An in vivo study to record bite force until denture dislodgement of an existing and new maxillary denture with and without use of denture adhesive

2018 ◽  
Vol 10 (1) ◽  
pp. 6-12
Author(s):  
Chandrakala .V ◽  
Nandeeshawar. D.B
Keyword(s):  
P Value ◽  
Complete Dentures ◽  
Time Intervals ◽  
Denture Adhesive ◽  
Group I ◽  
Comparison Results ◽  
Denture Adhesives ◽  
Student’S T ◽  
Student’S T Test

OBJECTIVES: Thoughadequate retention is a basic requirement, there are situations in which it is not possible to obtain desirable optimal retention. Because of ill effects to supporting tissues due to many mechanical aids for retention, many patients frequently resort to the use of denture adhesives. Due to technique sensitivity and limitations of many techniques to measure the retention of a complete denture, this study was planned to evaluate and compare the BFDD with the following aims and objectives; • To measure BFDD in an existing denture without and with use of denture adhesive. • To measure BFDD in new denture without and with use of denture adhesive. • To compare BFDD between an existing and new denture without and with use of denture adhesive. METHODOLGY: Among total of twenty edentulous subjects, Group I& Group II for Method A & B were made. The data obtained by BFDD measurements were statistically analyzed using ANOVA for different time intervals and student’s t-test for group wise comparison. RESULTS AND CONCLUSION: The results of the study showed that consistent improvements were observed in BFDD when adhesive was used. The p-value was highly significant (p<0.001 HS) at all time intervals for both existing and new set of complete dentures.

Rate of occupational leg swelling is greater in the morning than in the afternoon

2009 ◽  
Vol 24 (1) ◽  
pp. 21-25 ◽  
Author(s):  
C E Q Belczak ◽  
J M P de Godoy ◽  
R N Ramos ◽  
M A de Oliveira ◽  
S Q Belczak ◽  
...  
Keyword(s):  
P Value ◽  
Compression Stockings ◽  
Shift Workers ◽  
Group Iii ◽  
Group I ◽  
Time Period ◽  
Before And After ◽  
Working Day ◽  
Student’S T ◽  
Student’S T Test

The aim of this study was to investigate the rate of occupational leg swelling depending on the time period of the working day. Volumetric variations of the legs of 70 hospital employees, enrolled in three groups, were evaluated. Group I: 35 morning shift workers; Group II: 35 afternoon shift workers; and Group III: 15 individuals randomly selected from Groups I and II, who were evaluated on the day they worked 12 hours consecutively. Volumetry was performed before and after each shift for both legs of the participants in Groups I and II. For Group III volumetry was performed early in the morning, at noon and in the evening. For statistical analysis, the Student's t-test and Mann-Whitney test were used with an alpha error of 5% being considered acceptable ( P value < 0.05). Significant increases in volume were recorded for the limbs in all three groups ( P value < 0.001). On comparing Groups I and II, the accumulation of fluids was significantly higher in the morning than in the afternoon ( P value < 0.003). Asymptomatic workers may present with oedema of the legs during their work with the rate of oedema being different for morning and afternoon shifts. The possibility of wearing compression stockings should be considered for this type of work.

scholarly journals A Study to Evaluate and Compare Efficacy of Denture Adhesives in Complete Denture Patients

2018 ◽  
Vol 06 (01) ◽  
pp. 007-013
Author(s):  
Supreet Chhabra ◽  
Sandeep Garg ◽  
Nidhi Kalra
Keyword(s):  
Complete Denture ◽  
P Value ◽  
Time Intervals ◽  
Intergroup Comparison ◽  
Significant Difference ◽  
Denture Adhesives ◽  
Spss Software ◽  
Edentulous Patients ◽  
Post Hoc

Abstract Aim To evaluate and compare the retentive ability of commonly available denture adhesives in completely edentulous patient at different time intervals. Materials and Methods Ten completely edentulous patients were included in the present in vivo study. Complete dentures were fabricated, and retention of maxillary denture was recorded with and without denture adhesives (Fixon Supergrip powder, Fittydent paste, Super Poligrip powder, and Fit Fix powder) at 15 minutes, 1 hour, and 2 hours intervals for all patients. Force at which denture dislodged was recorded with digital force gauge and was considered as retentive value. Data obtained were tabulated and subjected to statistical analysis using SPSS software version 17.5 (Trial version). Intragroup comparison was done using paired t-test. Intergroup comparison was done using analysis of variance (ANOVA) followed by post hoc Tukey's test. p-Value ≤ 0.05 was considered significant in all tests. Results Mean retention force of maxillary complete denture achieved with all four denture adhesives was significantly better than without adhesive at all time intervals. Intragroup comparison showed that each adhesive exhibited no change (p ≤ 0.05) in retention from 15 minutes to 2 hours interval except Fixon Supergrip powder adhesive which showed significant decrease (p = 0.009) in retention from 1 hour to 2 hours. Intergroup comparison revealed no statistically significant difference in retention of maxillary dentures with different denture adhesives at all time intervals (p ≥ 0.05). Conclusion Within the limitations of the study, it was concluded from the present study that all four adhesives irrespective of their form can be used to improve retention of dentures.

