scholarly journals The Effect of Jamblang (Syzygium Cumini (L) Skeels) Leaves Ethanolic Extract on the Adhesion of Streptococcus Mutans to Hydroxyapatite

2018 ◽  
Author(s):  
Suzanna Sungkar ◽  
Dewi Agustina ◽  
Al Supartinah ◽  
Tetiana Haniastuti
Keyword(s):  
Streptococcus Mutans ◽  
Ethanolic Extract ◽  
Syzygium Cumini

THE EFFECT OF ETHANOLIC EXTRACT OF Syzygium cumini LEAVES ON THE GROWTH OF Streptococcus mutans

2018 ◽  
Vol 21 (2) ◽  
pp. 32-36
Author(s):  
Suzanna Sungkar ◽  
Tetiana Haniastuti ◽  
Al Supartinah Santoso ◽  
Dewi Agustina
Keyword(s):  
Streptococcus Mutans ◽  
Antibacterial Effect ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Tooth Surface ◽  
Syzygium Cumini ◽  
Liquid Chromatograph ◽  
Molar Teeth ◽  
Deciduous Molar ◽  
Layer Chromatography

Streptococcus mutans plays an important role in the pathogenesis of caries. This bacteria has virulence properties involve in the formation of biofilm on tooth surface. Due to its antibacterial effect, Jamblang leaf may be used as an agent to prevent caries. Objective: This study aimed to elucidate the effects of ethanolic extract of Jamblang leaves on the growth of S. mutans. Methods: Analysis of active compounds was carried out using thin layer chromatography (TLC) and Liquid Chromatograph-Mass Spectrography (LC-MS). Samples of S. mutans were isolated from children’s carious deciduous molar teeth. Growth test was done by dilusion technique. Aquadest was used as a negative control. Results: TLC and LC-MS showed the presence of the flavonoid, tannin, and terpenoid Kruskall-Wallis test showed significant differences (p<0.05) among the groups, indicating that Jamblang leaves ethanolic extract decreased the growth of S.mutans. The higher concentrations of the extract, the less number of S.mutans colonies grown. No colony of S. mutans at 22.5% of extract’s concentration. Conclusion: Jamblang leaves ethanolic extract reduces the growth of             S. mutans. Concentration of 22.5%Jamblang leaves ethanolic extracthas bacteriocid effect. Key words: Ethanolic extract of Jamblang (Syzygium cumini) leaves, growth, Streptococcus mutans

Susceptibility of animal pathogenic bacteria to an ethanolic extract from jambolan (Syzygium cumini) leaves

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AL Magalhães ◽  
G Melo ◽  
N Gabriel ◽  
G Gabas ◽  
G Gonçalves ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Ethanolic Extract ◽  
Syzygium Cumini

scholarly journals Perfil fitoquímico e determinação da atividade antimicrobiana de Syzygium cumini (L.) Skeels (Myrtaceae) frente a microrganismos bucais

2015 ◽  
Vol 17 (4 suppl 3) ◽  
pp. 1091-1096
Author(s):  
N.A.D.E.O. CARTAXO-FURTADO ◽  
T.O. SAMPAIO ◽  
M.A. XAVIER ◽  
A.D.D.E. MEDEIROS ◽  
J.V. PEREIRA
Keyword(s):  
Candida Albicans ◽  
Streptococcus Mutans ◽  
Syzygium Cumini ◽  
Streptococcus Oralis

RESUMO Este estudo teve como objetivo determinar o perfil fitoquímico e avaliar a atividade antimicrobiana in vitro do extrato etanólico da casca do caule de Syzygium cumini(L.) Skeels frente a microrganismos bucais. O perfil fitoquímico do extrato foi traçado através da determinação espectrofotométrica quantitativa para verificar o teor de taninos, flavonóides, saponinas e polifenóis. A atividade antimicrobiana foi determinada através da Concentração Inibitória Mínima (CIM), por meio da técnica de microdiluição em caldo, utilizando-se as seguintes linhagens de microrganismos: Streptococcus mutans (25175), Streptococcus oralis (10557) e Candida albicans (10231). Uma quantidade apreciável de fitocontituintes foi observada, especialmente de taninos (100,58 ± 1,81). Os extratos apresentaram atividade antimicrobiana inibindo o crescimento das linhagens em estudo, destacando-se essa atividade sobre o crescimento de C. albicans (CIM=250 µg/mL). Já as CIMs para Streptococcus foram baixas. Diante dos resultados expostos, pode-se concluir que o perfil fitoquímico foi traçado e que, dentre os microrganismos testados, o extrato etanólico da casca de S. cumini apresentou forte potencial de inibição sobre o crescimento de C. albicans e fraca inibição frente aos Streptococcus testados. Este estudo sugere que mais pesquisas devem ser realizadas dando continuidade à bioprospecção, por meio de análises experimentais com essa espécie vegetal, objetivando, no futuro, que essa planta possa ser utilizada clinicamente para tratar candidose bucal.

