scholarly journals COMPLEX ADDITIVE BASED ON SHELLFISH FLOUR IN COMPOUND FEEDSTUFF FOR STURGEONS

2019 ◽  
pp. 66-73
Author(s):  
Anna Aleksandrovna Bakhareva ◽  
Yulia Nikolaevna Grozesku ◽  
Alexander Nickolaevich Nevalennyy ◽  
Yulia Valerievna Sergeyeva ◽  
Nikolay Aleksandrovich Franov
Keyword(s):  
Positive Impact ◽  
Physiological State ◽  
Biologically Active ◽  
Russian Sturgeon ◽  
Control Group ◽  
Range Limit ◽  
Complex Additive ◽  
Control Variant ◽  
Control Evaluation ◽  
Blood Characteristics

The paper describes the experiments on evaluating the effect of complex additive based on shellfish flour on the physiological state of sturgeon fingerlings, which were conducted in the laboratories of Astrakhan State Technical University. Feeding was conducted with starting and productive feedstuff, according to branch standard recipes. As crab flour contains a large amount of protein, 10% fish flour was substituted for the complex additive. The experiments were conducted in reservoirs with temperature control. Evaluation of the cultivation results showed that in the pilot group the mass of Russian sturgeon fingerlings was higher than in the control group, using preventive additives that contributed to the correct growth of skeleton. In the pilot group the number of species with symptoms of scoliotic illness was lower, while in the control group this figure was relatively high. Evaluation of physiological state revealed the positive effect of complex additive on the blood characteristics of reared fingerlings of Russian sturgeon. It should be pointed out that in general physiological parameters of fish were within normal standards, however in the control variant there were signs of anemia, hemoglobin was registered at the lower range limit. Whereas for the fish fed with preventive feedstuff this factor was slightly increased. Biochemical analysis revealed higher concentration of protein in fish grown on feedstuff with complex additive. There was recorded a different amount of fat in the flesh of Russian surgeon fingerlings: in the species fed with preventive additive it was 14.1, while in the species of the control variant it was relatively higher - 16.7. The liver of fish who received food with complex additives was morphologically consistent with the norm and had a homogeneous granular consistency, with no signs of fat accumulation in the cytoplasm of hepatocytes. The liver of fish in the control group had a loose consistency and mosaic color, with distinct fatty dystrophy. Thus, the biologically active food additive has had a positive impact on the growth and evolution of Russian sturgeon fingerlings.

Influence of feed additive Vitartil on the productive traits and biochemical parameters of steers’ blood

2021 ◽  
pp. 25-32
Author(s):  
S. S. Mirgalimova ◽  
A. O. Trufanova ◽  
R. R. Fatkullin
Keyword(s):  
Physiological State ◽  
Relative Number ◽  
Blood Parameters ◽  
The Body ◽  
Biologically Active ◽  
Feed Additive ◽  
Control Group ◽  
Vital Functions ◽  
Productive Traits ◽  
Experimental Group

The physiological state of animals is to a certain extent characterized by hematological indicators, since blood occupies a special place in the body. By transferring nutrients and biologically active substances, the blood performs the general regulation of vital functions of the body. The use of Vitartil as a feed additive in the diets of animals leads to an increase in glycolytic processes and a decrease in the body’s need for oxygen delivery, which contributes to the growth of the animal body. The purpose of the research was to study the changes in blood parameters taking into account the age of Hereford steers against the background of the use of Vitartil feed additive to the main diet and its effect on the productive traits of animals. In order to carry out the experiment two groups of steers-analogs of Hereford breed have been formed at the age of 6 months per 10 heads in each. The difference between the groups was that the steers of the experimental group have been received the feed additive Vitartil in addition to the main diet. The greater yield of the meat part was in the steers of the experimental group in comparison with the herdmates of the control group. This indicator in the experimental group was 78,9 %, while in the control group it was lower by 1,6 %. The animals of the experimental group were superior to their herdmates in terms of meat weight by 1,4 kg or by 8,8 %. The relative number of bones was lower in the experimental group and amounted to 18,4 %, and in the control group 19,2 %. The meat content index was high in the steer have been received the biologically active additive Vitartil and was 4,3, and in the control group 4,0. It has been found that the use of Vitartil feed additive to the main diet of Hereford steers increases the blood content of hemoglobin and glucose, which has a certain effect on the morphological and chemical composition of meat, as well as increases its energy value.