scholarly journals Effect of ondansetron on spinal induced hypotension in caesarean deliveries

2020 ◽  
Vol 8 (4) ◽  
pp. 193-199
Author(s):  
Pujan Balla ◽  
Anil Shrestha ◽  
Ninadini Shrestha ◽  
Navindra Bista ◽  
Moda Nath Marhatta
Keyword(s):  
Spinal Anesthesia ◽  
Elective Caesarean Section ◽  
P Value ◽  
Chi Square ◽  
Induced Hypotension ◽  
Intergroup Comparison ◽  
Chi Square Test ◽  
The Mean ◽  
Student’S T ◽  
Student’S T Test

Background: Spinal anesthesia is the preferred technique of anesthesia employed for caesarean sections. However, it is very often complicated by hypotension. Different drugs and techniques have been used to prevent the hypotension induced by spinal anesthesia. In this study, the effect of ondansetron on the prevention of hypotension after spinal anesthesia was evaluated. Objectives: To determine the effect of prophylactic ondansetron on prevention of spinal induced hypotension in elective caesarean section. Methodology: Eighty-six parturients planned for elective caesarean deliveries were randomized into two groups of 43 each. Group O received Ondansetron 4 mg (4 ml) and Group S received Normal Saline (4 ml) intravenously 10 minutes prior to spinal anesthesia. Blood pressure, heart rate, phenylephrine requirements, occurrence of nausea and vomiting and APGAR scores of neonates were compared between the groups. Hemodynamic data was analyzed using Student’s t-test for intergroup comparison and ANOVA was used for intragroup comparison. Categorical data was analyzed using Pearson Chi-Square test. For all determinants, p-value <0.05 was considered significant. Results: Occurrence of hypotension in Group O (20.9 %) was significantly lower than in Group S (72.1%) (p < 0.05). The mean arterial pressure was significantly higher in Group O at 2, 6, 8, 12 and 14 minutes (p < 0.05). The use of phenylephrine (37.21 mcg vs. 146.51 mcg, p < 0.05) and occurrence of nausea (11.6%, vs. 41.9% p < 0.002) was significantly lower in ondansetron group. Conclusion: Ondansetron is effective in preventing spinal induced hypotension in elective caesarean sections.

Heparan sulphate and hyaluronic acid components of the glycocalyx do not play a role in flow-mediated dilation of the iliac in the anaesthetized pig

2019 ◽  
Vol 97 (8) ◽  
pp. 746-752
Author(s):  
T. Ruane-O’Hora ◽  
D. O’Malley ◽  
M.M. Buckley ◽  
F. Markos
Keyword(s):  
Shear Stress ◽  
Hyaluronic Acid ◽  
Heparan Sulphate ◽  
Flow Mediated Dilation ◽  
Similar Increase ◽  
Shear Stress Sensor ◽  
Before And After ◽  
Student’S T ◽  
Student’S T Test

The shear-stress sensor function of vascular glycocalyx heparan sulphate and hyaluronic acid was investigated in vivo by assessing flow-mediated dilation before and after their removal. Heparinase III exposure (100 mU·mL−1 for 20 min;n = 6) did not significantly affect flow-mediated dilation of the iliac, from 0.42 ± 0.08 mm (mean ± SEM) to 0.34 ± 0.07 mm after (P = 0.12; paired Student’s t test) for a statistically similar increase in shear stress; 18.24 ± 4.2 N·m−2 for the control and 15.8 ± 3.6 N·m−2 for the heparinase III experiment (P = 0.18). Hyaluronidase exposure (0.14–1.4 mg·mL−1 for 20 min; n = 8) also did not significantly reduce flow-mediated dilation of the iliac, which averaged 0.39 ± 0.08 mm before and 0.38 ± 0.09 mm after (P = 0.11) for a statistically similar increase in shear stress; 11.90 ± 3.20 N·m−2 for the control and 9.8 ± 3.33 N·m−2 for the hyaluronidase experiment (P = 0.88). Removal of both heparan sulphate and hyaluronic acid was confirmed using immunohistochemistry. Neither the heparan sulphate nor the hyaluronic acid components of the glycocalyx mediate shear-stress-induced vasodilation in conduit arteries in vivo.

