scholarly journals Analysis of polymorphism of SNP markers of genes involved in nonshivering thermogenesis, UCP1 (rs1800592), UCP2 (rs659366) and UCP3 (rs2075577) in Yakuts and Chukchi

2020 ◽  
pp. 97-98
Author(s):  
А.А. Никанорова ◽  
Н.А. Барашков ◽  
Е.Е. Дьяконов ◽  
С.С. Находкин ◽  
В.Г. Пшенникова ◽  
...  
Keyword(s):  
Snp Markers ◽  
Eastern Siberia ◽  
Nonshivering Thermogenesis ◽  
Extreme Climate ◽  
First Time

Впервые был проведен анализ частот аллелей полиморфизмов генов UCP1 (rs1800592), UCP2 (rs659366) и UCP3 (rs2075577) в популяциях якутов и чукчей, проживающих в условиях экстремального климата Восточной Сибири. For the first time an analysis of the frequencies of alleles polymorphism of the genes UCP1 (rs1800592), UCP2 (rs659366) and UCP3 (rs2075577) were studied in the Yakut and Chukchi populations, living in the extreme climate of Eastern Siberia.

New and interesting lichen records for Republic of Sakha (Yakutia). III

2017 ◽  
Vol 51 ◽  
pp. 220-231 ◽  
Author(s):  
S. V. Chesnokov ◽  
L. A. Konoreva ◽  
L. N. Poryadina ◽  
A. G. Paukov ◽  
E. S. Kusnetsova ◽  
...  
Keyword(s):  
Lichen Species ◽  
Eastern Siberia ◽  
First Time

Lichen specimens collected in 2008, 2015 and 2016 in Central (Olekminsky district), Eastern (Oimyakon district) and Southern (Aldan, Neryungri districts) Yakutia were studied. As a result 16 lichen species are recorded for Yakutia for the first time, among them 8 species are new to Eastern Siberia and one species — Ramonia himelbrantii — new to Asia. At present the list of lichens of Yakutia numbers about 820 species.

Foreign photographers in Siberia: photography as a mean of dehumanization

Neophilology ◽  
2019 ◽  
pp. 566-573
Author(s):  
Evgeniy P. Ekimov
Keyword(s):  
Scientific Discourse ◽  
The Internet ◽  
Russian Society ◽  
Eastern Siberia ◽  
State Archive ◽  
Cultural Research ◽  
Russian State ◽  
The Republic ◽  
The 19Th Century ◽  
First Time

This cultural research is the analysis of the foreign photographers’ activities in Siberia from the second half of the 19th century to the present time. We consider the issue of dehumanization of Russian society and culture by means of foreign photography. On the basis of real photographs published on the Internet, the author compiled a list of all Western photographers who visited Siberia and proved their destructive and countercultural, political, and non-artistic goals aimed at weakening the Russian state and Russian people dehumanization; we confirmed it by the final relevant foreign publications. Some research materials are documents of the State Archive of the Republic of Buryatia and are the first time in scientific discourse. Until now, researchers consid-ered the activities of foreign photographers in Eastern Siberia mainly in the specialty of history, exclusively as a source base positively. The novelty of this cultural research lies in the fact that foreign photography of Eastern Siberia is considered from the perspective of the tasks set for for-eign photographers by their foreign customers, as well as from aesthetic and artistic positions. Thus, we prove the negative nature of the foreign photographers’ activities in Eastern Siberia.

scholarly journals First Records of Potamic Leech Fauna of Eastern Siberia, Russia

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Irina A. Kaygorodova ◽  
Elena V. Dzyuba ◽  
Natalya V. Sorokovikova
Keyword(s):  
River Basin ◽  
Lake Baikal ◽  
Eastern Siberia ◽  
Free Living ◽  
Lena River ◽  
Baikal Basin ◽  
Lake Baikal Basin ◽  
Unidentified Species ◽  
First Time

We studied the fauna of leech and leech-like species inhabiting main water streams of Eastern Siberia and its tributaries, which are attributed to Lake Baikal basin and Lena River basin. Here we present their list for the first time. This study was mainly aimed for free-living parasitic and carnivorous leeches whereas piscine parasites were not included specially. In total, the potamic leech fauna of Eastern Siberia includes 12 described species belonging to 10 genera. Representatives of three unidentified species of two genera Erpobdella and Barbronia have been also recorded.

