Relatioship of Some Biochemical Variance with Hepatitis Patients

Hepatitis is a viral disease; it has a wide distribution among peoples in different countries' and it has more than five common types named; A, B, C, D and E. The serum level of total protein, albumin and ferritin was estimated in patients with chronic hepatitis B and C, in male and female aged from 19 – 50 years; at the same time same variance was measured in apparently normal healthy volunteers. A patient with other liver disease was excluded from this search. The average values for total protein, albumin,and ferritin for normal volunteers are (5.33, 4.724 and 51.485 g/ dl) respectively for male and 5.342, 4.733 and 51.667 g/ dl in thefemale. While its value in HBV was (3.399, 2.878 and 77.909 g/dl) for male and 3.429, 3.092 and 137.091g/dl in female respectively. While in HCV, the value for total protein, albumin and ferritin was (4.045, 3.462 and 151.182 g/dl) respectively in male and 3.838, 3.391 and 68.167 respectively in thefemale. Using statistical analysis, the results indicate that there is a significant value for all variances when compared with the control in both cases B and C. The p-value was highly significant its value in HBV male patients is 6.4E-19, 5.11E-17 and 1.96E-12 for total protein, albumin and ferritin respectively and 1.6E-18, 2.03E-15 and 3.65E-24 for female. While in type HCV male patients the p- values were 8.01E-10, 1.9E-10 and 5.13E-17 for total protein, albumin and ferritin respectively, in female the values are 1.79E-16, 3.36E-12 and 1.78E-05 respectively.The results indicate also a positive correlation between all of the variance in the two types of patients

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P14.11 Severe treatment-induced myelosuppression is more frequent in female malignant glioma patients and associated with reduced overall survival

Neuro-Oncology ◽

10.1093/neuonc/noab180.136 ◽

2021 ◽

Vol 23 (Supplement_2) ◽

pp. ii39-ii40

Author(s):

P S Zeiner ◽

K Filipski ◽

M Forster ◽

M Voss ◽

E Fokas ◽

...

Keyword(s):

Overall Survival ◽

Median Overall Survival ◽

Adverse Outcome ◽

Female Gender ◽

P Value ◽

Systematic Analysis ◽

P Values ◽

Concomitant Radiochemotherapy ◽

Cell Lineages ◽

Male Patients

Abstract BACKGROUND An association of treatment-related myelotoxicity with female gender has been previously suggested. However, a systematic analysis of the prognostic relevance of radiochemotherapy-related cytopenia involving the different blood cell lineages is lacking. MATERIAL AND METHODS We retrospectively analyzed cytopenia during temozolomide-based concomitant radiochemotherapy (RCT) in 493 glioma patients. Histological grading, molecular pathology, surgical procedures and median overall survival (OS) were recorded. The extent of cytopenia was correlated with gender and outcome. RESULTS Treatment-induced severe cytopenia (leuko-, lympho-, neutro- and thrombocytopenia) occurred much more often in female than in male glioma patients (40.8 vs. 13.9%, p-value <0.0001). In female patients with IDH-wildtype high-grade astrocytomas there was a negative correlation of severe leuko-, lympho- and thrombocytopenia during temozolomide RCT with OS (36 vs. 54, 37 vs. 54 and 36 vs. 57 weeks, respectively; all p-values <0.05). In male patients there was also a trend for this unfavorable effect. Additionally, severe cytopenia correlated with reduced temozolomide dose exposure during RCT (all p-values <0.05 in total cohort) and reduced dose exposure was independently associated with worse OS (p-values <0.05 in the total and female cohort). CONCLUSION Our data confirm that women are at higher risk for treatment-induced cytopenia during RCT which is associated with a significant decrease in OS. From our data, it appears plausible that reduced temozolomide dose exposure during RCT is at least in part responsible for this finding. Immunosuppression of patients with severe cytopenia may be an independent contributor to adverse outcome.

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STEROID HORMONES AND THEIR BINDING IN PLASMA OF MALE PATIENTS WITH FATTY LIVER, CHRONIC HEPATITIS AND LIVER CIRRHOSIS

Acta Endocrinologica ◽

10.1530/acta.0.0790275 ◽

1975 ◽

Vol 79 (2) ◽

pp. 275-285 ◽

Cited By ~ 65

Author(s):

H. K. Kley ◽

E. Nieschlag ◽

W. Wiegelmann ◽

H. G. Solbach ◽

H. L. Krüskemper

Keyword(s):

