scholarly journals PENGARUH PEMBERIAN TRANS FATTY ACID (TFA) DARI MARGARIN DAN MINYAK KELAPA SAWIT YANG DIPANASKAN BERULANG TERHADAP KADAR GLUKOSA DARAH PUASA PADA TIKUS WISTAR

2017 ◽  
Vol 11 (1) ◽  
pp. 69
Author(s):  
Retno Larasati ◽  
Bambang Wirjatmadi ◽  
Merryna Adriani
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Trans Fatty Acid ◽  
Palm Oil ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Control Group Design ◽  
Treatment Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels

The purpose of this study was to know differences in fasting blood glucose levels among both the control and treatment groups were given Trans Fatty Acid of groceries margarine and oil is heated rapidly. This research is true experimental design to study Post Test Only Control Group Design. The sample size in this study was 25 rats wistar strain males were divided into 5 groups: the first group was the control, the second group by of margarine that is heated by the content of TFA 1%, the third group by the addition palm oil, which is heated repeats to content TFA 1%, the fourth group by margarine are heated with TFA content of 2%, and the fifth group by the addition of palm oil, which is heated repeats to the TFA content of 2%. Treatment was given for 4 weeks, after the laboratory examination of fasting blood glucose at the end of the treatment. Data fasting blood glucose levels in all groups were tested by one-way ANOVA with 95% confidence level. The results showed that TFA may increase the levels of fasting blood glucose treatment groups compared with the control group, and the differences in levels of fasting blood glucose between treatment groups was not influenced by the amount of content TFA but due to different types of TFA given that of margarine and palm oil that is heated Repeat.Keywords: fasting glucose, TFA, margarine, oil heated, rats

scholarly journals The Potential of Strawberry, Rome Beauty Apple, and New Combination on Fasting Blood as Supporting Diet Therapy in Patients with Type II Diabetes Mellitus

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Niken Yuliwati ◽  
Riezky Faisal Nugroho
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Type Ii ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Post Hoc ◽  
Diabetes Melitus

Strawberries (Fragaria x ananassa) and Rome beauty apples (Malus sylvestris) contain high antioxidants to reduce oxidative stress and improve the glycemic response with diabetes mellitus (DM) type II. This study aimed to analyze the effect of strawberries, Rome beauty apples, and their combination to decrease fasting blood glucose levels of type II DM patients. This experimental research used a randomized pre-post-test with a control group design. Subjects were 44 patients divided into four groups: K (control, not given the fruit), P1 (strawberries 200 g/day), P2 (apples 300 g/day), and P3 (the combination strawberries 100 g/day, apples 150 g/day) for 14 days in February–March 2019 in Surakarta. The inclusion criteria were DM patients aged 40–55 years who received oral antidiabetic drug therapy. Exclusion criteria were type II DM patients who, based on the doctor's diagnosis, had complications such as gastritis, hypertension, chronic renal failure, heart disease, liver disease, stroke, cancer, patients with consumption of antioxidant supplements. Mean of blood glucose level on K (149.82±39.125), P1 (141.00±38.079), P2 (128.73±31.841), and P3 (177.73±50.176). Analysis paired t test results showed a significant difference between before and after treatment (p=0.045). To find out which group was the most meaningful, the Bonferroni post hoc test. Decrease of fasting blood glucose levels with group K (−10.55, p>0.05), P1 (−30.18, p<0.05), P2 (40.27, p<0.05), and P3 (−32.91, p<0.05). ANOVA test was used to analyze, and the post hoc Bonferroni test with a control comparison was performed, resulting in p=0.028, in P2 and p>0.05 in P1 and P3. In conclusion, strawberries, Rome beauty apples, and their combination significantly decreased fasting blood glucose levels of type II DM patients, with the highest and most significant decrease in Rome beauty apples. POTENSI STROBERI, APEL ROME BEAUTY, DAN KOMBINASI BARU TERHADAP GULA DARAH PUASA SEBAGAI PENUNJANG TERAPI DIET PADA PASIEN DIABETES MELITUS TIPE IIStroberi (Fragaria x ananassa) dan apel Rome beauty (Malus sylvestris) mengandung antioksidan tinggi untuk mengurangi stres oksidatif dan memperbaiki respons glikemik pada diabetes melitus (DM) tipe II. Tujuan penelitian adalah menganalisis pengaruh buah stroberi, apel Rome beauty, dan kombinasinya terhadap penurunan kadar glukosa darah puasa pasien DM tipe II. Jenis penelitian eksperimen dengan rancangan randomized pre-post-test dengan control group design. Subjek penelitian 44 pasien yang dibagi empat kelompok, yaitu K (kontrol tidak diberi buah), P1 (stroberi 200 g/hari), P2 (apel Rome beauty 300 g/hari) dan P3 (kombinasi stroberi 100 g/hari dan apel 150 g/hari) selama 14 hari pada bulan Februari–Maret 2020 di Surakarta. Kriteria inklusi adalah pasien DM usia 40–55 tahun yang mendapat terapi obat antidiabetik oral. Kriteria eksklusi adalah pasien DM tipe II yang berdasar atas diagnosis dokter mengalami komplikasi seperti mag, hipertensi, gagal ginjal kronik, penyakit jantung, penyakit hati, strok, kanker, dan pasien dengan konsumsi suplemen antioksidan. Kadar glukosa darah rerata pada K (149,82±39,125), P1 (141,00±38,079), P2 (128,73±31,841), dan P3 (177,73±50,176). Hasil analisis paired t test menunjukkan terdapat perbedaan yang signifikan antara sebelum dan sesudah perlakuan (p=0,045). Untuk mengetahui kelompok mana yang paling bermakna, dilakukan Uji Post Hoc Bonferroni. Penurunan kadar glukosa darah puasa pada K (−10,55; p>0,05), P1 (−30,18; p<0,05), P2 (−40,27; p<0,05), dan P3 (−32,91; p<0,05). Analisis dilakukan dengan uji ANOVA dan Uji Post Hoc Bonferroni dengan perbandingan kontrol menghasilkan p=0,028 pada P2 serta p>0,05 pada P1 dan P3. Simpulan, pemberian stroberi, apel Rome beauty, dan kombinasinya signifikan menurunkan kadar glukosa darah puasa pasien DM tipe II dengan penurunan tertinggi dan bermakna pada apel Rome beauty.

