The Potential of Strawberry, Rome Beauty Apple, and New Combination on Fasting Blood as Supporting Diet Therapy in Patients with Type II Diabetes Mellitus

Strawberries (Fragaria x ananassa) and Rome beauty apples (Malus sylvestris) contain high antioxidants to reduce oxidative stress and improve the glycemic response with diabetes mellitus (DM) type II. This study aimed to analyze the effect of strawberries, Rome beauty apples, and their combination to decrease fasting blood glucose levels of type II DM patients. This experimental research used a randomized pre-post-test with a control group design. Subjects were 44 patients divided into four groups: K (control, not given the fruit), P1 (strawberries 200 g/day), P2 (apples 300 g/day), and P3 (the combination strawberries 100 g/day, apples 150 g/day) for 14 days in February–March 2019 in Surakarta. The inclusion criteria were DM patients aged 40–55 years who received oral antidiabetic drug therapy. Exclusion criteria were type II DM patients who, based on the doctor's diagnosis, had complications such as gastritis, hypertension, chronic renal failure, heart disease, liver disease, stroke, cancer, patients with consumption of antioxidant supplements. Mean of blood glucose level on K (149.82±39.125), P1 (141.00±38.079), P2 (128.73±31.841), and P3 (177.73±50.176). Analysis paired t test results showed a significant difference between before and after treatment (p=0.045). To find out which group was the most meaningful, the Bonferroni post hoc test. Decrease of fasting blood glucose levels with group K (−10.55, p>0.05), P1 (−30.18, p<0.05), P2 (40.27, p<0.05), and P3 (−32.91, p<0.05). ANOVA test was used to analyze, and the post hoc Bonferroni test with a control comparison was performed, resulting in p=0.028, in P2 and p>0.05 in P1 and P3. In conclusion, strawberries, Rome beauty apples, and their combination significantly decreased fasting blood glucose levels of type II DM patients, with the highest and most significant decrease in Rome beauty apples. POTENSI STROBERI, APEL ROME BEAUTY, DAN KOMBINASI BARU TERHADAP GULA DARAH PUASA SEBAGAI PENUNJANG TERAPI DIET PADA PASIEN DIABETES MELITUS TIPE IIStroberi (Fragaria x ananassa) dan apel Rome beauty (Malus sylvestris) mengandung antioksidan tinggi untuk mengurangi stres oksidatif dan memperbaiki respons glikemik pada diabetes melitus (DM) tipe II. Tujuan penelitian adalah menganalisis pengaruh buah stroberi, apel Rome beauty, dan kombinasinya terhadap penurunan kadar glukosa darah puasa pasien DM tipe II. Jenis penelitian eksperimen dengan rancangan randomized pre-post-test dengan control group design. Subjek penelitian 44 pasien yang dibagi empat kelompok, yaitu K (kontrol tidak diberi buah), P1 (stroberi 200 g/hari), P2 (apel Rome beauty 300 g/hari) dan P3 (kombinasi stroberi 100 g/hari dan apel 150 g/hari) selama 14 hari pada bulan Februari–Maret 2020 di Surakarta. Kriteria inklusi adalah pasien DM usia 40–55 tahun yang mendapat terapi obat antidiabetik oral. Kriteria eksklusi adalah pasien DM tipe II yang berdasar atas diagnosis dokter mengalami komplikasi seperti mag, hipertensi, gagal ginjal kronik, penyakit jantung, penyakit hati, strok, kanker, dan pasien dengan konsumsi suplemen antioksidan. Kadar glukosa darah rerata pada K (149,82±39,125), P1 (141,00±38,079), P2 (128,73±31,841), dan P3 (177,73±50,176). Hasil analisis paired t test menunjukkan terdapat perbedaan yang signifikan antara sebelum dan sesudah perlakuan (p=0,045). Untuk mengetahui kelompok mana yang paling bermakna, dilakukan Uji Post Hoc Bonferroni. Penurunan kadar glukosa darah puasa pada K (−10,55; p>0,05), P1 (−30,18; p<0,05), P2 (−40,27; p<0,05), dan P3 (−32,91; p<0,05). Analisis dilakukan dengan uji ANOVA dan Uji Post Hoc Bonferroni dengan perbandingan kontrol menghasilkan p=0,028 pada P2 serta p>0,05 pada P1 dan P3. Simpulan, pemberian stroberi, apel Rome beauty, dan kombinasinya signifikan menurunkan kadar glukosa darah puasa pasien DM tipe II dengan penurunan tertinggi dan bermakna pada apel Rome beauty.

