scholarly journals Differences of Main Levels of Serum P-Selectin and Trombosite in Severe Preeclampsia and Eclampsia

2017 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Joserizal Serudji ◽  
Yudha Meiriza Kartika ◽  
Erkadius Erkadius
Keyword(s):  
Maternal Morbidity ◽  
World Wide ◽  
Serum Levels ◽  
Severe Preeclampsia ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Activated Platelets ◽  
Maternal Morbidity And Mortality ◽  
Main Complication

Preeclampsia-eclampsia is a main complication of pregnancy in which the incidence is increasing world-wide and is associated with maternal morbidity and mortality. P-selectin (CD62P) is released from the cell surface and circulation as soluble molecules in the plasma. Both forms of, as membrane and soluble forms, p-selectin is an agonist of the process of thrombosis and inflammation. This research was conducted by cross sectional method in maternity emergency room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from June 2015 through the sample size is met with 20 patients of severe preeclampsia and 8 patients of eclampsia, who met the inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using t-test to determine differences in mean serum levels of p-selectin and platelet of severe preeclampsia and eclampsia. Differences in mean serum levels of p-selectin and plate-let in the two groups were statistically significant (p = 0.000). Activated platelets at eclampsia is higher than severe preeclampsia, which is indicated by the high levels of p-selectin serum and low platelets remaining in eclampsia than severe preeclampsia.Keywords: P-selectin, Platelet, Severe Preeclampsia, Eclampsia

scholarly journals PERBEDAAN RERATA KADAR AKTIVIN A SERUM MATERNAL ANTARA PREEKLAMSIA BERAT DENGAN BUKAN PREEKLAMSIA BERAT

2019 ◽  
Vol 1 (1) ◽  
pp. 30-37
Author(s):  
Dovy Djanas ◽  
Bayu Pramudyo Ariwibowo ◽  
Hafni Bachtiar
Keyword(s):  
Serum Levels ◽  
Activin A ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Tnf Α ◽  
The Mean ◽  
In Pregnancy

At the start of preelampsia there is a failure of cytotrophoblst invasion into the maternal spiral arteries that will lead to decreased uteroplacetal perfusion which will be followed by the failure of the unit fetoplacenter to get enough oxygen from the room intervillous that ultimately lead to a state of hypoxia in placenta. This will cause the expenditure of TNF-α dan IL-1β from placenta and a factors called hypoxia-inducible transcription factors that will spur the trophoblast to produce activin A lot more. This research was conducted by cross sectional method in maternal room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from August 2015 until February 2016 with 20 patients of severe preeclampsia and 20 patients not severe preeclampsia, who met inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using Mann-Whitney test to determine difference in mean maternal activin A serum levels of severe preeclampsia and not severe preeclampsia. The mean maternal serum levels of activin A in severe preeclampsia is 32,55 ± 1,84 ng/ml and in pregnancy with no severe preeclampsia is 8,59 ± 0,59 ng/ ml. Difference in mean maternal serum level of activin A in the two groups was statistically significant (p=0,001). Ma-ternal serum activin A levels is significantly higher in severe preeclampsia than pregnancy with no severe preeclampsia.Keywords: Activin A, severe preeclampsia, not severe preeclampsia

scholarly journals PERBEDAAN RERATA FAKTOR HEMOSTASIS PADA PREEKLAMPSIA BERAT DAN EKLAMPSIA

2019 ◽  
Vol 2 (1) ◽  
pp. 10-15
Author(s):  
Dyhan Purna Setia ◽  
Ferdinal Ferry ◽  
Dovy Djanas
Keyword(s):  
Medical Record ◽  
Cross Sectional Study ◽  
Severe Preeclampsia ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Hemostatic Factors ◽  
The Mean ◽  
The Difference ◽  
D Dimer