scholarly journals Pengaruh Pemberian Minuman Fungsional Terhadap Penurunan Kadar Glukosadarah Puasa Pada Penderita Diabetes Melitus

2019 ◽  
Vol 4 (2) ◽  
pp. 114
Author(s):  
Tutut Zikra Anjani ◽  
Suhaema Suhaema ◽  
Fifi Lutfiah ◽  
Ni Ketut Sri Sulendri
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Female Gender ◽  
Simple Random Sampling ◽  
Control Group ◽  
Risk Category ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test

Indonesia is currently the fourth country with the largest number of DM patients in the world. Functional food is beneficial for the health of DM patients, for example bananas and soybeans. Kepok bananas contain dietary fiber inulin and antioxidants (β carotene). Soybeans contain isoflavones, fiber, and proteins in the form of amino acids arginine and glycine. This study aims to look at the effect of giving functional drinks a mixture of soybean and banana milk on decreasing fasting blood glucose levels in type II DM patients. Type of Quasy-experimental research with pre test and post test with control group design. Subjects were taken using the Simple Random Sampling method and the subjects involved until the end of the study were 26 people. The intervention was carried out for 14 days and given as much as 330 ml. The equality of the subject characteristics of the two groups was analyzed using the chy squere test, and the effect of giving intervention materials on decreasing blood glucose levels was tested by independent t test. The results of the study were characteristics (84.6%) aged 50-60 years, (53.8%) female gender, (57.1%) having a family history of disease, 58.4% using glibenclamide anti-hyperglycemic drugs and BMI average in the risk category. . Result Δ It is known that there is an effect of giving functional drinks on decreasing fasting blood glucose levels where the average change is 11.5 mg / dl (p = 0.03). 

scholarly journals Pengaruh pemberian susu almond terhadap glukosa darah puasa pada tikus diabetes

2019 ◽  
Vol 7 (2) ◽  
pp. 86-91
Author(s):  
Ryta Ristantia Ningsih ◽  
Enny Probosari ◽  
Binar Panunggal
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
Glucose Measurement ◽  
Control Group ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Background: Type 2 Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that occurs due to abnormalities in insulin secretion and insulin action. Diet plus high fiber can help control glucose levels. Almond contains fiber, vitamin E, and magnesium that contributes to the fasting blood glucose levels. This study aimed to analyze the effect of almond milk to the fasting blood glucose diabetic rats.Method: This study used an experimental design with pre-post test control group design. The sample were Rattus norvegicus Wistar which were divided into 4 groups: K (-), K (+), A1 and A2. Almond milk was given in the group treatmeant for 14 days with a dose of 4.32 ml and 8.64 ml. Fasting blood glucose measurement taken before and after treatment used Oxidase Glucose - Peroxidase Aminoantypirin (GOD PAP). Analysis of data used paired t-test, ANOVA and Post Hoc.Results: The fasting blood glucose levels decreased significantly (p = 0.01) in the treatment group which were intervened with almond milk. A decrease in fasting blood glucose levels in a dose treatment group 1 for 116.96 ± 4.45 (p = 0:01), whereas in the group treated at a dose of 2 for 155.53 ± 3.15 (p = 0.01). There were a significant difference in decreased of the fasting blood glucose levels between the two treatment groups (p = 0.01).Conclusion:  Giving a dose almond milk 4.32 ml and 8.64 ml for 14 days can lower the fasting blood glucose levels significantly.

