scholarly journals Efektivitas Ekstrak daun Sirih Merah (Piper crocatum Ruiz & Pav.) terhadap Kadar Glutation Peroksidase dan Kadar Glukosa Darah Tikus Jantan Hiperglikemik

Life Science ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Syahrizal Ramadhan ◽  
Retno Sri Iswari ◽  
Aditya Marianti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Wistar Rat ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetes Melitus

Diabetes mellitus (DM) is a group of metabolic diseases with characteristics of hyperglycemia that occur due to abnormal insulin secretion, insulin action, or both. In diabetes mellitus, it is very easy to occur the formation of excess free radicals which later can cause damage to the pancreas. The body is normally protected from oxidative stress by antioxidants such as superoxide dismutase (SOD), catalase (H2O2 oxidoreductase), and glutathione peroxidase (GPx). This research is an experimental study with posttest control group design. 25 Wistar strain male rats were divided into five treatment groups (positive control given glibenclamide drug 0.09 mg/200 gBB, a negative control was not treated, and red betel leaf extract treatment dose 100, 200, and 400 mg/kg BB). The research procedure included the conditioning of hyperglycemic with alloxan induction of 120 mg/kgBB, extraction of red betel using maceration method with 70% ethanol solvent, treatment by giving the red betel leaves extract orally for 28 days and measure the value of blood glucose and GPx using spectrophotometric methods. The research data was analyzed using one way ANOVA and linear regression. The red betel leaves extract that given to the male Wistar Rat for 28 days gave a significant effect on the value of blood glucose and GPx. The effect given by red betel leaves on blood glucose levels is 4.9%While the effect given by red betel leaves on GPx levels is 91.1%. The conclusion of this research is red betel leaves extract that given to the male Wistar Rat for 28 days gave a significant effect on the value of blood glucose and GPx. The dosage of 400 mg/kgBB is an effective dose in reducing blood glucose levels and increasing GPx levels   Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin, atau keduanya. Diabetes melitus   mudah   sekali   terjadi pembentukan   radikal   bebas   berlebih   yang nantinya   dapat meyebabkan kerusakan pada pankreas. Tubuh dalam keadaan normal terlindungi dari stres oksidatif oleh antioksidan seperti superoksida dismutase (SOD), katalase (H2O2 oksidoreduktase), dan glutation peroksidase (GPx). Penelitian ini merupakan penelitian eksperimental dengan posttest control group design. Sebanyak 25 ekor tikus jantan strain Wistar dibagi dalam lima kelompok perlakuan (kontrol posistif diberi obat glibenklamid 0,09 mg/200 gBB, kontrol negatif tidak diberi perlakuan, dan perlakuan ekstrak daun sirih merah dosis 100, 200, dan 400 mg/kg BB). Prosedur penelitian meliputi pengkondisisan hiperglikemik dengan induksi aloksan 120 mg/kgBB, ekstraksi daun sirih merah menggunakan metode maserasi dengan pelarut etanol 70%, perlakuan dengan pemberian ekstrak daun sirih merah secara oral selama 28 hari, serta pengukuran kadar glukosa darah dan kadar GPx dengan metode spektrofotometri. Analisis data menggunakan teknik oneway ANOVA dan regresi linier. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirih merah berpengaruh signifikan pada kadar glukosa dan kadar GPx setelah 28 hari perlakuan. Pengaruh yang diberikan daun sirih merah terhadap kadar glukosa darah adalah sebesar 4,9%, sedangkan pengaruh yang diberikan daun sirih merah terhadap kadar GPx adalah sebesar 91,1%. Simpulan dari penelitian ini adalah pemberian ekstrak daun sirih merah pada tikus jantan hiperglikemik secara oral selama 28 hari berpengaruh terhadap kadar glukosa darah dan kadar GPx. Dosis 400 mg/kgBB merupakan dosis efektif dalam menurunkan kadar glukosa darah dan menaikkan kadar GPx.

scholarly journals Pemberian ekstrak air buah sawo (Manilkara zapota L.) menurunkan kadar glukosa darah tikus (rattus norvegicus) diabetes mellitus

