Effectiveness of Giving Muntingia Calabura Leaves and Muntingia Calabura Fruit (Muntingia Calabura L) on Blood Sugar Levels In Type 2 Diabetes Mellitus Patients: Literature Review

Introduction : Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia caused by abnormalities in insulin secretion, thus impacting on blood glucose levels. Calabura muntingia leaves are traditionally used as an alternative medicine because they contain flavonoid compounds which have anti-diabetic properties. In general, it is known that how to make traditional medicine is by boiling it, where the solvent only uses water so that the polar compounds will be attracted. The purpose of this study is to explain effectiveness the effect of administration between calabura muntingia leaves and calabura muntingia fruit through a review of studies related to blood sugar levelsin the last ten years.Method : Search for journals or articles using Scopus, Proquest, and Scholar indexed databases using appropriate keywords. The Center for Review and Dissemination and The Joanna Briggs Institute was used to assess the quality of the study. The framework used for the review is PICOS and the inclusion criteria used are English and Indonesian journals published in 2010 to 2020. Data analysis and tabulation are carried out in articles or journals. Title, abstract, full text and methodology are assessed to determine the eligibility of the article or journal.Results : Six hundred and forty-one articles were identified, there were eleven articles that fit the research criteria. The leaves of muntingia calabura and fruit of muntingia calabura contain flavonoids and saponins which can reduce blood sugar levels. A flavonoid compound that is thought to have activity in reducing blood glucose levels is quercetin.Conclusion : The form of extract, infusion, juice and stew did not change the content of the calabura muntingia plant.

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THE EFFECTS OF CORN FLOUR WITH TEMPEH FLOUR SUPPLEMENTATION FEEDING IN DIABETES MELLITUS WISTAR RATS TOWARD BLOOD GLUCOSE LEVEL

Jurnal Ilmiah Kedokteran Wijaya Kusuma ◽

10.30742/jikw.v4i2.10 ◽

2017 ◽

Vol 4 (2) ◽

pp. 24

Author(s):

Fatifa Asmarani ◽

Bambang Wirjatmadi ◽

Merryana Adriani

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Wistar Rats ◽

Control Group ◽

Standard Diet ◽

Corn Flour ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Sugar Levels

Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukey's Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.

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HUBUNGAN KECEMASAN DENGAN KADAR GLUKOSA DARAH PENDERITA DIABETES MELLITUS DI WILAYAH KERJA PUSKESMAS SUMBERSARI BANTUL KEC. METRO SELATAN KOTA METRO

JURNAL WACANA KESEHATAN ◽

10.52822/jwk.v2i1.39 ◽

2017 ◽

Vol 2 (1) ◽

pp. 5

Author(s):

Ludiana Ludiana

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Standard Deviation ◽

Blood Sugar ◽

Glucose Levels ◽

Blood Glucose Levels ◽

The World ◽

Patients With Diabetes ◽

Sugar Levels ◽

The Relationship

Diabetes mellitus is a chronic metabolic disorder marked increase in blood glucose. According to the World Health Organization (WHO) in 2013 the incidence of diabetes mellitus in the world reached 347 million people in Indonesia alone ranks among the seven countries with the highest diabetes prevalence of 7.6 million people. Among the causes of the increase in blood glucose levels in diabetics is due to psychological factors, namely anxiety. In the pre-survey results in Puskesmas Sumbersari Bantul note that from 8 patients with diabetes mellitus, there are 6 people experiencing anxiety and 2 do not complain any signs of anxiety. The purpose of this study was to determine the relationship of anxiety with blood glucose levels of diabetics mellitus in Puskesmas Sumbersari Bantul District of South Metro City. The type quantitative research, form design used is cross sectional. The population in this study are patients with diabetes mellitus in Puskesmas Sumbersari Bantul District of South Metro totaling 408 samples taken as many as 41 people. The analysis in this study using the test Person Product Moment. Statistical analysis showed that anxiety patients with diabetes mellitus are at an average score of 27.44 with a standard deviation of 4.353 and the average blood sugar levels of people with diabetes mellitus are at 339.78 mg / dL with a standard deviation of 74.742. In the Person Product Moment test results proved no relationship anxiety with blood sugar levels of people with diabetes mellitus (p-value = 0.000 <a 0.05). Pearson correlation results obtained value of 0.817 towards a positive correlation with the strength of the relationship is very strong. Conclusions research shows there is an anxiety relationship with blood glucose levels of diabetics mellitus.