scholarly journals The Effectiveness of Vitamin D Addition to Decreasing Blood Glucose Levels of Hyperglycemic Mice Model with Glimepirid Therapy

2020 ◽  
Vol 6 (2) ◽  
pp. 71
Author(s):  
Tsintani Nur Aristiana ◽  
Cholis Abrori ◽  
Muhammad Ali Shodikin
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Negative Control ◽  
Control Group ◽  
Mice Model ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Low 25-hydrocyvitamin D (25(OH)D3) levels are usually found in patients with type 1 and type 2 diabetes mellitus. This study aims to compare the effectiveness of fasting blood glucose levels in hyperglycemic mice model with glimepirid single therapy, hyperglycemic mice model with vitamin D, and mice model of hyperglycemic with glimepirid therapy plus vitamin D. This study used the true experimental research design with the randomized posttest only control group design. There were 25 male mice (Mus musculus) strain Balb/C with 20-30 g body weight and 2-3 months old which were grouped into 5 groups. The negative control group (K1) was injected with placebo and the positive control group (K2) was injected with STZ 150 mg/kgBW i.p. Groups P1, P2, and P3 were given STZ injection of 150 mg/kgBW i.p and given glimepirid 0.26 mg/kgBW; vitamin D 6,5 ml/kgBW; glimepirid 0,26 mg/kgBW with vitamin D supplementation 6,5 ml/kgBW. The results of the Tukey post hoc tests obtained differences in the mean of delta KGD between groups P1 and K2 = 122,55; in group P2 with K2 = 81,60; and in group P3 with K2 = 74,40. From these data, it can be concluded that in the group given glimepirid plus vitamin D there was no additional effectiveness in decreasing fasting blood glucose levels of hyperglycemic mice model compared to the group given only glimepirid therapy and the group given vitamin D alone. Keywords: diabetes mellitus, vitamin D, glimepiride, streptozotocin.

scholarly journals Potency of Swallow Nest Extract (Collocalia fuciphago) as Pancreaprotector Through Oxidative Mechanism in Rats (Rattus norvegicus) Induced by Streptozotocin

2018 ◽  
Vol 14 (1) ◽  
pp. 15
Author(s):  
Agnes Frethernety ◽  
Satriyandi M ◽  
Francisca Diana Alexandra
Keyword(s):  
Blood Glucose ◽  
Rattus Norvegicus ◽  
Fasting Blood Glucose ◽  
Water Extract ◽  
Clinical Syndrome ◽  
Control Group ◽  
P Value ◽  
Treatment Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract: Diabetes mellitus is a clinical syndrome with characteristics of hyperglycemia. Hyperglycemia can lead to the formation of excessive free radical compounds that trigger oxidative stress, especially on pancreatic β cells. Swallow nest contains amino acids which are insulin-forming compounds and glutathione that can act as a major reducing agent and antioxidant defense. The purpose of this study is to analyze the effect of swallow’s nest water extract as a pancreaprotector through oxidative mechanism in rats (Rattus norvegicus) induced by streptozotocin. The rats induced by streptozotocin at a dose of 40 mg/kg BW and then randomly divided into 4 groups. Control groups were given aquades and 3 treatment groups, respectively were administered swallow’s nest water extract at doses of 1, 10, 100 mg/kg BW for 21 days. Fasting blood glucose levels were measured on 7, 14 and 21 day. MDA measured after  the animal is determined  at day 28th.Level of  fasting blood glucose and MDA were analyzed by statistic using Kruskal Wallis test followed by multiple comparisons Mann Whitney test. There was a significant decrease in fasting blood glucose level with p = 0.04 in all treatment groups compared the control group. The administration of swallow nest extract significantly decreased MDA pancreas with p value = 0.000 and dose 100 mg/kgBW extract of swallow’s nest significantly decrease pancreatic MDA level. The administration of swallow’s nest water extract shows decrease of fasting blood sugar and has a protective effect on the rats’ pancreas  through oxidative mechanism. Keywords: Swallow's nest extract, MDA

scholarly journals Pengaruh Pemberian Aspartam terhadap Kadar Glukosa Darah Tikus Diabetes Melitus Diinduksi Aloksan