2016 ◽  
Vol 3 (3) ◽  
pp. 180
Author(s):  
Effatul Afifah
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

<p><strong>ABSTRACT</strong><br /><br /><em><strong>Background</strong>: Diabetes mellitus (DM) is a chronic metabolic problem disorder characterized by hyperglicemia which is caused by insulin deficiency produced by β-pancreas cells, thus causing abnormalities of carbohydrate, protein, and fat metabolism, and tend to cause complications. </em></p><p><em><strong>Objectives</strong>: To know the effect of sapodilla extract water on blood glucose level of diabetic induce mice. </em></p><p><em><strong>Methods</strong>: This was an experimental study with pre-post control group design. Sapodilla extract water (EABS) was fed to group of mice with alloxan diabetes induction. Twenty four DM induced mice were separated into 4 groups, e.g. control without and with medication of glibenclamide, EABS 1 (treated with 3.6 mL/200 g body weight), and EABS 2 (treated with 7.2 mL/200 g body weight). Mice were then measured for their blood glucose level at the day of 3, 14, and 30. </em></p><p><em><strong>Results</strong>: EABS 1 and EABS 2 decreased blood glucose levels at week of 1st, 2nd, and 3rd after induction. The greatest reduction was shown by EABS 2 at the 3rd week. EABS decreased blood glucose level of mice induced DM and signifi cantly shown at glibenclamide group, followed by EABS 2 and EABS 1.</em></p><p><em><strong>Conclusions</strong>: EABS reduced blood glucose levels of diabetic mice and signifi cantly shown for glibenclamide group, followed by EABS 2 and EABS 1.</em></p><p><strong>KEYWORDS</strong>:<em> diabetes mellitus, sapodilla extract water, blood glucose</em></p><p><br /><strong>ABSTRAK</strong></p><p><em><strong>Latar belakang</strong>: Diabetes mellitus (DM) merupakan penyakit gangguan metabolik kronis yang ditandai dengan hiperglikemia yang disebabkan oleh kekurangan insulin yang dihasilkan oleh sel β-pankreas sehingga menimbulkan kelainan metabolisme karbohidrat, protein dan lemak, dan cenderung menimbulkan komplikasi.</em></p><p><em><strong>Tujuan</strong>: Mengetahui efek pemberian ekstrak buah air sawo terhadap kadar glukosa darah tikus yang diinduksi DM.</em></p><p><em><strong>Metode</strong>: Penelitian ini merupakan penelitian eksperimental murni dengan rancangan pre-post test control group design dengan memberikan intervensi ekstrak buah air sawo (EABS) pada kelompok tikus yang diberikan induksi DM menggunakan aloksan. Sebanyak 24 tikus yang diinduksi DM dikelompokkan ke dalam 4 perlakuan, antara lain kontrol tanpa dan dengan pengobatan glienclamide, EABS 1 (diberi 3,6 mL/200 g berat badan), dan EABS 2 (7,2 mL/200 g berat badan). Tikus diukur kadar gula darahnya pada hari ke-3, 14, dan 30. </em></p><p><em><strong>Hasil</strong>: EABS mampu menurunkan kadar glukosa darah pada tikus, baik pada kelompok EABS 1 maupun EABS 2 pada minggu ke-1, ke-2, dan ke-3 setelah induksi. Hasil penurunan kadar glukosa yang paling besar terjadi pada kelompok EABS 2 pada minggu ke-3 perlakuan. EABS dapat menurunkan kadar glukosa darah tikus yang diinduksi DM dan paling signifi kan terjadi pada kelompok glibenclamide diikuti oleh EABS 2 dan EABS 1.</em></p><p><em><strong>Kesimpulan</strong>: EABS mampu menurunkan kadar glukosa darah pada tikus yang diinduksi alloxan.</em></p><p><strong>KATA KUNCI</strong><em>: diabetes mellitus, ekstrak air buah sawo, glukosa darah</em></p>

scholarly journals Pengaruh Pemberian Aspartam terhadap Kadar Glukosa Darah Tikus Diabetes Melitus Diinduksi Aloksan

