scholarly journals Adipokines level and insulin resistance in abdominally obese patients with acute ischemic non-lacunar hemispheric stroke

2019 ◽  
pp. 60-65
Author(s):  
M. Delva ◽  
N. Lytvynenko
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Serum Level ◽  
Abdominal Obesity ◽  
Obese Patients ◽  
Normal Body ◽  
Hemispheric Stroke ◽  
Significant Difference ◽  
Normal Body Weight ◽  
Transient Elevation

It has been examined serum concentrations of adiponectin, leptin and insulin resistance HOMA-IR index among patients with abdominal obesity II class and normal body weight patients in the acute phase of ischemic non-lacunar (atherothrombotic and cardioembolic) hemispheric strokes. There was absence of any significant difference in adipokines concentration and insulin resistance in normal body weight patients with acute stroke. Under the conditions of acute ischemic non-lacunar hemispheric stroke, patients with abdominal obesity II class have sustained reduction of adiponectin serum level at 1st and 10th day after stroke and transient elevation of leptin serum level, as well as HOMA-IR index at 1st day with subsequent return to basal values on the 10th day. The extents of these neuroendocrine changes in abdominally obese patients have a direct association with cerebral infarction volumes. These neuroendocrine peculiarities may be, at least partly, one reason of more severe stroke in abdominally obese patients.

scholarly journals TRAUMATIC DISEASE PECULIARITIES COURSE, ITS DIAGNOSTICS AND TREATMENT AT POLYTRAUMA IN SUFFER OBESE PATIENTS

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Obese Patients ◽  
Prognostic Features ◽  
Normal Body ◽  
Significant Difference ◽  
Normal Body Weight

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.

scholarly journals POS0358 EVALUATION OF THE EFFECT OF mTOR EXPRESSION ON THE CLINICAL MANIFESTATIONS OF KNEE OSTEOARTHRITIS IN OBESE AND NORMAL WEIGHT PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 409.2-409
Author(s):  
E. Strebkova ◽  
E. Tchetina ◽  
L. Alekseeva
Keyword(s):  
Body Weight ◽  
Knee Pain ◽  
Mammalian Target Of Rapamycin ◽  
Clinical Manifestations ◽  
Normal Weight ◽  
Womac Pain ◽  
Obese Patients ◽  
Normal Body ◽  
Knee Oa ◽  
Normal Body Weight

Background:Currently, a large number of molecular biological and genetic markers are known to be involved in the development of osteoarthritis (OA). The mammalian target of rapamycin (mTOR) signaling pathway is responsible for chondrocyte proliferation, cartilage matrix production, and cell growth. OA is characterized by increased mTOR synthesis, which is accompanied by an increase in proliferative activity and destruction of chondrocytes. Obesity is an important factor in the progression of knee OA. The study of mTOR expression in patients with OA and obesity is an urgent task in the development of personalized OA therapy.Objectives:To determine the expression of mTOR in patients with knee OA in combination with obesity and normal body weight. To evaluate the effect of mTOR on the clinical manifestations of OA in patients with different body mass index (BMI).Methods:The study included 73 female patients aged 45-65 y.o. with Kellgren-Lawrence stage II-III knee OA. The patients were divided into 2 groups: group 1 (n=50) with obesity (BMI > 30 kg / cm2) and group 2 (n=23) with normal or increased body weight (BMI < 30 kg/cm2). The average age of patients with obesity is 56.5 ± 5.87 years, without obesity - 58.7 ± 5.43 years. Clinical manifestations were evaluated by a WOMAС. RNA was isolated from the patients ‘ blood samples, which was used to determine the expression of mTOR.Results:Patients with knee OA with and without obesity did not differ in age. OA develops at an earlier age in obese patients, than in non-obese patients (p < 0.001). Patients from 1 group had a high BMI > 30 kg/m2 at the onset of OA. Obese patients had more severe knee OA is significantly more often detected: Kellgren-Lawrence stage III was determined in 10% of obese patients and in 4.35% - without obesity (p < 0.001). Significantly higher values of the WOMAC index pain, stiffness, joint functional failure, and total WOMAC were observed in obese patients (p = 0.006, p = 0.039, p = 0.037, and p = 0.014, respectively). Obese patients had higher VAS pain scores (p < 0.05) compared to patients with a lower BMI. Obese patients had a higher mTOR expression (p < 0.05) of 8.02±8.62, compared to non-obese patients. High mTOR expression was associated with VAS knee pain (r=0.78; p < 0.05) and WOMAC pain (r=0.89; p<0.05) in obese patients (Table 1).Table 1.Correlation of m-TORParametersmTOR (1 group, n=50)mTOR (2 group, n=23)Body weightр > 0,05р > 0,05Pain (VAS)r=0,78; р<0,05p = 0,07; r = 0,45Pain (WOMAC)r=0,89; р<0,05р > 0,05Total WOMACр > 0,05р > 0,05Conclusion:Our study showed that patients with obesity and knee OA have higher rates of mTOR expression, compared to patients with normal body weight. High mTOR expression correlates with the severity of knee pain in obese patients. Thus, the evaluation of mTOR expression in obese patients and knee OA plays an important role in predicting the severity of clinical manifestations of OA, and may influence the choice of personalized therapy tactics for such patients.Disclosure of Interests:None declared