scholarly journals The investigation of the influence which is done as a result of macleaya cordata and biologically active additives on the carbohydrate metabolism in pigs

2019 ◽  
Vol 21 (93) ◽  
pp. 137-142
Author(s):  
I. O. Zhukova ◽  
A. A. Molchanov ◽  
I. O. Kostiuk ◽  
O. M. Bobrytska ◽  
N. I. Lonhus ◽  
...  
Keyword(s):  
Carbohydrate Metabolism ◽  
Hematological Parameters ◽  
Physiological State ◽  
Antioxidant Properties ◽  
Meat Products ◽  
Hemoglobin Concentration ◽  
Biologically Active ◽  
Control Group ◽  
High Productivity ◽  
Macleaya Cordata

Pork production plays a significant role in meat balance of Ukraine. High productivity of pigs is accompanied with increased intensity of metabolic processes and intense functional activity of all organs and systems, which requires additional support. To grow a healthy livestock, it is necessary to use preparations and biologically active forage plant additives that help a body to realize productive qualities, fight against various pathogens, but do not harm the animal body and are safe in the production of meat products for human nutrition. The influence of phytobiotic of the cardiac macleaya (Macleáya cordáta R. Br.) has been investigated separately and in combination with vegetable additives (buckwheat, ground onion and buckwheat husks) as a source of flavonoids on the physiological state and carbohydrate metabolism of pigs. It has been determined that application of only macleaya supplements to the 30 and 60 days of studies leads to an increase in the number of erythrocytes by 16.7% and 23.2% (P < 0.05) and hemoglobin concentration by 30.7% and 37.9% (P < 0.01), as well as activation of anaerobic glycolysis, as evidenced by a significant increase in glucose concentration by 96.4–48.0% (P < 0.01), lactate by 71.4–55.2%, (P < 0.01) and activity of lactate dehydrogenase at 18.6–29.4% (P < 0.05) and reduction of pyruvate content by 34.0–13.4% (P < 0.01) and activity of alkaline phosphatase – by 66.2% and 76.8% (P < 0.01) in the corresponding terms of research. While using macleaya with green buckwheat, buckwheat and onion husks, the hematological parameters and parameters of carbohydrate metabolism were at the level of the control group, confirming the significant decrease in the concentration of glucose and lactate compared with the control and shift ratio lactate / pyruvate towards pyruvate. This fact suggests that bioflavonoids, which are part of plant additives, have not only antioxidant properties, but also serve as a correction and stabilizer of carbohydrate metabolism and mitigate the side hypoxic effects of alkaloids of phytobiotic of the macleaya cordata.

scholarly journals ВПЛИВ МІКРОЕЛЕМЕНТІВ ТА ГУМІЛІДУ НА ВІДТВОРНУ ФУНКЦІЮ ТЕЛИЦЬ УКРАЇНСЬКОЇ М’ЯСНОЇ ПОРОДИ

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 44-48
Author(s):  
V. Gryban ◽  
D. Mylostiva ◽  
E. Pecheniy
Keyword(s):  
Trace Elements ◽  
Physiological State ◽  
Reproductive Function ◽  
Protein Composition ◽  
Biologically Active ◽  
Control Group ◽  
Group I ◽  
Group Ii ◽  
The Impact ◽  
Experimental Group

The article presents research data on the impact of deficient dietary microelements (cobalt and selenium) and biologically active supplement Humilid  on the indicators of the reproductive function of heifers after the first calving. We have found out that Humilid and trace elements influence on the physiological state of reproductive organs and stimulate the sexual heat of animals. Regarding the duration of the period from calving to fertilized insemination, the difference between the control and experimental groups is more visible. Thus, the service period in the experimental group I (under the influence of Humilid) was 293.2 days, which is 2.6 days less than in the control group. In the experimental group II (under the influence of cobalt and selenium), it was, respectively, by 3.9 days less than in the control one. This may indicate that the minerals and dietary supplements contribute to more rapid recovery of the ovarian cycle. Protein composition of blood serum was investigated in the study of the biochemical spectrum of blood. Balancing the nutrition of animals with deficient dietary microelements and adding Humilid increase the concentration of protein molecules, which is visible from the indicator of crude protein and its components - albumen and globulin.In comparison with animals in the control group, a total protein level of heifers in the experimental group I was higher by 8.8% (P <0.05), and in the experimental group II - by 8.6% (P <0.05). This may indicate the increased intensity of synthetic and redox processes in heifers’ bodies in preovulatory period which serve best for the insemination.The level of albumen was also higher by 8.0 and 7.3% respectively under the influence of Humilid and trace elements in relation to the control group, indicating the improvement of transport of substances, in our case estradiol.As far as globulin is concerned, the growth of this class of proteins was marked by 9.4 and 9.6%, indicating the improvement of the level of resistance of the organism. Thus, the increase in blood biochemical parameters creates certain conditions in heifers’ body to improve their insemination.

