scholarly journals Powerful Statistical Tests for Ordered Data

2020 ◽  
Author(s):  
Juergen Koefinger ◽  
Gerhard Hummer
Keyword(s):  
Statistical Tests ◽  
X Rays ◽  
Test Statistics ◽  
Chi Square ◽  
P Values ◽  
Gamma Distributions ◽  
Versatile Tool ◽  
Chi Square Test ◽  
Common Sign ◽  
Ordered Data

<p>The inference of models from one-dimensional ordered data subject to noise is a fundamental and ubiquitous task in the physical and life sciences. A prototypical example is the analysis of small- and wide-angle solution scattering experiments using x-rays (SAXS/WAXS) or neutrons (SANS). In such cases, it is common practice to check the quality of a fit by using Pearson's chi-square test, which ignores the order of the data. We usually plot the residuals and check visually for systematic deviations without quantifying them. To quantify these deviations, we developed test statistics based on the distributions of the lengths of the runs of the signs of the residuals. Specifically, we use the probability of run-length distributions, for which we provide analytical expressions, to rank them and to calculate their P-values. We introduce the Shannon information distribution as an elegant and versatile tool for calculating P-values. We find that these distributions follow shifted gamma distributions, such that they are summarized by three parameters only. We show for a set of six models that our test statistics are more powerful than Pearson's chi-square test and common sign-based tests. We provide an open source Python 3 implementation of our tests free of charge at https://github.com/bio-phys/hplusminus.</p>

scholarly journals Powerful Statistical Tests for Ordered Data

2020 ◽  
Author(s):  
Juergen Koefinger ◽  
Gerhard Hummer
Keyword(s):  
Statistical Tests ◽  
X Rays ◽  
Test Statistics ◽  
Chi Square ◽  
P Values ◽  
Gamma Distributions ◽  
Versatile Tool ◽  
Chi Square Test ◽  
Common Sign ◽  
Ordered Data

<p>The inference of models from one-dimensional ordered data subject to noise is a fundamental and ubiquitous task in the physical and life sciences. A prototypical example is the analysis of small- and wide-angle solution scattering experiments using x-rays (SAXS/WAXS) or neutrons (SANS). In such cases, it is common practice to check the quality of a fit by using Pearson's chi-square test, which ignores the order of the data. We usually plot the residuals and check visually for systematic deviations without quantifying them. To quantify these deviations, we developed test statistics based on the distributions of the lengths of the runs of the signs of the residuals. Specifically, we use the probability of run-length distributions, for which we provide analytical expressions, to rank them and to calculate their P-values. We introduce the Shannon information distribution as an elegant and versatile tool for calculating P-values. We find that these distributions follow shifted gamma distributions, such that they are summarized by three parameters only. We show for a set of six models that our test statistics are more powerful than Pearson's chi-square test and common sign-based tests. We provide an open source Python 3 implementation of our tests free of charge at https://github.com/bio-phys/hplusminus.</p>

scholarly journals Powerful Statistical Tests for Ordered Data

2021 ◽  
Author(s):  
Juergen Koefinger ◽  
Gerhard Hummer
Keyword(s):  
Statistical Tests ◽  
X Rays ◽  
Test Statistics ◽  
Chi Square ◽  
P Values ◽  
Gamma Distributions ◽  
Versatile Tool ◽  
Chi Square Test ◽  
Common Sign ◽  
Ordered Data

<p>The inference of models from one-dimensional ordered data subject to noise is a fundamental and ubiquitous task in the physical and life sciences. A prototypical example is the analysis of small- and wide-angle solution scattering experiments using x-rays (SAXS/WAXS) or neutrons (SANS). In such cases, it is common practice to check the quality of a fit by using Pearson's chi-square test, which ignores the order of the data. We usually plot the residuals and check visually for systematic deviations without quantifying them. To quantify these deviations, we developed test statistics based on the distributions of the lengths of the runs of the signs of the residuals. Specifically, we use the probability of run-length distributions, for which we provide analytical expressions, to rank them and to calculate their P-values. We introduce the Shannon information distribution as an elegant and versatile tool for calculating P-values. We find that these distributions follow shifted gamma distributions, such that they are summarized by three parameters only. We show for a set of six models that our test statistics are more powerful than Pearson's chi-square test and common sign-based tests. We provide an open source Python 3 implementation of our tests free of charge at https://github.com/bio-phys/hplusminus.</p>

