Micro Evaluation of Sulphonamide in Biological Samples by Coupling Reaction

2020 ◽  
Vol 10 (03) ◽  
pp. 509-512
Author(s):  
Aliaa A. Razzak Mohammed ◽  
Ahmed J. Muklive Al-Ogaidi ◽  
Abeer Abdul Razak Mohammed
Keyword(s):  
Biological Samples ◽  
Structural Changes ◽  
Antitumor Agents ◽  
Low Cost ◽  
Preliminary Investigation ◽  
Target Material ◽  
Coupling Reaction ◽  
Amino Compound ◽  
Stability Factor ◽  
Colored Complex

Sulphonamide is considered a turning point for therapeutic science. Structural changes in sulphonamide can lead to the formation of various drugs used for combating different diseases. Sulphonamide can be used in different applications, such as, antitumor agents, carbonic anhydrase inhibitors, anti-bacterials, hypoglycaemic agents, protease inhibitors, and diuretics. The most important thing for this assay is to find a modified approach to assess sulphonamide by utilizing an organic reaction that depends on a process of coupling between our target material (sulphonamide) with 4-amino antipyrine in basic media of phosphate buffer (pH = 11.3), forming a colored complex containing a higher molar absorptivity (wavelength = 457 nanometers). A preliminary investigation test was done to determine the typical condition for this reaction to determine the concentration curve for the interval 8.25 × 10-9 to 1.15 × 10-2 ppm, and the absorptivity molar was 2.1 × 104 L.mol-1.cm-1, RSD value greater than 1.12%, with a percentage of recovery of approximately 99.88%. We obtained the result and got the approved mole ratio for this reaction about 1:1 (sulphonamide:diazotized amino compound); the value of the stability factor reached 2.8 × 106 L.mol-1. This proposal could be used for a fair assessment for sulphonamide determination, which has different advantages, such as, low-cost economy, no need for an expert, simplicity, no need for more time, and high-quality results in the requirement of rapid and excellent determination. This approach can be utilized for validation of sulphonamide in different active biological samples with higher efficiency.

scholarly journals MICRO DETERMINATION OF DOPAMINE IN BIOLOGICAL SAMPLES BY COUPLING REACTION

2018 ◽  
Vol 22 (4) ◽  
Author(s):  
AHMED JASSIM MUKLIVE AL-OGAIDI
Keyword(s):  
Mole Fraction ◽  
Biological Samples ◽  
Azo Dye ◽  
Coupling Reaction ◽  
Stability Factor ◽  
Relative Standard ◽  
The Stability ◽  
Fraction Method ◽  
Orange Color

The paper presents the development of an analytical method to determine dopamine by coupling reaction with diazotized solution of 4-Aminoantipyrine in basic media to give a compound with a single azo dye salt having orange color soluble in water.  A calibration curve for a range of concentration (9.14x10<sup>-5</sup> – 2.28x10<sup>-3</sup> μg.mL<sup>-1</sup>) was realized and the value of molar absortivity was 1.5x103 L.mol<sup>-1</sup>.cm<sup>-1</sup>, with a relative standard deviation more than 1.26% and a recovery 98.77%. As we study the nature of the azo dye by mole fraction method, from the practical value we found that the mole fraction of the dye compound is 1:1 (dopamine: 4- amino antipyrine) and the stability factor reach to 1.4x106 L.mol<sup>-1</sup>. The described procedure is very simple, low-time-consuming, provides high throughput of examined samples, and could be used for routine screening and confirmatory analyses as well. The method was successfully validated to the analysis of the dopamine in biological samples.

scholarly journals MICRO DETERMINATION OF DOPAMINE IN BIOLOGICAL SAMPLES BY COUPLING REACTION

2016 ◽  
Vol 22 (4) ◽  
pp. 7-12
Author(s):  
AHMED JASSIM MUKLIVE AL-OGAIDI
Keyword(s):  
Mole Fraction ◽  
Biological Samples ◽  
Azo Dye ◽  
Coupling Reaction ◽  
Stability Factor ◽  
Relative Standard ◽  
The Stability ◽  
Fraction Method ◽  
Orange Color

The paper presents the development of an analytical method to determine dopamine by coupling reaction with diazotized solution of 4-Aminoantipyrine in basic media to give a compound with a single azo dye salt having orange color soluble in water. A calibration curve for a range of concentration (9.14x10-5 – 2.28x10-3 μg.mL-1) was realized and the value of molar absortivity was 1.5x103 L.mol-1.cm-1, with a relative standard deviation more than 1.26% and a recovery 98.77%. As we study the nature of the azo dye by mole fraction method, from the practical value we found that the mole fraction of the dye compound is 1:1 (dopamine: 4- amino antipyrine) and the stability factor reach to 1.4x106 L.mol-1. The described procedure is very simple, low-time-consuming, provides high throughput of examined samples, and could be used for routine screening and confirmatory analyses as well. The method was successfully validated to the analysis of the dopamine in biological samples.

