scholarly journals Effect of Diet Supplemented with Dennettia tripetala Fruits on Serum Antioxidants and Biochemical Parameters of Albino Rats

2020 ◽  
Vol 4 (1) ◽  
pp. 16-21
Author(s):  
Adebiyi H. Yetunde ◽  
Dauda Muhammed ◽  
Babatunde O. Richard ◽  
Odey O. Bernard ◽  
Aderemi C. Omolaiye ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Hypolipidemic Effect ◽  
Formulated Diet ◽  
Significant Difference ◽  
Dennettia Tripetala ◽  
Group 2 ◽  
Biochemical Analyses

AbstractThis study was carried out to determine the effect of dietary supplementation of Dennettia tripetala on some biochemical parameters of rats. Twenty-five rats were used and were divided in to five groups of 5 rats. Group 1 served as control while group 2-5 were fed dietary inclusion of Dennettia tripetala fruits for 28 days. After the feeding trials, the rats were sacrificed and blood was collected for biochemical analyses. The serum concentration triglyceride and glucose were significantly lowered (p<0.05) while total protein, catalase and high-density lipoprotein were significantly higher (p<0.05) in rats fed with the formulated diet. There was no significant difference (p<0.05) in the serum level of superoxide dismutase, albumin, cholesterol and low-density lipoprotein of rats fed with the formulated diet. In conclusion, the study has shown that dietary inclusion of Dennettia tripetala fruits has hypoglycaemic, antioxidant and hypolipidemic effect. Therefore, it may help in the prevention of coronary heart disease, diabetes mellitus and cancer.

scholarly journals Effects of Energy Drink in Combination with Two Different Brands of Alcohol on Some Biochemical Parameters of Male Albino Rats

2020 ◽  
Vol 5 (9) ◽  
pp. 707-710
Author(s):  
Okuda, A. Frank ◽  
Ehiwario, N. Julius ◽  
Oshilim, O. Anthony
Keyword(s):  
Biochemical Parameters ◽  
Energy Drink ◽  
Control Group ◽  
Albino Rats ◽  
Treatment Groups ◽  
Group 4 ◽  
Significant Difference ◽  
Group 2 ◽  
Biochemical Analyses ◽  
Group 1

This study was carried out to ascertain the effect of energy drink and mixture of energy drink with different brands of alcohol on some biochemical parameters. Sixteen (16) male albino rats weighing 120- 160g were divided into four (4) groups. The groups were divided thus: Group 1: Control- feed and water ad libitum, Group 2: 3.75ml/kg Bullet Energy drink only, Group 3: 3.75ml/kg Bullet energy drink + 1ml/kg of 41% alcohol dry gin and Group 4: 3.75ml/kg Bullet energy drink + 1ml/kg of 5.1% alcoholic beer. The experiment lasted for 28 days after which the animals were fasted for 12 hours before they were sacrificed and their blood collected for biochemical analyses. There was a significant increase in body weight of animals in group 2-4 and also the glucose concentration was elevated. The result presented in table 2 showed that there is a statistically significant difference (p<0.05) in the level of ALT and ALP in treatment groups when compared to the control group (1). Also, elevated level of cholesterol and triglycerides were also observed. From this data, we may conclude that there are high risk of constantly taking energy drink alone or in combination with alcohol.

scholarly journals HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters

2019 ◽  
Vol 18 ◽  
Author(s):  
Sandra Maria Barbalho ◽  
Ricardo José Tofano ◽  
Marcela Bueno de Oliveira ◽  
Karina Rodrigues Quesada ◽  
Mariana Ricci Barion ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Potential Role ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Clinical Intervention ◽  
Atherogenic Indices ◽  
Significant Difference ◽  
Atheroma Plaque ◽  
Intervention Trials

