scholarly journals THE INFLUENCE OF POSTOPERATIVE ANALGESIA TECHNIQUES ON SPLANCHIC BLOOD FLOW IN CHILDREN WITH INTRAABDOMINAL HYPERTENSION

2021 ◽  
pp. 32-39
Author(s):  
V. M. Perova-Sharonova
Keyword(s):  
Blood Flow ◽  
Negative Correlation ◽  
Postoperative Analgesia ◽  
Intravenous Infusion ◽  
Direct Method ◽  
Foley Catheter ◽  
Significant Negative Correlation ◽  
Splanchnic Blood Flow ◽  
Intraabdominal Pressure ◽  
Abdominal Hypertension

Introduction. Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) often develop in critically ill patients and can lead to affected splanchnic blood flow, intestinal mucosal ischemia, bacterial translocation, sepsis, and multiorgan dys-function. There is limited literature data on the effect of analgesic methods on splanchnic blood flow in IAG / AСS. The aim of the study was to define the effect of different postoperative analgesia techniques on splanchnic blood flow in children with appendicular peritonitis with IAH. Materials and methods. The study included 115 children who underwent surgery for appendicular peritonitis. Children were randomized into three groups depending on the method of postoperative analgesia: “Opioids” (n = 36; intravenous infusion of morphine 10 μg/kg/h); “Lidocaine” (n = 40; intravenous infusion of lidocaine 1.5 mg/kg/h); “EDA” (n = 39; epidural infusion 0.25% bupivacaine 0.4 mg/kg/h). Postoperatively intraabdominal pressure (IAP) was measured 4 times a day using the standard in-direct method through a Foley catheter in the bladder. According to the IAP level and presence of organ dysfunction patients in each group were divided in subgroups: “Without IAH”, “IAH” and “ACS”. The diameters and linear velocities of blood flow in the superior mesenteric artery (SMA) and portal vein (PV) were detected using US. The blood flow indices in SMA and PV (BFISMA, BFIPV, ml/min/m2) were calculated. Results. BFISMA and BFIPV were significantly higher in children without IAH than in children with IAH (p <0.0001) and ACS (p <0.0001). Among patients in all subgroups, BFISMA was significantly higher in the groups “Lidocaine” (p <0.05) and “EDA” (p <0.0001) compared with the group “Opioids”. BFIPV was higher in the group “EDA” (p <0.05) in children with IAH and in the groups “Lidocaine” (p <0.0001) and “EDA” (p <0.0001) in children with ACS compared with children of all subgroups in the group “Opioids”. Among the children without IAH a statistically significant negative correlation between IAP and BFISMA was observed only in the group “Opioids” (rs = -0.5; p <0.001). Among the children with IAH and ACS, a statistically significant negative correlation between IAP and BFISMA was observed in all analgesia groups, but it was weakest in the group “EDA” (rs = -0.24; p <0.04 and rs = -0.39; p <0.05, respectively). In the group “Opioids” a statistically significant negative correlation between IAP and BFIPV was observed only in the children with IAH (rs=-0.31; p<0.01) and ACS (rs=-0.4; p<0.0001). Conclusions. Epidural analgesia is the most optimal method of analgesia for the effect on impaired splanchnic blood flow in children with peritonitis complicated with intra-abdominal hypertension. Intravenous analgesia with lidocaine may be an alternative to epidural anesthesia.

scholarly journals Retinal Nerve Fibre Layer and Ophthalmic Artery Blood Parameters in Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma

2021 ◽  
Author(s):  
Hacı Koç ◽  
Faruk Kaya ◽  
Ümit İpeksoy
Keyword(s):  
Blood Flow ◽  
Negative Correlation ◽  
Ophthalmic Artery ◽  
Significant Negative Correlation ◽  
Doppler Imaging ◽  
Control Group ◽  
Artery Blood Flow ◽  
Pseudoexfoliative Glaucoma ◽  
Flow Parameters ◽  
Significant Difference