Analisis Faktor Determinan Pelaksanaan Inisiasi Menyusu Dini Oleh Bidan Di Rumah Sakit Umum Anutapura Palu

2018 ◽  
Vol 1 (1) ◽  
pp. 34
Author(s):  
Ni Nyoman Novita ◽  
Gusman Arsyad
Keyword(s):  
Emergency Room ◽  
Peer Support ◽  
Statistical Tests ◽  
Bivariate Analysis ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Implementation Processes ◽  
Chi Square Test ◽  
The Government

Implementation of IMD in hospitals has decreased from the previous year and has not reached the target set by the government. Some IMD implementation processes have not been carried out according to applicable standards. So that babies do not get an IMD in accordance with existing SOPs. The purpose of this study was to determine the determinant factors associated with the implementation of the IMD by midwives in the Midwifery and Maternity Room Emergency Room (IGD) at the Anutapura General Hospital in Palu. This research method is analytical with cross sectional approach. The population of this study was that all midwives in the obstetrics emergency room and maternity room at Anutapura Palu Hospital were 37 respondents. The sample in this study is total sampling. The analysis used was univariate, and bivariate analysis using the chi square test with a confidence level of 95% (α = 0.05). The results of statistical tests on variable knowledge of midwives with the implementation of IMD p value: 0.018 (p value <0.05). APN training with the implementation of IMD p value: 0.697 (p value> 0.05). length of work with the implementation of IMD p value: 0.029 (p value <0.05). and peer support with the implementation of IMD p value: 0.007 (p value <0.05). Conclusions there is a relationship between knowledge, length of work, peer support with the implementation of the IMD, and training factors that have nothing to do with IMD implementation. The strongest factor in the relationship is peer support. It is recommended that the Anutarapura Palu Hospital be able to motivate midwives so that they can further enhance their role in the implementation and provide support to their colleagues so that the implementation of the IMD can be carried out in accordance with applicable standards.Keywords: Knowledge, APN Training, Duration of work, Implementation of IMD

Association between tumor mutational burden (TMB) and immune-related adverse events (irAEs) in patients (pts) with metastatic urothelial carcinoma (mUC) during checkpoint immunotherapy.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 489-489
Author(s):  
Elie W. Akl ◽  
Pier Vitale Nuzzo ◽  
Elio Adib ◽  
Amin Nassar ◽  
Sarah Abou Alaiwi ◽  
...  
Keyword(s):  
Sequencing Data ◽  
Chi Square ◽  
P Values ◽  
Exact Test ◽  
Radiological Data ◽  
Tumor Mutational Burden ◽  
Chi Square Test ◽  
Metastatic Urothelial Carcinoma ◽  
Multivariable Regression ◽  
The Relationship

489 Background: Immune checkpoint inhibition (ICI) has greatly improved clinical outcomes for pts with mUC and other cancers. ICI is associated with a class of AEs, deemed irAEs due to immune activation. Nonetheless, biomarkers associated with irAE are still lacking. We hypothesized that the immune response against neoantigens is partly responsible for irAEs and investigated the association between irAEs, TMB and response to ICI. Methods: We identified patients with mUC at Dana Farber Cancer Institute who were treated with ICI (monotherapy or combination) and had available tumor sequencing data through Oncopanel. TMB was calculated using the number of non-synonymous exonic mutations per megabase. The severity of irAEs was graded using CTCAE v.5.0. Mann-Whitney U test was performed to identify association between TMB, incidence and grade of irAEs. A cut-off of 10/mb was assigned for TMB. Fisher’s exact test was used to evaluate the radiologic response between pts with and without irAEs and low vs. high TMB. Multivariable linear regression was used to assess the relationship between TMB, irAEs and response. p-values were adjusted using Benjamini-Hochberg method. Results: Of 101 pts with mUC who met the inclusion criteria, 32 (32%) reported irAEs. 6 (6%) were grade (G)1, 20 (20%) were G2, and 6 (6%) were G3. Median(m) time on therapy was 84 days for pts without irAEs and 88 days for pts with irAEs. Pts with irAEs had higher mTMB (15.4/mb) compared to pts with no irAEs (9.8) ( p = 0.01). In pts on monotherapy (93), those with irAEs (n=27) had a higher mTMB (15.13/mb) compared to pts with no irAEs (n=66) (mTMB = 10.20/mb) ( p = 0.01). Out of 94 pts with radiological data, response was achieved in 16 (50%) pts with irAE vs 10 (16%) pts with no irAE ( p < 0.001). When both irAE and response were included in a multivariable regression, the association between irAE and TMB was not significant ( p = 0.4). Pts with both irAE and high TMB had a response rate of 56% which was significantly higher than those with either irAE but low TMB (28.6%) or high TMB but no irAE (21.2 %) or low TMB and no irAE (10.3%) (Chi-square test p = 0.002; FDR corrected p-values for individual comparisons in Table). There was no association between TMB and irAE grade. Conclusions: Higher TMB was associated with higher incidence of irAEs in pts with mUC on ICIs. Moreover, pts with both high TMB and irAEs exhibited better response rates than those with only high TMB or irAEs, suggesting that they may provide complementary tumor and host characteristics. Further evaluation in mUC is needed to confirm this relationship between TMB, irAEs and response in a larger cohort and explore specific mutational signatures that may be associated with irAEs. [Table: see text]