scholarly journals Effects of early unilateral mandibular first molar extraction on condylar and ramal vertical asymmetry

2014 ◽  
Vol 08 (02) ◽  
pp. 178-183 ◽  
Author(s):  
Koray Halicioglu ◽  
Mevlut Celikoglu ◽  
Suleyman K. Buyuk ◽  
Ahmet E. Sekerci ◽  
Celal Candirli
Keyword(s):  
Asymmetry Index ◽  
T Test ◽  
Control Group ◽  
Missing Teeth ◽  
Anterior Crowding ◽  
Mandibular Asymmetry ◽  
Group I ◽  
Student’S T ◽  
Mandibular First Molar ◽  
Student’S T Test

ABSTRACT Objective: The objective of the following study is to investigate the mandibular vertical asymmetry in a group of patients with early unilateral mandibular first molar extractions. Materials and Methods: Mandibular asymmetry index measurements (condylar, ramal and condylar-plus-ramal) were performed on the panoramic radiographs of a study group including 51 patients (mean age: 18.60 ± 1.11 years) and a control group of 51 patients (mean age: 18.53 ± 1.29 years). Group I included patients with a unilateral mandibular first molar extracted before the age of 12 years. Group II included patients with no extractions and had excellent Class I relationships, no missing teeth and slight or moderate anterior crowding. A paired t-test was used to determine possible statistically significant differences between the sides for the measurements. Student's t-test was used for the comparison of asymmetry index values between the groups and genders. Results: No group showed statistically significant sex-or side-specific differences for posterior vertical height measurements. Condylar asymmetry index and ramal asymmetry index measurements were not statistically different between the groups, while condylar-plus-ramal asymmetry index (CRAI) measurements were statistically different between the groups (P = 0.019). Conclusions: A slight difference for CRAI value was found in patients with early unilateral mandibular first molar extractions.

Effect of in Vivo Treatment with Delta9-THC on Mice Adrenal Gland

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
E. Moura ◽  
C. Esteves-Pinto ◽  
M.P. Serrão ◽  
I. Azevedo ◽  
M. Vieira-Coelho
Keyword(s):  
Adrenal Gland ◽  
Hpa Axis ◽  
Chronic Administration ◽  
Test Results ◽  
Gland Weight ◽  
Adrenal Gland Weight ◽  
Reduce Activity ◽  
Student’S T ◽  
Student’S T Test

Introduction:The efficacy of antidepressants has been linked in part to their ability to reduce activity of the hypothalamic-pituitary-adrenal (HPA) axis; however, the mechanism by which antidepressants regulate the HPA axis is largely unknown. Recent research has demonstrated that endocannabinoids can regulate the HPA axis and exhibit antidepressant potential.Aim:The purpose of this study was therefore to evaluate the effect of chronic administration of delta-9-tetrahydrocannabinol (delta9-THC) on the adrenal gland of mice.Methods:Delta9-THC (10 mg/kg, 1 THC:1 chremophor:18 saline) or vehicle (CT, 1 chremophor:18 saline) was administered i.p. for 10 days to C57Bl6 mice aged 15 weeks. At the end of the study rats were placed in metabolic cages. Noradrenaline (NA) and adrenaline (AD) levels in samples and tissues were evaluated by HPLC-ED. Statistical analysis was done by ANOVA followed by Student's t test. Results are presented as mean±SEM.Results:Treatment with delta9-THC did not produce changes in mice weight (CT: 25±1; delta9-THC: 24±1 g, n=5-6) but produced a significant reduction in adrenal gland weight (CT: 1.4±0.2; delta9-THC: 0.6±0.1* mg, n=5-6, *P˂0.01). However, treatment with delta9-THC did not produce significant changes in NA and AD adrenal content (NA: 7.5±2.1, 5.3±0.6; AD: 14.1±1.1, 11.1±2.1 nmol, CT and delta9-THC respectively, n=5-6) or in NA and AD urine levels (NA: 0.88±0.06, 1.18±0.17; AD: 0.64±0.07, 0.81±0.09 nmol/24h, CT and delta9-THC respectively, n=5-6).Conclusion:Chronic treatment with delta9-THC reduces adrenal gland weight in mice. These results suggest that endocannabinoids may act directly at the adrenal gland to regulate the HPA axis.

scholarly journals CLINICAL BIOCHEMISTRY DATABASE ANALYSIS: A RESTRICTED DIALYSIS COHORT /