Abstract PurposeThis study investigates the relationship between ophthalmic artery blood flow parameters and retinal nerve fiber layer (RNFL) thickness in eyes with pseudoexfoliation. MethodsThree comparisons were made in this study. In the first, eyes without glaucoma with pseudoexfoliation in any of the eyes were compared with the control group. In the second, eyes with pseudoexfoliation and without glaucoma were compared with those with pseudoexfoliation and glaucoma. In the third, cases with glaucoma and pseudoexfoliation were compared with the control group. Ophthalmic artery colour Doppler imaging measurements were performed in all patients. Also, peripapillary RNFL analysis was performed. ResultsA statistically significant difference was found between the total RNFL measurements according to group (p = 0.012; p < 0.05). From the paired comparisons, the total RNFL measurements from the control group were higher than the group without glaucoma (p = 0.010). No statistically significant difference was found between the total RNFL measurements of the other groups (p > 0.05). In the pseudoexfoliative glaucoma (PXG) group, there was a statistically significant negative correlation between total RNLF and Peak systolic velocity (PSV) (r = -0.743; p < 0.01). There was also a statistically significant negative correlation between total RNLF and End diastolic velocity (EDV) (r = -0.691; p < 0.01). There was no significant relationship between total RNLF and resistive index (RI) measurements (p > 0.05). ConclusionPseudoexfoliation syndrome(PXS) caused a decrease in the PSV and EDV values of ophthalmic artery blood flow parameters. Again, PXS caused a decrease in total RNFL, RNFL S, RNFL I and RNFL T thickness values.

Thrombin generation in paediatric patients with congenital heart disease

2008 ◽  
Vol 28 (S 01) ◽  
pp. S61-S66 ◽  
Author(s):  
G. Cvirn ◽  
A. Rosenkranz ◽  
B. Leschnik ◽  
W. Raith ◽  
W. Muntean ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Negative Correlation ◽  
Congenital Heart ◽  
Thrombin Generation ◽  
Significant Negative Correlation ◽  
Peak Height ◽  
Global Test ◽  
Paediatric Patients ◽  
Age Range

SummaryThrombin generation was studied in paediatric patients with congenital heart disease (CHD) undergoing cardiac surgery using the calibrated automated thrombography (CAT) in terms of the lag time until the onset of thrombin formation, time to thrombin peak maximum (TTP), endogenous thrombin potential (ETP), and thrombin peak height. The suitability to determine the coagulation status of these patients was investigated. Patients, material, methods: CAT data of 40 patients with CHD (age range from newborn to 18 years) were compared to data using standard coagulation parameters such as prothrombin (FII), antithrombin (AT), tissue factor pathway inhibitor (TFPI), prothrombin fragment 1.2 (F 1.2), thrombin-antithrombin (TAT), activated partial thromboplastin time (aPTT), and prothrombin time (PT). Results: A significant positive correlation was seen between ETP and FII (p < 0.01; r = 0.369), as well as between peak height and F II (p < 0.01; r = 0.483). A significant negative correlation was seen between ETP and TFPI values (p < 0.05; r = –0.225) while no significant correlation was seen between peak height and TFPI. A significant negative correlation was seen between F 1.2 generation and ETP (p < 0.05; r = –0.254) and between F 1.2 generation and peak height (p < 0.05; r = –0.236). No correlation was seen between AT and ETP or peak. Conclusions: CAT is a good global test reflecting procoagulatory and inhibitory factors of the haemostatic system in paediatric patients with CHD.

Negative Correlation Between Serum Levels of Homocysteine and Apolipoprotein M

2019 ◽  
Vol 19 (2) ◽  
pp. 120-126
Author(s):  
J. Wei ◽  
Y. Yu ◽  
Y. Feng ◽  
J. Zhang ◽  
Q. Jiang ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Hepg2 Cells ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Mrna Levels ◽  
Rt Pcr ◽  
Apolipoprotein M ◽  
Protein Mass ◽  
Protein Levels ◽  
Phosphoinositide 3 Kinase