Abstract Background Dyslipidemias are associated with atherosclerosis and cardiovascular diseases. Recently, non-high-density lipoprotein cholesterol (non-HDL-c) has emerged as a new target for assessment and prediction of risk of cardiovascular disease (CVD) and is closely associated with atheroma plaque progression. Objectives To evaluate associations between HDL-c and non-HDL-c levels and anthropometric and biochemical parameters and with the Castelli risk indexes I and II. Methods 300 randomly selected people were subdivided into two groups: patients with normal values for non-HDL-c and patients with altered values for non-HDL-c. These parameters were analyzed for associations with glycemia, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), Castelli Index I (CI-I), Castelli Index II (CI-II), waist circumference (WC), body mass index (BMI) and presence of metabolic syndrome (MS). Results Glycemia, TC, TG, LDL-c, CI-I, CI-II, WC and BMI were all significantly different between subjects with normal and altered values of HDL-c and non-HDL-c. TC and WC both exhibited significantly higher values among patients with abnormal non-HDL-c when compared to patients with abnormal HDL-c. A significant difference was observed in occurrence of MS among patients with altered values of HDL-c and non-HDL-c. Conclusions Our results show that both HDL-c and non-HDL-c are associated with insulin resistance, dyslipidemia, atherogenic indices, and obesity. There is therefore a need for randomized clinical intervention trials examining the potential role of non-HDL-c as a possible primary therapeutic target.

scholarly journals Evaluation of Oxidative Stress and some Biochemical Parameters in Normal Pregnant Women

2020 ◽  
Vol 8 (1) ◽  
pp. 17-23
Author(s):  
Musher I. Kakey ◽  
Kamaran K. Abdoulrahman ◽  
Gulbahar R. Uthman
Keyword(s):  
Pregnant Women ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
First Trimester ◽  
Control Group ◽  
Sod Activity ◽  
Nonsignificant Difference ◽  
Group 2

Pregnancy is associated with many metabolic changes in normal pregnant woman, this leads to change in physiological, biochemical, and hematological parameters drastically. The test subjects were selected among those attending to Maternity Teaching Hospital in Erbil Governorate between March 2017 and August 2017. Four groups of individuals were included in this study, 230 pregnant women divided into three groups (Group 1 first trimester, Group 2 second trimester, and Group 3 third trimester) and Group 4 contained 90 nonpregnant women as control. Full automatic chemical analyzer (Cobas C311, Germany) was used to determine the biochemical parameters. The EL ×800 Absorbance Microplate Reader from BioTek (USA) instruments is used to measure the activity of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in serum. The results of this study showed a significant increase in serum albumin, glucose, total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine, urea, cholesterol, low-density lipoprotein, and MDA in pregnant women as compared to the control group, also show significant decrease in high-density lipoprotein (HDL) level, SOD activity, and CAT activity in pregnant women as compared to nonpregnant women, and nonsignificant difference in uric acid, and HDL.

Effects of Dehulled Adlay on Plasma Glucose and Lipid Concentrations in Streptozotocin-induced Diabetic Rats fed a Diet Enriched in Cholesterol

2006 ◽  
Vol 76 (5) ◽  
pp. 299-305 ◽  
Author(s):  
Yeh ◽  
Chiang ◽  
Chiang
Keyword(s):  
Adipose Tissue ◽  
Plasma Glucose ◽  
Functional Food ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Significant Difference

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a cereal food for humans and has been also used as a superior medical herb substance and functional food for traditional treatment of diabetes in China. However, its scientific basis as a functional food is still unclear. The purpose of this study was to investigate the effect of dietary dehulled adlay on plasma lipid and glucose concentrations in diabetic rats. The diabetic male Sprague-Dawley (SD) rats, induced by injection of streptozotocin (60 mg/kg subcutaneously), were fed a cholesterol-rich diet (0.5% cholesterol) containing corn starch or dehulled adlay for four weeks. After completion of the experimental period, the abdominal adipose tissue and liver of rats were excised and weighed, and the plasma glucose, triglyceride, and lipoprotein cholesterol concentrations were assayed. The results showed that diabetic rats fed a dehulled adlay diet exhibited a greater adipose tissue weight (9.36 ± 3.43 vs. 5.39 ± 3.04 g, p < 0.05) and a reduced food intake (39.3 ± 5.9 vs. 61.0 ± 11.7 g/day, p < 0.05) when compared with animals fed a cornstarch diet. Significantly decreased plasma glucose (261.6 ± 96.6 vs. 422.1 ± 125.4 mg/dL, p < 0.05), total cholesterol (289.4 ± 140.6 vs. 627.3 ± 230.5 mg/dL, p < 0.05), and triglyceride (52.3 ± 14.4 vs. 96.5 ± 36.6 mg/dL, p < 0.05) levels were observed in rats fed the dehulled adlay diet. In addition, the ingestion of dehulled adlay appears to significantly decrease plasma low-density lipoprotein (LDL) plus very low-density lipoprotein (VLDL) cholesterol concentrations. Rats fed a dehulled adlay diet showed an increase in fecal weight and cholesterol contents of stools. Although a significantly decreased plasma thiobarbituric reactive substances (TBARS) value was observed in diabetic rats fed the dehulled adlay diet (6.2 ± 3.4 vs. 11.0 ± 3.8 nmol malondialdehyde (MDA)/mL, p < 0.05), no significant difference in the hepatic TBARS value was observed between the two dietary groups. Results from the present study suggest that dehulled adlay exhibited not only a hypolipidemic effect but also displayed a hypoglycemic ability in diabetic rats, indicating that dehulled adlay may play an important role in the regulation of plasma lipid and glucose metabolisms in diabetic rats induced by streptozotocin.

