scholarly journals Novel herbs and drugs for endometriosis management: A review on current and futuristic therapies

2021 ◽  
Vol 12 (2) ◽  
pp. 1404-1414
Author(s):  
Komal S ◽  
Harikrishnan N ◽  
Gejalakshmi S ◽  
Kayalvizhi S ◽  
Hemamalini Baskaran ◽  
...  
Keyword(s):  
Reproductive Age ◽  
Public Health Issue ◽  
Medical Treatments ◽  
Novel Treatments ◽  
Chemical Treatments ◽  
Novel Drugs ◽  
Anti Oxidant ◽  
Gynecological Disease ◽  
Immediate Surgery ◽  
Endometriosis Surgery

A disorder with estrogen dependency comprising of inflammatory lesions outside the uterus, causing pain and inflammation in pelvis and affecting women of reproductive age with infertility and post reproductive age is endometriosis. Endometriosis is viewed as public health issue with a major impact on quality of life of women. Medically advanced computational and chemical treatments are available to treat the progression of the disease by diagnostic imaging, clinical examinations, imaging and laparoscopy often leading to immediate surgery. A warrantable rethinking on the diagnosis and management of endometriosis is to be assessed and medical treatments should be considered as first-line option for therapeutic relief for endometriosis by suppressing the systemic estrogen levels providing desirable efficacy and safety, prior to performing endometriosis surgery. The aim of this review is to describe natural products, hormonal and non-hormonal compounds that suppress the progression of endometriosis. Various herbal, conventional and traditional therapies are investigated to treat gynecological disease, endometriosis. The information in this paper include various studies assessing the use of novel treatments in addition to the herbal and hormonal products in the endometriosis therapy. Most of the studies involved were in scrutinizing the pharmacological activity profiles of various sources of drugs in endometriosis treatment, hormonal drugs involved suppression and regulation of various hormones along with various factors like anti-inflammatory, anti-oxidant, anti-proliferative and apoptotic, anti-angiogenic, anti-invasive, immunomodulatory, and estrogen modulating activity. However, novel drugs and medicinal plants are also reviewed here to draw attention to the molecules of drugs that target at multiple points for rational therapeutic treatment of endometriosis.

scholarly journals Sexual Function in Women With and Without Female Genital Mutilation in Reproductive Age in South of Iran

2021 ◽  
Author(s):  
Mahshid Bokaie ◽  
Samaneh Hatefi ◽  
Shahnaz Mojahed ◽  
Nasibeh Roozbeh
Keyword(s):  
Sexual Function ◽  
Female Genital Mutilation ◽  
Reproductive Age ◽  
Public Health Issue ◽  
P Value ◽  
Women Of Reproductive Age ◽  
Genital Mutilation ◽  
Significant Difference ◽  
The Impact ◽  
Female Genital

Abstract Objectives: Female genital mutilation (FGM) is an important public health issue, especially in developing countries and it is still done in some parts of Iran. This study aimed to investigate the effect of FGM on the sexual function of women of reproductive age in Hormozgan province/IRAN.Study design: This study is a descriptive-analytical case-control study that was conducted in 2020 on 209 married women of reproductive age (15-49) in rural areas of Minab and Sirik counties in Hormozgan province/IRAN. Main outcome measures: The reliable and valid questionnaire FSFI for assessing female sexual function in the two groups was used after to obtain informed and voluntary consent from all participants and data with SPSS v: 16 software and with using descriptive/ Analytical statistics tests with a significant level of 0.05 were examined. Results: There is a significant difference between mutilated and non-mutilated women in the total score of sexual function(22.18±3.23 versus 23.41±2.52 respectively, p=0.023) and the domains of lubrication(3.04±0.62 versus 3.3±0.53 respectively, P=0.000), orgasm(3.81±0.63 versus 4.08±0.47 respectively, P=0.003), and sexual satisfaction(5.09±0.1 versus 5.37±0.87 respectively, P=0.017) But in the domains of desire, arousal, and pain in the two groups was no significant difference(P-value>0.05). Conclusion: FGM maybe leads to sexual dysfunction. Although most women were reluctant to perform mutilation on their daughters, more educational Actions are suggested to educate women about the impact of female mutilation on their sexual function. Counseling programs are also recommended to improve the sexual function of mutilated women.