Background: Homocysteine (Hcy) has been suggested as an independent risk factor for atherosclerosis. Apolipoprotein M (apoM) is a constituent of the HDL particles. The goal of this study was to examine the serum levels of homocysteine and apoM and to determine whether homocysteine influences apoM synthesis. Methods: Serum levels of apoM and Hcy in 17 hyperhomocysteinemia (HHcy) patients and 19 controls were measured and their correlations were analyzed. Different concentrations of homocysteine (Hcy) and LY294002, a specific phosphoinositide 3- kinase (PI3K) inhibitor, were used to treat HepG2 cells. The mRNA levels were determined by RT-PCR and the apoM protein mass was measured by western blot. Results: We found that decreased serum apoM levels corresponded with serum HDL levels in HHcy patients, while the serum apoM levels showed a statistically significant negative correlation with the serum Hcy levels. Moreover, apoM mRNA and protein levels were significantly decreased after the administration of Hcy in HepG2 cells, and this effect could be abolished by addition of LY294002. Conclusions: resent study demonstrates that Hcy downregulates the expression of apoM by mechanisms involving the PI3K signal pathway.

scholarly journals Daytime nap and nighttime breastfeeding are associated with toddlers’ nighttime sleep

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Machiko Nakagawa ◽  
Hidenobu Ohta ◽  
Rinshu Shimabukuro ◽  
Yoko Asaka ◽  
Takayo Nakazawa ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Sleep Diary ◽  
Daytime Nap ◽  
Nighttime Sleep

AbstractThe purpose of the present study is to examine the association between toddlers' sleep arrangements and their nighttime sleep duration and other sleep variables. For this investigation, we performed a study in which child activity and sleep levels were recorded using actigraphy. The parents of 1.5-year-old toddlers (n = 106) were asked to attach an actigraphy unit to their child’s waist with an adjustable elastic belt and complete a sleep diary for 7 consecutive days. Questionnaires were used to assess the sleep arrangements of the toddlers. There was a significant negative correlation between nap duration and nighttime sleep duration, suggesting that longer nap sleep induces shorter nighttime sleep duration. Among the sleep arrangements, such as nighttime breastfeeding or co-sleeping, only nighttime breastfeeding predicted shorter nighttime sleep duration. Our findings indicate that shorter naps induce a longer nighttime sleep in 1.5-year-old toddlers while nighttime breastfeeding decreases their nighttime sleep duration.

scholarly journals Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1061
Author(s):  
Wajdy J. Al-Awaida ◽  
Baker Jawabrah Al Hourani ◽  
Samer Swedan ◽  
Refat Nimer ◽  
Foad Alzoughool ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Vaccine Development ◽  
Case Fatality ◽  
Significant Negative Correlation ◽  
Reference Sequence ◽  
Genome Sequences ◽  
Positive Correlation ◽  
Case Fatality Ratio ◽  
Epidemiological Surveys

The outbreak of coronavirus disease 2019 (COVID-19), by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly developed into a worldwide pandemic. Mutations in the SARS-CoV-2 genome may affect various aspects of the disease including fatality ratio. In this study, 553,518 SARS-CoV-2 genome sequences isolated from patients from continents for the period 1 December 2020 to 15 March 2021 were comprehensively analyzed and a total of 82 mutations were identified concerning the reference sequence. In addition, associations between the mutations and the case fatality ratio (CFR), cases per million and deaths per million, were examined. The mutations having the highest frequencies among different continents were Spike_D614G and NSP12_P323L. Among the identified mutations, NSP2_T153M, NSP14_I42V and Spike_L18F mutations showed a positive correlation to CFR. While the NSP13_Y541C, NSP3_T73I and NSP3_Q180H mutations demonstrated a negative correlation to CFR. The Spike_D614G and NSP12_P323L mutations showed a positive correlation to deaths per million. The NSP3_T1198K, NS8_L84S and NSP12_A97V mutations showed a significant negative correlation to deaths per million. The NSP12_P323L and Spike_D614G mutations showed a positive correlation to the number of cases per million. In contrast, NS8_L84S and NSP12_A97V mutations showed a negative correlation to the number of cases per million. In addition, among the identified clades, none showed a significant correlation to CFR. The G, GR, GV, S clades showed a significant positive correlation to deaths per million. The GR and S clades showed a positive correlation to number of cases per million. The clades having the highest frequencies among continents were G, followed by GH and GR. These findings should be taken into consideration during epidemiological surveys of the virus and vaccine development.