Features of the course of acute pancreatitis in patients with obesity

2019 ◽  
Vol 91 (5) ◽  
pp. 1-5 ◽  
Author(s):  
Andriy Kebkalo ◽  
Olha Tkachuk ◽  
Adrian Reyti
Keyword(s):  
Acute Pancreatitis ◽  
Body Weight ◽  
Mortality Rate ◽  
The Body ◽  
Obese Patients ◽  
Correlation Relationship ◽  
Systemic Complications ◽  
Key Words Acute Pancreatitis ◽  
Normal Body ◽  
Normal Body Weight

Abstract The purpose of the study is to investigate the course of acute pancreatitis in obese patients, the development of local and systemic complications and mortality rates. Materials and methods We have taken and analyzed 482 histories of acute pancreatitis, who has been treatmented at Kyiv Regional Clinical Hospital from January 1, 2011 to February 2, 2019. The data were statistically processed in the Exel 2010 program using a descriptive method using relative , absolute numbers, mean square deviations and their errors. A correlation relationship between variables was studied using the Pearson criterion (R2). Testing the significance of the difference between the two independent groups was carried out with the help of the t-criterion of the Student. Results In our study we had 482 patients, 260 patients (54%) had obesity (the study group), for comparison, a control group of patients with normal body weight was chosen, the total number of which was 222 (46%) patients. Obesity patients had a higher average age (55.4 ± 9.4 years, p = 0.01), also they had statistically greater percentage of severe cases of acute pancreatitis (85 (32.7%) vs 16 (7.2%); p = 0.01 *). We note the increase in the percentage of the course of severe pancreatitis in patients with weight gain from 10.20% to 53.93% (p = 0.03) *. Obesity patients had the longer bed-days in the hospital than in patients with normal body weight. In addition, they observed an increase of twice the bed in the reanimation and intensive care unit (5.8 ± 0.8 vs 2.7 ± 0.5 days, p = 0.01 *). When investigating the mortality rate, it should be noted that the main cause of death was the progression of organ failure of 30 (6.3%), pulmonary embolism (TB) - 15 (3.1%) and DIC 18 (3.7%) . Conclusions. The presence of obesity in patients involves a high risk of severe acute pancreatitis, this risk increases with an increase in the body mass index. In addition, in obese patients we have a higher bed-day in-patient and in-patient-care settings, which increases the total cost of treatment and requires a cost-effective algorithm in the future. A high mortality rate in obese patients requires improved treatment algorithm. Key words: acute pancreatitis, obesity.

scholarly journals INFLUENCE OF HYGIENIC AND DIETARY HABITS ON INCIDENCE OF DENTAL CARIES IN YOUNG NORMAL-WEIGHT AND OVERWEIGHT SCHOOLCHILDREN

2019 ◽  
Vol 19 (4) ◽  
pp. 77-82
Author(s):  
O.V. Sheshukova ◽  
A. V. Veretilnik
Keyword(s):  
Body Weight ◽  
Dental Caries ◽  
Dietary Habits ◽  
Normal Weight ◽  
Permanent Teeth ◽  
Overweight Children ◽  
Normal Body ◽  
Dental Examination ◽  
Significant Difference ◽  
Normal Body Weight