Download Full-text

Pengaruh Pemberian Aspartam terhadap Kadar Glukosa Darah Tikus Diabetes Melitus Diinduksi Aloksan

Jurnal Kesehatan Andalas ◽

10.25077/jka.v3i3.134 ◽

2014 ◽

Vol 3 (3) ◽

Author(s):

Ega Purnamasari ◽

Eti Yerizel ◽

Efrida Efrida

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Control Group ◽

Control Group Design ◽

Group Design ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Post Test ◽

Diabetes Melitus

AbstrakAspartam merupakan gula pengganti rendah kalori yang sering dikonsumsi oleh pengidap diabetes, tetapi keamanannya masih kontroversi. Intensitas rasa manis aspartam yang tinggi diduga dapat menurunkan kadar glukosa darah. Penelitian lain menyebutkan hasil metabolisme aspartam berupa asam aspartat dan fenilalanin dapat menjadi prekursor glukosa melalui glukoneogenesis. Tujuan penelitian ini ialah untuk mengetahui pengaruh pemberian aspartam terhadap kadar glukosa darah tikus diabetes melitus diinduksi aloksan. Penelitian ini adalah penelitian eksperimental dengan post-test only control group design. Sampel penelitian ini terdiri dari 20 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol negatif (KN), kontrol positif (KP), perlakuan 1 (P1), perlakuan 2 (P2). Aloksan 150 mg/kgBB diinduksikan pada kelompok KP dan P2, aspartam 315 mg/kgBB diberikan pada kelompok P1 dan P2 selama 4 minggu. Kadar glukosa darah puasa diukur setelah 4 minggu menggunakan spektrofotometer. Hasil penelitian ini didapatkan rerata kadar glukosa darah puasa kelompok KN (88,39 mg/dL), KP (134,11 mg/dL), P1 (93,95 mg/dL), dan P2 (66,66 mg/dL). Analisis data dengan Uji ANOVA nilai p= 0,000 (p<0,05), terdapat perbedaan kadar glukosa darah puasa yang bermakna pada semua kelompok. Keimpulan penelitian ini adalah terdapat pengaruh pemberian aspartam terhadap penurunan kadar glukosa darah puasa tikus diabetes melitus diinduksi aloksan.Kata kunci: aspartam, kadar glukosa darah, diabetes melitus, aloksanAbstractAspartame is a low-calorie sugar substitute that is often consumed by people with diabetes, but the safety of aspartame is still controversial. The high intensity of aspartame sweetness could be expected to lower blood glucose levels. Other study said the results of the metabolism of aspartame such aspartic acids and phenylalanine which can be a precursor of glucose through gluconeogenesis. The purpose of this study was to determine the effect of aspartame on blood glucose levels of alloxan induced diabetic rats. This study is an experimental study with a post-test only control group design. Twenty male Wistar rats were divided into 4 groups: negative control (KN), positive control (KP), treatment 1 (P1), treatment 2 (P2). Alloxan 150 mg/kg body weight induced in KP and P2 groups, aspartame 315 mg/kg body weight administered on P1 and P2 groups for 4 weeks. Fasting blood glucose levels were measured after 4 weeks using a spectrophotometer. The results of this study, the mean fasting blood glucose levels KN group (88.39 mg/dL), KP (134.11 mg/dL), P1 (93.95 mg/dL), and P2 (66.66 mg/dL). Data were analyzed using ANOVA test, p-value=0.000 ( p<0.05 ), there are differences in fasting blood glucose levels were significant in all groups. The conclusions of this study is the provision of aspartame in alloxan induced diabetic rats can cause a decrease in blood glucose levels significantly.Keywords: aspartame, blood glucose levels, diabetes mellitus, alloxan