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Ega Purnamasari ◽  
Eti Yerizel ◽  
Efrida Efrida
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Diabetes Melitus

AbstrakAspartam merupakan gula pengganti rendah kalori yang sering dikonsumsi oleh pengidap diabetes, tetapi keamanannya masih kontroversi. Intensitas rasa manis aspartam yang tinggi diduga dapat menurunkan kadar glukosa darah. Penelitian lain menyebutkan hasil metabolisme aspartam berupa asam aspartat dan fenilalanin dapat menjadi prekursor glukosa melalui glukoneogenesis. Tujuan penelitian ini ialah untuk mengetahui pengaruh pemberian aspartam terhadap kadar glukosa darah tikus diabetes melitus diinduksi aloksan. Penelitian ini adalah penelitian eksperimental dengan post-test only control group design. Sampel penelitian ini terdiri dari 20 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol negatif (KN), kontrol positif (KP), perlakuan 1 (P1), perlakuan 2 (P2). Aloksan 150 mg/kgBB diinduksikan pada kelompok KP dan P2, aspartam 315 mg/kgBB diberikan pada kelompok P1 dan P2 selama 4 minggu. Kadar glukosa darah puasa diukur setelah 4 minggu menggunakan spektrofotometer. Hasil penelitian ini didapatkan rerata kadar glukosa darah puasa kelompok KN (88,39 mg/dL), KP (134,11 mg/dL), P1 (93,95 mg/dL), dan P2 (66,66 mg/dL). Analisis data dengan Uji ANOVA nilai p= 0,000 (p<0,05), terdapat perbedaan kadar glukosa darah puasa yang bermakna pada semua kelompok. Keimpulan penelitian ini adalah terdapat pengaruh pemberian aspartam terhadap penurunan kadar glukosa darah puasa tikus diabetes melitus diinduksi aloksan.Kata kunci: aspartam, kadar glukosa darah, diabetes melitus, aloksanAbstractAspartame is a low-calorie sugar substitute that is often consumed by people with diabetes, but the safety of aspartame is still controversial. The high intensity of aspartame sweetness could be expected to lower blood glucose levels. Other study said the results of the metabolism of aspartame such aspartic acids and phenylalanine which can be a precursor of glucose through gluconeogenesis. The purpose of this study was to determine the effect of aspartame on blood glucose levels of alloxan induced diabetic rats. This study is an experimental study with a post-test only control group design. Twenty male Wistar rats were divided into 4 groups: negative control (KN), positive control (KP), treatment 1 (P1), treatment 2 (P2). Alloxan 150 mg/kg body weight induced in KP and P2 groups, aspartame 315 mg/kg body weight administered on P1 and P2 groups for 4 weeks. Fasting blood glucose levels were measured after 4 weeks using a spectrophotometer. The results of this study, the mean fasting blood glucose levels KN group (88.39 mg/dL), KP (134.11 mg/dL), P1 (93.95 mg/dL), and P2 (66.66 mg/dL). Data were analyzed using ANOVA test, p-value=0.000 ( p<0.05 ), there are differences in fasting blood glucose levels were significant in all groups. The conclusions of this study is the provision of aspartame in alloxan induced diabetic rats can cause a decrease in blood glucose levels significantly.Keywords: aspartame, blood glucose levels, diabetes mellitus, alloxan

scholarly journals UJI ANTIDIABETIK EKSTRAK ETANOL BUNGA PEPAYA (Carica papaya L.) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 160
Author(s):  
Adinda Fransisca Pongoh ◽  
Edwin De Queljoe ◽  
Henki Rotinsulu
Keyword(s):  
Blood Glucose ◽  
Rattus Norvegicus ◽  
Carica Papaya ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Control Group ◽  
Homogeneity Test ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels

