scholarly journals The analysis of the pharmaceutical supply with medicines used in insect allergy therapy and approaches to the development of new medicines in the form of a gel for the local treatment

2021 ◽  
Vol 7 (3) ◽  
Author(s):  
T. V. Popova ◽  
A. S. Nemchenko ◽  
H. P Kukhtenko

According to the World Allergy Organization, allergies occur in 10 % to 40 % of the world’s population. Currently, the number of such patients in Europe is about 150 million people. It is projected that in the next decade there will be more than 250 million people, 5 % of whom have a predisposition to insect allergies (IA).Aim. To analyze the range of drugs used in the local treatment of IA and approaches to the development of new domestic drugs in the form of a gel.Materials and methods. The scientific publications of domestic and foreign authors, data from official sites on the subject, ICD-10, materials of the State Register of Medicines of Ukraine, directory Compendium, Protocol for medical care for insect allergies, as well as methods of the system analysis, comparison, graphical, analytical and the content analysis were used.Results. The regimen of IA treatment has been studied depending on the severity (mild, moderate, severe, anaphylactic shock), which is given in the Protocol of medical care for insect allergies in accordance with the Order of the Ministry of Health of Ukraine from 03.07.2006 No.432. It is considered that IA is treated with the subgroup “D04A A – Antihistamines for topical application”, which has only 5 drugs (including release forms); among them 80 % of medicines are foreign, 60 % are produced in the form of a gel. It is very insufficient because of the fact that there are consequences of insect bites during the local therapy of children since constant scratching of the bite sites is a threat of infection of wounds and delay their healing.Conclusions. On the example of the pharmaceutical composition in the form of a gel, the expediency for developing new domestic drugs that are available compared to foreign ones for the local therapy in IA, and manifestations of allergic reactions to insect bites has been proven.

2013 ◽  
Vol 10 (01) ◽  
pp. 33-37 ◽  
Author(s):  
M. Klinkman ◽  
D. Goldberg

SummaryThis paper describes the necessity of adapting the major classifications of mental disorders exemplified by the ICD-11 and the DSM-5 for the special needs of primary medical care. An earlier version of the classification – the ICD-10-PHC – is described, and the process of adapting it is described in detail. The new 28 item version of the classification is described, and the procedures to be adopted in the Field Trials to be held during 2013 are set out, together with the specific problems these field trials will address.


2020 ◽  
Vol 17 (1) ◽  
pp. 58-67
Author(s):  
N. A. Kabanova ◽  
I. K. Alekseeva

The article is devoted to the assessment of potential investment risks of the pharmaceutical company “R-Pharm” JSC with the aim of identifying the highest priority risks and developing methods for minimizing them. The relevance of the study is determined by the fact that the pharmaceutical business is characterized by a high degree of social orientation and annually invests $ 140 billion in the development of production and research, which determines the need for a risk-based approach to ensure the return on investment. The subject of this article is the investment risks of pharmaceutical companies, and the subject of research is the domestic pharmaceutical company “R-Pharm”. In order to assess the potential investment risks of “R-Pharm” JSC, the authors used elements of simulation modeling and system analysis. The proposed methods to minimize key investment risks are aimed at improving the efficiency of investment activities and is recommended as an element of the strategic planning of the company.


Author(s):  
Aleksey Klokov ◽  
Evgenii Slobodyuk ◽  
Michael Charnine

The object of the research when writing the work was the body of text data collected together with the scientific advisor and the algorithms for processing the natural language of analysis. The stream of hypotheses has been tested against computer science scientific publications through a series of simulation experiments described in this dissertation. The subject of the research is algorithms and the results of the algorithms, aimed at predicting promising topics and terms that appear in the course of time in the scientific environment. The result of this work is a set of machine learning models, with the help of which experiments were carried out to identify promising terms and semantic relationships in the text corpus. The resulting models can be used for semantic processing and analysis of other subject areas.


Author(s):  
Pyotr Ivanov

In this article, based on the study and analysis of operational-search legislation, scientific publications, law enforcement practice and the criminal situation in the field of legalization, the operationalsearch counteraction to the legalization of income received from the Commission of tax crimes is considered. The paper focuses on the stages (stages) of laundering, the existing points of view on this account, as well as on the methods of illegal withdrawal of funds abroad. The author of the article aimed to develop scientifically based proposals and recommendations for improving the effectiveness of this type of activity by the territorial bodies of internal Affairs and their divisions of economic security and anti-corruption. It is proposed to put forward and work out operational search versions within the subject of study, as well as to develop, taking into account the methods (schemes) used by criminals to launder criminal proceeds and illegally withdraw funds abroad for the purpose of their subsequent legalization, operational search measures to document their criminal actions. In addition, the author recommends constant monitoring of money laundering methods based on operational and investigative practices. The results and key conclusions formulated in this article can be used in the theory and practice of operational investigative activities of internal Affairs bodies to counteract the legalization of income received from tax crimes.