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Potential Effects of Alkaloid vindolicine Substances in Tapak Dara Leafs (Catharanthus roseus (L.) G. Don) in Reducing Blood Glucose Levels

Journal Of Medicine & Health ◽

10.28932/jmh.v2i4.1057 ◽

2019 ◽

Vol 2 (4) ◽

Author(s):

Agung B S Satyarsa

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Catharanthus Roseus ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Sugar Levels

Diabetes mellitus is a degenerative disease that commonly found and related to an unhealthy lifestyle and genetic factors. Current management of diabetes mellitus includes control of blood sugar levels and prevention of complications. Recent studies found that many phytochemicals have the potential to control blood sugar levels in patients with diabetes. Alkaloid substances from leaves of Tapak Dara have an effect on decreasing blood glucose. This review article aims to describe the potential effects of the Alkaloid vindolicine from Tapak Dara leaves (Catharanthus Roseus L.) in reducing blood glucose levels in patients with type 2 diabetes mellitus. The activity of vindolicine alkaloid against ? cells in previous studies has shown to improve ? cells activity and induce insulin secretion thus preventing further hyperglycemia. In addition, the vindolicine alkaloid also has a role in activating pancreatic ?-TC6 cells and carrying out an immediate reaction in blood vessels. As conclusion, further research is needed to prove the maximum effect of the utilization of tread leaf extract as well as the toxicity test to determine the toxic effects of the alkaloid substances in the tread leaf. Keywords: Type 2 Diabetes Mellitus, Vindolicine Alkaloid, Tapak Dara, blood glucoselevels

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Efektivitas Relaksasi Progresif dalam Mengurangi Gejala Depresi Pasien Diabetes Melitus Tipe 2

Jurnal Kesehatan ◽

10.26630/jk.v9i3.1084 ◽

2018 ◽

Vol 9 (3) ◽

pp. 451

Author(s):

Hotma Rumahorbo ◽

Nani Avianti ◽

Desmaniarti Zaini

Keyword(s):

Diabetes Mellitus ◽

Depressive Symptoms ◽

Blood Glucose ◽

Blood Sugar ◽

Progressive Relaxation ◽

Hospital Treatment ◽

Depression Symptoms ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Sugar Levels

The prevalence of Diabetes Mellitus (DM) in Indonesia shows an increase from 1.1% in 2007 to 2.1% in 2013, with the most cases being Type 2 Diabetes Mellitus. DM is a chronic disease that cannot be cured but can be controlled by healthy lifestyle and medicine. DM patients who cannot control their blood sugar levels, they will experience acute and chronic complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, causing the patient to undergo hospital treatment for the management of blood sugar levels and complaints arising from the accompanying illness. This situation makes the patient stress and depression which will aggravate the disease. This study was to measure the effectiveness of progressive relaxation interventions on depressive symptoms of DMT-2 patients. The study design used Quasi-Experimental two groups pre and post-test design, with 61 samples consisting of 31 intervention groups and 30 control groups. The intervention group was given guidance and progressive relaxation exercises 2 times a day for 3 consecutive days with a duration of 30 minutes each exercise. The results showed that progressive relaxation interventions in DMT-2 patients reduced depression scores by -11,368 units significantly (p=0.001). Variable that makes it difficult to reduce depression symptoms were blood glucose levels. Blood glucose levels were increasing depression scores by 0.012 units. The conclusion was a progressive relaxation intervention effectively reduce depression scores of DMT-2 patients. Controlling the patient's blood glucose levels is important in improving the effectiveness of progressive relaxation interventions to reduce depressive symptoms of DMT-2 patients.

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Gambaran Diabetes Melitus Sebagai Komorbid Pada Kejadian Covid-19 : Scoping Review

Prosiding Seminar Nasional Kesehatan ◽

10.48144/prosiding.v1i.804 ◽

2021 ◽

Vol 1 ◽

pp. 1128-1137

Author(s):

Laili Hikmawati ◽

S Sugiharto

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Scoping Review ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Sugar Levels ◽