Objective : To find the difference in mean hemostatic factors in severe preeclampsia and eclampsia.Method : The study was analytic descriptive using a cross sectional study design by looking at the subject's Medical Record according to the time and place of research. The sample is the entire medical record of pregnant women who suffer from preeclampsia and eclampsia in the obstetric and gynecology departments of Dr. M. Djamil Padang Hospital in the period 15 January 2016 to 31 December 2017. The assessment was in the form of assessed platelet levels, PT, APTT and D-Dimer. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using consecutive sampling techniques taken from the Medical Record Dr. M.Djamil Padang. Statistical analysis to assess significance using the T-Test.Result : The severity the condition of pregnancy the lower the platelet mean and PT. Significant differences were obtained between platelets in PEB and eclampsia (p> 0.05). The mean PT, APTT and D-Dimer showed no significant differences in pregnancy conditions. Statistical test with T-Test did not show significant differences in mean PT, APTT, and D-dimer between eclampsia and PEB (p> 0.05).Conclusion : There were significant differences in mean in platelets, whereas in PT, APTT, and D-dimers in PEB and eclampsia there were no significant differences.Keywords: Pregnancy, severe preeclampsia, eclampsia, platelets, PT, APTT, D-Dimer.

scholarly journals Maternal Cystatin C Serum is Higher in Women with Severe Preeclampsia

2014 ◽  
pp. 22-27 ◽  
Author(s):  
Kurnia M. Isasari ◽  
Wim T Pangemanan ◽  
Iskandar Zulqarnain ◽  
Kemas Rahadiyanto
Keyword(s):  
Serum Level ◽  
Observational Study ◽  
Cystatin C ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Analytic Approach ◽  
Inclusion Criteria ◽  
Cross Sectional

Objective: To determine the comparison between maternal cystatin C serum in severe preeclampsia and normal pregnancy. Method: This was an observational study with cross sectional analytic approach. The subjects are sixty women with severe preeclampsia and normal pregnancy who met inclusion criteria. The maternal serum level of cystatin C was automatically measured with Particle Enhanced Nephelometric Assay (PENIA). Result: Mean serum level of cystatin C in severe preeclampsia was 1.169 ± 0.311 mg/l. Mean serum level of cystatin C in normal pregnancy was 0.929 ± 0.166. There was a significant differences between maternal serum levels of cystatin C in women with severe preeclampsia compared with women with normal pregnancy. Conclusion: There was a significant differences between maternal serum levels of cystatin C in severe preeclampsia compared with normal pregnancy. Keywords: cystatin C, endotheliosis glomerulus, severe preeclamp

scholarly journals Hubungan Kadar Albumin Serum dengan Morbiditas dan Mortalitas Maternal Pasien Preeklampsia Berat dan Eklampsia di RSUP Dr. M. Djamil Padang

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Yunike Veronika ◽  
Joserizal Resudji ◽  
Susila Sastri
Keyword(s):  
Serum Albumin ◽  
Maternal Mortality ◽  
Maternal Morbidity ◽  
Cross Sectional Study ◽  
Severe Preeclampsia ◽  
Morbidity And Mortality ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Maternal Morbidity And Mortality