scholarly journals Concept of Granthi with reference to uterine fibroid: An Ayurveda review

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
Jaya Umate ◽  
Soudamini Chaudhari
Keyword(s):  
Life Span ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Modern Science ◽  
Reproductive Age ◽  
Significant Morbidity ◽  
Reproductive Life ◽  
Reproductive Life Span ◽  
Gynecological Disease ◽  
Reproductive Age Group

Uterine fibroids are the commonest benign tumor of the uterus and also the commonest benign solid tumor in the female. It can cause significant morbidity in women of a reproductive life span. The exact cause of uterine fibroid is unknown. Prevalence of uterine fibroid 5 -20 % of women in the reproductive age group. It can cause significant morbidity in women of a reproductive life span. Not all fibroids cause symptoms. 50% of women are asymptomatic. Fibroids mainly cause symptoms like menorrhagia, dysmenorrhea and cause pressure symptoms on adjacent viscera i. e. bladder, uterus, rectum which affects the everyday activities of women. In Ayurveda all gynecological disease explained under the term yonivyapad. It can be explained as the anatomical and functional abnormalities of the female reproductive system. In Ayurveda granthi can be correlated with the uterine fibroid. In modern science uterine fibroid treats medically, surgically. But it is challenging to establish a satisfactory conservatory medical treatment to date. so in Ayurveda the main purpose is the management of granthi by samprapti vighatan by use of medicine.

A Detailed Review on Herbal Treatments for Treatment of PCOS- Polycystic ovary syndrome (PCOS)

2021 ◽  
Vol 02 ◽  
Author(s):  
Ankita Wal ◽  
Pranay Wal ◽  
Nikita Saraswat ◽  
Simran Wadhwa
Keyword(s):  
Side Effects ◽  
Sleep Disturbances ◽  
Reproductive Age ◽  
Tinospora Cordifolia ◽  
Ocimum Sanctum ◽  
Tribulus Terrestris ◽  
Asparagus Racemosus ◽  
Anti Oxidant ◽  
Diseased Condition ◽  
Positive Effect

Background: The review gives a brief about PCOS and the symptoms related to the disease. Around 2.2 to 26% cases of PCOS are present globally. The disorder generally occurs in the reproductive age group women. The review has a mention of few herbs which can be used to correct the diseased condition. The various herbs have positive effect on the diseased condition and can be used to cure symptoms like hypothyroidism, hyperplasia, obesity, diabetes, Menorrhagia, sleep disturbances, cardiovascular problems, hyperlipidemia, hirsutism, infertility, irregular menstrual cycle, etc. The search engines used are PubMed, various review articles, etc. Methods: The method involved in the review includes various medicinal herbs that have seen to affect women having various gynecological disorders like Poly Cystic Ovarian Syndrome, Uterine Fibroids, and Endometriosis. Materials: The herbs included in the review include Bauhinia variegata useful in hormone imbalance, Phyllanthus emblica, Terminalia bellirica, Terminalia chebula, and Commiphora wightii are used to regulate the hormones, Cinnamon cassia acts as an anti-oxidant, Tribulus terrestris improves reproductive dysfunction, Hypericum perforatum regulates depression, Commiphora myrrha prevents menorrhagia, Nigella sativa controls cholesterol, Saraca asoca has estrogenic action, Asparagus racemosus promotes folliculogenesis, Tinospora cordifolia regulates menstrual flow, Ocimum sanctum as an anti-oxidant. Conclusion:: The plants taken had positive effect on women with PCOS without causing any side-effects. The natural herbs used for the treatment of PCOS did not have any side effects and treated the diseased condition naturally. The review is to understand the natural plants available for the treatment of the disease naturally. The herbs can be used individually or can be used in combination.