Download Full-text

Pengaruh Pemberian Minuman Fungsional Terhadap Penurunan Kadar Glukosadarah Puasa Pada Penderita Diabetes Melitus

Jurnal Gizi Prima ◽

10.32807/jgp.v4i2.140 ◽

2019 ◽

Vol 4 (2) ◽

pp. 114

Author(s):

Tutut Zikra Anjani ◽

Suhaema Suhaema ◽

Fifi Lutfiah ◽

Ni Ketut Sri Sulendri

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Female Gender ◽

Simple Random Sampling ◽

Control Group ◽

Risk Category ◽

Control Group Design ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Post Test

Indonesia is currently the fourth country with the largest number of DM patients in the world. Functional food is beneficial for the health of DM patients, for example bananas and soybeans. Kepok bananas contain dietary fiber inulin and antioxidants (β carotene). Soybeans contain isoflavones, fiber, and proteins in the form of amino acids arginine and glycine. This study aims to look at the effect of giving functional drinks a mixture of soybean and banana milk on decreasing fasting blood glucose levels in type II DM patients. Type of Quasy-experimental research with pre test and post test with control group design. Subjects were taken using the Simple Random Sampling method and the subjects involved until the end of the study were 26 people. The intervention was carried out for 14 days and given as much as 330 ml. The equality of the subject characteristics of the two groups was analyzed using the chy squere test, and the effect of giving intervention materials on decreasing blood glucose levels was tested by independent t test. The results of the study were characteristics (84.6%) aged 50-60 years, (53.8%) female gender, (57.1%) having a family history of disease, 58.4% using glibenclamide anti-hyperglycemic drugs and BMI average in the risk category. . Result Δ It is known that there is an effect of giving functional drinks on decreasing fasting blood glucose levels where the average change is 11.5 mg / dl (p = 0.03).

Download Full-text

The Effectivity of Tomato and Guava Combination Juice and Guava Juice Administration on Blood Glucose Level in Patients with Type II Diabetes Mellitus

KnE Life Sciences ◽

10.18502/kls.v4i15.5739 ◽

2019 ◽

Author(s):

Hasneli . ◽

Safyanti . ◽

Ainil Mardhiyah

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Health Center ◽

Type Ii Diabetes ◽

Fasting Blood Glucose ◽

Type Ii Diabetes Mellitus ◽

Control Group ◽

Type Ii ◽

Glucose Levels ◽

Blood Glucose Levels

This study aims to determine the effectivity of tomato and guava juice combination with guava juice on blood glucose levels of patients with type II diabetes mellitus in the work area of Kuranji Padang Health Center in 2019. This quasi-experimental study used a pretest-posttest design with a control group. The population of this study was all patients with type II diabetes mellitus in the working area of Kuranji Health Center, Padang City. Sampling is done by purposive sampling. The number of samples was 24 people, divided into treatment groups and a control group. The data obtained were analyzed by two different dependent tests and an independent t-test. The results of statistical tests showed that there were significant differences between the average decrease in fasting blood glucose levels of respondents who were given tomato and guava combination juice with respondents who were given guava juice (p = 0,026). People with diabetes mellitus are expected to consume tomato and guava combination juice as a form of complementary therapy.

Download Full-text

Pengaruh Terapi Dzikir Terhadap Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2

WIRARAJA MEDIKA ◽

10.24929/fik.v10i1.942 ◽

2020 ◽

Vol 10 (1) ◽

pp. 41-47

Author(s):

Sitti Fatimah M. Arsad ◽

Erna Rochmawati ◽

Arianti Arianti

Keyword(s):

Blood Glucose ◽

Metabolic Disorders ◽

Intervention Group ◽

Control Group ◽

Test Design ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Post Test ◽

Diabetes Melitus

Abstract Diabetes mellitus is a chronic disease with metabolic disorders in the form of increased blood glucose levels caused by disruption of insulin secretion or insulin efficacy. Management of diabetes can be done by pharmacology or nonphamacology therapy. One of the nonpharmacological therapies is dhikr therapy. The study design used quasy experiment with the control group pre-post test design. The collected samples are 40 diabetes patients with simple random technique. The research sample was divided into 2 groups,control and intervention group, each of which was 20 respondents. Data analysis uses independent t-test. The results showed that dzikir therapy of sentences thayibah, asmaul husna and prayers performed every day for 2 weeks could significantly reduce patients blood glucose levels (p = 0.000) or p <0.05. Key Words : Dhikr Therapy, Blood Glucose Level, Type 2 Diabetes Melitus

