scholarly journals Phyllanthin: A Potential Lead Molecule for the Future Needs

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
Mohammed Azam ◽  
Makula Ajitha
Keyword(s):  
Physicochemical Properties ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Comprehensive Review ◽  
Toxicity Studies ◽  
Future Needs ◽  
The Future ◽  
Anti Inflammatory

Phyllanthin is an active lignan present in various Phyllanthus species and number of studies revealed that it exhibits various biological activities that include antioxidant, hepatoprotective, anticancer, antidiabetic, immunosuppressant and anti-inflammatory activities. After thorough examination of existing literature it was discovered that there is currently no comprehensive review available on this significant phytocompound. Hence, an attempt was made to present the physicochemical properties, enhancement techniques of yield and bioavailability, synthesis, pharmacological applications and toxicity studies of phyllanthin. This report also highlights semisynthetic derivatives and mechanisms of action of phyllanthin for various biological activities.

scholarly journals PHARMACOLOGICAL IMPORTANCE OF MORINGA CONCANENSIS NIMMO LEAF: AN OVERVIEW

2019 ◽  
pp. 27-31
Author(s):  
AMERENDRA SINGH ◽  
JAI NARAYAN MISHRA ◽  
SANTOSH KUMAR SINGH
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
Medicinal Uses ◽  
Plant Life ◽  
Crude Extracts ◽  
The Future ◽  
Anti Inflammatory ◽  
Scientific Facts

In the current years, the use of traditional medicine is increasing and gaining popularity. The extracts of Moringa concanensis Nimmo leaves have reported many medicinal uses. In the previous few decades, a massive quantity of scientific facts concerning plants, crude extracts, and quite a number supplies from plant life as medicinal dealers has come to light. M. concanensis is a plant whose components are oftentimes used in the medicinal treatments. There are good sized anecdotal facts about the organic undertaking of M. concanensis which includes anticancerous, antibacterial, antifungal, analgesic, and anti-inflammatory type of activities. The leaves of M. concanensis had been located to contain a higher quantity of triterpenoids and flavonoids. The existing assessment includes the phytochemical, ethnopharmacological, and pharmacological reviews of M. concanensis. The future scope of the plant has been emphasized with a view to isolate bioactive moieties which should be used for multifarious biological activities.

scholarly journals Bioactivities and Future Perspectives of Chaetoglobosins

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Jinhua Chen ◽  
Wenzhou Zhang ◽  
Qingfeng Guo ◽  
Weijiang Yu ◽  
Yongna Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Large Class ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Chaetomium Globosum ◽  
Future Perspectives ◽  
Anti Inflammatory ◽  
Anti Hiv ◽  
Fungal Secondary Metabolites

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

scholarly journals A Comprehensive Review of Aminochalcones

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5381
Author(s):  
Rimsha Irfan ◽  
Shikufa Mousavi ◽  
Meshari Alazmi ◽  
Rahman Shah Zaib Saleem
Keyword(s):  
Cancer Cells ◽  
Biological Activities ◽  
Aromatic Rings ◽  
Amino Groups ◽  
High Potency ◽  
Comprehensive Review ◽  
Current Review ◽  
One Stop ◽  
Anti Inflammatory

Chalcones, members of the flavonoid family, display a plethora of interesting biological activities including but not limited to antioxidant, anticancer, antimicrobial, anti-inflammatory, and antiprotozoal activities. The literature cites the synthesis and activity of a range of natural, semisynthetic, and synthetic chalcones. The current review comprehensively covers the literature on amino-substituted chalcones and includes chalcones with amino-groups at various positions on the aromatic rings as well as those with amino-groups containing mono alkylation, dialkylation, alkenylation, acylation, and sulfonylation. The aminochalcones are categorized according to their structure, and the corresponding biological activities are discussed as well. Some compounds showed high potency against cancer cells, microbes, and malaria, whereas others did not. The purpose of this review is to serve as a one-stop location for information on the aminochalcones reported in the literature in recent years.

scholarly journals Pharmaceutical, Ethnopharmacological, Phytochemical and Synthetic Importance of Genus Aerva: A Review

2018 ◽  
Vol 13 (3) ◽  
pp. 1934578X1801300
Author(s):  
Sara Musaddiq ◽  
Kiran Mustafa ◽  
Sajjad Ahmad ◽  
Samina Aslam ◽  
Basharat Ali ◽  
...  
Keyword(s):  
Biological Activities ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
Biochemical Compounds ◽  
The World ◽  
The Future ◽  
Medicinal Properties ◽  
The Common

Aerva plants are known widely for their exceptional medicinal uses. They have been employed conventionally for their medicinal properties by the common folk in several regions of the world. This indicates the efficacy of these remarkable herbs. They are also known for their multiple biological activities such as antioxidant, antibacterial, antilithiatic, hepatoprotective, antidiabetic, anticancer, antihyperlipidemic and nephroprotective potential. These pharmacological actions are associated with the presence of valuable nutrients and biochemical compounds such as sterols/terpenes, flavonoids, alkaloids, phenolics and sugars. The proper utilization of the substances obtained from these plants can enhance the finesse of the capabilities of these plants. These plants are not only medicinally important but are significantly serving several other scientific purposes. In the prospect of medicinal, scientific uses and the bioavailability of precious chemicals of Aerva species, a comprehensive review is compiled, which focuses on the detailed profile of biochemical compounds, pharmacological functions and biological activities of Aerva plants. The review also discusses the synthetic importance and the toxicity of these plants. The study aims to compile comprehensively what is already done and what more is needed to be done in the future investigations related to Aerva species.