ABSTRACT This study aims to determine the antidiabetic activity of papaya flower ethanol extract (Carica papaya L.) against male white rats (Rattus norvegicus) induced by alloxan. This research is experimental. Fifteen rats were divided into 5 treatment groups, each group consisted of 3 rats. The first group was the negative control group given Aquades, the second group was positive control given Glibenklamid, the three groups were 200 mg dose variation groups, four groups were 400 mg dose variations, and the five groups were 800 mg dose variations. Previously, rats were examined fasting blood glucose levels, then mice were induced by an alloxan dose of 120 mg / kgBW intraperitoneally. On the 3rd day blood glucose levels were examined and then treated according to groups for 7 days, measurement of blood glucose levels after the treatment was carried out once every 3 days namely day 3, day 7, and day 10. Data obtained were then analyzed statistically using SPSS , including normality test (Shapiro-Wilk), homogeneity test (Levene), ANOVA test (One way). The results of this study indicate that Papaya Flower (Carica papaya L.) Ethanol Extract can provide the best blood glucose level reduction effect at a dose of 800 mg. Keywords : Antidiabetic, Papaya Flower Extract (Carica papaya L.), Diabettes Mellitus, Male White Rat (Rattus norvegicus), Aloxan.  ABSTRAK Penelitian ini bertujuan untuk mengetahui efektivitas Antidiabetik Ekstrak Etanol Bunga Pepaya (Carica papaya L.) Terhadap Tikus Putih Jantan (Rattus norvegicus) Yang Diinduksi Aloksan. Penelitian ini bersifat eksperimental. Sebanyak 15 ekor tikus dibagi ke dalam 5 kelompok perlakuan masing- masing kelompok terdiri dari 3 ekor tikus. Kelompok pertama kelompok Kontrol negatif yang diberikan Aquades, Kelompok kedua Kontrol Positif yang diberikan Glibenklamid, kelompok tiga kelompok variasi dosis 200 mg, kelompok empat kelompok variasi dosis 400 mg, dan kelompok lima kelompok variasi dosis 800 mg. Sebelumnya tikus dilakukan pemeriksaan kadar glukosa darah puasa, selanjutnya tikus diinduksi Aloksan dosis 120 mg/kgBB secara intraperitoneal. Pada hari ke 3 diperiksa kadar Glukosa darah kemudian diberikan perlakuan sesuai kelompok selama 7 hari, pengukuran kadar glukosa darah setelah perlakuan dilakukan 3 hari sekali yaitu hari ke 3, hari ke 7, dan hari ke 10. Data yang diperoleh kemudian dianalisis secara statistik menggunakan SPSS, meliputi uji normalitas (Shapiro-Wilk), uji homogenitas (Levene), uji ANOVA (One way). Hasil penelitian ini menunjukkan bahwa Ekstrak Etanol Bunga Pepaya (Carica papaya L.)  dapat memberikan efek penurunan kadar glukosa darah yang paling baik yaitu pada dosis 800 mg. Kata kunci : Antidiabetik, Ekstrak Bunga pepaya (Carica papaya L.), Diabettes Mellitus, TikusPutih Jantan (Rattus norvegicus), Aloksan.

scholarly journals UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BUAH CABAI MERAH ( Capsicum annuum L. ) TERHADAP MENCIT PUTIH JANTAN

2019 ◽  
Vol 9 (1) ◽  
pp. 86 ◽  
Author(s):  
Zulkarni Zulkarni
Keyword(s):  
Blood Glucose ◽  
Capsicum Annuum ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
Capsicum Annuum L ◽  
Blood Glucose Levels ◽  
Significant Difference

This Research was conducted to determine the effect of ethanol extract from red chilli (Capsicum annuum L)in lowering blood glucose levels of hyperglycemic male white mices. This study used 30 malewhitemices and divided into 6 groups: negative control group, the positive control group, the treatmentgroup withdosage of 200 mg / kgweight, 400 mg / kgwieght, 600 mg / kg weight and a comparison group with glibenclamide with dosage of 5 mg / kgweightadministered orally for 21 days. The level of fasting blood glucose was checked 6 days after dexamethasone induced, and after the ethanol extract of red chilies on day 7th, 14th, and 21st. The data was analyzed statistically with one –way and two-way Anova by usingSPSS16 program and proceed with the test Duncan to look the significant difference between treatments. The results showed that the ethanol extract from red chilies with a dosage of 200mg / kgweight, 400mg / kgweight, 600 mg / kgweight showed the effect in lowering blood sugar levels in male white mices hyperglycemia significantly (p <0.05). The duration ethanol extract of red chili affected blood glucose levels. The most effective duration in lowering blood glucose levels is the administration of a preparation within 21 days.

scholarly journals PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Pipit Festi W
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Mus Musculus ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

 Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000  It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000  that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

scholarly journals Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

2020 ◽  
Vol 9 (1) ◽  
pp. 61-67
Author(s):  
Natalia Desy Putriningtyas ◽  
Intan Permatasari ◽  
Dita Oktaviani ◽  
Anastasia Servia Raha ◽  
Siti Wahyuningsih
Keyword(s):  
Blood Glucose ◽  
Functional Food ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Fruit Peel ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Significant Difference

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

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