Download Full-text

PERANAN METODE PENGOBATAN ISLAM CUPPING THERAPY DALAM PENURUNAN KADAR GLUKOSA DARAH

MIQOT Jurnal Ilmu-ilmu Keislaman ◽

10.30821/miqot.v40i1.217 ◽

2016 ◽

Vol 40 (1) ◽

Author(s):

Cut Khairunnisa ◽

M. Fikri Fadli

Keyword(s):

Blood Glucose ◽

International Diabetes Federation ◽

Cupping Therapy ◽

Wilcoxon Test ◽

Control Group ◽

P Value ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Post Test ◽

Diabetes Melitus

Abstrak: Cupping therapy sudah lama dipakai oleh sebagian umat muslim dan menempati kedudukan populer di antara berbagai metode terapi alternatif lain. Bukti-bukti penelitian medis modern juga menguatkan manfaat terapi yang dianjurkan oleh Nabi. Banyak ahli pengobatan yang mengetahui khasiat cupping therapy dalam mengobati penyakit. Menurut International Diabetes Federation (IDF), pada tahun 2013 Indonesia menempati peringkat ketujuh penderita diabetes. Penelitian ini bertujuan untuk mengetahui pengaruh cupping therapy terhadap kadar glukosa darah pada pasien Klinik Sehat dr. Abdurrahman Medan tahun 2014. Penelitian ini menggunakan metode pra-eksperimental dengan satu kelompok pre-test dan post-test tanpa kelompok kontrol dan sampel diperoleh melalui random dengan sampel 32 orang. Berdasarkan uji Wilcoxon dengan á=0,05 didapatkan p-value=0,021 yang berarti terdapat perbedaan yang signifikan antara rerata kadar glukosa darah sebelum dan setelah cupping therapy (p-value < á). Abstract: The Role of Islamic Treatment Method “Cupping Therapy” to Decrease Blood Glucose Levels. Cupping therapy has long been used by most Muslims and it has occupied as prominent position among therapeutic approaches.The proof of medical modern research lately have been supports expediency therapy which recommended by the prophet. Nowdays,many medical experts who know the benefits of cupping therapy in treating diseases. Diabetes melitus is a disease that is directly related to blood glucose levels. According to the International Diabetes Federation (IDF) in 2013, there were 382 million people suffer from diabetes melitus worldwide and Indonesia as seventh ranks in the world. This study aims to determine the effect of cupping therapy on blood glucose levels in patients of Klinik Sehat dr. Abdurrahmân Medan in 2014. The Study used pre-experimental method with one group pre-test and post-test without a control group and sample took by randomization with a sample of 32 people. Based on the Wilcoxon test with á = 0.05 obtained p-value = 0.021 that means there were a significant differences in mean blood glucose levels before and after cupping therapy (p-value < á). Kata Kunci: pengobatan Islam, cupping therapy, kadar gula darah

Download Full-text

PENGARUH PEMBERIAN TRANS FATTY ACID (TFA) DARI MARGARIN DAN MINYAK KELAPA SAWIT YANG DIPANASKAN BERULANG TERHADAP KADAR GLUKOSA DARAH PUASA PADA TIKUS WISTAR

The Indonesian Journal of Public Health ◽

10.20473/ijph.v11i1.2016.69-77 ◽

2017 ◽

Vol 11 (1) ◽

pp. 69

Author(s):

Retno Larasati ◽

Bambang Wirjatmadi ◽

Merryna Adriani

Keyword(s):