scholarly journals Effect of Guiera senegalensis and Natron on Serum Indices of Cardiac Function of Postpartum Rats

2021 ◽  
pp. 32-46
Author(s):  
Aminu Lailaba Abubakar ◽  
Jabir Aliyu Danyaya ◽  
Kabiru Abubakar ◽  
Magaji Umar Faruk ◽  
Yusuf Saidu
Keyword(s):  
Body Weight ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Guiera Senegalensis ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Peripartum cardiomyopathy (PPCM) is a rare but devastating cardiac failure of indeterminate etiology occurring in late pregnancy or early puerperium. The prevalence of PPCM in Northern Nigeria could be attributed to the unique customary puerperal practices of prolonged consumption oflarge quantities of Guiera senegalensis and Natron. This study investigated the effect of decoction of G. senegalensis with and without Natron on cardiac markers, lipid profile and histology ofheart in postpartum female albino rats using standard methods.Thirty-five (35)female albino rats of body weights 190-200 g of five month were randomly grouped into seven (7) of five rats each. Group 2, 3 and 4 were orally administered with 100, 200 and 300 mg/kg body weight of G. senegalensis. Group 5, 6 and 7 were orally administered with 100, 200 and 300 mg/kg body weight (1:1) of G. senegalensis and Natron by gavage, whereas group 1 received distilled water. The study revealed significant (p< 0.05) decrease in triglyceride(TG) in group 2 to VII, high density lipoproteincholesterol (HDL-c) in group 2, 5 and 6, very low density lipoprotein- cholesterol (VLDL-c) in group 3 to V, couples with significant (p< 0.05) increase in low density lipoprotein cholesterol (LDL-c) in group 2, 3, 5 and 7, and for (AIX) in group 2, total cholesterol(TC) in group 2, 3 and 7 when compared with control. Significant (p< 0.05) increase in Lactate dehydrogenase (LDH) in group 3 to 7, and Myoglobin (MB) in group 3 was observed. Significant (p< 0.05) decrease in Troponin I (TnI) in group 2 and 4 was seen. There were no significant (p>0.05) changes in Troponin T (Tn T), aspartate amino transferase (AST) and Creatine Kinase(CK-NAC) of the treatment group when compared to control group. Histopathological examination of section of the heart revealed ventricular dilatation, hypertrophied with enlarged nuclei, stretched, and irregular and mural thrombi in group 2 to 4 and 7. Inflammation in group 5 and 7, Pigment deposited in group 4 to 7 and Mild fibrosis in group 3 were observed. The study demonstrates that consumption of G. senegalensis and Natron for 28 days’induces dyslipidemia and causes changes in the heart of postpartum rats and thus may contribute to the pathogenesis of PPCM.

scholarly journals A Study to Compare Hypolipidemic Effects of Allium Sativum (Garlic) Alone and in Combination with Atorvastatin or Ezetimibe in Experimental Model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sudipta Sil ◽  
Uttam Kumar Roy ◽  
Supreeti Biswas ◽  
Purnendu Mandal ◽  
Keya Pal
Keyword(s):  
Allium Sativum ◽  
Statistical Tests ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Atherogenic Diet ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Medical College ◽  
Cardiovascular Morbidity And Mortality ◽  
Significant Difference