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Ega Purnamasari ◽  
Eti Yerizel ◽  
Efrida Efrida
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Diabetes Melitus

AbstrakAspartam merupakan gula pengganti rendah kalori yang sering dikonsumsi oleh pengidap diabetes, tetapi keamanannya masih kontroversi. Intensitas rasa manis aspartam yang tinggi diduga dapat menurunkan kadar glukosa darah. Penelitian lain menyebutkan hasil metabolisme aspartam berupa asam aspartat dan fenilalanin dapat menjadi prekursor glukosa melalui glukoneogenesis. Tujuan penelitian ini ialah untuk mengetahui pengaruh pemberian aspartam terhadap kadar glukosa darah tikus diabetes melitus diinduksi aloksan. Penelitian ini adalah penelitian eksperimental dengan post-test only control group design. Sampel penelitian ini terdiri dari 20 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol negatif (KN), kontrol positif (KP), perlakuan 1 (P1), perlakuan 2 (P2). Aloksan 150 mg/kgBB diinduksikan pada kelompok KP dan P2, aspartam 315 mg/kgBB diberikan pada kelompok P1 dan P2 selama 4 minggu. Kadar glukosa darah puasa diukur setelah 4 minggu menggunakan spektrofotometer. Hasil penelitian ini didapatkan rerata kadar glukosa darah puasa kelompok KN (88,39 mg/dL), KP (134,11 mg/dL), P1 (93,95 mg/dL), dan P2 (66,66 mg/dL). Analisis data dengan Uji ANOVA nilai p= 0,000 (p<0,05), terdapat perbedaan kadar glukosa darah puasa yang bermakna pada semua kelompok. Keimpulan penelitian ini adalah terdapat pengaruh pemberian aspartam terhadap penurunan kadar glukosa darah puasa tikus diabetes melitus diinduksi aloksan.Kata kunci: aspartam, kadar glukosa darah, diabetes melitus, aloksanAbstractAspartame is a low-calorie sugar substitute that is often consumed by people with diabetes, but the safety of aspartame is still controversial. The high intensity of aspartame sweetness could be expected to lower blood glucose levels. Other study said the results of the metabolism of aspartame such aspartic acids and phenylalanine which can be a precursor of glucose through gluconeogenesis. The purpose of this study was to determine the effect of aspartame on blood glucose levels of alloxan induced diabetic rats. This study is an experimental study with a post-test only control group design. Twenty male Wistar rats were divided into 4 groups: negative control (KN), positive control (KP), treatment 1 (P1), treatment 2 (P2). Alloxan 150 mg/kg body weight induced in KP and P2 groups, aspartame 315 mg/kg body weight administered on P1 and P2 groups for 4 weeks. Fasting blood glucose levels were measured after 4 weeks using a spectrophotometer. The results of this study, the mean fasting blood glucose levels KN group (88.39 mg/dL), KP (134.11 mg/dL), P1 (93.95 mg/dL), and P2 (66.66 mg/dL). Data were analyzed using ANOVA test, p-value=0.000 ( p<0.05 ), there are differences in fasting blood glucose levels were significant in all groups. The conclusions of this study is the provision of aspartame in alloxan induced diabetic rats can cause a decrease in blood glucose levels significantly.Keywords: aspartame, blood glucose levels, diabetes mellitus, alloxan

scholarly journals BLOOD GLUCOSE LEVELS AND THE MICROSCOPIC STRUCTURE OF KIDNEY WISTAR RAT DIABETES MELLITUS UNDER THE EFFECT OF LAWSONIA INERMIS (LINN.) LEAVES ETHANOLIC EXTRACT

2018 ◽  
Vol 11 (4) ◽  
pp. 257
Author(s):  
Mutiara Indah Sari ◽  
Maya Anjelir Antika ◽  
Dwi Rita Anggraini
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Wistar Rat ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Lawsonia Inermis ◽  
Control Group Design ◽  
Glucose Levels