Fatty Acid ◽

Blood Glucose ◽

Trans Fatty Acid ◽

Palm Oil ◽

Fasting Blood Glucose ◽

Control Group ◽

Control Group Design ◽

Treatment Groups ◽

Glucose Levels ◽

Blood Glucose Levels

The purpose of this study was to know differences in fasting blood glucose levels among both the control and treatment groups were given Trans Fatty Acid of groceries margarine and oil is heated rapidly. This research is true experimental design to study Post Test Only Control Group Design. The sample size in this study was 25 rats wistar strain males were divided into 5 groups: the first group was the control, the second group by of margarine that is heated by the content of TFA 1%, the third group by the addition palm oil, which is heated repeats to content TFA 1%, the fourth group by margarine are heated with TFA content of 2%, and the fifth group by the addition of palm oil, which is heated repeats to the TFA content of 2%. Treatment was given for 4 weeks, after the laboratory examination of fasting blood glucose at the end of the treatment. Data fasting blood glucose levels in all groups were tested by one-way ANOVA with 95% confidence level. The results showed that TFA may increase the levels of fasting blood glucose treatment groups compared with the control group, and the differences in levels of fasting blood glucose between treatment groups was not influenced by the amount of content TFA but due to different types of TFA given that of margarine and palm oil that is heated Repeat.Keywords: fasting glucose, TFA, margarine, oil heated, rats

Download Full-text

Pengaruh pemberian susu almond terhadap glukosa darah puasa pada tikus diabetes

JURNAL GIZI INDONESIA ◽

10.14710/jgi.7.2.86-91 ◽

2019 ◽

Vol 7 (2) ◽

pp. 86-91

Author(s):

Ryta Ristantia Ningsih ◽

Enny Probosari ◽

Binar Panunggal

Keyword(s):

Blood Glucose ◽

Treatment Group ◽

Metabolic Diseases ◽

Fasting Blood Glucose ◽

Glucose Measurement ◽

Control Group ◽

Control Group Design ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference

Background: Type 2 Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that occurs due to abnormalities in insulin secretion and insulin action. Diet plus high fiber can help control glucose levels. Almond contains fiber, vitamin E, and magnesium that contributes to the fasting blood glucose levels. This study aimed to analyze the effect of almond milk to the fasting blood glucose diabetic rats.Method: This study used an experimental design with pre-post test control group design. The sample were Rattus norvegicus Wistar which were divided into 4 groups: K (-), K (+), A1 and A2. Almond milk was given in the group treatmeant for 14 days with a dose of 4.32 ml and 8.64 ml. Fasting blood glucose measurement taken before and after treatment used Oxidase Glucose - Peroxidase Aminoantypirin (GOD PAP). Analysis of data used paired t-test, ANOVA and Post Hoc.Results: The fasting blood glucose levels decreased significantly (p = 0.01) in the treatment group which were intervened with almond milk. A decrease in fasting blood glucose levels in a dose treatment group 1 for 116.96 ± 4.45 (p = 0:01), whereas in the group treated at a dose of 2 for 155.53 ± 3.15 (p = 0.01). There were a significant difference in decreased of the fasting blood glucose levels between the two treatment groups (p = 0.01).Conclusion: Giving a dose almond milk 4.32 ml and 8.64 ml for 14 days can lower the fasting blood glucose levels significantly.

Download Full-text

The Effectiveness of Vitamin D Addition to Decreasing Blood Glucose Levels of Hyperglycemic Mice Model with Glimepirid Therapy

Journal of Agromedicine and Medical Sciences ◽

10.19184/ams.v6i2.10206 ◽

2020 ◽

Vol 6 (2) ◽

pp. 71

Author(s):