Thermal Management in Laser Assisted Machining: A Preliminary Study

2003 ◽  
Author(s):  
Tien-Chien Jen ◽  
Rajendra Jadhav ◽  
Yau-Min Chen ◽  
Samih Omari
Keyword(s):  
Structural Changes ◽  
Local Heating ◽  
Preliminary Investigation ◽  
Cutting Tools ◽  
Target Material ◽  
Material Structure ◽  
High Temperature Strength ◽  
Drilling Process ◽  
Mechanical And Thermal Properties ◽  
Surface Microstructures

The use of laser in manufacturing has gained considerable attention recently. In non-reactive processes, the laser beam is used either to machine, to weld, or to modify the target material structure by local heating. In addition to elevating the surface temperature of the target, this local heating may significantly alter the material crystalline structure; change its phase, and thus the electrical, mechanical and thermal properties. For reliability and consistency, it is necessary to control effectively the laser-based manufacturing processes. Specifically, the induced micro-structural changes due to the heat transfer mechanisms have to be analyzed. Most importantly, the thermal effect on the sub-surface microstructures and the generated thermal stress distribution need to be well quantified. The application of lasers in manufacturing has distinctive advange when dealing with ceramic material. The use of advanced ceramics has doubled in the past ten years, and is expected to grow at an even faster pace in the new millennium. The superior properties, such as low weight, high temperature strength and wear/corrosion resistance, of these structural ceramics make them the preferred materials in various applications including bearings, rollers/followers, valves, engines, cutting tools and even artificial joints in the human body. The major goal of this study is to develop an innovative laser-assisted drilling process through innovative tool design and cooling method. A preliminary investigation of the effect of donut-shaped laser heat input on the temperature distribution in the workpiece is studied numerically and experimentally.

Concept to Support the Flexibility of Manufacturing System through Reconfigurable Structure Based on Modular Design

2015 ◽  
Vol 816 ◽  
pp. 536-546
Author(s):  
Vladimír Rudy ◽  
Andrea Lešková
Keyword(s):  
Flexible Manufacturing ◽  
Manufacturing Systems ◽  
Structural Changes ◽  
Modular Design ◽  
Production Systems ◽  
Low Cost ◽  
Modular Construction ◽  
Production Platform ◽  
Flexible Adaptation ◽  
Reconfigurable Structure

This article deals about the challenges of structural changes in manufacturing conditions. The objective of this paper is to present the modular workstations concept based on miniaturization and re-configurability trends. The article is aimed at problems of designing of production systems with a modular construction structure. The modular structure allows an individual and flexible adaptation to varying requirements but also the realization of low-cost solutions for creation of new or modernized production base. The goal is to present the example of modular workstations solutions that correspond with new designing approach. The specification of basics principles, which should help to designing flexible manufacturing systems, discussed in this paper are: modularity; integrability; convertibility; diagnosability; customization. The theoretical part provides an overview of fundamental design principles in manufacturing structures. In the first part of this article are discussed the specification of basic flexibility types in production system and the main impacts influencing design of manufacturing structures. The closing section of the article provides the specification of example solution of adjustable production platform with modular frame (called desktop factory).

scholarly journals Quantifying Soil Compaction in Persimmon Orchards Using ISUM (Improved Stock Unearthing Method) and Core Sampling Methods

Agriculture ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 266 ◽  
Author(s):  
Ehsan Moradi ◽  
Jesús Rodrigo-Comino ◽  
Enric Terol ◽  
Gaspar Mora-Navarro ◽  
Alexandre Marco da Silva ◽  
...  
Keyword(s):  
Ecosystem Services ◽  
Soil Erosion ◽  
Bulk Density ◽  
Soil Compaction ◽  
Structural Changes ◽  
Low Cost ◽  
Positive Contribution ◽  
The Core ◽  
Core Sampling ◽  
Core Method

Agricultural activities induce micro-topographical changes, soil compaction and structural changes due to soil cultivation, which directly affect ecosystem services. However, little is known about how these soil structural changes occur during and after the planting of orchards, and which key factors and processes play a major role in soil compaction due to cultivation works. This study evaluates the improved stock unearthing method (ISUM) as a low-cost and precise alternative to the tedious and costly traditional core sampling method, to characterize the changes in soil compaction in a representative persimmon orchard in Eastern Spain. To achieve this goal, firstly, in the field, undisturbed soil samples using metallic core rings (in January 2016 and 2019) were collected at different soil depths between 45 paired-trees, and topographic variations were determined following the protocol established by ISUM (January 2019). Our results show that soil bulk density (Bd) increases with depth and in the inter-row area, due to the effect of tractor passes and human trampling. The bulk density values of the top surface layers (0–12 cm) showed the lowest soil accumulation, but the highest temporal and spatial variability. Soil consolidation within three years after planting as calculated using the core samples was 12 mm, whereas when calculated with ISUM, it was 14 mm. The quality of the results with ISUM was better than with the traditional core method, due to the higher amount of sampling points. The ISUM is a promising method to measure soil compaction, but it is restricted to the land where soil erosion does not take place, or where soil erosion is measured to establish a balance of soil redistribution. Another positive contribution of ISUM is that it requires 24 h of technician work to acquire the data, whereas the core method requires 272 h. Our research is the first approach to use ISUM to quantify soil compaction and will contribute to applying innovative and low-cost monitoring methods to agricultural land and conserving ecosystem services.