 Objective: Lawsonia inermis (Linn.) leaves are one of the alternative medicines to treat diabetes mellitus in Indonesia. We investigated the blood glucose level (BGL) of the L. inermis (Linn.) leaves ethanolic extract (LLEE) leaves and evaluated the histopathological alterations in diabetic rats.Methods: This study was an experimental study with posttest - only control group design. Alloxan (120 mg/kg, intraperitoneally)-induced diabetic rats. 35 of Wistar rats (Rattus norvegicus) were divided randomly into five groups, i.e. K: Normal control, P1: Diabetic control, and P2, P3, and P4 (200 mg/kg body weight [BW], 400 mg/kg BW, and 600 mg/kg BW of LLEE, orally) for 28 days. At the end of the treatment, the rats were sacrificed to obtain the kidney for histopathological evaluation using hematoxylin and eosin technique. BGLs were conducted using a glucose meter (GlucoDR).Results: One-way ANOVA test showed that dose 400 mg/kg BW of the LLEE was related to BGL of alloxan-induced diabetic rats (p=0.000). The histopathological of kidney showed glomerular inflammation (GI), epithelial membrane lining degeneration, vascular congestion, and interstitial tubule hemorrhage at diabetic control (P1). Meanwhile, treated with 600 mg/kg BW of LLEE (P4) showed increase cellular regeneration as normal architecture of the kidney.Conclusion: The LLEE at dose 400 mg/kg BW effective decreased BGL and was able to restore the kidney destruction of alloxan-induced diabetic rats at dose 600 mg/kg BW.

scholarly journals PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Pipit Festi W
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Mus Musculus ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

 Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000  It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000  that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

scholarly journals The Potential of Strawberry, Rome Beauty Apple, and New Combination on Fasting Blood as Supporting Diet Therapy in Patients with Type II Diabetes Mellitus

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Niken Yuliwati ◽  
Riezky Faisal Nugroho
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Type Ii ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Post Hoc ◽  
Diabetes Melitus