Tsintani Nur Aristiana ◽

Cholis Abrori ◽

Muhammad Ali Shodikin

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Negative Control ◽

Control Group ◽

Mice Model ◽

Control Group Design ◽

Glucose Levels ◽

Blood Glucose Levels

Abstract Low 25-hydrocyvitamin D (25(OH)D3) levels are usually found in patients with type 1 and type 2 diabetes mellitus. This study aims to compare the effectiveness of fasting blood glucose levels in hyperglycemic mice model with glimepirid single therapy, hyperglycemic mice model with vitamin D, and mice model of hyperglycemic with glimepirid therapy plus vitamin D. This study used the true experimental research design with the randomized posttest only control group design. There were 25 male mice (Mus musculus) strain Balb/C with 20-30 g body weight and 2-3 months old which were grouped into 5 groups. The negative control group (K1) was injected with placebo and the positive control group (K2) was injected with STZ 150 mg/kgBW i.p. Groups P1, P2, and P3 were given STZ injection of 150 mg/kgBW i.p and given glimepirid 0.26 mg/kgBW; vitamin D 6,5 ml/kgBW; glimepirid 0,26 mg/kgBW with vitamin D supplementation 6,5 ml/kgBW. The results of the Tukey post hoc tests obtained differences in the mean of delta KGD between groups P1 and K2 = 122,55; in group P2 with K2 = 81,60; and in group P3 with K2 = 74,40. From these data, it can be concluded that in the group given glimepirid plus vitamin D there was no additional effectiveness in decreasing fasting blood glucose levels of hyperglycemic mice model compared to the group given only glimepirid therapy and the group given vitamin D alone. Keywords: diabetes mellitus, vitamin D, glimepiride, streptozotocin.

Download Full-text

Efektivitas Ekstrak daun Sirih Merah (Piper crocatum Ruiz & Pav.) terhadap Kadar Glutation Peroksidase dan Kadar Glukosa Darah Tikus Jantan Hiperglikemik

Life Science ◽

10.15294/lifesci.v8i1.29994 ◽

2019 ◽

Vol 8 (1) ◽

pp. 86-94 ◽

Cited By ~ 1

Author(s):

Syahrizal Ramadhan ◽

Retno Sri Iswari ◽

Aditya Marianti

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Wistar Rat ◽

Male Rats ◽

Control Group ◽

Control Group Design ◽

Group Design ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Diabetes Melitus

Diabetes mellitus (DM) is a group of metabolic diseases with characteristics of hyperglycemia that occur due to abnormal insulin secretion, insulin action, or both. In diabetes mellitus, it is very easy to occur the formation of excess free radicals which later can cause damage to the pancreas. The body is normally protected from oxidative stress by antioxidants such as superoxide dismutase (SOD), catalase (H2O2 oxidoreductase), and glutathione peroxidase (GPx). This research is an experimental study with posttest control group design. 25 Wistar strain male rats were divided into five treatment groups (positive control given glibenclamide drug 0.09 mg/200 gBB, a negative control was not treated, and red betel leaf extract treatment dose 100, 200, and 400 mg/kg BB). The research procedure included the conditioning of hyperglycemic with alloxan induction of 120 mg/kgBB, extraction of red betel using maceration method with 70% ethanol solvent, treatment by giving the red betel leaves extract orally for 28 days and measure the value of blood glucose and GPx using spectrophotometric methods. The research data was analyzed using one way ANOVA and linear regression. The red betel leaves extract that given to the male Wistar Rat for 28 days gave a significant effect on the value of blood glucose and GPx. The effect given by red betel leaves on blood glucose levels is 4.9%While the effect given by red betel leaves on GPx levels is 91.1%. The conclusion of this research is red betel leaves extract that given to the male Wistar Rat for 28 days gave a significant effect on the value of blood glucose and GPx. The dosage of 400 mg/kgBB is an effective dose in reducing blood glucose levels and increasing GPx levels Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin, atau keduanya. Diabetes melitus mudah sekali terjadi pembentukan radikal bebas berlebih yang nantinya dapat meyebabkan kerusakan pada pankreas. Tubuh dalam keadaan normal terlindungi dari stres oksidatif oleh antioksidan seperti superoksida dismutase (SOD), katalase (H2O2 oksidoreduktase), dan glutation peroksidase (GPx). Penelitian ini merupakan penelitian eksperimental dengan posttest control group design. Sebanyak 25 ekor tikus jantan strain Wistar dibagi dalam lima kelompok perlakuan (kontrol posistif diberi obat glibenklamid 0,09 mg/200 gBB, kontrol negatif tidak diberi perlakuan, dan perlakuan ekstrak daun sirih merah dosis 100, 200, dan 400 mg/kg BB). Prosedur penelitian meliputi pengkondisisan hiperglikemik dengan induksi aloksan 120 mg/kgBB, ekstraksi daun sirih merah menggunakan metode maserasi dengan pelarut etanol 70%, perlakuan dengan pemberian ekstrak daun sirih merah secara oral selama 28 hari, serta pengukuran kadar glukosa darah dan kadar GPx dengan metode spektrofotometri. Analisis data menggunakan teknik oneway ANOVA dan regresi linier. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirih merah berpengaruh signifikan pada kadar glukosa dan kadar GPx setelah 28 hari perlakuan. Pengaruh yang diberikan daun sirih merah terhadap kadar glukosa darah adalah sebesar 4,9%, sedangkan pengaruh yang diberikan daun sirih merah terhadap kadar GPx adalah sebesar 91,1%. Simpulan dari penelitian ini adalah pemberian ekstrak daun sirih merah pada tikus jantan hiperglikemik secara oral selama 28 hari berpengaruh terhadap kadar glukosa darah dan kadar GPx. Dosis 400 mg/kgBB merupakan dosis efektif dalam menurunkan kadar glukosa darah dan menaikkan kadar GPx.