scholarly journals PLANTARUM PROBIOTIC PRODUCT IN THE DIETS OF PREGNANT GOATS AND ITS EFFECT ON THE GROWTH AND DEVELOPMENT OF FEMALE BABY GOATS

2021 ◽  
pp. 75-79
Author(s):  
I.A. Funk ◽  
◽  
N.I. Vladimirov ◽  
Keyword(s):  
Body Weight ◽  
Growth And Development ◽  
Physiological State ◽  
Live Weight ◽  
Biologically Active ◽  
Control Group ◽  
Research Findings ◽  
Probiotic Product ◽  
Growth Energy ◽  
Female Baby

To obtain viable offspring of animals, much attention is paid to the physiological state of the mothers. To ensure the normal physiological and immune status of pregnant animals, biologically active and environmentallyfriendly drugs, in particular probiotic products are widely used. The prospects for the use of probiotic products in animal hus-bandry are determined to their ability to optimize digestion and accelerate the absorption of nutrients due to their composition of live and biologically active strains of probi-otic microorganisms. This paper presents the research findings on the growth and development of Saanen type female baby goats whose mothers received the experi-mental probiotic product Plantarum with their diets. The research targets were Saanen type pregnant goats and their offspring (female baby goats). To conduct the experi-ment, 4 groups of pregnant goats comparable regarding the live weight and age were formed; then 4 groups of fe-male baby goats were formed from their offspring. The pregnant goats of the control group received the basic diet of the farm; the basic diets of the 2nd, 3rd and 4th groups during the second half of pregnancy was supplemented with the probiotic product Plantarum in doses of 0.4 mL per kg of body weight per day, 0.6 mL per kg of body weight per day and 0.8 mL per kg of body weight per day, respec-tively. It was found that supplementing the diets of preg-nant goats with different doses of the experimental probi-otic product Plantarum during the second half of pregnancy contributed to increased growth energy of the obtained offspring (female baby goats).

scholarly journals To studying the development of technological stress in the organism of piglets during the influence of the feed additives «Praimiks Bionorm K»

2018 ◽  
Vol 20 (87) ◽  
pp. 8-12
Author(s):  
V.G. Stoyanovskyy ◽  
O.I. Kamratska ◽  
I.A. Kolomiіets ◽  
O.I. Slepokura
Keyword(s):  
Physiological State ◽  
Feed Additives ◽  
The Body ◽  
Stressful Events ◽  
Biologically Active ◽  
Control Group ◽  
Feed Supplement ◽  
Beef Breed ◽  
Stress Isolation ◽  
Technological Stress