Chronic Hepatitis ◽

Liver Disease ◽

Fatty Liver ◽

Plasma Concentrations ◽

Cirrhosis Of The Liver ◽

Cirrhotic Patients ◽

Male Patients ◽

Young Subjects ◽

Altered Liver ◽

Old Men

ABSTRACT Oestrone (E1), oestradiol (E2), testosterone (T), androstenedione (A) and cortisol (F) as well as LH and the percentage of binding of E1, E2, T and F in plasma were measured and compared in normal young and old male subjects and in male patients with fatty liver, chronic hepatitis and cirrhosis of the liver. The alterations seen were most marked in the cirrhotic patients, but were partially also found in patients with fatty liver and in normal old subjects: a definite increase in E1, a smaller increase in E2, a decrease in T and a rise in LH. F remained unchanged. The ratios of E2/T and E1/T were higher in cirrhotic patients than in healthy young subjects. As the percentage of bound T in plasma rose, the oestrogen/androgen imbalance was greater in patients with liver disease and in old subjects than the ratio of total hormone plasma concentration indicates. The biological relevance of the extremely high E1 plasma concentrations in patients with cirrhosis of the liver is not known. It is suggested that the combination of elevated E1 and E2 and reduced T, which is strongly bound by increased sexual hormone binding globulin (SHBG) may be responsible for gynaecomastia and hypogonadism in chronic liver diseases. As similar alterations of steroid plasma concentrations and their binding to plasma proteins are found both in patients with liver disease and in old men, these changes may be caused by the same mechanism: namely an altered liver function.

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Genetic Polymorphisms Associated with Priapism in Sickle Cell Disease.

Blood ◽

10.1182/blood.v108.11.789.789 ◽

2006 ◽

Vol 108 (11) ◽

pp. 789-789

Author(s):

Laine Elliott ◽

Allison E. Ashley-Koch ◽

Jude Jonassaint ◽

Jennifer Price ◽

Jason Galloway ◽

...

Keyword(s):

Genetic Variation ◽

Linkage Disequilibrium ◽

Sickle Cell Disease ◽

Candidate Genes ◽

Sickle Cell ◽

P Value ◽

Cell Disease ◽

P Values ◽

History Of ◽

Male Patients

Abstract Priapism, a painful and prolonged erection, has been reported to occur in 30–45% of male patients with sickle cell disease (SCD). However, little is known about the pathological processes and genetic risk factors that contribute to the occurrence of priapism. The identification of genetic variables that are associated with priapism may therefore help define both critical pathophysiologic mechanisms not otherwise apparent, as well as patients at increased risk. We examined genetic variation in our sample of 199 unrelated, adult (>18 years), male patients with Hb SS and Hb Sβ0-thalassemia, 83 (42%) of whom reported a history of priapism. Candidate genes for association with priapism were identified based on their involvement in adhesion, coagulation, inflammation, and cell signaling. Additionally, we examined genes involved in NO biology (NOS2, NOS3, SOD1, SLC4A1). Finally, we also examined polymorphisms in the KLOTHO gene, which has previously been associated with priapism. We examined a total of 389 SNPs in 48 candidate genes. Except for the gene encoding the β2 adrenergic receptor, SNP genotyping was performed by TaqMan, using Assays-on-Demand or Assays-by-Design genotyping products (Applied Biosystems). Allele tests were used to detect genetic associations with priapism. Strong evidence of association was found for SNP rs7526590 in the transforming growth factor-β receptor, type III (TGFBR3) gene (p=.00058), SNP rs10244884 in the aquaporin (AQP1) gene (p=.00068), and SNP rs3768780 in the integrin αV (ITGAV) gene (p=0.00090). A second ITGAV SNP (rs3768778), in linkage disequilibrium (r2=.59) with the first, also showed association with priapism (p=.00888). The A1 subunit of coagulation factor XIII (F13A1) had four SNPs (hcv1860621, rs1032045, rs1674074, rs381061) with p-values less than 0.010 (p-values = 0.00156, 0.00415, 0.00648, and 0.00712, respectively). The linkage disequilibrium among these F13A1 SNPs is negligible (r2 <.15). We also adjusted for multiple testing using the Benjamini-Hochberg procedure (significance threshold <.10). SNP rs7526590 in TGFBR3, SNP rs10244884 in AQP1 and SNP rs3768780 in ITGAV each had a false discovery rate (FDR) p-value of .09834. SNP rs1674074 in F13A1 had an FDR p-value of .12733. The other SNPs in F13A1 had large FDR p-values, close to .30. We did not detect an association between priapism and genetic variation in the Klotho gene, as was previously reported by Nolan et al. (2005). Specifically, SNPs rs2249358, rs211234 and rs211239 showed a virtually identical distribution of genotypes for individuals with and without a history of priapism. However, our population is not identical to the previous study, which included patients as young as 10 years old. In conclusion, our data support the hypothesis that genetic variation is associated with risk for priapism among males with SCD and suggest that genes involved in the TGFβ pathway, coagulation, cell adhesion and cell hydration pathways may be important.