scholarly journals Confronting Theories of Firm Growth in Light of Degrees-of-Freedom Analysis

2015 ◽  
Vol 22 (74) ◽  
pp. 385-404
Author(s):  
Sérgio Fernando Loureiro Rezende ◽  
Ricardo Salera ◽  
José Márcio de Castro
Keyword(s):  
Degrees Of Freedom ◽  
Firm Growth ◽  
Dynamic Capabilities ◽  
Statistical Tests ◽  
Explanatory Power ◽  
Stage Theory ◽  
Chi Square ◽  
Growth Optimum ◽  
Chi Square Test ◽  
Do So

This article aims to confront four theories of firm growth – Optimum Firm Size, Stage Theory of Growth, The Theory of the Growth of the Firm and Dynamic Capabilities – with empirical data derived from a backward-looking longitudinal qualitative case of the growth trajectory of a Brazilian capital goods firm. To do so, we employed Degree of Freedom-Analysis for data analysis. This technique aims to test the empirical strengths of competing theories using statistical tests, in particular Chi-square test. Our results suggest that none of the four theories fully explained the growth of the firm we chose as empirical case. Nevertheless, Dynamic Capabilities was regarded as providing a more satisfactory explanatory power.

scholarly journals Maternal mortality in the indigenous and non-indigenous population in Pará: contribution to the surveillance of deaths

2017 ◽  
Vol 21 (4) ◽  
Author(s):  
Deivid Ramos dos Santos ◽  
Laura Maria Vidal Nogueira ◽  
Bárbara Lopes Paiva ◽  
Ivaneide Leal Ataide Rodrigues ◽  
Lívia Félix de Oliveira ◽  
...  
Keyword(s):  
Maternal Mortality ◽  
Indigenous Population ◽  
Statistical Tests ◽  
Public Health Problem ◽  
The State ◽  
Indigenous Women ◽  
Chi Square ◽  
Live Births ◽  
Historical Series ◽  
Chi Square Test

Abstract Objective: To analyze the occurrence of Maternal Mortality in general and in the indigenous population in the state of Pará. Method: A quantitative, analytical and retrospective study was performed, covering a historical series from 2005 to 2014. For the analysis of the results, non-parametric statistical tests, the Chi-square test and the G test were processed in the BioStat 5.0 software program. Results: A total of 884 maternal deaths were reported in the state of Pará, corresponding to a Mortality Rate of 60.7 per 100,000 live births for non-indigenous women and 135.8 per 100,000 live births for indigenous women. Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and puerperium corresponded to 30.5% (n = 270). Conclusion and Implications for the Practice: Maternal mortality remains a serious public health problem in the state of Pará, clearly demonstrating that indigenous pregnant women require greater care, since they showed higher Maternal Mortality Rates when compared to non-indigenous women.

scholarly journals Analysis of Healthy Latrine Ownership Factors in the Coastal Area of Lapulu Village, Kendari City