The article is devoted to increasing the preserving and survival of piglets in conditions of industrial cultivation, where their organism is exposed to constant effects of adverse technological factors. The state of stress that occurs in this case leads to a decrease in the rate of growth and resistance of the young to a variety of diseases and can ultimately cause death of animals. One of the most promising directions for preventing the negative effects of stress and increasing the overall resistance of the piglet organism is the search, development and introduction of dietary supplements that increase physiological processes in the body, improve metabolism, increase the energy of growth, increase the yield of meat products. The purpose of the work was to find out the physiological state of a piglet organism during the period of weaning at the influence of the biologically active feed supplement «Praimiks Bionorm K» in the conditions of the SEPC «Komarnivsky». The research was carried out on piglets of 5 – 60-day-old age of the Poltava beef breed. Technological stress was the weaning of piglets at 40 days of age and the group maintenance of them with a change in the structure of the ration during the growing season. Piglets of the experimental group, together with the main feed, were additionally fed with «Praimiks Bionorm K» in the amount of 9.0 g/100 kg of feed (manufacturer – biotechnology company «Ariadna» Odessa). According to the results of the conducted research, it was found that the process of adaptation of the organism of the piglets of the control group to the stress isolation after 5 days was accompanied by an increase in blood hemoglobin concentration in 1.35 times (P < 0.01), the number of leukocytes – by 1.21 times (P < 0.05) at the expense of rodent and segmental neutrophils and monocytes – 1.54 times (P < 0.01), with a decrease in the number of eosinophils – 3.0 times (P < 0.001) and lymphocytes – 1.15 times (P < 0.01), compared with the period before weaning. 20 days after weaning in the K group, there was a decrease in the number of eosinophils in the blood by 2.25 times in the blood and lymphocytes by 1.25 times (P < 0.01), in the increase in the cellular and segmental neutrophils by 2.15 and 1.90 times, monocytes – by 1.85 times (P < 0.01) in comparison with the period before weaning. Neutrophilia, lymphopenia and eosinopenia were the most pronounced and persistent signs of stress in the piglets of the K group that arose out of the regulatory influence of glucocorticoids. While using biologically active feed supplement «Praimiks-Bionorm K» 5 days after weaning in the blood of piglets, the content of hemoglobin increased by 1.26 times; after 20 days its concentration increased by 1.22 times, as well as the increase in the number of leukocytes in 1.22 times (P < 0.01), neutrophils of rod-nuclei – 2.0 times, segmental ones – 1.37 times (P < 0.01), compared to control. The obtained results indicate that the use of BAFA «Praimiks Bionorm-K» allows to prevent the development of stressful events in the piglet organism, improve the status of the cellular level of nonspecific resistance and the level of productivity during the period of weaning and at different stages of development of the stress reaction after weaning.

scholarly journals The effectiveness of new feed additives on the basis of lactulose in growing rabbits

2020 ◽  
Vol 12 ◽  
pp. 52-60
Author(s):  
O.A. Knyazhеchenko ◽  
◽  
I.A. Semenova ◽  
A.A. Mosolov ◽  
M.V. Frolova ◽  
...  
Keyword(s):  
Blood Cells ◽  
Positive Impact ◽  
Physiological State ◽  
White Blood Cells ◽  
Live Weight ◽  
Feed Additives ◽  
The Body ◽  
Natural Resistance ◽  
Control Group ◽  
Absolute Increase

Aim. To study the feasibility of using feed additives containing powdered feed preparations with different lactulose content in the amount of 5 g/kg of extruded compound feed together with the main diet in terms of the effect on the quality indicators of raw materials and the natural resistance of the body of experimental rabbits. Materials and Methods. The effectiveness was evaluated after the control slaughter at the age of 150 days in the number of 5 heads from each group. The change in live weight was determined when the rabbits reached the age of 75, 105, 135 and 150 days by weighing on an electronic scale. The physiological state and resistance of rabbits were evaluated by hematological parameters. The obtained materials were processed by the methods of variation statistics. Results. The analysis of dynamics of changes of alive weight of animals showed that feed supplementation with lactulose had a positive impact on the growth of animals the live weight of rabbits in groups I and II were greater at 3.8 and 6.2% absolute increase in live weight during the period of experience increased by 5.3 and 7.9%, respectively, compared to control. At the same time, the effect of supplements on blood parameters should also be noted. In our studies, the rabbits of the experimental groups had an advantage over the rabbits of the control group in terms of the level of red blood cells by 0.94·1012 g/l (18.7%) and 1.12·1012 g/l; white blood cells - by 0.50·109 (7.2%) g/l and 0.59·109 g/l (8.5%), respectively. The level of hemoglobin in the blood of rabbits increased by the end of the experiment in the control group by 3.7%, in I – by 12.5%, in II – by 15.9%. Conclusion. Based on the presented results, it can be concluded that the data on quantitative changes in blood were due to the influence of feed additives, which contributed to an increase in the natural resistance of rabbits, and the best indicators were achieved by rabbits of the II experimental group.

scholarly journals Growth and development dynamics of Hyplus meat breed of young rabbits under the influence of «Humilid» feed additive

2020 ◽  
pp. 96-101
Author(s):  
V. A. Utkina ◽  
◽  
L. M. Stepchenko ◽  
Keyword(s):  
Body Weight ◽  
Growth And Development ◽  
Physiological State ◽  
The Body ◽  
Biologically Active ◽  
Daily Weight Gain ◽  
Feed Additive ◽  
Control Group ◽  
Age Related ◽  
Experimental Group