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Gender Comparison of Medical Student Microsurgical Skills in a Laboratory Model

Journal of Reconstructive Microsurgery ◽

10.1055/s-0038-1626694 ◽

2018 ◽

Vol 34 (05) ◽

pp. 359-362 ◽

Cited By ~ 4

Author(s):

Rowena Sudario-Lumague ◽

Yuan-Cheng Chiang ◽

Tsan-Shiun Lin

Keyword(s):

Statistical Analysis ◽

Medical Students ◽

Laboratory Model ◽

P Value ◽

Chang Gung Memorial Hospital ◽

Male And Female ◽

Gender Comparison ◽

Standard Scale ◽

Significant Difference ◽

Numeric Scale

Background Perceived gender-related differences in surgical skills could limit opportunities available for any aspiring surgeon. There should be more available literature and logical analysis of these observations. The objective of this study is to evaluate the microsurgical skills of male and female medical students using a standard scale in the laboratory. Methods This study included medical students enrolled in the Kaohsiung Chang Gung Memorial Hospital from 2002 to 2015 who were evaluated by a senior consultant for their microsurgical skills. A standard numeric scale was used to evaluate their suturing technique after basic microsurgical training. Differences in the scores between male and female medical students were evaluated using statistical analysis. Results A total of 578 medical students were included in the study. There were 393 males (68%) and 185 females (32%). Using statistical analysis, there is no significant difference in the distribution of scores (p-Value = 0.78) and mean scores (p-Value = 0.75) between the two groups. Conclusions This study shows that microsurgical skills of male and female medical students are similar. Equal opportunities in the eventual pursuit of the surgical specialties should be available regardless of gender.

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Diphtheria serology in adults in Central Java and East Java, Indonesia: the importance of continuous diphtheria vaccination

African Health Sciences ◽

10.4314/ahs.v21i3.23 ◽

2021 ◽

Vol 21 (3) ◽

pp. 1148-1154

Author(s):

Sunarno ◽

Febriyani Asri ◽

Subangkit ◽

Mursinah ◽

Herna ◽

...

Keyword(s):

Statistical Analysis ◽

Immune Status ◽

Geometric Mean ◽

P Value ◽

Cytotoxicity Test ◽

Geometric Mean Titer ◽

P Values ◽

Central Java ◽

The Status ◽

The Relationship

Background: Vaccination increase immunity against diphtheria, yet will decrease by aging. Therefore, boosters are needed to be done regularly. Objectives: This study aims to determine the immunity to diphtheria for the population of 16 years old and above. Methods: The sample of study were 295 collected blood serums by Riskesdas project in 2013, the criteria was above 15 years of age and originating from the Provinces of Central Java or East Java inclusively. Immunity assessment was based on antibody titer (IgG) against diphtheria using Vero Cell cytotoxicity test. Statistical analysis was performed using the X2 test. Results: The full protective IgG titer (>0.1 IU/ml) at the age of 16-20 years included 75% sample with a geometric mean titer (GMT) of 0.19 IU/ml. Yet, at the age of 21-60 years and > 60 years, full protective IgG titers only cover 45.5% and 33.3% sample with GMT respectively 0.06 IU / ml. Statistical analysis showed the relationship between age and immune status with p-value 0.003. Otherwise, no relationship between the status of immunity with sex and residency with p-values of 0.16 and 0.43. Conclusions: The immune status against diphtheria at the age of above 15 years decreases with aging. Keywords: Adult; diphtheria; Indonesia; serology.

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HYPONATREMIA;

The Professional Medical Journal ◽

10.29309/tpmj/2017.24.11.670 ◽

2017 ◽

Vol 24 (11) ◽

pp. 1647-1651

Author(s):

Riaz Ahmed Javid ◽

Ayesha Ghafoor ◽

Ifrah Ahmed

Keyword(s):

Hepatic Encephalopathy ◽

Cross Sectional Study ◽

P Value ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Male And Female ◽

Male Patients ◽

The Difference ◽

Study Setting

Objectives: To find out the frequency of hyponatremia in cases of hepaticencephalopathy. Study Design: Cross-sectional study. Setting: Department of Medicine DGKhan Hospital, DG Khan. Period: July 2016 to December 2016. Material and Methods: Total80 patients with hepatic encephalopathy either male or female were selected for this study.Hyponatremia was assessed in these selected patients. Results: Mean age of the patientswas 38.34 ± 11.140 years. Hyponatremia was found in 31 (39%) patients. Hyponatremia wasnoted in 13 (41.94%) patients of age group 18-36 years and 18 (36.73%) patients of age group37-55 years. Statistically insignificant association of hyponatremia with age was seen with pvalue 0.6467. Hyponatremia was found in 21 (40.38%) male patients and 10 (35.71%) femalepatients. But the difference of frequency of hyponatremia between male and female patients wasstatistically insignificant with p value 0.8109. Conclusion: Results of this study showed a higherpercentage of hyponatremia in patients with HE. Male were more victim of HE as compared tofemale but insignificant association of hyponatremia with gender is noted. Findings of presentstudy showed that there is insignificant association of hyponatremia with grade of HE, socioeconomicstatus, area of residence and age.