scholarly journals Non-metal boron atoms on CuB12 monolayer as efficient catalytic sites for urea production

2022 ◽  
Author(s):  
Changyan Zhu ◽  
Chaoxia Wen ◽  
Miao Wang ◽  
Min Zhang ◽  
Yun Geng ◽  
...  
Keyword(s):  
Low Cost ◽  
Coupling Reaction ◽  
Promising Alternative ◽  
Mild Conditions ◽  
Catalytic Sites ◽  
Urea Production

Electrocatalytic C-N coupling reaction to convert CO2 and N2 into urea under mild conditions has been proposed to be a promising alternative experimentally, but the development of high-stable, low-cost and...

scholarly journals Molecularly Imprinted Polymer Based Sensors for Medical Applications

Sensors ◽  
2019 ◽  
Vol 19 (6) ◽  
pp. 1279 ◽  
Author(s):  
Yeşeren Saylan ◽  
Semra Akgönüllü ◽  
Handan Yavuz ◽  
Serhat Ünal ◽  
Adil Denizli
Keyword(s):  
Surface Modification ◽  
Homeland Security ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Structural Changes ◽  
Low Cost ◽  
Dimensional Structure ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Physical And Chemical

Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.

Knee Prostheses Reverse Engineering: A Preliminary Investigation

2020 ◽  
Author(s):  
Marco Rossoni ◽  
Daniele Regazzoni ◽  
Andrea Vitali ◽  
Giorgio Colombo ◽  
Luca Spandre ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Reverse Engineering ◽  
Knee Arthroplasty ◽  
Mechanical Performance ◽  
Low Cost ◽  
Preliminary Investigation ◽  
Orthopedic Procedures ◽  
Computer Assisted ◽  
Knee Prostheses ◽  
Total Knee

Abstract Total Knee Arthroplasty is one of the most commonly performed orthopedic procedures and it is expected to grow in the next future. In the last past years, computer-assisted procedures represent one of the trends that are transforming the way of practicing medicine. Cornering the Total Knee Arthroplasty, digital models of the joints have been used to carry out simulation of their kinematics and mechanical performance. Whilst for the 3D digital reconstruction of the patient geometry several studies have been conducted, an approximated geometry of the prosthesis has been several times employed, with undeniable consequences on the final results. This paper aims at comparing two non-contact reverse engineering technologies to acquire the shape of femoral components employed for total knee arthroplasty. A high-level device (Konika Minolta Vivid 9i) and a mid-low cost laser (NextEngine) has been compared. For the comparison, a systematic procedure of acquisition and elaboration of the results has been adopted in order to have as unbiased as possible results. The procedure involves the use of the proprietary software of the scanners for the elaboration of the raw data and the meshing procedure has been kept the same for all the models. Since the as-is acquired mesh is of high-resolution, a decimation procedure has been carried out in order to make the 3D models lighter and easier to be handled. Once the decimation procedure has been evaluated comparing the original and the simplified models to one another, the digitalized models have been compared with the measurements taken from a coordinate measuring machines. As a preliminary result, the two lasers seem to be adequate to accomplish the reverse engineering process as required by this application. Of course, the mid-low cost laser would be preferable whether the performance will be confirmed to be (statistically) equal.

Visible-light-mediated semi-heterogeneous black TiO2/nickel dual catalytic C (sp2)–P bond formation toward aryl phosphonates

2020 ◽  
Vol 49 (47) ◽  
pp. 17147-17151
Author(s):  
Mehdi Koohgard ◽  
Haniehsadat Karimitabar ◽  
Mona Hosseini-Sarvari
Keyword(s):  
Visible Light ◽  
Nickel Catalyst ◽  
Noble Metals ◽  
Low Cost ◽  
Bond Formation ◽  
Coupling Reaction ◽  
Black Tio2

The combination of black TiO2 nanoparticles (NPs) with a nickel catalyst provides a low-cost, sustainable, and reusable alternative photoredox/nickel system to a homogeneous counterpart (noble metals) in C(sp2)−P coupling reaction.

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