This paper presents the analysis of foreign and domestic literature on the current state of the epidemic of obesity and evidence of its association with oral disease. The aim of this study was to assess the hygienic and dietary habits of overweight and normal-weight young schoolchildren and their association with dental caries. Materials and methods. The study included 628 children aged 6-11 years studying at primary schools of Poltava. We measured anthropometric data, assessed physical development, collected anamnestic data of children and carried out clinical dental examination. The oral hygienic state was assessed by using the simplified hygienic Green-Vermillion index (1964). Results. According to the findings of anthropometric survey obtained, we found out that 32, 64% (205 children) of the children were overweight. Having analyzed the data obtained by the questionnaire, it is safe to say that there is no noticeable difference in the hygienic habits between the primary schoolchildren involved in the study. Only about 70% of them brush their teeth every day, but only 15% of children get assistance from their parents or siblings. Such data are alarming due to the fact that as young children usually cannot clean their teeth properly therefore children under 10 should be under the control or guidance of their parents when brushing the teeth. Dietary habits of the overweight and normal-weight children are significantly different. The index of hygiene in children with excess body weight was within 2.1 scores that corresponds to unsatisfactory hygiene; children with normal body weight demonstrated significantly lower indicators ranging within 1.8 scores. The results of the dental examination showed that the caries prevalence was 60.78% and 58.63% for children with normal weight and excessive weight, respectively. Those figures did not differ significantly from the indicated age group of children with excessive and normal body weight. The study of the caries intensity showed that in the normal-weight children the df + DMF index was 1.89 ± 0.01, and the overweight children had the df + DMF 1.82 ± 0.04 index: thus, no significant difference was revealed. Caries of temporary teeth in children with excessive body weight was significantly seldom detected than in the group of children with normal body weight (2.46 ± 0.05 and 2.82 ± 0.02, respectively). The results of examining children with overweight and obesity demonstrated significantly lower intensity index of complicated caries of temporary teeth (1.07 ± 0.04 and 1.28 ± 0.02, respectively). Conclusions. Consequently, there is no significant difference in the hygienic habits between normal-weight and overweight children. As for dietary habits, there is a significant difference revealed by questioning the children. There is no difference in the hygienic index in the children of these two groups. The prevalence of caries was within the normal limits. A significant difference has been found in determining the caries intensity of permanent teeth in young school children of the studied groups. It is noteworthy that lower rates of caries intensity and its complications affecting temporary teeth have been found out in the overweight children when compared with peers having normal body weight; the patterns in the growth of the caries intensity for permanent teeth in the overweight children have been determined as well. Mostly due to inadequate hygiene, lack of balanced nutrition and adherence to a diet rich in carbohydrates, young children are especially vulnerable category of dental patients.

scholarly journals The mTOR kinase and its associated proteins in skin cells isolated during abdominoplasty in patients with normal body weight and obesity

2020 ◽  
pp. 40-46
Author(s):  
С.Г. Морозов ◽  
А.Е. Копасов
Keyword(s):  
Body Weight ◽  
Signaling Pathways ◽  
Complete Medium ◽  
Obese Patients ◽  
Kinase Signaling ◽  
Normal Body ◽  
Skin Cells ◽  
Mtor Kinase ◽  
Associated Proteins ◽  
Normal Body Weight

Цель работы - измерение уровня белков, ассоциированных с сигнальными путями киназы mTOR (mTOR, Raptor, Rictor, 4Е-ВР1 p70-S6K1, AKT) в клетках кожи выделенных при операции абдоминопластики у пациентов с нормальной массой тела и ожирением. Основное значение исследования - установление участия сигнальных путей киназы mTOR в патогенетических процессах при ожирении и их роли в развитии послеоперационных осложнений при операции абдоминопластики. Методика. Клетки кожи выделяли из операционного материала ферментативной обработкой, затем восстанавливали в полной среде, после чего проводили иммунотипирование маркеров рецепторов и внутриклеточных белков моноклональнми антителами меченными флуоресцентными красителями Интенсивность флуоресценции анализировали на проточном цитометре. Результаты. Проведено сравнение уровня белков, связанных с сигнальными путями киназы mTOR, в выделенных после абдоминопластики клетках кожи при ожирении и нормальной массе тела. Было установлено повышение уровня белков, ассоциированных с киназой mTOR, в клетках кожи пациенток с ожирением. Показано при ожирении преимущественное участие первого комплекса mTORC1 в активации клеток. Установлено повышение активности вторичных мессенджеров киназы mTOR - фактора 4E-BP1 и рибосомальной киназы p70-S6K1, передающих сигналы на рибосомы для синтеза белка в фибробластах и кератиноцитах кожи пациентов с ожирением после абдоминопластики. Заключение. Полученные данные отражают патогенетические особенности ожирения, что может иметь значение в развитии послеоперационных осложнений, наблюдаемых у пациенток с ожирением после абдоминопластики. Aim. To measure expression of kinase mTOR-associated proteins (mTOR, Raptor, Rictor, 4E-BP1 p70-S6K1, AKT) in skin cells isolated from patients with normal body weight and obesity after abdominoplasty. The importance of this study was in determining the role of mTOR kinase signaling pathways in the pathogenesis of obesity and obesity-associated complications after abdominal surgery. Methods. Skin cells were isolated from surgical material by enzymic treatment, restored in a complete medium, and then stained with monoclonal antibodies to receptors and intracellular proteins. The fluorescence intensity was analyzed with a flow cytometer. Results. Expression of proteins associated with mTOR kinase signaling pathways was compared in isolated skin cells from patients with obesity and normal body weight. Increased mTOR protein expression was found to be associated with obesity. The first mTORC1 complex primarily contributed to the activation of skin cells from obese patients after abdominoplasty. Activities of mTOR second messengers, 4E-BP1 kinase and ribosomal kinase p70-S6K1, which transmit signals to ribosomes for protein synthesis, were elevated in skin fibroblasts and keratinocytes of patients with obesity after abdominoplasty. Conclusion. Results of this study delineated features of the pathogenesis of obesity that may be related with postoperative complications of abdominoplasty typical for obese patients.