2019 ◽  
pp. 83-88
Author(s):  
E. N. Valiev ◽  
E. N. Veysov

The importance of the subject of this study is attributable to the need of developing the theory and practice of formation of bank marketing, its features and new trends associated with this concept. Prospects for the development of banks and their ability to quickly and efficiently address new challenges presented by the market can be determined through modern forms, methods of management and creative use of financial marketing opportunities.Aim. The presented study aims to examine the specific aspects, principles, conditions, factors of emergence, and prospects for the development of bank marketing and forms of its management in modern economic conditions.Tasks. The authors identify the major trends and perspective directions in the development of bank marketing in Azerbaijan at the current stage.Methods. As its methodological and theoretical basis, this study uses a systems approach to the analysis of its subject, conceptual approaches outlined in the works of Azerbaijani, Russian, and foreign scientists in the field of bank marketing. These methods are used to determine the essence of bank marketing, present the types and organization of marketing research, and identify the characteristic traits, new forms, and directions for the development of bank marketing.Results. The study uses general scientific methods of cognition in various aspects to identify characteristic traits, trends, and new directions of bank marketing. A review of scientific publications shows that academic papers tend to focus on general conceptual approaches to the practical application of marketing. The authors believe that the issues of organization of a comprehensive bank management system, its implementation based on innovations in the promotion of banking products and services in the financial market, and substantiation of channels for their distribution among consumers are insufficiently explored. This makes the subject of this study extremely relevant due to the inevitable optimization of the organizational structure of banks through comprehensive implementation of the marketing system.Conclusions. Theoretical and practical issues of bank marketing are examined. As a result, the specific features and characteristic traits of this mechanism, conditions and factors for its emergence, and its prospects in the context of the digital economy are analyzed.


Author(s):  
Matthew J. Genge

Drawings, illustrations, and field sketches play an important role in Earth Science since they are used to record field observations, develop interpretations, and communicate results in reports and scientific publications. Drawing geology in the field furthermore facilitates observation and maximizes the value of fieldwork. Every geologist, whether a student, academic, professional, or amateur enthusiast, will benefit from the ability to draw geological features accurately. This book describes how and what to draw in geology. Essential drawing techniques, together with practical advice in creating high quality diagrams, are described the opening chapters. How to draw different types of geology, including faults, folds, metamorphic rocks, sedimentary rocks, igneous rocks, and fossils, are the subjects of separate chapters, and include descriptions of what are the important features to draw and describe. Different types of sketch, such as drawings of three-dimensional outcrops, landscapes, thin-sections, and hand-specimens of rocks, crystals, and minerals, are discussed. The methods used to create technical diagrams such as geological maps and cross-sections are also covered. Finally, modern techniques in the acquisition and recording of field data, including photogrammetry and aerial surveys, and digital methods of illustration, are the subject of the final chapter of the book. Throughout, worked examples of field sketches and illustrations are provided as well as descriptions of the common mistakes to be avoided.


2021 ◽  
pp. 115-120
Author(s):  
T.M. Tagiyeva ◽  

Presented is the analysis of scientific and theoretical approaches to the problem of migration in modern science. Migration is a complex concept in modern science, and therefore attracts attention of many social and humanitarian sciences. It is determined that this direction of scientific research was originated already in ancient historical science then became the subject of study of economic science. Today, thanks to increased interest in this area of social life, theoretical and methodological foundations have emerged for an integrated approach to the analysis of any social phenomenon, associated with migration. This is evident from the number of scientific publications in the world, related to the analysis and forecasting of specific processes and situations of migration. In the future, methodology of research in this area will be enriched through the use of capabilities of mathematics and statistics methods, as well as achievements of psychological science.