The research objective is to establish Hyplus meat breed of young rabbits and to determine growth and development characteristics during the period from weaning to slaughter age under conditions of the biologically active feed additive of humic nature «Humilid» introducted into their general diet. The control and experimental groups of animals were formed according to the principle of similar groups. Experiment study lasted for 35 days, including 7 days preparatory period, 21 days research period and 7 days aftereffect period. The young rabbits of the control and experimental groups were fed with the main diet, which included compound feed with an individual calculation of nutrients per animal. The young rabbits of the experimental group were additionally injected with a biologically active feed additive «Humilid» in the form of an aqueous solution in an amount of 5 mg/kg of body weight according to the active substance to the main diet for 21 days. During the experiment, the effect of «Humilid» on the growth and development of young rabbits and their physiological state was studied. The weighing of young rabbits in the experimental groups was carried out once a week. At the same time, their body weight was determined on average and average daily growth, the safety of the livestock, in addition, the weight and mass index of the liver, heart and kidneys after slaughter by the calculation method. With the introduction of the feed additive «Humilid» to young rabbits, an increase in the body weight of the animals is observed throughout the experiment. The body weight on average of young animals of the experimental group exceeded this indicator in comparison with animals in the control group by 17.2 % (p˂0.001). Under the conditions of the introduction of the biologically active feed additive «Humilid» over the period of the experiment, the average daily weight gain of young rabbits in the experimental group was higher by 20.7 % (p˂0.01) compared to this indicator in the animals of the control group, respectively. The safety of the livestock was 100% in both groups. However, it should be noted that young rabbits of the control group had more pronounced motor activity and signs of anxiety than the animals of the experimental group, which obtained the feed additive of humic nature «Humilid». When «Humilid» was used in the diet, the mass of organs and the index of their development in young rabbits in the experimental and control groups of animals were within the range of age-related changes, which indicates the non-toxic effect of this additive.

Blood fatty acids in the development and correction of metabolic syndrome

2016 ◽  
Vol 88 (8) ◽  
pp. 30-34 ◽  
Author(s):  
T P Novgorodtseva ◽  
Yu K Denisenko ◽  
M V Antonyuk ◽  
N S Yubitskaya ◽  
E G Lobanova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Positive Impact ◽  
Leukotriene B4 ◽  
Biologically Active ◽  
Control Group ◽  
Mead Acid ◽  
King Crab

Aim. To investigate the composition of plasma fatty acids (FA) and red blood cells and the level of eicosanoids in patients with metabolic syndrome (MS) and to assess whether metabolic disturbances may be corrected during a cycle use of an ω-3 polyunsaturated fatty acid (PUFA). Subjects and methods. Examinations were made in 46 patients, including Group 1 (a control group) of 15 persons without MS components; Group 2 of 31 patients with MS, Group 3 of 16 MS patients who had taken an ω-3 PUFA for 6 months, and Group 4 of 15 MS patients who had received the drug for 12 months. The composition of plasma FA and red blood cells was analyzed on a gas-liquid chromatograph. An enzyme immunoassay was used to measure the serum levels of tumor necrosis factor-α (TNF-α) and eicosanoids (thromboxane B2, 6-keto-prostaglandin F1α, leukotriene B4). A biologically active additive from the king crab (Paralithodes camtschatica) hepatopancreas was used as a source of ω-3 PUFA. Results. Having a higher proportion of linoleic and α-linolenic acids in the plasma, the patients were found to have decreased levels of ω-3 and ω-6 PUFAs (linoleic and α-linolenic, arachidonic, and eicosapentaenoic acids) and a larger proportion of Mead acid and saturated FAs (myristic and stearic acids) in the red blood cells, suggesting that that cellular blood FA transfer was impaired and FAs were absorbed by cells. Their serum samples showed the high levels of leukotriene B4, 6-keto-prostaglandin F1α, and thromboxane A2. The long-term (6- and 12-month) use of ω-3 PUFA from the king crab hepatopancreas had a positive impact in modifying the lipid FA composition of red blood cells and in eliminating deficiencies of physiologically important ω-3 and ω-6 PUFAs in the blood cells. Conclusion. The findings suggest that FAs and their metabolites play an important role in the pathogenesis of MS and that dietary ω-3 PUFA should be incorporated into a package of preventive and therapeutic measures for MS.