Peculiar features of obesity and metabolic disorders in the children presenting with Prader-Willi syndrome

2014 ◽  
Vol 60 (1) ◽  
pp. 24-31 ◽  
Author(s):  
N N Volevodz ◽  
E A Bogova ◽  
M V Nemtsova ◽  
M A Ermakova ◽  
T O Chernova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Lean Mass ◽  
Metabolic Disorders ◽  
Control Group ◽  
Similar Degree ◽  
Prader Willi Syndrome ◽  
Normal Body ◽  
Normal Body Weight ◽  
Prepubertal Age

Aim. The nalysis of peculiar features of obesity and metabolic disorders in the children presenting with Prader-Willi syndrome (PWS). Results of clinical, hormonal, and metabolic studies are presented obtained by the observation of 45 children of the prepubertal age suffering from obesity despite the normal body weight. The control group was comprised of 47 children presenting with exogenous constitutional obesity. The percent content of fatty mass in the patients with PWS and obesity was higher than in those with exogenous constitutional obesity (p=0.01) despite a similar degree of obesity. In contrast, the percent content of lean mass in the patients of the former group was significantly smaller (p<0.01). The prevalence of insulin resistance among the children with PWS and obesity was 11.1% compared with 42.5% in those with exogenous constitutional obesity (p=0.013). The blood leptin level, occurrence of dyslipidemia. and percent content of fatty mass in the children with PWS in the absence of obesity were similar to those in the patients with exogenous constitutional obesity.

DETERMINATION OF ADOLESCENT FOOD HABITS ON THE BASIS OF AGE, HEIGHT AND WEIGHT

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
ALBHA TIWARI ◽  
VIMLESH KUMAR TIWARI
Keyword(s):  
Body Weight ◽  
Fast Food ◽  
Food Habits ◽  
Age Groups ◽  
Normal Body ◽  
Lower Body Weight ◽  
Significant Difference ◽  
Normal Body Weight ◽  
Difference Body

Significant differences between nutritional and fast food habits were observed at the 13-15 years and 16-18 years age groups of boys and girls respectively. The girls in the age group and boys had non-significant difference. Body weight showed non-significant difference for fast food and nutritional diet for boys and girls. Body weight of boys increased by 8.90% over normal body weight of 13-15 years. Lower body weight was observed in 16-18 boys adolescent and 13-15 years and 16-18 years girls where body weight was lower than normal body weight. Fast food did not affect in the enhancement of body weight. Nutritional food had significant role in boy weight increase in both age groups.

scholarly journals Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 134
Author(s):  
Evgeniy Ovsyannikov ◽  
Sergey Avdeev ◽  
Andrey Budnevsky ◽  
Yanina Shkatova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Weight ◽  
Anxiety And Depression ◽  
Chronic Obstructive ◽  
Monitoring Device ◽  
Obese Patients ◽  
Obstructive Pulmonary Disease ◽  
Normal Body ◽  
Normal Body Weight ◽  
Anxiety Depression