2019 ◽  
pp. 20-23
Author(s):  
Serhii TKACHENKO ◽  
Olena POTYSHNIAK ◽  
Yevheniia POLIAKOVA

One of the reasons that at present in research and production associations and industrial enterprises, according to the degree of implementation, analysis is almost the most backward management function, in our opinion, is still insufficient attention on the part of economic services of these production links to issues of formation of analytical information processing. Having overcome, in principle, the psychological barrier of misunderstanding the advantages of using modern computer technology in production management, the economic services of enterprises in a number of cases have not yet realized that they should be both initiators of the functional development of the management system and direct participants in the new technology for the implementation of management functions, including and analysis function. The use of electronic digital machines in economic analysis is one of the indispensable conditions for achieving its efficiency and complexity. The problem of improving the function of economic analysis is becoming the subject of increasing attention, both from a large number of specialists, and from higher education institutions and various research organizations. The increasing attention to the problem of improving integrated economic analysis is evidenced by the fact that it is the subject of consideration at International, All-Ukrainian, Regional scientific and practical conferences, seminars and is significantly reflected in the recommendations of these forums. At the same time, it should be noted that the methodology of the approach, the breadth of coverage in solving the problem, the focus and depth of development in many cases by different authors are far from the same and not equivalent. Therefore, when conducting an analytical review of scientific publications, in our opinion, it is advisable to evaluate existing developments in a certain order, namely: firstly, works that emphasize the importance and need to improve the function of economic analysis without indicating specific ways to solve this problem; secondly, works examining specific forms of organizing economic analysis in management systems. The latter, in particular, include: works in which the dispersal and implementation of individual analysis tasks are proposed as part of various functional subsystems of the control system; works whose authors consider it possible to combine the tasks of economic analysis with the tasks of other management functions in one of the generally accepted subsystems of the management system; works in which the allocation of analysis tasks to an independent functional subsystem of the control system is justified.


2021 ◽  
Vol 6 (1(82)) ◽  
pp. 38-43
Author(s):  
A. Kurbatov ◽  
L. Kurbatova

The greatest crisis, which is being experienced by the world economy, has not come unexpectedly, since it was predicted with a sufficient degree of precision. Moreover, the matters, causing obstacles for the transformation in the period of transition from the mixed economy to the intellectual economy, have been studied well enough and the technologies of the harmonious transformation have not just been developed but also successfully approbated. However, the crisis is escalating with increasing strength, and many analysts are warning against the risk of irreversible losses, that threaten the mankind with self-destruction due to the effect of 'the lacuna' and 'the gap' between the speed of changes in life conditions and the velocity of growth of human and humanity abilities to adapt to fast changing conditions of ecological, economic, technological and political reality. As anticipated, the main problem turned out to be the intellectual inertia. Despite the fact that the system analysis of the global crisis in education, which does not any longer provide the human and humanity with the proper competencies, even those necessary for the survival, was published by F.G.Coobles back in 1968, the approaches which are long outdated and, therefore, have become dangerous, are still widely spread all over the world. The reports of the Roman club have repeatedly highlighted that the overcoming of 'the lacuna' effect requires new approaches to education, but this has not led to large scale practical results, in spite of the fact, that the task of the development of the new system of the continuous anti-crisis education (for all ages) was accomplished back in the USSR and the experimental model proved to be efficient in process of the 20 years approbation in conditions of the Russian Federation. The psychological bareers arising during the transition from the programme goal method to the system-synergetic approach, from the crisis model of economy to value-sense one, from the subject-object relations to the subject-subject ones and others, have turned to be hard to overcome without the help of specialists, equipped with the methods of the value-sense management, which enable each subject, experiencing the negative impact of the modern economic crisis, to successfully overcome it. This article is dedicated to the peculiarities of the author's scientific-practical school of the value-sense management as a means of overcoming the modern economic crisis. 


2020 ◽  
Vol 28 ◽  
pp. 78-88
Author(s):  
Bruno César Góes ◽  
Willian Aparecido Leoti Zanetti ◽  
Renato Jaqueto Góes ◽  
Camila Pires Cremasco ◽  
Fernando Ferrari Putti ◽  
...  

The use of alternative systems seeking unsustainability in agricultural production in Brazil, has developed strongly with the use of No-Tillage System (NTS), therefore remodeling the production system. For the production efficiency, it is necessary to use suitable crops as plant cover, depending on the region where the no-tillage system will be set, in which sorghum and millet crops were very positive. Thus, the objective of the work is to perform a systematic literature review on papers approaching the subject with the use of sorghum and millet as a vegetative cover for subsequent no-tillage. It is possible to verify a concentration of the studies after the 2000 decade, in the Southeastern and Central-Western regions of Brazil.


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