2021 ◽  
Vol 4 (1) ◽  
pp. 29-37
Author(s):  
Sitti Marya Ulva ◽  
Sinar Jannah
Keyword(s):  
Statistical Tests ◽  
Sampling Technique ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Associated ◽  
Community Ownership ◽  
Land Availability ◽  
Tidal Area ◽  
Chi Square Test

The percentage of families in Lapulu Village that had healthy latrines was 64,84% who met the health requirements and 35,16% who did not meet the health requirements in 2019. This shows that the ownership of healthy latrines is still lower than the national achievement. This study aims to determine the factors associated with low ownership of healthy latrines in the coastal areas of Lapulu Village, Kendari City. The research design was observational, with a cross-sectional approach. The population in this study was 437 respondents, while the study sample was 209 respondents. The sampling technique used was proportional random sampling technique. The analysis were performed using the Chi-Square test. The results of statistical tests with chi-square obtained the value of land availability (p-value=0,000), knowledge (p-value=0,031), and income (p-value=0,000). It can be concluded that there is a relationship between land availability, knowledge, and income levels associated with low ownership of healthy latrines in the tidal area of ​​Lapulu Village, Kendari City. Therefore, it is hoped that the community and local government will establish this inter sector collaboration with related agencies to increase community ownership of healthy latrines.

scholarly journals PERBEDAAN SUHU TUBUH BAYI BARU LAHIR ANTARA BAYI YANG BERHASIL MELAKUKAN INISIASI MENYUSU DINI DAN BAYI YANG TIDAK BERHASIL MELAKUKAN INISIASI MENYUSU DINI

2019 ◽  
Vol 2 (2) ◽  
pp. 133
Author(s):  
Aprilia Aprisanti Reyani
Keyword(s):  
Body Temperature ◽  
Random Sampling ◽  
Statistical Tests ◽  
The Body ◽  
Breastfeeding Initiation ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
The Difference ◽  
Cross Sectional Design

Latar Belakang :Kehangatan dada ibu dapat menghangatkan bayi, sehingga apabila bayi diletakan di dada ibunya segera setelah melahirkan atau dilakukan Inisiasi Menyusu Dini, dapat menurunkan resiko hipotermia dan menurunkan kematian bayi baru lahir akibat kedinginan atau hipotermia. Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui perbedaan suhu tubuh bayi baru lahir antara bayi yang berhasil melakukan IMD dan bayi yang tidak berhasil melakukan IMD Metode  :Analitik,desain cross sectional,populasi semua bayi baru lahir, sampel bayi barulahir, teknik Non Random Sampling, pengumpulan data dengan menggunakan Lembar Observasi dengan menggunakan uji Chi-Square dengan nilai signifikan α = 0.05 yaitu bila hasil uji statistik menunjukan p ≤ α maka H0 ditolak. Hasil      :Suhu tubuh bayi baru lahir yang berhasil melakukan IMD sebagianbesardengansuhutubuhtidakhipotermisebanyak 20 bayi (87%) Suhu tubuh bayi baru lahir yang tidak berhasil melakukan IMD sebagianbesardengansuhutubuhhipotermisebanyak 8 bayi (66,7%). Dari hasil uji statistik diperoleh hasil nilai p = 0,005 < α = 0.05 maka H1 diterima, artinya ada Perbedaan suhu tubuh bayi baru lahir yang berhasil melakukan IMD dan yang tidak berhasil melakukan IMD Kesimpulan :Terdapat perbedaan suhu tubuh bayi baru lahir antara bayi yang berhasil melakukan IMD dan bayi yang tidak berhasil melakukan IMD.   Kata kunci : Inisiasi Menyusu Dini, Suhu Tubuh Bayi Baru Lahir                                                                                               THE DIFFERENCE BODY TEMPERATURE BETWEEN BABIES WHO SUCCESSFULLY INITIATE BREASTFEEDING EARLY AND BABIESWHO FAIL TO INITIATE EARLY BREASTFEEDING AT RSIA KIRANA SIDOARJO 2019  Background : The warmth of the mother’s chest can warm the baby, so that when the baby is in the mother’s breast immediately after birth or initiated early breastfeeding can reduce the mortality rate of newborns due to hypotermia.Purpose :the purpose of this study was to determine the difference in body temperature of newborns between infants who successfully initiated early breastfeeding and infants who did not succeed in initiating early breastfeedingMethods : analytical, cross sectional design, population 40 newborns, samples 35 newborns, Non Random Sampling techniques, the data accumulation using observation sheets and using chi-square test, with significant value α = 0.05 is when the statistical test results show p ≤ α then Ho is rejected.Result : The body temperature of the newborn who succeeded in initiating early breastfeeding was 36.78ºC with 23 (65.7%) of infants none having hypothermia, the newborn baby's body temperature that did not succeed in doing this early breastfeeding was 35.78ºC With 8 infants experiencing hypothermia, while 4 babies with normal temperature. From the results of statistical tests obtained results with the value p = 0,000 <α = 0.05 then H1 accepted, meaning there is a difference in body temperature of a newborn who successfully initiated early breastfeeding and who did not succeed in Early Breastfeeding Initiation. Conclusion : There is a difference in the body temperature of a newborn between infants who successfully initiated breastfeeding and infants who are not successful in initiating early breastfeeding....Keywords : Early breastfeedinginitiation, newborns temperature