Sorosaccus sibiricus Prynada (Ginkgoales) from the Middle Jurassic deposits of the Irkutsk Coal Basin, Eastern Siberia

Palaeobotany ◽  
2018 ◽  
Vol 9 ◽  
pp. 5-17
Author(s):  
N. V. Nosova ◽  
N. M. Zavialova ◽  
A. I. Kiritchkova ◽  
E. I. Kostina
Keyword(s):  
Middle Jurassic ◽  
Pollen Grains ◽  
Eastern Siberia ◽  
Coal Basin ◽  
New Findings ◽  
Irkutsk Coal Basin ◽  
First Time

New findings of pollen cones of Sorosaccus sibiricus Prynada were studied in detail from the Aalenian—Bajocian Prisayan Formation of two localities in the Irkutsk coal basin (Ust’-Baley and Vladimirovka). Specimens of S. sibiricus previously described from Ust’-Baley (Heer, 1876) were reexamined. It was revealed that S. sibiricus differs from other species of Sorosaccus in a shape of the apical (free from the microsporangia) part of the microsporophylls. Microsporophylls of S. sibiricus consist of a petiole and a wide-oval distal lamina with acute apex, commonly bending upward. The lamina was often folded and became lanceolate, linear, or fan-shaped with uneven to toothed margin. Microsporangia (6—8) are oval in outline, helically attached to the petiole. Pollen grains were extracted from S. sibiricus microsporangia for the first time. They are oval to boat-shaped in outline, monosulcate and differ from other known Sorosaccus pollen grains by the verrucate surface of the exine. The diagnosis of the species Sorosaccus sibiricus is emended.

Genetic variants involved in the cGAS-STING pathway to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3 and TRIBE trials.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 3535-3535
Author(s):  
Jingyuan Wang ◽  
Yi Xiao ◽  
Fotios Loupakis ◽  
Sebastian Stintzing ◽  
Hiroyuki Arai ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Cell Activation ◽  
Killer Cell ◽  
Progression Free Survival ◽  
Dendritic Cell Maturation ◽  
Vital Role ◽  
Snp Markers ◽  
Sting Pathway ◽  
The Impact ◽  
First Time

3535 Background: The intracellular DNA sensor stimulator of interferon genes (STING) plays a vital role in anti-tumor immune responses by recognition of self-DNA from tumors and by-products of genomic instability. Activation of STING was reported to enhance cetuximab mediated natural killer cell activation and dendritic cell maturation. Previous reports suggested that polymorphisms of cGAS-STING can affect innate immune response. Therefore, we hypothesized that genetic variants in the cGAS-STING pathway may predict first-line treatment outcome in mCRC pts treated with bevacizumab/cetuximab-based chemotherapy. Methods: Genomic DNA from blood samples of pts enrolled in two independent randomized trials, FIRE-3 (cetuximab arm, n = 129; bevacizumab arm, n = 107) and TRIBE (bevacizumab arm, n = 215), was genotyped through the OncoArray, a customized array manufactured by Illumina including approximately 530K SNP markers. The impact on outcome of 7 selected SNPs in 3 genes involved in the STING pathway (cGAS, STING, IFNB1) was analyzed. Results: In the Cetuximab cohort, pts with STING rs1131769 any T allele (N = 29) showed significantly shorter overall survival (36.3 vs 56.07 months) compared to carriers of C/C (N = 95) in both univariate (hazard ratio [HR] = 2.08; 95% confidence interval [CI]: 1.06-4.07; p = 0.003) and multivariate (HR = 2.98; 95%CI 1.35-6.6; p = 0.00848) analysis; Pts carrying IFNB1 rs1051922 any A allele (N = 68) showed significant shorter progression-free survival (10.23 vs 14.1 months) than carriers of G/G (n = 59) in both univariate (HR = 1.87; 95%CI 1.26-2.78; p = 0.00163) and multivariate (HR = 2.03; 95%CI 1.25-3.3; p = 0.004) analysis. No association were observed in the bevacizumab cohort of TRIBE and FIRE-3. Conclusions: Our study demonstrates for the first time that STING and IFNB1 polymorphisms could predict outcomes of Cetuximab-based treatment in mCRC patients; These finding may provide insight for the combination of STING agonist and anti-EGFR treatment in mCRC patients.

scholarly journals Evaluation of the Genetic Diversity of Xylella fastidiosa Strains from Citrus and Coffee Hosts by Single-Nucleotide Polymorphism Markers