AbstrakPreeklampsia dan eklampsia merupakan penyebab utama morbiditas dan mortalitas ibu dan bayi di dunia, dimana terjadi penurunan albumin serum (hipoalbuminemia) sehingga tekanan hipovolemik intravaskular berkurang. Tujuan penelitian ini adalah untuk mengetahui hubungan kadar albumin serum dengan morbiditas dan mortalitas maternal pasien preeklampsia berat dan eklampsia. Penelitian ini bersifat analitik observasional retrospektif dilakukan dengan desain cross sectional study. Populasi penelitian adalah seluruh data rekam medis pasien preeklampsia berat dan eklampsia di RSUP Dr. M. Djamil Padang periode Januari 2012 – Desember 2012. Sampel ditetapkan dengan teknik total sampling sehingga didapatkan sampel sebanyak 133 kasus. Pengolahan data dilakukan secara komputerisasi dan analisis dengan uji chi-square. Hasil penelitian menunjukkan angka kejadian morbiditas maternal adalah 33,8%, mortalitas maternal 3,8% dan 3,8% pasien dengan hipoalbuminemia. Dari hasil analisis, tidak terdapat hubungan yang bermakna antara kadar albumin serum dengan morbiditas dan mortalitas maternal pasien preeklampsia berat dan eklampsia, dimana nilai p=1 untuk hubungan kadar albumin serum dengan morbiditas maternal dan p=0,177 untuk hubungan kadar albumin serum dengan mortalitas maternal pasien preeklampsia berat dan eklampsia (p>0,05).Kata kunci: preeklampsia berat, eklampsia, albumin serum AbstractPreeclampsia and eclampsia are major causes of maternal and fetal morbidity and mortality in the world, in which serum albumin decreases (hypoalbuminemia) so hypovolemic intravascular pressure will be reduced. The objective of this study was to determine the relation between serum albumin levels and maternal morbidity and mortality of severe preeclampsia and eclampsia patients. A retrospective observational analytical research was conducted with a cross sectional study design. The study population was the entire medical records of severe preeclampsia and eclampsia patients in RSUP Dr. M. Djamil Padang, period January 2012 – December 2012. The sample was determined by total sampling technique which obtained a sample of 133 cases. Data processing was computerized and analyzed by chi-square test. The incidence of maternal morbidity was 33.8%, maternal mortality was 3.8%, and 3.8% patients were with hypoalbuminemia. The analysis result obtained there was no significant correlation between serum albumin levels and maternal morbidity and mortality of severe preeclampsia and eclampsia patients, in which p=1 for serum albumin levels correlation with maternal morbidity and p=0.177 for serum albumin levels correlation with maternal mortality of severe preeclampsia and eclampsia patients (p>0.05).Keywords: severe preeclampsia, eclampsia, serum albumin

scholarly journals The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia

2021 ◽  
Vol 5 (1) ◽  
pp. 82-89
Author(s):  
David Perdana ◽  
Defrin Defrin ◽  
Firdawati Firdawati
Keyword(s):  
Early Onset ◽  
Sampling Method ◽  
Late Onset ◽  
Serum Levels ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Difference

The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsiaKeywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of  HIF-1α

scholarly journals MATERNAL SEPSIS;

2019 ◽  
Vol 26 (05) ◽  
Author(s):  
Fehmida Parveen Memon ◽  
Majida Khan ◽  
Samya Aijaz
Keyword(s):  
Maternal Morbidity ◽  
Tertiary Care ◽  
Morbidity And Mortality ◽  
University Hospital ◽  
P Value ◽  
Care Hospital ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Maternal Morbidity And Mortality ◽  
Maternal Sepsis

Objectives: To determine the thrombocytopenia as marker of maternal sepsis and its related maternal morbidity and mortality at tertiary care Hospital. Study Design: Cross-sectional study. Setting: Gynaecological and Obstetrical department of Liaquat University Hospital, Hyderabad. Period: 6 months from March 2017 to August 2017. Material and Methods: All the pregnant females with diagnosis of sepsis were enrolled in the study. All the females with chronic hepatitis were excluded. After complete clinical examination every women underwent 5cc blood sample for complete blood picture. Thrombocytopenia was characterized as a platelet count below 150.000/mm3. Data regarding maternal mortality and maternal complications was filled in the proforma. Results: Total 120 septic mothers were included in the study, 70 patients had thrombocytopenia and 50 were with normal platelets. Most of the women 71.7% were with age groups of 20-30 years. Out of total women 65.0% were un-booked. According to the maternal morbidity, septic shock was most common 36.7%, multi-organ failure was in 08.3%, prolonged Hospital stay was in 16.7%, ICU admission occurred in 18.3% patients, while renal failure, respiratory failure, hepatic failure, coagulopathy and metabolic acidosis were found with percentage of 09.2%, 02.5%, 10.8%, 10.8% and 03.3% respectively. Mortality rate was found among 8.3% out of total cases. Almost all complications were higher among women with thrombocytopenia as compare to women with normal platelets level, while statistically p-value was quite insignificant. Mortality was significantly high among patients with thrombocytopenia p-value 0.032. Conclusion: It was concluded that thrombocytopenia is a good marker for adverse outcome among septic mothers. Maternal morbidity and mortality was higher among septic women with thrombocytopenia.