Strawberries (Fragaria x ananassa) and Rome beauty apples (Malus sylvestris) contain high antioxidants to reduce oxidative stress and improve the glycemic response with diabetes mellitus (DM) type II. This study aimed to analyze the effect of strawberries, Rome beauty apples, and their combination to decrease fasting blood glucose levels of type II DM patients. This experimental research used a randomized pre-post-test with a control group design. Subjects were 44 patients divided into four groups: K (control, not given the fruit), P1 (strawberries 200 g/day), P2 (apples 300 g/day), and P3 (the combination strawberries 100 g/day, apples 150 g/day) for 14 days in February–March 2019 in Surakarta. The inclusion criteria were DM patients aged 40–55 years who received oral antidiabetic drug therapy. Exclusion criteria were type II DM patients who, based on the doctor's diagnosis, had complications such as gastritis, hypertension, chronic renal failure, heart disease, liver disease, stroke, cancer, patients with consumption of antioxidant supplements. Mean of blood glucose level on K (149.82±39.125), P1 (141.00±38.079), P2 (128.73±31.841), and P3 (177.73±50.176). Analysis paired t test results showed a significant difference between before and after treatment (p=0.045). To find out which group was the most meaningful, the Bonferroni post hoc test. Decrease of fasting blood glucose levels with group K (−10.55, p>0.05), P1 (−30.18, p<0.05), P2 (40.27, p<0.05), and P3 (−32.91, p<0.05). ANOVA test was used to analyze, and the post hoc Bonferroni test with a control comparison was performed, resulting in p=0.028, in P2 and p>0.05 in P1 and P3. In conclusion, strawberries, Rome beauty apples, and their combination significantly decreased fasting blood glucose levels of type II DM patients, with the highest and most significant decrease in Rome beauty apples. POTENSI STROBERI, APEL ROME BEAUTY, DAN KOMBINASI BARU TERHADAP GULA DARAH PUASA SEBAGAI PENUNJANG TERAPI DIET PADA PASIEN DIABETES MELITUS TIPE IIStroberi (Fragaria x ananassa) dan apel Rome beauty (Malus sylvestris) mengandung antioksidan tinggi untuk mengurangi stres oksidatif dan memperbaiki respons glikemik pada diabetes melitus (DM) tipe II. Tujuan penelitian adalah menganalisis pengaruh buah stroberi, apel Rome beauty, dan kombinasinya terhadap penurunan kadar glukosa darah puasa pasien DM tipe II. Jenis penelitian eksperimen dengan rancangan randomized pre-post-test dengan control group design. Subjek penelitian 44 pasien yang dibagi empat kelompok, yaitu K (kontrol tidak diberi buah), P1 (stroberi 200 g/hari), P2 (apel Rome beauty 300 g/hari) dan P3 (kombinasi stroberi 100 g/hari dan apel 150 g/hari) selama 14 hari pada bulan Februari–Maret 2020 di Surakarta. Kriteria inklusi adalah pasien DM usia 40–55 tahun yang mendapat terapi obat antidiabetik oral. Kriteria eksklusi adalah pasien DM tipe II yang berdasar atas diagnosis dokter mengalami komplikasi seperti mag, hipertensi, gagal ginjal kronik, penyakit jantung, penyakit hati, strok, kanker, dan pasien dengan konsumsi suplemen antioksidan. Kadar glukosa darah rerata pada K (149,82±39,125), P1 (141,00±38,079), P2 (128,73±31,841), dan P3 (177,73±50,176). Hasil analisis paired t test menunjukkan terdapat perbedaan yang signifikan antara sebelum dan sesudah perlakuan (p=0,045). Untuk mengetahui kelompok mana yang paling bermakna, dilakukan Uji Post Hoc Bonferroni. Penurunan kadar glukosa darah puasa pada K (−10,55; p>0,05), P1 (−30,18; p<0,05), P2 (−40,27; p<0,05), dan P3 (−32,91; p<0,05). Analisis dilakukan dengan uji ANOVA dan Uji Post Hoc Bonferroni dengan perbandingan kontrol menghasilkan p=0,028 pada P2 serta p>0,05 pada P1 dan P3. Simpulan, pemberian stroberi, apel Rome beauty, dan kombinasinya signifikan menurunkan kadar glukosa darah puasa pasien DM tipe II dengan penurunan tertinggi dan bermakna pada apel Rome beauty.

scholarly journals Pengaruh Progresive Muscle Relaxation Terhadap Penurunan Kadar Glukosa Darah Pada Penderita Diabetes Melitus Di Wilayah Kerja Puskesmas Ogan Lima Kecamatan Abung Barat Lampung Utara

2021 ◽  
Vol 3 (2) ◽  
pp. 285-295
Author(s):  
Umi Romayati Keswara ◽  
Rahma Elliya ◽  
Maya Maya
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Muscle Relaxation ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Test Results ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetes Melitus