scholarly journals EFFECTIVENESS OF A JAVANESE TURMERIC ETHANOL EXTRACT FOR ERADICATING STREPTOCOCCUS MUTANS AND PORPHYROMONAS GINGIVALIS BIOFILMS

2019 ◽  
pp. 27-31
Author(s):  
DEWI FATMA SUNIARTI ◽  
AGOENG TJAHAJANI SARWONO ◽  
MARINA ROSYANA
Keyword(s):  
Streptococcus Mutans ◽  
Porphyromonas Gingivalis ◽  
Growth Phase ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Growth Phases

Objective: We aimed to determine the effectiveness of an identified Javanese turmeric ethanolic extract (IIJTEE) for eradicating biofilms formed byStreptococcus mutans, Porphyromonas gingivalis, or both.Methods: Such biofilms during different growth phases were exposed to various concentrations of an IJTEE to determine its effects on bacterialproliferation.Results: The effectiveness of the IJTEE in eradicating the S. mutans biofilm was concentration-dependent but not when used to treat P. gingivalis andS. mutans - P. gingivalis biofilms.Conclusion: The effectiveness of the IJTEE for eradicating biofilms formed by S. mutans, P. gingivalis, and S. mutans plus P. gingivalis biofilms dependedon the growth phase of the biofilm. Thus, IJTEE eradicated biofilms formed by S. mutans, P. gingivalis, or both.

scholarly journals AN INVITRO COMPARATIVE EVALUATION OF ANTICANDIDAL HERBS (GINGER & TURMERIC) ON STREPTOCOCCUS MUTANS

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Bafna Harshal P ◽  
Lunawat Sadhana R ◽  
Vathar Jagdishchandra ◽  
Kalantharakath Thanveer ◽  
Ricky Pal Singh ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Ethanolic Extract ◽  
Antimicrobial Effect ◽  
Positive Control ◽  
Negative Control ◽  
Dimethyl Formamide ◽  
Zone Of Inhibition ◽  
Ginger Extract ◽  
Inert Solvent

Aim: To comparatively evaluate the antimicrobial effect of turmeric and ginger extracts on Streptococcus mutans in in-vitro conditions. Material & Method: An in-vitro experimental study was conducted in a laboratory setting. Ethanolic extract of Ginger and Turmeric was prepared separately by cold masseration technique. The extract of each was then diluted with an inert solvent, Dimethyl Formamide, to obtain 5 different concentrations (2%, 4%, 6%, 8%, and 10%) of each. 0.2% chlorhexidine was used as a positive control and dimethyl formamide was used as negative control. The different extracts, along with controls, were then subjected to microbiological investigation to determine which gave a wider zone of inhibition against streptococcus mutans. The zone of inhibition was measured in millimeters. Results: Turmeric extracts presented the largest zone of inhibition 33mm at the concentration of 8%, while Ginger extract showed a zone of inhibition of 34mm at the concentration of 10%. Conclusion: Ethanolic extract of Turmeric demonstrated antimicrobial activity against Strptococcus Mutans at a lower concentration than that of Ginger. Keywords: Ginger, Turmeric, Streptococcus Mutans.

scholarly journals Thrombolytic, CNS Depressant and Anti-Diarrhoeal Activities of Ethanolic Extract of Bark of Syzygium cumini L. Skeels: An In-Vivo and In-Vitro Study

2018 ◽  
Vol 8 (3) ◽  
pp. 129-136
Author(s):  
Fokhrul Abedin ◽  
Md. Saddam Hussain ◽  
Areful Islam ◽  
Niloy Sen ◽  
Abhijit Das ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Ethanolic Extract ◽  
Vitro Study ◽  
Syzygium Cumini ◽  
Cns Depressant

scholarly journals Ethanolic Extract of Syzygium cumini Causes Toxic Effects on Ethanol-induced Liver and Kidney Damage in Albino Wistar Rats: A Biochemical and Histological Study

2022 ◽  
Vol 16 (1) ◽  
pp. 63-72
Author(s):  
Abba Aji Manu ◽  
◽  
Bello Muhammad Musa ◽  
Martha Orendu Oche Attah ◽  
Helga Ishaya Bedan ◽  
...  
Keyword(s):  
Histological Study ◽  
Kidney Tissue ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Syzygium Cumini ◽  
Tissue Samples ◽  
Inflammatory Conditions ◽  
Therapeutic Value ◽  
Liver And Kidney ◽  
Wistar Albino Rats