scholarly journals Productivity of bumpers for the microelemental correction of their rations

2018 ◽  
Vol 20 (83) ◽  
pp. 247-250
Author(s):  
T.V. Farionik
Keyword(s):  
Trace Elements ◽  
Total Protein ◽  
Physiological State ◽  
Organic Ligand ◽  
The Body ◽  
Biologically Active ◽  
Age And Growth ◽  
Control Group ◽  
Hemoglobin Content ◽  
Chelate Compounds

One of the most important factors in the full feeding of animals is the optimal supply of nutrients and biologically active substances, namely, trace elements. Lacking or excessive MI in rations leads to a disturbance of metabolism in the body, inhibits development and growth, reduces productive qualities, and, by reducing immunity, causes various diseases. The final factor is the close interconnection of trace elements with proteins, carbohydrates, fats, which ultimately reflects on the physiological state of a living organism. Soil and climatic conditions of the central region are characterized by a lack of feed and water of the following trace elements: cobalt, copper, iron, manganese, zinc. The bioavailability of these microelements for the animal organism is lower than the physiological norm. Increase of biological availability of trace elements by tissues of an organism can be achieved due to their connection with an organic ligand, and in our case with an essential amino acid methionine, thus creating chelating compounds – metionates. The purpose of the article is to analyze the influence of chelate compounds on the protein metabolism of fattening bulls. The results of hemoglobin studies showed us that its content was also dependent on the applied trace elements. Similarly, an increase in the number of erythrocytes also increased the concentration of hemoglobin. Three months after the application of corrective supplements, the hemoglobin content in the blood of experimental bovine animals in the 2, 3, 4th experimental groups was increased compared to the control group. In addition, a similar picture was observed in the dynamics during the whole experimental period of fattening. The best effect on the hemoglobin content in the blood was shown by the addition of chelates (metionates) in the 4th experimental group, which is also confirmed statistically. The results of the obtained data indicate that the correctional additives of the microelements and their chelates (metionates) used by us increase the level of total protein in the blood serum of fattening bulls. During the trial period, their concentration in the bulls of the control group also increased, but this is due to the age and growth of animals. However, in the Bugites of experimental groups, the content of total protein significantly increased under the influence of corrective supplementation of trace elements, and especially under the influence of their chelate compounds (metionates). Already three months after the micronutrient supplement was fed, the level of total protein in the serum of bulls in all experimental groups significantly increased compared to the animals in the control group.

Antioxidant status of blood in patients with vibration disease

2019 ◽  
pp. 978-982 ◽  
Author(s):  
N. N. Malyutina ◽  
A. F. Bolotova ◽  
R. B. Eremeev ◽  
A. Zh. Gilmanov ◽  
D. Yu. Sosnin
Keyword(s):  
Antioxidant Activity ◽  
Blood Serum ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Main Group ◽  
Biologically Active ◽  
Antioxidant Systems ◽  
Control Group ◽  
Vibration Disease ◽  
Total Antioxidant

Introduction. The overwhelming number of publications contains only data on the content of individual antioxidants, but not on the overall antioxidant activity of the blood in patients with vibration disease.The aim of the study was to determine the total antioxidant activity of blood serum in patients with vibration disease.Materials and methods. Th e main group consisted of 30 people diagnosed with “Vibration disease” of 1 degree (n=21) and 2 degrees (n=9). Th e control group consisted of 30 clinically healthy men, comparable in age with the main group (p=0.66). Th e total activity of antioxidant systems of blood plasma was evaluated photometrically using the test system “Total antioxidant status-Novo” (“Vector-best”, Russia).Results. The indicator of the total antioxidant status (TAS) was 1,038±0.232 mmol/l in the examined main group, against 1,456±0.225 mmol/l in the examined control group (p<0.000001). Th e coefficient of variation (CV) in patients with vibration disease was 22.35%, 1.45 times higher than in the control group (15.45%). In the main group there was a positive correlation between age and TAS (R=0.525), in the control group there was no such relationship (R=0.095). Th e degree of decrease depended on the severity of vibration disease.Conclusions. 1. The development of vibration disease is accompanied by a decrease in the antioxidant status of blood serum. 2. Th e degree of decrease in the antioxidant status of blood serum correlates with the severity of vibration disease. 3. Reduction of TAS can serve as a pathogenetic justification of the need to include drugs and/or biologically active additives with antioxidant activity in therapy

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