387 The moderating effect of emotion regulation strategies in the relationship between insomnia severity and bedtime procrastination

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A153-A154
Author(s):  
Huisu Jeon ◽  
Sonhye Jeoung ◽  
Goeun Kim ◽  
Hyeyoung An ◽  
Hyojin Nam ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Emotional Regulation ◽  
Significant Negative Correlation ◽  
Moderating Effect ◽  
Active Regulation ◽  
Support Seeking ◽  
Regulation Strategies ◽  
Bedtime Procrastination ◽  
The Relationship ◽  
Insomnia Severity

Abstract Introduction Bedtime Procrastination (BP) is defined as the behavior of going to bed later than intended, despite the absence of external factors. Bedtime procrastination is also prevalent among insomnia patients, and is associated with various sleep problems. Recent studies suggest emotional regulation as a mechanism of the procrastination behavior that is the conceptual foundation of bedtime procrastination. Emotional regulation difficulties are also associated with insomnia, but there is still a lack of research on the relationship between insomnia, emotional regulation strategies and bedtime procrastination. Thus, the study assumed that severity of insomnia would affect bedtime procrastination, and examined the moderating effect of the emotional regulation strategies in this relationship. Methods This study was conducted in 376 adults (mean age 23.73 ±2.14 years, 84.6% females). Participants were asked to answer Bedtime procrastination scale (BPS), an emotional regulation strategy checklist, and the Insomnia severity scale (ISI). Results As a result, a significant positive correlation was found between insomnia severity and bedtime procrastination (r=.286, p&lt;.01), and avoidant/distractive regulation style (r=.101, p&lt;.05). active regulation style (r=-.172, p&lt;.01) and support seeking regulation style (r=-.102, p&lt;.01) showed a significant negative correlation with the severity of insomnia. Bedtime procrastination behavior showed significant negative correlation only with active regulation style (r=-.151, p&lt;.01). Support seeking regulation style moderated the relationship between insomnia and bedtime procrastination behavior (B=.0165, 95%, CI=.0014, .0316). The interaction effect between insomnia and support seeking regulation style was also significant (∆R^2=.0112, p&lt;.05), indicating that the effect of insomnia on bedtime procrastination depends on the level of use of the support seeking regulation style. Conclusion These findings suggest that the level of support seeking regulation style is meaningful in terms of how insomnia affects bedtime procrastination. Support (if any) This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea(NRF-2018S1A5A8026807)

scholarly journals Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

2021 ◽  
pp. 1-8
Author(s):  
Foad Alzoughool ◽  
Huda Al Hourani ◽  
Manar Atoum ◽  
Sajedah Bateineh ◽  
Hanan Alsheikh ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Biochemical Parameters ◽  
Significant Positive Correlation ◽  
Glycosylated Hemoglobin ◽  
Significant Negative Correlation ◽  
Diabetic Patients ◽  
Positive Correlation ◽  
Obesity Indices ◽  
Group Serum