scholarly journals How far is too far? A nationwide cross-sectional study for establishing optimal hospital access time for Korean pregnant women

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e031882 ◽  
Author(s):  
Mi Young Kwak ◽  
Seung Mi Lee ◽  
Hyun Joo Kim ◽  
Sang Jun Eun ◽  
Won Mo Jang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Maternal Morbidity ◽  
Cross Sectional Study ◽  
Obstetric Complications ◽  
Access Time ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hospital Access ◽  
Maternal Morbidity And Mortality ◽  
Delivery Unit

ObjectivesAccess to a delivery unit is a major factor in determining maternal morbidity and mortality. However, there is little information about the optimal access time to a delivery unit. This study aimed to establish the optimal hospital access time (OHAT) for pregnant women in South Korea.DesignNationwide cross-sectional study.SettingWe used the National Health Insurance System database of South Korea.ParticipantsWe analysed the data of 371 341 women who had experienced pregnancy in 2013.Primary and secondary outcome measuresAccess time to hospital was defined as the time required to travel from the patient’s home to the delivery unit. The incidence of obstetric complications was plotted against the access time to hospital. Change-point analysis was performed to identify the OHAT by determining a point wherein the incidence of obstetric complications changed significantly. As a final step, the risk of obstetric complications was compared by type among pregnant women who lived within the OHAT against those who lived outside the OHAT.ResultsThe OHAT associated with each adverse pregnancy outcomes were as follows: inadequate prenatal care, 41–50 min; preeclampsia, 51–60 min; placental abruption, 51–60 min; preterm delivery, 31–40 min; postpartum transfusion, 31–40 min; uterine artery embolisation, 31–40 min; admission to intensive care unit, 31–40 min; and caesarean hysterectomy, 31–40 min. Pregnant women who lived outside the OHAT had significantly higher risk for obstetric complications than those who lived within the OHAT.ConclusionsOur results showed that the OHAT for each obstetric complication ranged between 31 and 60 min. The Korean government should take the OHAT under consideration when establishing interventions for pregnant women who live outside OHAT to reduce maternal morbidity and mortality.

scholarly journals Mental Health in Health Students during Coronavirus Disease-19: Systematic Review

2021 ◽  
Vol 9 (F) ◽  
pp. 205-210
Author(s):  
Agus Purnama ◽  
Susaldi Susaldi ◽  
Halma Zahro Mukhlida ◽  
Hilma Hasro Maulida ◽  
Nyimas Heny Purwati
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Mental Health Problems ◽  
Cross Sectional Study ◽  
Poor Mental Health ◽  
Inclusion Criteria ◽  
Letters To The Editor ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Psychological Conditions

Purpose: This study aims to examine the description of mental health characteristics of health students who conducted studies during the COVID-19 pandemic. Methods: The design of this study is to use a systematic review approach by collecting several articles from a database that has been selected consisting of Springer. , ScienceDirect and ProQuest with articles published in 2020. Search for articles was carried out by entering the keyword "mental health AND student AND COVID-19". The search for this article was limited to inclusion criteria and exclusion criteria. The inclusion criteria in this study were health students who were still conducting studies during the COVID-19 pandemic and a cross-sectional study design, while the exclusion criteria were non-health students, only abstracts and books, and letters to the editor. Results: After a search on the selected database, the results are 677 Springer articles, 554 direct articles, and 1348 ProQuest articles. 11 were removed for duplicates, 444 full texts were reviewed and 6 articles matched inclusion and exclusion criteria. The results of the 6 articles that were reviewed showed that the majority of health students reported mental health problems such as anxiety, depression, stress, and another emotional status. Where moderate and severe levels of anxiety were experienced by some Health students who carried out education during the Covid-19 pandemic. Conclusion: The COVID-19 pandemic has an impact on psychological conditions, especially on health students who are carrying out their education. Students report poor mental health conditions while carrying out home education by learning online during the COVID-19 pandemic.

