scholarly journals Comparisons of the Composition of Tobacco Smoke and the Smokes from Various Tobacco Substitutes

2007 ◽  
Vol 22 (4) ◽  
pp. 258-289 ◽  
Author(s):  
CR Green ◽  
JN Schumacher ◽  
RA Lloyd ◽  
A Rodgman
Keyword(s):  
Research And Development ◽  
Tobacco Smoke ◽  
Biological Properties ◽  
Consumer Acceptability ◽  
Mainstream Smoke ◽  
Reconstituted Tobacco Sheet ◽  
Considerable Research ◽  
Definition Of ◽  
Smoke Tobacco ◽  
Cigarette Design

AbstractBy the late 1970s, eight technologies in the design of a ‘less hazardous’ cigarette were classified as significant. The eight included: The tobacco blend, the filter tip, filter-tip additives, reconstituted tobacco sheet, paper additives, air dilution via paper porosity, expanded tobacco, and air dilution via filter-tip perforation. In addition to these eight cigarette-design technologies was another proposed technology which involved the incorporation of a substitute for some or all of the tobacco in the cigarette filler. Despite considerable research and development (R&D) effort on various tobacco substitutes that indicated the replacements in most instances fulfilled the definition of a ‘less hazardous’ cigarette with regard to the chemical and biological properties of their mainstream smoke, tobacco substitute-containing cigarettes failed to attain consumer acceptability. As a result, several marketed products containing tobacco substitutes had an extremely brief tenure in the marketplace. Outlined herein is a summary of some detailed research conducted on the composition of the mainstream smokes from cigarettes containing either all-substitute filler or fillers comprising various substitute and tobacco mixtures as well as an all-tobacco cigarette.

scholarly journals The Complexity of Tobacco and Tobacco Smoke

2011 ◽  
Vol 24 (5) ◽  
pp. 215-232 ◽  
Author(s):  
TA Perfetti ◽  
A Rodgman
Keyword(s):  
Tobacco Smoke ◽  
Complex Mixture ◽  
Operational Definition ◽  
Biological Properties ◽  
Complex Mixtures ◽  
Chemical Components ◽  
Detailed Knowledge ◽  
Polycyclic Aromatic ◽  
Definition Of ◽  
Risk Potential

AbstractTobacco and tobacco smoke are both complex mixtures. We previously reported 8430 unique chemical components identified in these complex mixtures but two years later our updated number was 8889. Addition of unlisted isomers raised these numbers to 8622 and 9081, respectively. Our previous number of 4994 identified tobacco components is now 5229; our previous number of 5315 identified tobacco smoke components is now 5685. An operational definition of a complex mixture is as follows: A complex mixture is a characterizable substance containing many chemical components (perhaps thousands) in inexact proportions.Detailed knowledge of the amount and type of each component within the substance is uncertain even with today's analytical technology. Although it has been estimated that as many as 100000 components are present in these complex mixtures, their analyses indicate that the vast majority of the mass of each of these complex mixtures accounts for the 8430 compounds reported previously. Over 98.7% of the mass of tobacco has been accounted for in terms of identified components in tobacco. Greater than 99% of the mass of whole smoke has been accounted for based on identified chemical components. Certainly, many more tobacco and tobacco smoke components are present in these complex mixtures but the total mass of these components obviously is quite small.One of the significant challenges we face as a scientific community is addressing the problems of determining the risk potential of complex mixtures. Many issues are associated with toxicological testing of the complex mixture of tobacco smoke. Conducting valid experiments and interpreting the results of those experiments can be quite difficult. Not only is the test agent a complex mixture but also the tests are performed on species that have complicated life-processes. Interpretations of test results are often paradoxical. Significant progress has been made in the toxicological evaluations of complex mixtures in the last 80 years. The challenges we face in terms of testing the biological properties of tobacco smoke are substantial. The statement by DIPPLE et al. in their summary of the research on polycyclic aromatic hydrocarbons from the 1930s through 1980 is equally true today for the cigarette smoke situation:…many important questions remain unanswered…many questions persist despite the considerable progress that has been made.

scholarly journals The Effect of Cigarette Design on the Content of Phenols in Mainstream Tobacco Smoke

2011 ◽  
Vol 24 (4) ◽  
pp. 187-193 ◽  
Author(s):  
S Dagnon ◽  
A Stoilova ◽  
I Ivanov ◽  
S Nikolova
Keyword(s):  
Tobacco Smoke ◽  
Significant Contribution ◽  
Total Content ◽  
Mainstream Smoke ◽  
Filter System ◽  
Polar Derivatives ◽  
Cigarette Mainstream Smoke ◽  
Selection Of ◽  
Cigarette Design ◽  
Charcoal Filter