BACKGROUND/AIM: The newly described proteins adropin and irisin are a highly conserved polypeptide that plays essential roles in metabolic and energy homeostasis, insulin resistance, and fat browning. The aim of this study is to evaluate the circulating levels of serum adropin and irisin in type 2 diabetes mellitus (T2DM) patients and also to elucidate possible relationships between serum adropin and irisin levels with anthropometric obesity indices and biochemical parameters. SUBJECTS AND METHODS: Single-center prospective observational study included 90 T2DM patients referred to the diabetes outpatient clinic. Height, weight, and waist circumference (WC) were measured. Body mass index (BMI) and waist to height ratio (WHtR) were calculated. Fasting blood glucose, glycosylated hemoglobin, serum lipids, creatinine, urea, and blood urea nitrogen were evaluated. Estimated glomerular filtration rate (GFR) was calculated, serum adropin and irisin were evaluated. RESULTS: The results showed a significant positive correlation between adropin and irisin in females but not in males (r = 0.311; P = 0.042). In males’ group, serum adropin levels showed significant negative correlation with serum glucose (–0.423, P = <  0.05), HbA1C (–0.364, P = <  0.05), and GFR (–0.355, P = <  0.05). In contrast, creatinine was showed a significant positive correlation with adropin in males (0.381, P = <  0.05). In females’ group, adropin showed a significant negative correlation with weight (–0.371, P = <  0.05), BMI (–0.349, P = <  0.05), WC (–0.402, P = <  0.01), and WHtR (–0.398, P = <  0.01). Contrary, in males’ group, serum irisin levels showed significant positive correlation with weight (0.338, P = <  0.05), BMI (0.332, P = <  0.05), WC (0.409, P = <  0.01), and WHtR (0.432, P = <  0.01). CONCLUSION: This study demonstrated that, in T2DM patients, circulating serum adrpoin correlated negatively with anthropometric obesity indices of obesity in females, while serum irisin was positively correlated with anthropometric obesity indices of obesity in males.

scholarly journals Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography

2003 ◽  
Vol 149 (6) ◽  
pp. 543-548 ◽  
Author(s):  
AG Rockall ◽  
SA Sohaib ◽  
D Evans ◽  
G Kaltsas ◽  
AM Isidori ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatic Steatosis ◽  
Cushing’S Syndrome ◽  
Negative Correlation ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Significant Negative Correlation ◽  
Cushing's Syndrome ◽  
Abdominal Fat ◽  
Visceral Fat Area

OBJECTIVE: Hepatic steatosis may occur in association with insulin resistance and obesity, two features commonly seen in Cushing's syndrome (CS). The aim of this report is to assess the prevalence of hepatic steatosis in patients with active CS using computed tomography (CT) and to identify any associations between hepatic steatosis, endocrine and biochemical variables and body fat distribution. PATIENTS AND MEASUREMENTS: We identified 50 patients with active CS in whom appropriate CT was available to allow measurement of liver and spleen attenuation. In 26 patients, abdominal fat measurements were also available. Serum markers of CS and liver function tests were recorded. RESULTS: Ten of 50 patients had a liver-to-spleen CT attenuation ratio (L/S) of less than 1, indicating hepatic steatosis. There was a significant negative correlation between both liver attenuation and L/S ratio with total abdominal fat area, visceral fat area, the percentage of visceral fat and the visceral to subcutaneous fat ratio; the strongest negative correlation was found between visceral fat area and L/S ratio (r=-0.638, P<0.001, n=26). L/S ratio positively correlated with alkaline phosphatase levels (r=+0.423, P=0.044, n=23) but with no other serum marker of CS activity or liver enzyme. CONCLUSIONS: We have demonstrated hepatic steatosis on CT in 20% of patients with active CS. The presence of hepatic steatosis was significantly correlated with total abdominal fat area and visceral fat area.

Associations among Job Satisfaction, Optimism, Pessimism, and Psychosomatic Symptoms for Employees in the Government Sector in Kuwait

2003 ◽  
Vol 93 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Owaied S. Al-Mashaan
Keyword(s):  
Job Satisfaction ◽  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Psychosomatic Symptoms ◽  
Government Sector ◽  
The Government

The present study examined associations among job satisfaction and optimism, pessimism, and psychosomatic symptoms in a sample of 718 Kuwaiti employees (350 men and 368 women). Men scored significantly higher than women on both the scales of Job Satisfaction and Optimism, while women scored significantly higher than men on both scales for Pessimism and Psychosomatic Symptoms. Job satisfaction scores correlated significantly and positively with Optimism scores and negatively with Pessimism scores. There was also a significant negative correlation between scores on Optimism and Pessimism, and a significant negative correlation between scores on Optimism and Psychosomatic symptoms. Results were discussed within the Kuwaiti context.

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