki kesejahteraan spiritual yang buruk. Hasil uji statistik didapatkan p value 0,000(p ≤ 0,05), terdapat hubungan antara kesejahteraan spiritual dengan kualitas hidup pada pasien kanker payudara di Poli Bedah RSUP Dr.M.Djamil Padang. Disimpulkan bahwa pasien kanker payudara dengan kesejahteraan spiritual buruk cenderung memiliki kualitas hidup buruk. Diharapkan kepada tenaga kesehatan melakukan penyuluhan dan informasi yang edukatif tentang kualitas hidup kanker payudara sehingga meningkatkan kesejahteraan spiritual.Kata kunci : kanker payudara; kualitas hidup; kesejahteraan spiritual THE RELATIONSHIP OF SPIRITUAL WELFARE WITH QUALITY OF LIFE IN BREAST CANCER PATIENTS IN SURGERY POLYCLINIC AT Dr. M. DJAMIL PROVINCIAL GENERAL HOSPITAL OF PADANG ABSTRACTIn Indonesia the increase of new cases and the number of deaths from breast cancer continues to increase. The situation experienced by breast cancer patients cause problems include physical changes, social functions, psychic and spiritual of someone. The impact of these problems will affect the quality of life of breast cancer patients. One of the factors that affect the quality of life of breast cancer patients is spiritual welfare. The purpose of this study was to determine the relationship of spiritual welfare with quality of life in breast cancer patients in Surgery Policlinic at Dr. M. Djamil Provincial General Hospital of Padang. The type of research used was analytic survey, cross sectional study design. The population in this study were all women with breast cancer who came through surgery polyclinic at  Dr. M. Djamil Provincial General Hospital of Padang as many as 509 people with samples were 83 people taken by accidental sampling technique. Univaria data were analyzed using frequency table and bivariate used Chi square. The results showed almost half 44.6%, of breast cancer patients had poor quality of life, more than half 53%,  had poor spiritual welfare. Statistical test results obtained p value 0,000 (p ≤ 0.05) means there is a relationship between spiritual welfare with quality of life in breast cancer patients at surgery polyclinic at  Dr. M. Djamil Provincial General Hospital of Padang.The results of this study can be concluded that breast cancer patients with poor spiritual welfare have poor quality of life, while breast cancer patients with spiritual well-being have good quality of life. It is expected that health workers to educate and educational information about the quality of life of breast cancer.Keywords : breast cance; quality of life; spiritual welfare

HUBUNGAN ANTARA UMUR DAN STATUS PERKAWINAN DENGAN KEJADIAN KANKER PAYUDARA DI INSTALASI BEDAH RUMAH SAKIT UMUM PUSAT DR. MOHAMMAD HOESIN PALEMBANG TAHUN 2012

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Rini Mayasari Rini Mayasari
Keyword(s):  
Breast Cancer ◽  
Marital Status ◽  
Cancer Incidence ◽  
Random Sampling ◽  
Breast Cancer Incidence ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Systematic Random Sampling ◽  
Breast Cancer Event

ABSTRACT Breast cancer on the mark with the growth or uncontrolled growth of cells that are excessive. Factors affecting the incidence of breast cancer include maternal age, marital status, family history, hormone use, radiation, manarche, and obesity. The purpose of this study was to determine the relationship between Age and Marital Status of Mother with Breast Cancer incidence in the Installation Surgeon General Hospital Dr. Mohammad Hoesin Palembang in 2012. The study design was analytical descriptive with the approach in which the independent variables Cross Sectional Age Mother and Status Perkawianan and dependent variables in breast cancer incidence collected at the same time. The study population was all women who develop breast cancer in the Installation General Hospital Surgery Center Dr. Mohammad Hoesin Palembang in 2012 and samples taken by systematic random sampling with a sample of 130 respondents. The results of univariate analysis of data showed that respondents had breast cancer with a percentage of total 58 (44.61%) while respondents who had not had breast cancer totaled 72 by the percentage (63.39%). Respondents by Age Mothers who are at risk amounted to 34 by the percentage (26.15%) while respondents with Age Mothers who are not at risk amounted to 96 by the percentage (73.85%). Respondents by Marital Status is married and the mother who totaled 69 by the percentage (53.07%) and Marital Status with the status of unmarried women totaled 61 by the percentage (46.03%). Of Chi-Square test results found no significant relationship between Age Mothers with Breast Cancer event in which the p value = 0.007, no significant relationship between Marital Status in Breast Cancer event in which the p value = 0.030. Based on the results of the study, researchers suggest counseling efforts, medical knowledge and improve the quality of health services in order to reduce the incidence of breast cancer..   ABSTRAK Kanker payudara di tandai dengan pertumbuhan atau perkembangan tidak terkontrol dari sel-sel yang berlebihan. Faktor-faktor yang mempengaruhi kejadian kanker payudara antara lain umur ibu, status perkawinan, riwayat keluarga, penggunaan hormon, radiasi, manarche, dan obesitas. Tujuan penelitian ini adalah untuk mengetahui hubungan antara Umur Ibu dan Status Perkawinan dengan kejadian Kanker Payudara di Instalasi Bedah Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2012. Desain Penelitian ini adalah deskriptif analitik dengan pendekatan Cross Sectional dimana variabel independen Umur Ibu dan Status Perkawianan dan variabel dependen kejadian kanker payudara dikumpulkan dalam waktu yang bersamaan. Populasi penelitian ini adalah semua ibu yang menderita kanker payudara di Instalasi Bedah Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2012 dan sampel di ambil secara systematic random sampling dengan jumlah sampel 130 responden. Hasil analisis univariat data menunjukan responden yang mengalami Kanker Payudara berjumlah 58 dengan persentase sebesar (44,61%) sedangkan responden yang tidak mengalami Kanker Payudara berjumlah 72 dengan persentase (63,39%). Responden dengan Umur Ibu yang beresiko berjumlah 34 dengan persentase (26,15%) sedangkan responden dengan Umur Ibu yang tidak beresiko berjumlah 96 dengan persentase (73,85%). Responden dengan Status Perkawinan ibu yang berstatus kawin berjumlah 69 dengan persentase (53,07%) dan Status Perkawinan ibu yang berstatus tidak kawin berjumlah 61 dengan persentase (46,03%). Dari hasil uji Chi-Square didapatkan ada hubungan bermakna antara Umur Ibu dengan kejadian Kanker Payudara dimana p Value = 0,007, ada hubungan bermakna antara Status Perkawinan dengan kejadian Kanker Payudara dimana p Value = 0,030. Berdasarkan hasil penelitian, peneliti menyarankan upaya-upaya penyuluhan, pengetahuan tenaga medis dan meningkatkan mutu pelayanan kesehatan guna menurunkan angka kejadian kanker payudara.