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Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs

Frontiers in Immunology ◽

10.3389/fimmu.2021.763323 ◽

2021 ◽

Vol 12 ◽

Author(s):

Kasra Honarmand Tamizkar ◽

Pooneh Gorji ◽

Mahdi Gholipour ◽

Bashdar Mahmud Hussen ◽

Mehrdokht Mazdeh ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Stage ◽

P Value ◽

Roc Curve Analysis ◽

Expression Ratio ◽

Male And Female ◽

Female Patients ◽

Male Patients ◽

Non Coding Rnas

Long non-coding RNAs (lncRNAs) have been recently reported to be involved in the pathoetiology of Parkinson’s disease (PD). Circulatory levels of lncRNAs might be used as markers for PD. In the present work, we measured expression levels of HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs in the circulation of patients with PD versus healthy controls. Expression of HULC was lower in total patients compared with total controls (Expression ratio (ER)=0.19, adjusted P value<0.0001) as well as in female patients compared with female controls (ER=0.071, adjusted P value=0.0004). Expression of PVT1 was lower in total patients compared with total controls (ER=0.55, adjusted P value=0.0124). Expression of DSCAM-AS1 was higher in total patients compared with total controls (ER=5.67, P value=0.0029) and in male patients compared with male controls (ER=9.526, adjusted P value=0.0024). Expression of SPRY4-IT was higher in total patients compared with total controls (ER=2.64, adjusted P value<0.02) and in male patients compared with male controls (ER=3.43, P value<0.03). Expression of LINC-ROR was higher in total patients compared with total controls (ER=10.36, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=4.57, adjusted P value=0.03 and ER=23.47, adjusted P value=0.0019, respectively). Finally, expression of MEG3 was higher in total patients compared with total controls (ER=13.94, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=8.60, adjusted P value<0.004 and ER=22.58, adjusted P value<0.0085, respectively). ROC curve analysis revealed that MEG3 and LINC-ROR have diagnostic power of 0.77 and 0.73, respectively. Other lncRNAs had AUC values less than 0.7. Expression of none of lncRNAs was correlated with age of patients, disease duration, disease stage, MMSE or UPDRS. The current study provides further evidence for dysregulation of lncRNAs in the circulation of PD patients.

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A Comparative Crossover Randomized Study of Miller and Macintosh Blade for Laryngoscopic View and Ease of Intubating Conditions in Adults

Archives of Anesthesia and Critical Care ◽

10.18502/aacc.v7i2.6288 ◽

2021 ◽

Author(s):

Kadirehally Bheemanna Nalini ◽

Anupama Gopal ◽

Sadasivan Shankar Iyer ◽

Nagaraj Mungasuvalli Chanappa

Keyword(s):

Statistical Analysis ◽

General Anaesthesia ◽

Adult Population ◽

Randomized Study ◽

Paediatric Population ◽

P Value ◽

Laryngoscopic View ◽

P Values ◽

Intubating Conditions ◽

Laryngoscope Blades

Background: Although several types of laryngoscope blades of different sizes and shapes are present, Miller (MIL) blade is the most preferable blade among paediatric population. However, there is dearth in the literature regarding the use of these blades in the adult population. This study aimed to compare the laryngoscopic view and ease of intubation using MIL and Macintosh (MAC) blade among adults. Methods: A total of 172 patients who were >18 years age, with ASA grades I and II, undergoing elective surgeries with general anaesthesia were included. Patients were distributed in two groups (MAC/MIL and MIL/MAC), where laryngoscopy was first done with MAC blade, followed by MIL blade in the MAC/MIL group and vice-versa in the MIL/MAC group. Grading of laryngoscopic views, number of attempts, ease of intubation and use of backward, upward, rightward pressure (BURP) were noted. R v 3.6.0 was used for statistical analysis and P values≤0.05 were considered as statistically significant. Results: MIL blade showed better laryngoscopic view compared to MAC blade (32.6% vs. 15.1%; P< 0.002). BURP application helped improve the laryngoscopic views with MAC blade. Intubation with MIL blade was easier with regards to ease of intubation and number of attempts 19 (P value<0.05). Conclusion: Glottis visualization is better with the MIL blade as compared to the MAC blade. Therefore, the MIL blade might be helpful in securing the airway among adult patients.

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