scholarly journals The Impact of Watching Television Sports Channels in Promotion of Sports Activities among the Students of University of Sargodha

2019 ◽  
Vol IV (I) ◽  
pp. 95-107
Author(s):  
Sajjad Ali ◽  
Muhammad Saqib Ilmas ◽  
Shajee Hassan
Keyword(s):  
Statistical Tests ◽  
Sampling Technique ◽  
Chi Square ◽  
Uses And Gratification ◽  
Uses And Gratification Theory ◽  
Chi Square Test ◽  
Set Up ◽  
The University ◽  
The Impact ◽  
Sports Activities

This study analyzes the impact of watching television sports channels on the promotion of sports activities among the students of the University of Sargodha. The aim of the study is to explore the impact of sports channels on students. Previous researches are used to set up the concepts of the present study. In this research, a survey technique is used to collect the data. The population of the study consists of male and female students of the University of Sargodha. In this research, the Stratified and Purposive sampling technique is used, through which specification characteristics of the respondent's demographics. The study explores the impact of sports channels in the view of Uses and Gratification Theory. The data for this study is collected through the use of a well-designed questionnaire. Chi-square test and other statistical tests like ANOVA and t-Test are applied to test the hypothesis. The finding shows that more the exposure to TV sports channels more the information level of students of the University of Sargodha.

scholarly journals POLIO VACCINATION

2018 ◽  
Vol 25 (01) ◽  
pp. 67-72
Author(s):  
Ahmad Ali ◽  
Liaqat Ali ◽  
Mussawar Shah ◽  
Naimatullah Khan ◽  
Muhammad Shafee ◽  
...  
Keyword(s):  
Viral Disease ◽  
Cultural Barriers ◽  
Religious Institutions ◽  
Test Statistics ◽  
Chi Square ◽  
Religious Background ◽  
Polio Vaccine ◽  
Polio Vaccination ◽  
Chi Square Test ◽  
Infantile Paralysis

Background: Polio is a viral disease causing infantile paralysis in the community.This study cultural and traditional barriers to Polio Vaccination. Pakistan in order to explore thecultural and traditional barriers in vaccination against polio. Setting: Tehsil Kwazakhela, Swat,KPK. Methods: A total of 200 respondents were selected from 364 household’s population. Aconceptual framework based on cultural barriers to polio vaccination (dependent variable) andimpediments to polio vaccination (dependent variable) was worked out and uni-variate analysisfor percentage and Chi square test statistics was carried out for association between variables.Results: At uni-variate level majority of the respondent’s i.e. 98% argued that misconceptionis a great issue in the area and 98.5% respondents treat the new born through traditional way.Furthermore, 79.5% masses were in favor of clergy’s fatwah and 95% were agreed that poliovaccine caused immodesty, 81.5% were facing hurdles due to religious background, and 68 %responded that polio vaccination affected from terrorism, 92% agreed that polio vaccination isagainst the prevalent culture. At bivariate level myth, clergies fatwah, polio vaccine is an Americanploy and common superstition spread by radicals were found significant with impediments topolio vaccination. Conclusion: A well patronized campaign over media through proper displayof victims from polio with explicit display of agonies from the victims is essential. Support fromclergies and other regional religious institutions will help in the success of campaign to fightagainst Polio.

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