A case of share psychotic disorder induced by mephedrone

2016 ◽  
Vol 33 (S1) ◽  
pp. S309-S309
Author(s):  
R.A. Baena ◽  
Y. Lázaro ◽  
J. Rodriguez ◽  
L. Olivares ◽  
A. Matas ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Scientific Literature ◽  
Case Reports ◽  
Rare Condition ◽  
Psychiatric History ◽  
Psychiatric Disturbance ◽  
Medical Treatments ◽  
Novel Drugs ◽  
Close Relationship ◽  
Competing Interest

IntroductionShare psychotic disorder “folie à deux” is a rare condition characterized by the transmission of delusional aspects from a patient to another linked by a close relationship. We report the case of two Spanish men who have experienced a combined delusional episode induced by mephedrone.ObjectivesDescribe a case of share psychotic disorder induced by mephedrone. Make a review on scientific literature about the use of mephedrone (little is known about the psychiatric consequences of the use of these compounds). The patients had no psychiatric history.AimsShow the danger of these novel drugs that are often bought as apparently safe and legal.ConclusionsShare psychotic disorder was first introduced by Lasegue and Falret who hypothesized that transmission of psychiatric disturbance from one person to another was possible under certain circumstances. The correlation of symptoms with the intake of these substances is supposed in the light of a negative psychiatric history and no other concomitant medical treatments. An important number of case reports documented deaths related to the ingestion of mephedrone. Another problem is that these substances are not detected by standard blood and urine test so that the diagnosis of intoxication is often delayed.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Impact of Seaweed-derived Xanthophyll Carotenoid on Obesity Management: Overview of the Last Decade

2020 ◽  
Author(s):  
Oyindamola Vivian Ojulari ◽  
Seul Gi Lee ◽  
Ju-Ock Nam
Keyword(s):  
Biological Activities ◽  
Antioxidant Properties ◽  
In Vivo Studies ◽  
Health Issues ◽  
Major Health ◽  
Chemical Treatments ◽  
Anti Oxidant ◽  
Published Research

Present-day lifestyles associated with high calorie-fat intake and accumulation, as well as energy imbalance, has led to the development of obesity and its comorbidities, which have emerged as some of the major health issues globally. To combat the disease, many studies have reported the anti-obesity effects of natural compounds in foods, with some advantages over chemical treatments. Carotenoids, particularly xanthophyll derived from seaweeds, have attracted the attention of researchers due to their notable biological activities, which are associated mainly with their antioxidant properties. Their involvement in oxidative stress modulation, regulation of major transcription factors and enzymes as well as their antagonistic effects on various obesity parameters have been examined in both in-vitro and in-vivo studies. The present review is a collation of published research over the last decade on the anti-oxidant properties of seaweed xanthophyll carotenoids, with a focus on fucoxanthin and astaxanthin and their mechanisms of action in obesity prevention and treatment.

scholarly journals Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments

2021 ◽  
Vol 22 (18) ◽  
pp. 9905
Author(s):  
Antón L. Martínez ◽  
José Brea ◽  
Sara Rico ◽  
María Teresa de los Frailes ◽  
María Isabel Loza
Keyword(s):  
Mental Illness ◽  
Cognitive Impairment ◽  
Negative Symptoms ◽  
Genetic Factors ◽  
Cognitive Deficit ◽  
Pharmacological Treatments ◽  
Novel Treatments ◽  
Novel Drugs ◽  
Positive And Negative Symptoms ◽  
Effective Treatments

Schizophrenia is a major mental illness characterized by positive and negative symptoms, and by cognitive deficit. Although cognitive impairment is disabling for patients, it has been largely neglected in the treatment of schizophrenia. There are several reasons for this lack of treatments for cognitive deficit, but the complexity of its etiology—in which neuroanatomic, biochemical and genetic factors concur—has contributed to the lack of effective treatments. In the last few years, there have been several attempts to develop novel drugs for the treatment of cognitive impairment in schizophrenia. Despite these efforts, little progress has been made. The latest findings point to the importance of developing personalized treatments for schizophrenia which enhance neuroplasticity, and of combining pharmacological treatments with non-pharmacological measures.

scholarly journals Polycystic Ovary Syndrome: A Brief Review with Recent Updates

2020 ◽  
Vol 7 (2) ◽  
pp. 84-99
Author(s):  
Shahana Shermin ◽  
Aysha Noor ◽  
Samsad Jahan
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Health Workers ◽  
Polycystic Ovary ◽  
Signs And Symptoms ◽  
Reproductive Age ◽  
Treatment Modalities ◽  
Public Health Issue ◽  
Ovary Syndrome ◽  
Significant Public Health ◽  
Meta Analyses