Download Full-text

Efek Hipoglikemik Kecambah Beras Merah pada Tikus yang Diinduksi STZ-NA dengan Parameter Kadar Insulin, Indeks HOMA-IR dan HOMA β (Hypoglycemic Effect of Red Rice Germ on Insulin Levels, HOMA-IR, and HOMA β Index of STZ-NA Induced Rats)

Jurnal Agritech ◽

10.22146/agritech.16767 ◽

2017 ◽

Vol 36 (4) ◽

pp. 433

Author(s):

Nurhidajah Nurhidajah ◽

Nurrahman Nurrahman

Keyword(s):

Insulin Resistance ◽

Blood Glucose ◽

Insulin Level ◽

Control Group ◽

Standard Diet ◽

Red Rice ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Post Test ◽

Decrease Blood Glucose

The process of germination of grains such as rice, could increase some nutritional values of amino acids and dietary fiber. Red rice and its sprouts are believed to be able to decrease blood glucose in patients with diabetes mellitus (DM). The aim of this study was to evaluate the hypoglycemic effect of red rice sprouts in STZ-NA induced diabetic rats on blood glucose level, insulin level, and HOMA-IR and HOMA-β index. This experimental study was conducted based on randomized post test only control group design using 24 male Wistar rats aged 2.5 months. Rats were divided into 4 groups, one group without induction of STZ-NA fed with a standard diet (control) and three groups of STZ- NA induced with a standard diet, red rice and red rice germ. Experiments were conducted for 6 weeks. The results showed that sprouted red rice lowered blood glucose levels by 61.88 % and the value of HOMA-IR (insulin resistance parameters) by 56.82%. Insulin level increased by 16.35 % and HOMA-β by 763.6 %. This study showed that red rice germ was able to decrease blood glucose levels and increase insulin resistance of DM rats and the strength of the pancreatic beta cells. ABSTRAKProses perkecambahan biji-bijian seperti beras, dapat meningkatkan beberapa nilai gizi seperti asam amino dan serat pangan. Beras merah dan kecambahnya diyakini mampu menurunkan glukosa darah pada penderita diabetes melitus (DM). Tujuan penelitian ini adalah mengevaluasi efek hipoglikemik kecambah beras merah pada tikus diabetes yang diinduksi STZ-NA terhadap kadar glukosa darah, insulin, serta indeks HOMA-IR dan HOMA β. Penelitian ini bersifat eksperimental in vivo pada hewan coba tikus Wistar jantan usia 2,5 bulan sebanyak 24 ekor dengan desain penelitian randomized post test only control group. Tikus dibagi menjadi 4 kelompok, masing-masing 1 kelompok tanpa induksi STZ-NA dengan diet standar dan 3 kelompok diinduksi STZ-NA dengan diet standar, beras merah dan kecambah beras merah. Percobaan dilakukan selama 6 minggu. Hasil penelitian menunjukkan kecambah beras merah mampu menurunkan kadar glukosa darah sebesar 61,88 % dan nilai HOMA-IR (parameter resistensi insulin) 56,82 %. Kadar insulin meningkat 16,35 % dan HOMA β 763,6 %. Disimpulkan, kecambah beras merah mampu menurunkan kadar glukosa darah dan memperbaiki kondisi resistensi insulin tikus DM, dan kekuatan sel beta pankreas.

Download Full-text