Background: The therapeutic value of Syzygium cumini (S. cumini) has been documented in traditional medicine for the treatment of many diseases and ailments. Various preparations of this plant have been made and used especially for liver inflammatory conditions in livestock. Further, many liver diseases in humans are inflammatory conditions, which are caused by alcohol intake. This study sought to examine the effect of S. cumini on ethanol-induced hepatotoxicity in Wistar albino rats. Methods: Twenty-five rats were divided into five groups of five rats each. The first group was control and the other four were administered ethanol at varying doses to induce liver and kidney damages. Two doses of the S. cumini extract were administered at a concentration of 200 mg/kg or 400 mg/kg. Silymarin was administered to the last group at 10 mg/kg. The liver and kidney tissue samples were collected and preserved for histological analyses and the rat sera were analyzed for the associated biochemical biomarkers. Results: Histopathological analyses revealed pyknotic nuclei and distortion in the arrangement of the hepatocytes in extract-treated groups. The kidney tissue samples showed signs of interstitial bleeding and aggregation of lymphocytes in the peri-glomerular areas. The analyses of the biochemical parameters revealed that there were significant increases in the aspartate aminotransferase (AST), alanine transaminase (ALT), Urea and creatinine in the sera of the groups treated with the extract compared to those of the controls (P<0.05). Conclusion: The S. cumini extract caused elevation of serum hepatic and renal biomarkers at 400 mg/kg and did not have a hepatoprotective effect.

scholarly journals COMPARATIVE STUDY OF ALCOHOLIC AND AQUEOUS EXTRACTS OF SYZYGIUM CUMINI ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR RATS

2016 ◽  
Vol 9 (9) ◽  
pp. 182
Author(s):  
Shweta Sharma ◽  
Mehta Bk
Keyword(s):  
Alkaline Phosphatase ◽  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Hepatic Injury ◽  
Total Bilirubin ◽  
Ethanolic Extract ◽  
Aqueous Extracts ◽  
Syzygium Cumini ◽  
Standard Drug ◽  
Ethanolic Extracts

ABSTRACTObjective: In this investigation, the comparative hepatoprotective effect of aqueous and ethanolic extracts of Syzygium cumini (AESC and EESC,respectively) was studied on carbon tetrachloride (CCl4)-induced hepatic injury in rats. These findings were also compared with the standardhepatoprotective drug silymarin.Methods: Hepatotoxicity was induced by a single dose of CCl4 to healthy Wistar rats. Standard drug (100 mg/kg) and test extracts (500 mg/kg forboth) were given orally for 10 days; the effects were observed using different biochemical and histological methods.Results: In most of the studied parameters test extracts exhibited significant hepatoprotection, these were comparative to standard. Histologicalanalysis also revealed the protective nature of both the extracts.Conclusion: These results suggest that the SC extracts can ameliorate CCl4 induced hepatic injury. However, its ethanolic extract was found to berelatively less effective than aqueous extract. Indicated, some hydrophilic active compound of SC might work here.Keywords: Hepatoprotective, Carbon tetrachloride, Silymarin, Syzygium cumini, Alkaline phosphatase, Total bilirubin.

scholarly journals EFFECT OF COMBINATION OF TWO PLANT EXTRACTS ON DIABETES MELLITUS

2018 ◽  
Vol 10 (4) ◽  
pp. 49
Author(s):  
Jose Deepa ◽  
N. A. Aleykutty ◽  
Harindran Jyoti
Keyword(s):  
Glucose Uptake ◽  
Plant Extracts ◽  
Ethanolic Extract ◽  
High Sensitivity ◽  
Psidium Guajava ◽  
Alpha Amylase ◽  
Individual Plant ◽  
Syzygium Cumini ◽  
Standard Drug

Objective: To investigate the anti-diabetic activity of combined ethanolic extracts (1:1mixture) of dry leaves of Syzygium cumini and Psidium guajava belonging to the family Myrtaceae as well as to compare the anti-diabetic activity of these plants by in vitro methods.Methods: In vitro glucose uptake assay was performed on cultured L6 cell lines (rat myoblast cell line) and estimated the glucose uptake using high sensitivity glucose oxidase kit. In vitro alpha amylase inhibitory assay was performed on porcine alpha amylase and the absorbance was measured at 540 nm using a microplate reader. Acarbose was used as the standard in both the methods.Results: At a concentration of 100µg/ml the percentage glucose uptake by the combined ethanolic extract (1:1 mixture) of Syzygium cumini and Psidium guajava leaves was 43.95 while for acarbose the corresponding value was 51.71. At 100 μg/ml the percentage of glucose uptake by Syzygium cumini and Psidium guajava was 27.62 and 22.17 respectively. The percentage inhibition of alpha amylase by the combined ethanolic extract (1:1 mixture) of Syzygium cumini and Psidium guajava leaves at a concentration of 1000 µg/ml was 36.51 and it was 29.26 for Syzygium cumini and 23.43 for Psidium guajava. For acarbose the percentage inhibition of alpha amylase was 73.82 at the concentration of 1000 µg/ml.Conclusion: The combined extract of the leaves of the plants selected was found to be more effective than individual plant extracts against diabetes. The percentage glucose uptake of the combined extract was found to be closer to that of the standard drug acarbose. On comparison of two plants Syzygium cumini was found to be more active against diabetes than Psidium guajava. As the 1:1 mixture of the ethanolic extract is found to be more active, the combination of the two plants can be used to formulate drugs for treating diabetes.

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