2013 ◽  
Vol 33 (2) ◽  
pp. 162-168
Author(s):  
Martina Bellini ◽  
Paolo Paparella
Keyword(s):  
Retrospective Study ◽  
Clinical Biochemistry ◽  
Clinical Chemistry ◽  
P Value ◽  
Dialysis Patients ◽  
Database Analysis ◽  
Iron Storage ◽  
Inflammatory Profile ◽  
Student’S T ◽  
Student’S T Test

Summary Background: A retrospective study was undertaken to inves- tigate the biochemistry data of a restricted cohort of dialysis- related arthropathy patients. The aim of our study was to characterize this specific cohort of dialysis patients using a clinical chemistry database analysis. Methods: An elaboration of more than 160,000 items of biochemical data, collected from 2001 to 20|11, was made of 50 patients, 25 with dialysis-related arthropathy and 25 patients asymptomatic for arthropathy. A Student's t-test was applied, considering a P-value less than 0.05 as statistically significant. Results: Significant and relevant unexpected biochemical dif- ferences were found between the two groups of patients. The serum level of p2-microglobulin was similar, while fer- ritin values were significantly higher in symptomatic patients. We excluded the possibility that the ferritin difference between the two groups was due to different iron storage and to an inflammatory profile. Conclusions: The correct use of a biochemical database could permit to identify significant values which must be cor- related with clinical data, but which could be the first step to a wider research.

CD34+ Selection before Autologous Peripheral Blood Stem Cell Transplantation: Comparison of the Nexell Isolex 300i® and Miltenyi Biotec CliniMACS® Systems.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 1070-1070
Author(s):  
Simon Mantha ◽  
David G. Savage ◽  
Gwen L. Nichols ◽  
Donna Skerrett ◽  
Charles S. Hesdorffer
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Peripheral Blood ◽  
Plasma Cell Dyscrasia ◽  
P Value ◽  
Student’S T ◽  
Cd34 Selection ◽  
Number Of Cells ◽  
Student’S T Test

Abstract Autologous stem cell transplant has been used with variable success rates in the treatment of different malignancies. One of the potential causes of relapse is contamination of the stem cell collection by neoplastic cells. Purging the stem cells by CD34+ selection has been used to reduce such contamination. In this study two different devices were compared in their efficiency to achieve CD34+ selection of peripheral blood stem cells collected in individuals undergoing autologous transplant for breast cancer, neuroblastoma, plasma cell dyscrasia, lymphoma (both Hodgkin and non Hodgkin), rhabdomyosarcoma and amyloidosis. A total of 28 patients were randomized to CD34 selection on the Nexell Isolex 300i® system (NIS) or the Miltenyi Biotec CliniMACS® (MCMS) system. The prevalence of plasma cell dyscrasia was higher in the MCMS group (57%) than in the NIS group (22%). On the other hand, there were 2 cases of Hodgkin lymphoma and 2 cases of breast cancer in the NIS group, in comparison to none in the MCMS group. Average values for parameters of selection efficacy for the 19 patients transplanted are shown in table 1 (recovery = number of cells post / number of cells pre-selection X 100, viability measured with the trypan blue exclusion test). Transplant was done as per local protocols according to the type of malignancy. CD34+ cell dose was determined by institutional guidelines. Average values for engraftment are shown in table 2 (two patients who died before engraftment in the MCMS group were excluded from calculation of the mean values). One patient died of graft failure in the MCMS group in contrast to none in the NIS group. Although the numbers of patients are relatively low, this is the first randomized study in which the selection efficiency of the NIS and MCMS devices have been compared in patients receiving CD34-selected autografts. CFU-GM recovery and cell viability were lower, while neutrophil engraftment was slower in the MCMS group, but these differences were not statistically significant. Our data do not show any clinically significant advantage for either the NIS or MCMS selection device. Table 1 Device CD34+ recovery (%,range) CFU-GEMM recovery (%,range) CFU-GM recovery (%,range) Viability pre (%,range) Viability post (%,range) P-value calculated with Student’s t-Test. NIS 52 (16–76) 5 (1–14) 9 (0–42) 95 (91–99) 95 (90–99) MCMS 66 (48–75) 4 (1–5) 5 (0–9) 94 (80–99) 88 (60–100) P 0.17 0.71 0.57 0.69 0.16 Table 2 Device CD34+ infused (X 106/kg, range) Time to ANC ≥500 (days, range) Time to plt ≥20 (days, range) # Units plt P-value calculated with Student’s t-Test. NIS 3.6 (2.0–5.2) 12.2 (9–20) 15.9 (11–38) 19.4 (0–30) MCMS 3.6 (1.5–5.1) 15.1 (11- ∞) 16.8 (9-∞) 40.2 (6–150) P - 0.22 0.79 0.23

scholarly journals Comparative Evaluation of Antibacterial Efficacy of Four Toothpastes and Mouthwashes against Streptococcus mutans and Lactobacillus: An in vivo Study