ABSTRACT: THE EFFECT OF PROGRESIVE MUSCLE RELAXATION (PMR) ON REDUCING BLOOD GLUCOSE LEVELS IN PEOPLE WITH DIABETES MELLITUS IN THE WORK AREA OF OGAN LIMA HEALTH CENTER, WEST ABUNG DISTRICT, NORTH LAMPUNG Introduction: Diabetes mellitus (DM) is a non-communicable disease that often suffers. Diabetes mellitus (DM) is a non-communicable disease that often suffers.Purpose: To determine the effect of progresive muscle relaxation (PMR) on reducing blood glucose levels in people with diabetes mellitus.Method: This type of research is quantitative, quasi-experimental design using non equivalent control groups. The population in this study were all DM patients in the Work Area of Ogan Lima Health Center, West Abung District, North Lampung, with a total sample of 34 respondents. Data analysis used T test analysis (dependent and independent sample t-test).Results: The results of univariate analysis showed that the average blood glucose level of respondents in the pretest group was 247.29 ± 28.431 mg / dL and posttest 210.29 ± 28.711 mg / dL. The average level of respondent's blood glucose at pretest was 255.94 ± 30.738 mg / dL and posttest 230.76 ± 25.69 mg / dL. T-dependent test results obtained by the treatment group p-value = 0,000, and the control group p-value = 0.006. T-independent test results obtained p-value = 0.035.Conclusion: There was a significant difference between the blood glucose levels of diabetics in the treatment group and the control group. Suggestions are expected that health workers can apply PMR training as an alternative therapy for DM patients. Keywords :progresive muscle relaxation, blood glucose level, diabetes mellitus  Latar Belakang: Diabetes Melitus (DM) merupakan penyakit tidak menular yang sering diderita. Data di dunia sebanyak 422 juta orang dewasa hidup dengan diabetes, di Indonesia tahun 2018 prevalensi  diabetes meningkat dari 1,1% menjadi 2,0%, di Provinsi Lampung meningkat dari 0,8% menjadi1,6%, di Kabupaten Lampung Utara meningkat dari 0,9menjadi 1,07 %. Terapi komplementer untuk mengontrol kadar glukosa darah salah satunya dengan relaksasi otot progresif (Progresive Muscle Relaxation (PMR).Tujuan:Diketahui Pengaruh Progresive Muscle Relaxation (PMR) terhadap penurunan kadar glukosa  darah pada penderita diabetes melitus.Metode Penelitian:Jenis penelitian ini adalah kuantitatif, rancangan quasi eksperiment menggunakan non equivalent control group. Populasi dalam penelitian ini adalah seluruh pasien DM di Wilayah Kerja Puskesmas Ogan Lima Kecamatan Abung Barat Lampung Utara, dengan jumlah sampel sebanyak 34 responden.Analisis data menggunakan analisis uji T (dependent dan independent sample t-test).Hasil Penelitian: Hasil analisis univariat bahwa rata-rata kadar glukosa darah responden kelompok perlakuan saat pretest yaitu 247,29 ± 28,431 mg/dL dan posttest 210,29 ± 28,711 mg/dL. Rata-rata kadar glukosa darah responden saat pretest yaitu 255,94 ± 30,738 mg/dL dan posttest 230,76 ± 25,69mg/dL. Hasil uji t-dependen kelompok perlakuan diperoleh p-value=0,000, dan kelompok kontrol p-value=0,006. Hasil uji t-independen diperoleh p-value=0,035.Kesimpulan: Ada perbedaan yang signifikan antara kadar glukosa darah penderita diabetes melitus pada kelompok perlakuan dan kelompok kontrol. Saran diharapkan agar tenaga kesehatan dapat menerapkan latihan PMR sebagai alternative terapi pada pasien DM. Kata Kunci     : progresive muscle relaxation, kadar glukosa darah, diabetes melitus

scholarly journals Pengaruh Progresive Muscle Relaxation Terhadap Penurunan Kadar Glukosa Darah Pada Penderita Diabetes Melitus Di Wilayah Kerja Puskesmas Ogan Lima Kecamatan Abung Barat Lampung Utara

2021 ◽  
Vol 3 (2) ◽  
pp. 285-295
Author(s):  
Umi Romayati Keswara ◽  
Rahma Elliya ◽  
Maya Maya
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Muscle Relaxation ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Test Results ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetes Melitus