AbstractThe influence of cigarette design on the content of phenols in mainstream tobacco smoke was studied. The most abundant phenols - catechol, hydroquinone, phenol, o-, m-, and p-cresol, and resorcinol - were determined by HPLC with fluorescence detection. Hydroquinone and catechol made the most significant contribution to the total content of phenols with maximum values of 135.0 µg/cig and 95.7 µg/cig, respectively. The highest total content of phenols (330.9 µg/cig) was measured in the smoke of a Virginia tobacco cigarette. The total content of phenols (µg/cig) in cigarette mainstream smoke decreased linearly with increased filter ventilation, R2 = 0.9536. The results obtained indicate that filtration and ventilation can strongly influence the mainstream tobacco smoke content of phenol and its less polar derivatives, o-, m-, and p-cresol, which were reduced by up to 85%. Hydroquinone and catechol are less affected and only cigarettes with the special “recessed charcoal filter system” and cigarettes with filter ventilation over 50% showed significant reductions. On a per mg ‘tar’ basis the largest contributor to phenols in cigarette mainstream smoke was the selection of the tobacco type. The use of any standard commercial filter on an unfiltered cigarette can substantially reduce the yield of phenols in cigarette mainstream smoke. The use of special filters (e.g., the “recessed charcoal filter system”) or high levels of cigarette ventilation does not reduce the amount of phenols in tobacco smoke considerably when normalized on a per mg ‘tar’ basis.

scholarly journals The Expansion of Tobacco and Its Effect on Cigarette Mainstream Smoke Properties

2007 ◽  
Vol 22 (5) ◽  
pp. 319-345 ◽  
Author(s):  
CR Green ◽  
JN Schumacher ◽  
A Rodgman
Keyword(s):  
Particulate Matter ◽  
Biological Properties ◽  
Mainstream Smoke ◽  
Total Particulate Matter ◽  
Design Technology ◽  
Cigarette Mainstream Smoke ◽  
Considerable Detail ◽  
Cigarette Design

AbstractFor nearly four decades, the expansion of tobacco has been recognized as one of eight technologies significant in the design of a ‘less hazardous’ cigarette. The data previously presented at scientific conferences and/or published in several scientific monographs and journals on the effect of the expansion of tobacco on the composition and biological properties of the mainstream smoke from cigarettes containing it are summarized. In addition, previously unpublished data on the same subjects are presented in considerable detail. Included are 1) the effect of tobacco expansion on the yields of total particulate matter (TPM), nicotine, and several hundred components of cigarette mainstream smoke from control tobacco cigarettes vs. expanded tobacco cigarettes; 2) the changes in mainstream smoke yields of total particulate matter, nicotine, and specific smoke components produced by inclusion of various levels of expanded tobacco in a cigarette blend; and 3) the changes in composition of expanded tobacco. In the latter study, the decrease in levels of numerous significant flavorful components of the tobacco produced by expansion provides the need for inclusion of such compounds in flavor formulations. In study 2), the reductions in per cigarette yields of total particulate matter, nicotine, and several components of concern were determined and confirmed the significance of tobacco expansion as a cigarette design technology to produce what was originally defined as a ‘less hazardous’ cigarette but more recently as a ‘potential reduced exposure product’ (PREP).

Research and Development for Makeup Object Moderl Agent Layer about XML Standard of Profession Field

2011 ◽  
Vol 314-316 ◽  
pp. 2152-2157
Author(s):  
Huan Gu
Keyword(s):  
Research And Development ◽  
Programming Language ◽  
Language Model ◽  
Digital System ◽  
Data Type ◽  
Definition Of

This document explains and demonstrates how to construct JDF data agent tools on .NET Linq platform. This Agent has the ability to create a Job, to add Nodes to an existing Job, and to modify existing Nodes. It is based on the structure of JDF standard and the definition of markup, and packages the node of each layer and its complicated parameters and data type into the object, forming a programming language model that is based on JDF markup object, and reducing the complexity of developing the printing digital process software basing-on JDFXML standard, providing a reference for developing the same distributed digital system basing-on XML driver.

Universalization of the intelligence definition problem

2021 ◽  
Vol 26 (jai2021.26(1)) ◽  
pp. 10-20
Author(s):  
Shevchenko A ◽  
◽  
Sosnitsky A ◽  
Keyword(s):  
Research And Development ◽  
Strong Sense ◽  
Strict Sense ◽  
Intellectual Activity ◽  
General Scientific ◽  
Definition Of

The main problem today in the research and development of AI is the lack of a scientific definition of Intelligence, since it is impossible to do something incomprehensible. This fundamentally delegitimizes all developments in this area and science as a whole as a product of exclusively intellectual activity, and any scientific use of the term «Intelligence» in its strict sense is unreasonable. In this paper, this problem is solved by transition to a more general universal paradigm of cognition, which allowed us to deduce the desired definition and universal formalism of Intelligence in its strong sense. Unlike previous publications, the ontology and properties of Intelligence are specified here as necessary components of Intelligence, which are subject to subsequent concretization and materialization in different niches of existence. The results of the work are of both fundamental and applied general scientific importance for all technical and humanitarian applications of Intelligence

scholarly journals Composite Materials and Their Fiber Reinforcement Technology in Aerospace Field