Abstract Background: Dyslipidemia is a major cause of atherosclerosis and atherosclerosis induced conditions. Atorvastatin is an effective drug for dyslipidemia and reduce the risk of cardiovascular morbidity and mortality. Ezetimibe is used as an adjunct to statins hypercholesterolemia. Garlic is known for the hypolipidemic effect in traditional medicine. There are very limited studies comparing the additive effects of Allium sativum on atorvastatin and ezetimibe. Aims: To compare the additive hypolipidemic effects of Allium sativum with atorvastatin and ezetimibe. Setting and Design: The experimental study was done in Department of Pharmacology and Biochemistry, Burdwan Medical College, Burdwan from February 2014 - October 2015. Material and Methods: Dyslipidemia rat by (induced by atherogenic diet) were randomized into five groups of six rats in each and each cage was labelled for identification of different groups and treated with drugs (atorvastatin, ezetimibe, garlic homogenate, atorvastatin + garlic homogenate, ezetimibe + garlic homogenate) for twelve weeks and assessment of lipid profiles were done. Change of parameters checked for any significant difference by appropriate statistical tests. Results: Significant TC (Total Cholesterol) & TG (Triglyceride) concentrations reduction were maximum among ezetimibe group (51% and 47%) respectively. LDL (Low Density Lipoprotein) & VLDL (Very Low-Density Lipoprotein) concentrations reduction were maximum (62% and 26%) among combination of atorvastatin and garlic group when compared to other treatment groups. HDL (High Density Lipoprotein) concentration was maximally increased (31%) among combination ezetimibe and garlic group which was also statistically significant. Conclusion: Garlic have significant hypolipidemic effect when used in combination with atorvastatin and ezetimibe.

scholarly journals Hematological Parameters and Lipid Profile Changes in Albino Rats due to Administration of Ethanol Extract of Ipomea batatas Leaves

2021 ◽  
pp. 1-12
Author(s):  
M. O. Enemali ◽  
J. Akolo ◽  
G. S. Haruna ◽  
J. E. Bulus ◽  
P. J. Kassah ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Hematological Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Control Group ◽  
Albino Rats ◽  
Ipomea Batatas ◽  
Group 2

Leaves of I. batatas have been implicated in both the hematopoietic process and in the management of hyperlipidemia in man. The current study evaluated the hematopoietic potentials and the lipid profile stabilizing potential of ethanol leaf extract of I. batatas in albino rats. The study was carried out at the Department of Biochemistry and Molecular Biology of the Nasarawa State University, Keffi, between March 2019 and October 2019. The determination of the phytochemical composition of the leaves was carried out. Sixteen albino rats weighing between 100-150g were randomly distributed into 4 groups of 4 rats each. Animals in group 1 served as the control while animals in groups 2, 3, and 4 served as the test groups and were administered 200, 300 and 400g/kg body weight respectively of ethanol leaf extract of I batata for fourteen days following standard procedures. The extract contained terpenoids in high amount, flavonoids and alkaloids in moderate amounts, while glycosides, phenolic, and steroids were present in low amounts. WBC counts increased significantly across the test groups compared to the control. PLT decreased significantly (P = 0.05) in all the test groups when compared to the control group. MCV increased significantly (P = 0.05) in all the test groups when compared to the control group. MCH increased significantly (P = 0.05) in group 2 but decreased significantly in groups 3 and 4 when compared to the control group. The lipid profile parameters; triglycerides (TAG), total cholesterol (TC), low density lipoprotein (LDL-C) showed no significant changes but HDL-C decreased significantly in group 4 compared to the control. The outcome of this study revealed that the ethanol leaves extract of I. batatas may possess a hematopoietic effect but may not be effective in the management of hyperlipidemia.

scholarly journals HYPOLIPIDEMIC POTENTIAL OF METHANOLIC EXTRACT OF GRACILARIA CORTICATA ON STREPTOZOTOCIN-INDUCED DIABETIC RATS

2017 ◽  
Vol 10 (3) ◽  
pp. 402
Author(s):  
Sekar Subashini ◽  
Kavasseri Ganesan Kripa ◽  
Kodukur Viswanathan Pugalendi
Keyword(s):  
Diabetes Mellitus ◽  
Methanolic Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Standard Drug ◽  
Gracilaria Corticata