Association of CYP2D6*10 (c. 100 C>T) Genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yenny ◽  
Sonar S. Panigoro ◽  
Denni J. Purwanto ◽  
Adi Hidayat ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Ultra Performance Liquid Chromatography ◽  
Cross Sectional Study ◽  
Threshold Concentration ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Liquid Chromatography Tandem Mass

Background: Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END). Objective: The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer. Methods: A cross-sectional study was performed in 125 ambulatory patients with breast cancer consuming TAM at 20 mg/day for at least 4 months. The frequency distribution of CYP2D6*10 (c.100C>T) genotypes (C/C: wild type; C/T: heterozygous mutant; T/T: homozygous mutant) was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the results of which were subsequently confirmed by sequencing. The genotypes were categorized into plasma Z- END concentrations of <5.9 ng/mL and ≥5.9 ng/mL, which were measured using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results: Percentages of C/C, CT, and T/T genotypes were 22.4%, 29.6%, and 48.8%, respectively. Median (25-75%) Z-END concentrations in C/C, C/T, and T/T genotypes were 9.58 (0.7-6.0), 9.86 (0.7-26.6), and 3.76 (0.9-26.6) ng/mL, respectively. Statistical analysis showed a significant difference in median Z-END concentration between patients with T/T genotype and those with C/C or C/T genotypes (p<0.001). There was a significant association between CYP2D6*10 (c.100C>T) genotypes and attainment of plasma steady-state Z-END MTC (p<0.001). Conclusion: There was a significant association between CYP2D6*10 (c.100C>T) and attainment of plasma steady-state Z-END MTC in Indonesian breast cancer patients receiving TAM at a dose of 20 mg/day.

Overexpression of microRNA-21 in the Serum of Breast Cancer Patients

MicroRNA ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 58-63
Author(s):  
Batool Savari ◽  
Sohrab Boozarpour ◽  
Maryam Tahmasebi-Birgani ◽  
Hossein Sabouri ◽  
Seyed Mohammad Hosseini
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Tumor Resection ◽  
Tumor Grade ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Serum Samples ◽  
Post Surgery ◽  
Polymerase Chain

Background: Breast cancer is the most common cancer diagnosed in women worldwide. So it seems that there's a good chance of recovery if it's detected in its early stages even before the appearances of symptoms. Recent studies have shown that miRNAs play an important role during cancer progression. These transcripts can be tracked in liquid samples to reveal if cancer exists, for earlier treatment. MicroRNA-21 (miR-21) has been shown to be a key regulator of carcinogenesis, and breast tumor is no exception. Objective: The present study was aimed to track the miR-21 expression level in serum of the breast cancer patients in comparison with that of normal counterparts. Methods: Comparative real-time polymerase chain reaction was applied to determine the levels of expression of miR-21 in the serum samples of 57 participants from which, 42 were the patients with breast cancer including pre-surgery patients (n = 30) and post-surgery patients (n = 12), and the others were the healthy controls (n = 15). Results: MiR-21 was significantly over expressed in the serum of breast cancer patients as compared with healthy controls (P = 0.002). A significant decrease was also observed following tumor resection (P < 0.0001). Moreover, it was found that miR-21 overexpression level was significantly associated with tumor grade (P = 0.004). Conclusion: These findings suggest that miR-21 has the potential to be used as a novel breast cancer biomarker for early detection and prognosis, although further experiments are needed.

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