scholarly journals HUBUNGAN LAMANYA PEMBERIAN MAGNESIUM SULFATE PADA PASIEN PEB DAN EKLAMPSIA DENGAN KEJADIAN HIPERMAGNESIUM DI RSUP DR. M. DJAMIL PADANG

2018 ◽  
Vol 2 (1) ◽  
pp. 21-25
Author(s):  
Mayuliani Mayuliani ◽  
Dovy Djanas
Keyword(s):  
Pregnant Women ◽  
Magnesium Sulfate ◽  
Cross Sectional Study ◽  
Research Data ◽  
Severe Preeclampsia ◽  
Sectional Study ◽  
Inclusion Criteria ◽  
Chi Square ◽  
Cross Sectional ◽  
The Relationship

Objective :To find out the relationship between the duration of MgS04 administration in severe preeclampsia patients and eclampsia with the incidence of hypermagnesium.Method :This study is a comparative observational study using a cross sectional study design. The study was conducted in the medical record of Dr.M.Djamil Padang Hospital during the period January 1, 2016 to August 31, 2017 of pregnant women with severe preeclampsia and eclampsia, found 30 study subjects who met the inclusion criteria. Furthermore, data is recorded in a research form that has been provided, then carried out research data processing. Statistical analysis to assess significance using the chi-square test.Results : Magnesium levels increased in pregnant women with severe preeclampsia and eclampsia by 21 correspondents. Increased Magnesium levels in patients with severe preeclampsia and eclampsia who received MgS04 treatment for 48 hours by 16 correspondents (84.2%) and 5 correspondents with MgS04 administration for 24 hours.Conclusion : There is a significant relationship between the duration of Magnesium Sulfate with the incidence of hyperpermagnesium in patients with severe preeclampsia and eclampsia. Keywords: severe preeclampsia, eclampsia, magnesium sulfate, magnesium levels

scholarly journals EVALUASI KOMPETENSI BIDAN DALAM PEMASANGAN ALAT KONTRASEPSI DALAM RAHIM COPPER T 380A BERDASARKAN UMUR, PENDIDIKAN, PENGALAMAN PEMASANGAN DAN LAMA PRAKTIK DI KOTA PADANG

2019 ◽  
Vol 3 (1) ◽  
pp. 37-45
Author(s):  
Desmiwarti Desmiwarti ◽  
Hafni Bachtiar
Keyword(s):  
Intrauterine Device ◽  
Health Providers ◽  
Check List ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Education Experience

Midwives are health providers influential in helping families to choose appropriate contraception for patients. Midwives must have competence in providing midwifery services in particular IUD insertion. This study’s aim was to evaluate the competency of midwives in the insertion of an intrauterine device Copper T 380A based on their age, education, experience of insertion and duration of practice in Padang City. This study was done in puskesmas and private midwivery practice in Padang from September to December 2014 using cross-sectional method on 24 samples who met the inclusion criteria and not exclusion criteria. We conducted interviews and observed how the respondents perform IUD insertion by using a check- list. From this study, there was no significant association between age (p: 0.540, p> 0.05), education (p: 0.439, p> 0.05), experience of insertion (p: 0.472, p> 0.05) and duration of practice (p: 0.505, p> 0.05) with competency of IUD insertion. Most respondents have a good competence in IUD insertion. Part of the checklist the respondents frequently missed out were conseling to the patients and prevention of infection.Keywords: Midwives Competency, IUD insertion, Copper T-380a

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