ABSTRACTObjectives: Diabetes mellitus is associated with profound alterations in the levels of plasma lipids and the lipoprotein profile. Herbs and herbal drugpreparations find wide use in alleviating the complications of uncontrolled diabetes owing to their low cost and lesser side effects. This study wasaimed at establishing the hypolipidemic effect of methanolic extract of sea weed Gracilaria corticata on streptozotocin (STZ)-induced diabetic rats.Methods: STZ-induced Wistar male albino rats were administered with methanolic extract of Gracilaria corticata (MGC) at a dosage of 100 mg/kgBW/day per orally for 45 days. Glibenclamide (600 μg/kg BW/day) administered rats served as standard drug control. Animals were sacrificed on46th day, biochemical parameters associated with lipid metabolism were analyzed in blood and tissue samples, statistical significance determined.Results: Elevated levels of total cholesterol, triglycerides, and free fatty acids were observed in the plasma and tissues of diabetic rats as compared toMGC and glibenclamide treated groups. The diabetic rats also had elevated levels of low-density lipoprotein (LDL-C) and very low-density lipoprotein(VLDL-C) and decreased levels of high-density lipoprotein (HDL-C) while the MGC and glibenclamide treated rats showed near normal levels of theseindices.Conclusion: This study establishes the hypolipidemic potential of MGC in STZ-induced diabetic rats.Keywords: Gracilaria corticata, Diabetes mellitus, Hypolipidemic, Streptozotocin.

Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model

Chemotherapy ◽  
2018 ◽  
Vol 63 (1) ◽  
pp. 39-45
Author(s):  
Bulent Cetin ◽  
Guldal Esendagli Yılmaz ◽  
Berkan Armagan ◽  
Baris Afsar ◽  
Umut Demirci ◽  
...  
Keyword(s):  
Kupffer Cells ◽  
Rat Model ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Albino Rats ◽  
Tissue Samples ◽  
Experimental Rat Model ◽  
Group 3 ◽  
Group 2

Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an experimental rat model. Sixteen Wistar albino rats were divided into 3 groups: experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p < 0.050 for all) but none in any other parameter (p > 0.050). All rats in the control group had normal histological features; however, none of the rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.

scholarly journals Changes in Serum Levels of Lipid Profile Parameters and Proteins in Toxoplasma Gondii Seropositive Patients

2021 ◽  
pp. 801-810
Author(s):  
Hayder Z. Ali ◽  
Harith Saeed Al-Warid
Keyword(s):  
Toxoplasma Gondii ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Low Density ◽  
Serum Samples ◽  
Significant Difference ◽  
Age Range

The influence of Toxoplasma gondii on some biochemical parameters has lately gained an increasing attention. The aim of this study was to assess the levels of some biochemical parameters in Toxoplasma positive and negative subjects. An analytical case–control study was achieved in Baghdad for the period from October 2018 until March 2019. Forty nine females participated in this study, with an age range of 18-55 years. The participants were separated into two groups, namely Toxoplasma positive subjects (n=21) and Toxoplasma negative subjects (n=28), based on enzyme-linked immunosorbent assay (ELISA). Blood and serum samples were collected from all subjects to evaluate the serum levels of cholesterol, triglycerides, high density lipoprotein (HDL), very low density lipoprotein (VLDL), low density lipoprotein (LDL), total protein, total globulin and total albumin. The results showed non-significant differences between Toxoplasma positive and negative subjects for all the parameters, although cholesterol levels were lower  (mean 149 mg/dL; range 131.9-165.9 mg/dL) in Toxoplasma positive patients as compared to those in Toxoplasma negative subjects (161 mg/dL; 146.7-175 mg/dL).  In addition, triglycerides levels were lower  (160 mg/dL; 123.3-196.8 mg/dL) in Toxoplasma positive subjects as compared to the control subjects (165mg/dL; 134.2-195.3 mg/dL). The only significant difference was noticed among subjects with an age range of 26-35 years, where globulin level was significantly higher (p=0.023)  in Toxoplasma negative subjects as compared to that in Toxoplasma positive subjects.

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