2007 ◽  
Vol 97 (12) ◽  
pp. 1543-1549 ◽  
Author(s):  
Ester Wickert ◽  
Marcos Antonio Machado ◽  
Eliana G. M. Lemos
Keyword(s):  
Genetic Diversity ◽  
Single Nucleotide Polymorphism ◽  
Dna Sequences ◽  
Xylella Fastidiosa ◽  
Snp Markers ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

The aim of this study was to obtain information about genetic diversity and make some inferences about the relationship of 27 strains of Xylella fastidiosa from different hosts and distinct geographical areas. Single-nucleotide polymorphism (SNP) molecular markers were identified in DNA sequences from 16 distinct regions of the genome of 24 strains of X. fastidiosa from coffee and citrus plants. Among the Brazilian strains, coffee-dependent strains have a greater number of SNPs (10 to 24 SNPs) than the citrus-based strains (2 to 12 SNPs); all the strains were compared with the sequenced strain 9a5c. The identified SNP markers were able to distinguish, for the first time, strains from citrus plants and coffee and showed that strains from coffee present higher genetic diversity than the others. These markers also have proven to be efficient for discriminating strains from the same host obtained from different geographic regions. X. fastidiosa, the causal agent of citrus variegated chlorosis, possesses genetic diversity, and the SNP markers were highly efficient for discriminating genetically close organisms.

scholarly journals Microbiomes of the initial soils of mining areas of Yakutsk City (Eastern Siberia, Russia)

2020 ◽  
Vol 10 (1) ◽  
pp. 69-82
Author(s):  
Alexey Zverev ◽  
Alexey Petrov ◽  
Anastasia Kimeklis ◽  
Arina Kichko ◽  
Evgeny Andronov ◽  
...  
Keyword(s):  
Climatic Conditions ◽  
Russian Arctic ◽  
Soil Processes ◽  
Eastern Siberia ◽  
Arctic Zone ◽  
Mining Areas ◽  
The Family ◽  
Low Diversity ◽  
First Time ◽  
Spoil Banks

The microbiome of initial soils formed at the heaps and bottoms of surface sediment quarries in the surroundings of Yakutsk City(Eastern Siberia,Russia) has been characterized for the first time. In the initial Entisols, we detected Alphaproteobacteria (represented mainly by the family Rizobiales), Gammaproteobacteria, Actinobacteria, Acidobacteria, Bacteroidetes (mostly Chitinophagales), Deltaproteobacteria, and Chloroflexi. The lower soil horizons had a more homogenous species diversity taxonomy that was dominated by Gammaproteobacteria. The morphologically different horizons did not differ microbiologically. This is caused by the limited soil development and relatively slow rate of revegetation of the spoil banks and heaps of the quarries under the severe climatic conditions of the Eastern part of Russian Arctic zone. Based on our findings, we propose that the soil microbiomes in such recently abandoned quarries are characterized by low diversity, which is a characteristic feature of the polar soils surrounding Yakutsk. Data obtained can be used for elaboration of reclamation strategies with taking into account the information about key microbial drivers of soil processes.

scholarly journals Unraveling the Genetic Diversity and Population Structure of Bangladeshi Indigenous Cattle Populations Using 50K SNP Markers

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2381
Author(s):  
Mohammad Shamsul Alam Bhuiyan ◽  
Soo-Hyun Lee ◽  
Sheikh Mohammad Jahangir Hossain ◽  
Gautam Kumar Deb ◽  
Most Farhana Afroz ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Principal Component ◽  
Snp Markers ◽  
Gene Pools ◽  
Effective Population ◽  
Phylogenetic Tree Analysis ◽  
Indigenous Cattle ◽  
Geographic Separation ◽  
First Time ◽  
North Bengal

Understanding the genetic basis of locally adapted indigenous cattle populations is essential to design appropriate strategies and programs for their genetic improvement and conservation. Here, we report genetic diversity measures, population differentiation, and structure of 218 animals sampled from six indicine cattle populations of Bangladesh. Animals were genotyped with Illumina Bovine SNP50K BeadChip along with genotyped data of 505 individuals included from 19 zebu and taurine breeds worldwide. The principal component analysis (PCA) showed clear geographic separation between taurine and indicine lineages where Bangladeshi indigenous cattle clustered with South Asian zebu populations. However, overlapped clusters in PCA, heterozygosity estimates, and Neighbor-Joining phylogenetic tree analysis revealed weak genetic differentiation among the indigenous cattle populations of Bangladesh. The admixture analysis at K = 5 and 9 suggests distinct genetic structure of the studied populations along with 1 to 4% of taurine ancestry. The effective population size suggested a limited pool of ancestors particularly for Sahiwal and North Bengal Grey cattle. In conclusion, these findings shed insights into the genetic architecture of six indigenous cattle populations of Bangladesh for the first time and suggested as distinct gene pools without potential admixture with zebu or taurine populations.