2016 ◽  
Vol 1 (2) ◽  
pp. 60-65
Author(s):  
Jonathan E Sam ◽  
Paulaian Benin ◽  
Ruth H Beaulah ◽  
Gnanaseelan LNU ◽  
Lal Krishna ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Comparative Evaluation ◽  
Antibacterial Efficacy ◽  
Time Intervals ◽  
Group Iii ◽  
Antimicrobial Substances ◽  
Group I ◽  
Intergroup Comparison ◽  
Significant Difference

ABSTRACT Background Cariogenic microorganisms are the most important cause for occurrence of dental caries. Dentifrices and mouthwashes containing antimicrobial substances are proven to be effective in the eradication of these pathogens from the oral cavity. Aim To evaluate the antimicrobial efficacy of fluoride, chlorhexidine (CHX), herbal, and xylitol containing toothpastes and mouthwashes against Streptococcus mutans (S. mutans) and Lactobacillus (LB) in subjects within the age group of 18 to 22 years at time intervals of 1, 3, and 6 months. Materials and methods One hundred subjects were randomly divided into four groups. Group I: fluoride, group II: chlorhexidine, group III: herbal, group IV: xylitol and instructed to use toothpastes and mouthwashes containing the specific agents. Salivary samples were collected to evaluate the levels of S. mutans and LB at baseline, 1, 3, and 6 months. Bacterial levels were evaluated using caries risk test (CRT) kit. Data were analyzed using analysis of variance and post hoc test. Results During intragroup comparison, S. mutans levels in group I showed statistically significant difference among the four time intervals. On intergroup comparison, S. mutans levels after 6 months for groups I, II, III, and IV were 1.12, 1.16, 1.28, and 1.4 respectively. Conclusion It can be concluded that fluoride, CHX, and xylitol showed a significant reduction in S. mutans and LB count after a time period of 6 months while herbal group did not show a significant reduction in S. mutans and LB count at any intervals. How to cite this article Sam JE, Benin P, Beaulah RH, Gnanaseelan, Krishna L, Raja J. Comparative Evaluation of Antibacterial Efficacy of Four Toothpastes and Mouthwashes against Streptococcus mutans and Lactobacillus: An in vivo Study. J Oper Dent Endod 2016;1(2):60-65.

scholarly journals ACUTE APPENDICITIS

2015 ◽  
Vol 22 (09) ◽  
pp. 1212-1216
Author(s):  
Abdul Salam Memon ◽  
Shahida Khatoon ◽  
Riaz Ahmed Memon ◽  
Afzal Junejo
Keyword(s):  
Acute Appendicitis ◽  
Mean Platelet Volume ◽  
P Value ◽  
Platelet Volume ◽  
Chi Square ◽  
Chi Square Test ◽  
The Difference ◽  
Student’S T ◽  
Control Study ◽  
Student’S T Test

Objectives: To study mean platelet volume (MPV) in acute appendicitis andits correlation with leukocyte count. Study Design: Case control study Place and Duration:Department of Surgery, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabadfrom January 2013 to February 2014. Subjects and Methods: Subjects with clinical suspicionof acute appendicitis were selected according inclusion and exclusion criteria. A sample of 49acute appendicitis patients and 37 controls were studied. The Blood samples were collected insodium citrate vacutainers and processed on Sysmex KX 21 analyzers. The main analysis wasthe comparison of the difference of MPV between acute appendicitis and controls. Data wasanalyzed on SPSS version 21.0 by student’s t-test, Chi-square test and Pearson’s correlation (r)was used to evaluate association of MPV with platelet counts and leukocytes. A p-value of ≤0.05was taken significant. Results: The mean platelet volume and leukocytes were significantlyelevated in patients with acute appendicitis. MPV and leukocytosis in controls and cases werenoted as 7.93±2.1 vs. 9.10±2.9fl (p=0.0001) and 6980±120 vs. 13980±340 μL-1 respectively.MPV was positively correlated with leukocytosis (r=0.419) (p=0.0001), while Platelets showeda negative correlation. Conclusion: Elevated MPV and leukocytosis are observed in acuteappendicitis. MPV may be exploited for clinical diagnosis of acute appendicitis but in a properclinical context along with leukocytosis.

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