ABSTRACT: THE EFFECT OF PROGRESIVE MUSCLE RELAXATION (PMR) ON REDUCING BLOOD GLUCOSE LEVELS IN PEOPLE WITH DIABETES MELLITUS IN THE WORK AREA OF OGAN LIMA HEALTH CENTER, WEST ABUNG DISTRICT, NORTH LAMPUNG Introduction: Diabetes mellitus (DM) is a non-communicable disease that often suffers. Diabetes mellitus (DM) is a non-communicable disease that often suffers.Purpose: To determine the effect of progresive muscle relaxation (PMR) on reducing blood glucose levels in people with diabetes mellitus.Method: This type of research is quantitative, quasi-experimental design using non equivalent control groups. The population in this study were all DM patients in the Work Area of Ogan Lima Health Center, West Abung District, North Lampung, with a total sample of 34 respondents. Data analysis used T test analysis (dependent and independent sample t-test).Results: The results of univariate analysis showed that the average blood glucose level of respondents in the pretest group was 247.29 ± 28.431 mg / dL and posttest 210.29 ± 28.711 mg / dL. The average level of respondent's blood glucose at pretest was 255.94 ± 30.738 mg / dL and posttest 230.76 ± 25.69 mg / dL. T-dependent test results obtained by the treatment group p-value = 0,000, and the control group p-value = 0.006. T-independent test results obtained p-value = 0.035.Conclusion: There was a significant difference between the blood glucose levels of diabetics in the treatment group and the control group. Suggestions are expected that health workers can apply PMR training as an alternative therapy for DM patients. Keywords :progresive muscle relaxation, blood glucose level, diabetes mellitus  Latar Belakang: Diabetes Melitus (DM) merupakan penyakit tidak menular yang sering diderita. Data di dunia sebanyak 422 juta orang dewasa hidup dengan diabetes, di Indonesia tahun 2018 prevalensi  diabetes meningkat dari 1,1% menjadi 2,0%, di Provinsi Lampung meningkat dari 0,8% menjadi1,6%, di Kabupaten Lampung Utara meningkat dari 0,9menjadi 1,07 %. Terapi komplementer untuk mengontrol kadar glukosa darah salah satunya dengan relaksasi otot progresif (Progresive Muscle Relaxation (PMR).Tujuan:Diketahui Pengaruh Progresive Muscle Relaxation (PMR) terhadap penurunan kadar glukosa  darah pada penderita diabetes melitus.Metode Penelitian:Jenis penelitian ini adalah kuantitatif, rancangan quasi eksperiment menggunakan non equivalent control group. Populasi dalam penelitian ini adalah seluruh pasien DM di Wilayah Kerja Puskesmas Ogan Lima Kecamatan Abung Barat Lampung Utara, dengan jumlah sampel sebanyak 34 responden.Analisis data menggunakan analisis uji T (dependent dan independent sample t-test).Hasil Penelitian: Hasil analisis univariat bahwa rata-rata kadar glukosa darah responden kelompok perlakuan saat pretest yaitu 247,29 ± 28,431 mg/dL dan posttest 210,29 ± 28,711 mg/dL. Rata-rata kadar glukosa darah responden saat pretest yaitu 255,94 ± 30,738 mg/dL dan posttest 230,76 ± 25,69mg/dL. Hasil uji t-dependen kelompok perlakuan diperoleh p-value=0,000, dan kelompok kontrol p-value=0,006. Hasil uji t-independen diperoleh p-value=0,035.Kesimpulan: Ada perbedaan yang signifikan antara kadar glukosa darah penderita diabetes melitus pada kelompok perlakuan dan kelompok kontrol. Saran diharapkan agar tenaga kesehatan dapat menerapkan latihan PMR sebagai alternative terapi pada pasien DM. Kata Kunci     : progresive muscle relaxation, kadar glukosa darah, diabetes melitus

scholarly journals The Effectiveness of Vitamin D Addition to Decreasing Blood Glucose Levels of Hyperglycemic Mice Model with Glimepirid Therapy

2020 ◽  
Vol 6 (2) ◽  
pp. 71
Author(s):  
Tsintani Nur Aristiana ◽  
Cholis Abrori ◽  
Muhammad Ali Shodikin
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Negative Control ◽  
Control Group ◽  
Mice Model ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Low 25-hydrocyvitamin D (25(OH)D3) levels are usually found in patients with type 1 and type 2 diabetes mellitus. This study aims to compare the effectiveness of fasting blood glucose levels in hyperglycemic mice model with glimepirid single therapy, hyperglycemic mice model with vitamin D, and mice model of hyperglycemic with glimepirid therapy plus vitamin D. This study used the true experimental research design with the randomized posttest only control group design. There were 25 male mice (Mus musculus) strain Balb/C with 20-30 g body weight and 2-3 months old which were grouped into 5 groups. The negative control group (K1) was injected with placebo and the positive control group (K2) was injected with STZ 150 mg/kgBW i.p. Groups P1, P2, and P3 were given STZ injection of 150 mg/kgBW i.p and given glimepirid 0.26 mg/kgBW; vitamin D 6,5 ml/kgBW; glimepirid 0,26 mg/kgBW with vitamin D supplementation 6,5 ml/kgBW. The results of the Tukey post hoc tests obtained differences in the mean of delta KGD between groups P1 and K2 = 122,55; in group P2 with K2 = 81,60; and in group P3 with K2 = 74,40. From these data, it can be concluded that in the group given glimepirid plus vitamin D there was no additional effectiveness in decreasing fasting blood glucose levels of hyperglycemic mice model compared to the group given only glimepirid therapy and the group given vitamin D alone. Keywords: diabetes mellitus, vitamin D, glimepiride, streptozotocin.