scholarly journals New Data on Distribution and Morphological Characters of Cladocera (Daphniidae Straus, 1820) and Copepoda (Diaptomidae Sars, 1903, Cyclopidae Dana, 1846) in Lake Baikal

2020 ◽  
Vol 31 ◽  
pp. 76-92
Author(s):  
N. G. Sheveleva ◽  
◽  
E. A. Misharina ◽  
N .V. Makarkina ◽  
◽  
...  
Keyword(s):  
Species Diversity ◽  
Lake Baikal ◽  
Morphological Analysis ◽  
Morphological Characters ◽  
Water Bodies ◽  
Eastern Siberia ◽  
The South ◽  
First Finding ◽  
The Family ◽  
First Time

The species diversity of the superclass Crustacea only in Lake Baikal has 58 species of the superorder Cladocera and 52 species and subspecies from the subclass Соpepoda, 5 of them belong to the order Calanoida and 47 to the order Cyclopoida. Species that inhabit the waters of Olkhon Island are not included in this list. On the island there are temporary and permanent reservoirs, which by the chemical composition of the water are fresh or brackish. The species diversity of the island crustaceans includes 28 species, of which only 64 % are known for Baikal. This article gives a brief description of the morphology of rare and small species from the family Daphniidae: Ceriodaphnia megops Sars 1985; Diaptomidae: Arctodiaptomus (A.) wierzejskii (Richard, 1888) and Cyclopidae: Eucyclops arcanus Alekseev, 1990. The first two species were found in Lake Baikal, the third species – on Olkhon Island. Morphological analysis of the species was performed by means of a scanning electron microscope (SEM). A detailed description of the morphological features of C. megops, A. (A.) wierzejskii female and male, and E. arcanus female with illustrations is presented. Data on diaptomus and cyclopoid mouth appendages, tables with biometrical parameters of a cyclopoid are provided. Images of cyclopoid Р1–Р4 coxopodite and basal exopodite segment are shown for the first time. C. megops and A. (A.) wierzeskii crustaceans are rare species in the water bodies of the south of Central Asia, including Mongolia. A. (A.) wierzeskii population is the first finding in the water bodies of the south of Eastern Siberia and Baikal.

scholarly journals SIX LECTURES ON THE PREVENTION OF ENCEPHALITIS EPIDEMICS IN SIBERIA

2020 ◽  
pp. 61-110
Author(s):  
Lev Goldfarb
Keyword(s):  
Western Siberia ◽  
Clinical Presentation ◽  
Eastern Siberia ◽  
Sustained Reduction ◽  
Deadly Disease ◽  
Extensive Effort ◽  
The Republic ◽  
The Individual ◽  
And Control ◽  
First Time

This review summarizes the work of large teams of researchers to prevent two separate encephalitis epidemics in Siberia. The first three lectures sum up an extensive effort to study and control the Tick-borne enceph-alitis (TBE) epidemic in the Kemerovo region of Western Siberia. The study has helped to create a mathematical model that details the TBE epidemic process and offers a quantitative approach to the development of strategies for preventing TBE epidemics. Ten-year effort to combat TBE in the Kemerovo region led to a significant and sustained reduction in TBE morbidity and mortality. Fifty years after completion of this work, the proposed strategy has not been tested in other endemic regions, although the incidence of TBE worldwide has almost doubled, taking hundreds of lives and causing disability in thousands. The second disease described here is Viliuisk encephalomyelitis (VEM), first discovered 150 years ago in a small rural population of Eastern Siberia. The disease later spread to densely populated areas of the Republic of Sakha (Yakutia), reaching epidemic proportions. The three lectures on VEM provide an overview of multi-year studies on clinical presentation, neuropathology, pathogenesis, etiology, and epidemiology of VEM. We report here for the first time how a prolonged hospitalization of VEM patients during the acute and subacute phases of the disease prevent-ed transmission to susceptible individuals in their families and communities, which has helped to put an end to the further spread of this deadly disease. VEM is a new example of a local disease that has spread to a large territory and could potentially invade other countries if left unchecked. This review is based on a series of lectures delivered to different audiences at different times. The purpose of combining discrete topics in a single review is to emphasize approaches to solving problems, to illustrate the main results of the fight against Siberian epidemics and, when possible, reflect on the individual contribution of each researcher.

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