Background and objectives: Obesity and anxiety and/or depression are common comorbidities in patients with chronic obstructive pulmonary disease (COPD). For doctors treating COPD, cough has a certain importance as a symptom. The purpose of this study was to figure out how obesity and anxiety/depression may influence the subjective assessment of cough. Materials and Methods: 110 patients with COPD participated in the study. The patients were divided into two groups, one including obese patients, and the other including patients with normal body weight. All patients filled out the hospital anxiety and depression scale (HADS) questionnaire, evaluated the severity of their cough by using visual analogue scale (VAS) on the 1st and 10th day of treatment, and underwent a 12 h cough monitoring with a special cough monitoring device both on the 1st and the 10th day of treatment. Results: The severity of anxiety according to the HADS in patients with COPD and normal body weight was significantly higher than in patients with COPD and obesity, corresponding to 9.25 ± 1.37 and 8.20 ± 1.18 points, respectively (p = 0.0063). The patients with normal body weight and obesity, but without anxiety and depression, subjectively noted an improvement in their well-being on the 10th day of treatment (p = 0.0022, p = 0.0021, respectively). In subgroups with normal body weight and obesity with anxiety and/or depression, the mean values for VAS on day 10 did not change significantly (p = 0.1917, p = 0.1921, respectively). Also, patients from the subgroup with normal body weight and anxiety/depression had a significantly higher assessment of their cough on day 10 than obese patients with anxiety/depression (p = 0.0411). The VAS values correlated positively with the actual amount of cough (r = 0.42, p = 0.0122 and r = 0.44, p = 0.0054, respectively) in patients without anxiety and/or depression, while in patients with anxiety and/or depression, there was an inverse correlation between VAS values and cough (r = −0.38, p = 0.0034 and r = −0.40, p = 0.0231). Conclusions: It is important to diagnose and treat anxiety and depression in patients with COPD for a better prognosis and higher efficacy of medical treatments. While treating such patients, it is preferable to use a cough monitoring device for objective assessments, since the patients may exaggerate or underestimate their symptoms.

scholarly journals Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

2020 ◽  
Author(s):  
Anna Socha-Banasiak ◽  
Arkadiusz Michalak ◽  
Krzysztof Pacześ ◽  
Zuzanna Gaj ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Serum Concentrations ◽  
Normal Body ◽  
Normal Body Weight

Abstract Background: Fibroblast growth factor 19 (FGF19), Fibroblast growth factor 21 (FGF21) and Klotho are regulators of energy homeostasis. However, in the paediatric population the relationship between obesity, metabolic disorders and mentioned factors has not been clearly investigated. We analysed serum concentrations of FGF19, FGF21 and Klotho in children and adolescents with normal body weight as well as in overweight and obese subjects – and their associations with components of metabolic syndrome and insulin resistance (IR).Methods: The cross-sectional study conducted in the group of hospitalised children and adolescents. Laboratory investigation included serum ELISA tests for FGF19, FGF21, Klotho as well as lipid profile and oral glucose tolerance test for calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The clinical analysis included blood pressure measurement, body fat percentage estimation and assessing the prevalence of metabolic syndrome (MS) and its components. Results: The study was conducted on 174 children/adolescents aged 6-17 years divided into the following groups: with normal body weight (N=48), with obesity (N=92) and overweight subjects (N=34). Klotho levels were significantly higher in the group of subjects with obesity [median 168.6 pg/ml]) than those with overweight [131.3 pg/ml] and normal body weight [116.6 pg/ml] (p=0.0334). Median serum FGF21 level was elevated in the group of patients with MS in comparison to other subjects [136.2 pg/ml vs 82.6 pg/ml, p=0.0285]. Increased Klotho concentrations were noted in patients affected by IR compared with subjects with normal insulin sensitivity [185.3 pg/ml vs 132.6 pg/ml, p=0.0282]. Multivariable model for HOMA-IR showed FGF19 as an independent predictor for IR after adjusting for the pubertal stage and BMI Z-score.Conclusions: Klotho levels were associated with body weight status in children and adolescents. Moreover, Klotho, FGF19 and FGF21 concentrations correlated with IR status and traits of MS.

ROLE OF BODY WEIGHT AND BODY FIGURE IN THE DETERMINATION OF ADOLESCENT FOOD HABITS

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
ALBHA TIWARI ◽  
VIMLESH KUMAR TIWARI
Keyword(s):  
Body Weight ◽  
Fast Food ◽  
Food Habits ◽  
Age Groups ◽  
Normal Body ◽  
Lower Body Weight ◽  
Significant Difference ◽  
Normal Body Weight

Body weight showed non-significant difference for fast food and nutritional diet for 13-15 years old boys and girls adolescents. Body weight of boy’s adolescent increased over normal body weight of 13-15 years. Whereas, lower body weight was observed in 16-18 boys adolescent and 13-15 years and 16-18 years girls where body weight was lower than normal body weight. The general body figure of boys and girls adolescent have nutritional diet except fast food and nutritional food habits in girls of 13-15 yrs and 16-18 yrs girls of nanus body figure respectively. Interestingly, girls of 13-15 yrs, had fast food in diet whose body figure was midget. The t-test indicated that boys and girls body figure had highly significant differences in their food habits in both age groups 13-15 yrs and 16-18 yrs.

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