Polycystic ovary syndrome (PCOS) is a chronic, complex and the most common endocrine disorder observed in women of reproductive age. This syndrome is heterogeneous by nature and is characterized by a combination of signs and symptoms of androgen excess and ovarian dysfunction. It is a significant public health issue. PCOS is associated with many comorbidities and also has a number of long-term metabolic and other consequences. The prevalence is quite high and is increasing day by day. It is a syndrome to be prevented by awakening awareness both in health workers and patients. There are many areas of controversies starting from its diagnosis, pathogenesis, consequences and treatment modalities. This review is an attempt to summarize the evolution of the diagnosis and current management guidelines and also to look into the future approaches. An extensive search was made through the Cochrane database, available systematic reviews and meta-analyses and recent international guidelines for providing an updated scientific overview of PCOS. Delta Med Col J. Jul 2019 7(2): 84-99

scholarly journals Niclosamide suppresses macrophage-induced inflammation in endometriosis†

2020 ◽  
Vol 102 (5) ◽  
pp. 1011-1019 ◽  
Author(s):  
Nikola Sekulovski ◽  
Allison E Whorton ◽  
Tomoki Tanaka ◽  
Yasushi Hirota ◽  
Mingxin Shi ◽  
...  
Keyword(s):  
Cell Viability ◽  
Stromal Cells ◽  
Human Peripheral Blood ◽  
Treatment Options ◽  
Current Treatment ◽  
Reproductive Age ◽  
Cytokines And Chemokines ◽  
Secreted Factors ◽  
Limited Efficacy ◽  
Gynecological Disease

Abstract Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy of current treatment options, a critical need exists to develop new and effective treatments for endometriosis. Niclosamide is an efficacious and FDA-approved drug for the treatment of helminthosis in humans that has been used for decades. We have reported that niclosamide reduces growth and progression of endometriosis-like lesions via targeting STAT3 and NFĸB signaling in a mouse model of endometriosis. To examine the effects of niclosamide on macrophage-induced inflammation in endometriosis, a total of 29 stage III–IV endometrioma samples were used to isolate human endometriotic stromal cells (hESCs). M1 or M2 macrophages were isolated and differentiated from fresh human peripheral blood samples. Then, hESCs were cultured in conditioned media (CM) from macrophages with/without niclosamide. Niclosamide dose dependently reduced cell viability and the activity of STAT3 and NFκB signaling in hESCs. While macrophage CM stimulated cell viability in hESCs, niclosamide inhibited this stimulation. Macrophage CM stimulated the secretion of proinflammatory cytokines and chemokines from hESCs. Most of these secreted factors were inhibited by niclosamide. These results indicate that niclosamide is able to reduce macrophage-induced cell viability and cytokine/chemokine secretion in hESCs by inhibiting inflammatory mechanisms via STAT3 and/or NFκB signaling.

Phytotherapy in endometriosis: an up-to-date review

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Luigi Della Corte ◽  
Marco Noventa ◽  
Michal Ciebiera ◽  
Maria Magliarditi ◽  
Zaki Sleiman ◽  
...  
Keyword(s):  
Well Being ◽  
Medical Treatments ◽  
Promising Alternative ◽  
Estrogen Activity ◽  
Gynecological Disease ◽  
Anti Inflammatory ◽  
Hormonal Therapies ◽  
Benign Gynecological Disease ◽  
Complementary Strategy

AbstractEndometriosis is a benign gynecological disease which symptoms can provide a severe impact on patient’s quality of life with subsequent impact on psychological well-being. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Nevertheless, the efficacy of conventional medical treatments is limited or intermittent in most of the patients due to the associated side effects. Therefore, a woman with endometriosis often search for additional and alternative options, and phytotherapy might be a promising alternative and complementary strategy. Different medicinal plants, multicomponent herbal preparations, and phytochemicals were investigated for pharmacological proprieties in endometriosis therapy. In most of the cases, the effect on endometriosis was related to phenolic compounds, such as flavonoids and phenolic acids reporting anti-inflammatory, proapoptotic, antioxidant, and immunomodulatory functions. Moreover, some phytochemicals have been related to a strong phytoestrogenic effect modulating the estrogen activity. Although promising, available evidence is based on in vitro and animal models of endometriosis with a limited number of well-performed clinical studies. There are almost none randomized control trials in this area. Therefore, properly constructed clinical trials are mandatory to achieve more conclusive results about the promising role of phytotherapy in the management of endometriosis.

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