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Kailin Zhou
Keyword(s):  
Composite Material ◽  
Composite Materials ◽  
Research And Development ◽  
Carbon Fibers ◽  
Fiber Reinforcement ◽  
Space Structures ◽  
Advanced Composite ◽  
Advanced Composite Materials ◽  
Composites Materials ◽  
Definition Of

The need to reduce the overall weight of aeronautical and space structures while preserving or even improving their performances make the research and development in the field of advanced composite materials necessary for the advancement of aerospace technologies. This paper provides an overview of composite materials and their fiber reinforcement technology in aerospace field. We discuss the reasons for aircraft manufacturers and airlines to use composites and illustrate the definition of composite material. Then, we list the advantages and disadvantage of composite materials and cite different fiber reinforcement technologies of carbon fibers, aramid fiber, UHMWPE, etc. At last, we summarize the present and future applications of composites materials in aerospace and other civil fields. A conclusion is drawn that in the future, composite materials are set for their development, while continually decreasing its costs is still an important task.

scholarly journals OPTIMIZATION OF ZAKAT FUND MANAGEMENT IN REGIONAL ZAKAT INSTITUTION

2018 ◽  
Vol 6 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Tika Widiastuti ◽  
Imron Mawardi ◽  
Anidah Robani ◽  
Aam Slamet Rusydiana
Keyword(s):  
Economic Growth ◽  
Economic Development ◽  
Research And Development ◽  
Design Methodology ◽  
Fund Management ◽  
Threat Analysis ◽  
Gift Economy ◽  
Considerable Research ◽  
Societal Needs ◽  
The Government

Purpose: The implementation of zakat fund management especially in some zakat institutions is considered not optimum yet. This condition is represented by disparity between potential and actual collection. In Islam, the objective of zakat is not only to collect wealth and keep it idle, instead zakat should become a source of productive fund to fulfill societal needs. Some countries with advanced zakat institutions have developed zakat to become a pillar of economic development. Today, each zakat institution is competing against each other to innovate in zakat fund management. Empowerment in zakat institutions with the appropriate strategies will enhance zakat management and distribution for the betterment of zakat recipients (mustahiq) and the Muslim society at large. Design/Methodology/Approach: This research is aimed to analyze optimization of management in regional zakat institution with SWOT (strength, weakness, opportunity, threat) analysis approach with IFE-EFE Matrix. Descriptive qualitative analysis is used to explain optimization of fund in zakat institution. Major Findings:Findings of this research shows that zakat institution should improve their strategy by developing strength and turning threat into opportunities. Originality/Value: The study provides a guideline for regional zakat institution on how they can enhance their role and efficiency to boost the economic growth for the Islamic community in Indonesia. It may also be instrumental for the government to improve in efficiency and innovative manpower, considerable research and development in optimizing Islamic Gift Economy to enhance economic growth of the Islamic community of Indonesia.

Security Solutions for Intelligent and Complex Systems

2020 ◽  
pp. 1232-1271
Author(s):  
Stuart Armstrong ◽  
Roman V. Yampolskiy
Keyword(s):  
Complex Systems ◽  
Research And Development ◽  
Social Engineering ◽  
Great Power ◽  
Future Research ◽  
Negative Effects ◽  
Safety Issues ◽  
The World ◽  
Particular Solution ◽  
Definition Of

Superintelligent systems are likely to present serious safety issues, since such entities would have great power to control the future according to their possibly misaligned goals or motivation systems. Oracle AIs (OAI) are confined AIs that can only answer questions and do not act in the world, represent one particular solution to this problem. However even Oracles are not particularly safe: humans are still vulnerable to traps, social engineering, or simply becoming dependent on the OAI. But OAIs are still strictly safer than general AIs, and there are many extra layers of precautions we can add on top of these. This paper begins with the definition of the OAI Confinement Problem. After analysis of existing solutions and their shortcomings, a protocol is proposed aimed at making a more secure confinement environment which might delay negative effects from a potentially unfriendly superintelligence while allowing for future research and development of superintelligent systems.