scholarly journals Ethnobotanical uses, phytochemistry and biological activities of Clerodendrum paniculatum L. (Lamiaceae): A comprehensive review

2018 ◽  
Vol 8 (5-s) ◽  
pp. 28-34
Author(s):  
T.R. Prashith Kekuda ◽  
S.J. Sudharshan
Keyword(s):  
Biological Activities ◽  
Pharmacological Properties ◽  
Comprehensive Review ◽  
The Family ◽  
Anti Inflammatory ◽  
Ethnobotanical Uses

Clerodendrum L. is an important genus in the family Lamiaceae in terms of its medicinal values and pharmacological properties. The genus comprises of more than 500 species distributed worldwide. In this review, we present an updated information on ethnobotanical uses, phytochemistry and biological activities of Clerodendrum paniculatum L. (Lamiaceae). The plant is one the most spectacular Clerodendrum species and is grown commonly for ornamental purpose. The plant is reported to have ethnomedicinal importance as the plant is used as remedy for ailments and disorders such as wounds, typhoid, snakebite, jaundice, giddiness, malaria, anemia and hemorrhoids. Various phytochemicals such as rutin, quercetin, β-sitosterol, β-amyrin, lupeol, oleanolic aldehyde acetate, stigmasta-4,25-dien-3-one, and (3β)-stigmasta-4,22,25-trien-3-ol have been identified in C. paniculatum. The plant is shown to exhibit biological activities such as antimicrobial, antioxidant, anthelmintic, anti-inflammatory, antimutagenic, cytotoxic, hypolipidemic, insecticidal and anti-ageing activity. Keywords: Clerodendrum paniculatum L., Ethnobotanical, Traditional, Phytochemicals, Biological activities

scholarly journals Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

2020 ◽  
Vol 11 ◽  
Author(s):  
Natalie Vivien Gunter ◽  
Soek Sin Teh ◽  
Yang Mooi Lim ◽  
Siau Hui Mah
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Biological Activities ◽  
Mapk Signaling ◽  
Mechanisms Of Action ◽  
Related Factor ◽  
Wide Range ◽  
Anti Inflammatory

The pathogenesis of skin inflammatory diseases such as atopic dermatitis, acne, psoriasis, and skin cancers generally involve the generation of oxidative stress and chronic inflammation. Exposure of the skin to external aggressors such as ultraviolet (UV) radiation and xenobiotics induces the generation of reactive oxygen species (ROS) which subsequently activates immune responses and causes immunological aberrations. Hence, antioxidant and anti-inflammatory agents were considered to be potential compounds to treat skin inflammatory diseases. A prime example of such compounds is xanthone (xanthene-9-one), a class of natural compounds that possess a wide range of biological activities including antioxidant, anti-inflammatory, antimicrobial, cytotoxic, and chemotherapeutic effects. Many studies reported various mechanisms of action by xanthones for the treatment of skin inflammatory diseases. These mechanisms of action commonly involve the modulation of various pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor α (TNF-α), as well as anti-inflammatory cytokines such as IL-10. Other mechanisms of action include the regulation of NF-κB and MAPK signaling pathways, besides immune cell recruitment via modulation of chemokines, activation, and infiltration. Moreover, disease-specific activity contributed by xanthones, such as antibacterial action against Propionibacterium acnes and Staphylococcus epidermidis for acne treatment, and numerous cytotoxic mechanisms involving pro-apoptotic and anti-metastatic effects for skin cancer treatment have been extensively elucidated. Furthermore, xanthones have been reported to modulate pathways responsible for mediating oxidative stress and inflammation such as PPAR, nuclear factor erythroid 2-related factor and prostaglandin cascades. These pathways were also implicated in skin inflammatory diseases. Xanthones including the prenylated α-mangostin (2) and γ-mangostin (3), glucosylated mangiferin (4) and the caged xanthone gambogic acid (8) are potential lead compounds to be further developed into pharmaceutical agents for the treatment of skin inflammatory diseases. Future studies on the structure-activity relationships, molecular mechanisms, and applications of xanthones for the treatment of skin inflammatory diseases are thus highly recommended.

scholarly journals Zanthoxylum Species: A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological and Nutraceutical Applications

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4023
Author(s):  
Innocent Uzochukwu Okagu ◽  
Joseph Chinedu Ndefo ◽  
Emmanuel Chigozie Aham ◽  
Chibuike C. Udenigwe
Keyword(s):  
Plant Extracts ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Brain Diseases ◽  
Journal Articles ◽  
Food Ingredients ◽  
Comprehensive Review ◽  
Wide Geographical Distribution ◽  
Potential Sources ◽  
Medicinal Properties

Zanthoxylum species (Syn. Fagara species) of the Rutaceae family are widely used in many countries as food and in trado-medicinal practice due to their wide geographical distribution and medicinal properties. Peer reviewed journal articles and ethnobotanical records that reported the traditional knowledge, phytoconstituents, biological activities and toxicological profiles of Z. species with a focus on metabolic and neuronal health were reviewed. It was observed that many of the plant species are used as food ingredients and in treating inflammation, pain, hypertension and brain diseases. Over 500 compounds have been isolated from Z. species, and the biological activities of both the plant extracts and their phytoconstituents, including their mechanisms of action, are discussed. The phytochemicals responsible for the biological activities of some of the species are yet to be identified. Similarly, biological activities of some isolated compounds remain unknown. Taken together, the Z. species extracts and compounds possess promising biological activities and should be further explored as potential sources of new nutraceuticals and drugs.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

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