scholarly journals Analisis Intervensi Senam Diabetes dalam Upaya Menurunkan Kadar Gula Darah

2020 ◽  
Vol 2 (1) ◽  
pp. 41-50
Author(s):  
Eni Hastuti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Control Group ◽  
Control Group Design ◽  
Study Approach ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Quasi Experimental

This study aims to determine the effect of diabetes exercise on reducing blood glucose levels in people with diabetes. This type of research is a quasi-experimental design with a non-equivalent control group design with a simple case study approach. A case study conducted in 5 days for 30 minutes showed that Diabetes Gymnastics was effective in reducing blood sugar levels in people with Diabetes Mellitus by 7.1%. In conclusion, diabetes exercises conducted for five consecutive days, effectively lower blood glucose levels in people with diabetes.   Keywords: Diabetes Mellitus, Blood Sugar, Gymnastics

scholarly journals Effect of Hyperbaric Oxygen Therapy Combined with Golden Sea Cucumber (Stichopus hermanii Powder to the Level Of Blood Glucose Diabetic Wistar Rat Induced Porphyromonas gingivalis

DENTA ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 18
Author(s):  
Rafika Rusydia Darojati ◽  
Yoifah Rizka ◽  
Syamsulina Revianti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Porphyromonas Gingivalis ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Wistar Rat ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels

<p><strong><em>Background: </em></strong><em>Diabetes mellitus (DM) is a metabolic disorders characterized by hyperglycemia caused by oxidative stress. Porphyromonas gingivalis (P.g) is a periodontopathogen caused periodontitis exacerbate blood glucose levels (BGL). Hyperbaric oxygen therapy (HBOT) combined with stichopus hermanii (SH) has a role as an antioxidant and antibacterial agent. <strong>Purpopse: </strong>To analysis effect of HBOT, SH powder and combination of both to the level of blood glucose diabetic Wistar rat induced P.g. <strong>Materials and Methods: </strong>This study was pre-test-post-test control group design, using 20 male Wistar rat were divided into 5 groups, Group1 (STZ), Group2 (STZ+P.g), Group3 (STZ+P.g+HBOT), Group4 (STZ+P.g+SH powder), Group5 (STZ+P.g+HBO+SH). STZ induction intravenous for 4 days in a row. P.g. induction was exposure 3 times for 4 days. After therapy (7 days),</em> <em>sample blood tail vein of rat were taken for measure BGL by glucometer.<strong> Result: </strong>Level of blood glucose<strong> </strong>K1(</em><em>280.25±88.786)mg/dl, K2(372.25±135.662)mg/dl, K3(249.50±96.652)mg/dl, K4(172.00±82.077)mg/dl, K5(104.75±38.257)mg/dl. <strong>Conclusion:</strong> Induction of STZ increased the BGL but induction of P.g. cannot exacerbate BGL . HBOT combined with SH powder can reduce BGL in STZ and P.g. induction group.</em></p><p><strong><em>Keywords: </em></strong><em>Diabetes mellitus, periodontitis, blood glucose levels, Stichopus hermanii, hyperbaric oxygen.</em></p><p><strong><em>Correspondence:</em></strong><strong><em> </em></strong><em>Yoifah Rizka, Department of </em><em>Periodontology</em><em>, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, 5912191, E</em><em>mail address: <a href="mailto:[email protected]">[email protected]</a></em></p>

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