Forms of Pre-Caucasian brown trout S. trutta caucasicus (Dorofeeva, 1967) of the Caspian basin

Fisheries ◽  
2020 ◽  
Vol 2020 (5) ◽  
pp. 71-73
Author(s):  
Gazimagomed Magomedov ◽  
Zarema Alibekova ◽  
Rystam Rabazanov
Keyword(s):  
Brown Trout ◽  
Reproductive Potential ◽  
Morphological Characteristics ◽  
Limited Range ◽  
Biological Properties ◽  
Small Rivers ◽  
Continuous Change ◽  
The Caspian Sea ◽  
Natural Reproduction ◽  
Definition Of

A morphological analysis of brooks trout in Dagestan showed that each spawning herd is morphologically unique and differs from the rest in a certain set of characters. However, all of them, when comparing the age composition, spawning conditions, the extent of spawning migrations in rivers, etc. have a lot in common. All of them meet the definition of a population as a group of individuals united by panmixia, a single territory and isolated to one degree or another from similar groups within the species. The morphological characteristics of trout in the upper of rivers Avar, Andi, and Kara-Koysu further confirms the validity of this approach. Presumably, the structure of trout populations is in continuous change and the differences in morphological indicators are phenotypic in nature and reflect the biotic and abiotic conditions prevailing in this region. The interaction of variability and selection in the population maintains a mobile equilibrium of biological properties forms the passing (brown trout) and residential (trout) forms. The trout of Sulakriver breaks up into several local herds (trout of Avar Koysu, Andi Koysu, Kara-Koysu, etc.) with a specific and limited range of its migrations. To a certain extent, differing from neighboring ones, each of the herds maintains its integrity and does not mix with the rest. Thus, the brooks trout of Dagestan seem to combine two functions - the self-reproduction of local settled populations and generating migrant individuals in the Caspian trout (Terek, Samur, Kara-Su rivers, etc.). In the rivers of the Kara-Su system, regardless of the place of fishing and the season, trout is represented by almost 100% males. Naturally, the question arises: who ensures the reproduction of trout herds in the absence of females? At the same time, the Salmo truttacis caucasicus (Dorofeyeva, 1967) comes to spawn in these rivers, and its livestock is represented exclusively by females (70-80%). Therefore, brooks trout of the Kara-Su system rivers and the Salmo truttacis caucasicus, coming here to spawn, should be considered as a single reproduction fund. Eggs, laid by either a brown trout female or a trout female, can leave individuals, that roll into the sea and turn into a passing trout, and individuals that remain in the river will be called brooks trout. The total reproductive potential of small rivers of the Dagestan coast of the Caspian Sea is currently no less than in native salmon rivers (Terek, Samur). That is why small rivers play an important role in the natural reproduction of trout and brown trout. Among the small salmon rivers of Dagestan, the greatest fishery value have tributaries of the Sulak river, rivers of the Kara-Su system, Shura-ozen, Manas-ozen, etc. Significant differences in the climatic features of these areas inevitably affect the biology of trout inhabiting them.

scholarly journals Waterpipe tobacco smoke toxicity: the impact of waterpipe size

2019 ◽  
Vol 29 (Suppl 2) ◽  
pp. s90-s94 ◽  
Author(s):  
Cindy DeForest Hauser ◽  
Ronnae Mailig ◽  
Hannah Stadtler ◽  
Jenna Reed ◽  
Shi Chen ◽  
...  
Keyword(s):  
Tobacco Smoke ◽  
Membrane Integrity ◽  
Alveolar Cells ◽  
Engine Exhaust ◽  
Waterpipe Tobacco Smoking ◽  
Total Particle ◽  
Type Ii Alveolar Cells ◽  
Particle Sizer ◽  
Definition Of ◽  
The Impact

IntroductionWaterpipe tobacco smoking continues to show increasing popularity, especially among individuals between 18 and 22 years old. Waterpipe tobacco smoke (WTS) is a mixture of particulates and gases formed from the combustion of the charcoal and volatilisation and humidification of the tobacco+humectant+flavouring substrate known as shisha or mu’assel. As such, variation in the configuration of the waterpipe may affect the particles produced. Our study focuses on the effects of waterpipe size on the physical properties and cytotoxicity of the smoke produced.MethodsShisha type and headspace volume were held constant and a modified Beirut puff protocol was followed while the size of the waterpipe was varied. Particle concentrations and size distributions were measured using a TSI Engine Exhaust Particle Sizer. Type II alveolar cells were exposed to smoke at the air-liquid interface and two metrics of cell health analysed.ResultsIn a 30 min session, we observed a decrease in total particle concentration (1014–1013) and mass (10 000–2800 mg/m3) and an increase in particle size (125–170 nm) as pipe height increases from 22 to 55 cm and bowl size from 300 to 1250 mL. Smoke from all pipe sizes caused decreases in lysosomal function (>40%) and membrane integrity (>60%) 24 hours post 57 min exposure, and meet the National Institutes of Health definition of a cytotoxic agent (≥30% decrease in cell viability).ConclusionSmoke from waterpipes of all sizes causes significant alveolar cellular harm, indicating that this device needs regulation as a hazard to human health.

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