The Stability ◽

Diabetes Melitus

AbstractDiabetes mellitus (DM) is one of the comorbidities most susceptible to COVID-19 infection. The morbidity and mortality rates for diabetic patients who are infected with COVID-19 are also very high. This is related to blood sugar levels, immunity, and DM complications. The study aimed to describe DM as a comorbid of COVID-19. The study applied a scoping review method, by searching for articles through PubMed and ProQuest. The inclusion criteria are articles published in 2019-2021, and the respondents are diabetic patients. The results show that the average age of diabetic patients who infected COVID-19 was 64.24 years old, and mostly (52.7%) were female. Type 2 DM is most infected compared to other types of DM. The ACE-2 receptor owned by DM patients is the entry point for the SARS-CoV-2 virus into the human body. Blood glucose levels are a factor in the severity of COVID-19 patients with DM. Moreover, it is necessary to consider the administration of antidiabetics in the setting of COVID-19 related to the risk of hypoglycemia or other side effects. The progression of COVID-19 in patients with co-morbidities of diabetes mellitus is influenced by the stability of blood glucose levels and length of suffering. Therefore, it is recommended to monitor blood sugar levels regularly. For diabetic patients, it is advisable to always maintain health protocols because hyperglycemia conditions can stimulate chronic inflammation and weaken the immunity system against infection.Keywords: Comorbid, COVID-19, Diabetes Mellitus, Scoping Review AbstrakDiabetes mellitus (DM) merupakan salah satu penyakit penyerta yang paling rentan terinfeksi COVID-19. Angka morbiditas dan mortalitas pada diabetisi yang terinfeksi COVID-19 pun sangat tinggi. Hal tersebut terkait dengan kadar gula darah, imunitas, dan juga komplikasi dari DM. Penelitian ini bertujuan untuk mendeskripsikan DM sebagai komorbid pada kejadian COVID-19. Penelitian ini menggunakan metode scoping review, dengan mencari artikel melalui PubMed dan ProQuest. Artikel yang dianalisis adalah artikel yang diterbitkan 2019-2021, dengan respondennya adalah pasien DM. Berdasarkan hasil review dari kelima artikel diperoleh rata- rata usia diabetisi yang terinfeksi COVID-19 adalah 64,24 tahun, dimana 52,7% responden berjenis kelain perempuan. DM tipe 2 merupakan jenis DM yang paling banyak terinfeksi dibandingkan dengan DM tipe lain. Reseptor ACE-2 yang dimiliki pasien DM merupakan pintu masuk virus SARS-CoV-2 kedalam tubuh manusia. Kadar glukosa darah menjadi salah satu faktor tingkat keparahan pasien COVID-19 dengan DM. Dalam penanganannya, perlu pertimbangan dalam pemberian antidiabetika dalam setting COVID-19 terkait dengan risiko hipoglikemia ataupun efek samping lain. Progresifitas COVID-19 pada pasien dengan penyakit penyerta diabetes melitus dipengaruhi oleh kestabilan kadar gula darah dan lama menderita. Oleh karena itu, disarankan untuk dilakukan pemantauan kadar gula darah secara rutin. Bagi para diabetisi, disarankan untuk selalu menjaga protokol kesehatan karena kondisi hiperglikemia dapat merangsang inflamasi kronik dan melemahkan sistem pertahanan tubuh melawan infeksi.Kata kunci : COVID-19, Diabetes Mellitus, Komorbid, Scoping Review

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PERAN INFORMAL KELUARGA DALAM PENGENDALIAN KADAR GLUKOSA DARAH PADA PENDERITA DIABETES MELLITUS

Jurnal Ilmu Keperawatan Komunitas ◽

10.32584/jikk.v1i2.174 ◽

2018 ◽

Vol 1 (2) ◽

pp. 5

Author(s):

Rosalina Rosalina

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Blood Glucose Control ◽

Bivariate Analysis ◽

Glucose Levels ◽

Blood Glucose Levels ◽

The Family ◽

Sugar Levels

Diabetes mellitus is a disease or disorder of chronic metabolism with multiethiology characterized by high blood sugar (hyperglycemia). Diabetes Mellitus can not be cured but can be controlled by regulating blood sugar levels. One important factor in controlling blood sugar levels is the role of the family To know the correlation between family's informal role and the control of blood glucose levels in people with diabetes mellitus at RSUD Ungaran Semarang Regency.The design of this study was descriptive correlational with cross sectional approach with the number of population of 176 people and samples of 64 respondents by using accidental sampling method. Data collection tools used questionnaires. Data analysis used SPSS version 23.0. Bivariate analysis was processed by using chi square test. The informal role of the family in people with diabetes mellitus is mostly in good category (75.0%). Control of blood glucose level in people with diabetes mellitus is mostly in good category (62,5%). There is significant correlation between family informal role and blood glucose control in patients with diabetes mellitus at RSUD Ungaran Semarang Regency, with p value 0,043 <0,05 (α). There is correlation between family's informal role and the control of blood glucose levels in people with diabetes mellitus at RSUD Ungaran Semarang Regency.We recommend that patients with DM further improve the control of blood glucose levels by increasing the role of the family so as to prevent the occurrence of complications

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EFFECT OF HERBAL THERAPY STEEPING SALAM LEAF TO DECREASE IN BLOOD GLUCOSE LEVELS IN ELDERLY PATIENTS WITH DIABETES MELLITUS IN THE VILLAGE OF SUKODONO SUBDISTRICT OF SIDOARJO CITY

Malaysian Journal of Medical Research ◽

10.31674/mjmr.2021.v05i03.006 ◽

2021 ◽

Vol 5 (3) ◽

Author(s):

Novi Sari Anggraini ◽

Novi Sari Anggraini

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

The Elderly ◽

Herbal Therapy ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Sugar Levels ◽

The Village ◽

Paired T Test

Introduction: Diabetes mellitus is a metabolic disease most often occurs in the elderly due to decreased function of the pancreas which produce insulin function. The number of elderly patients with DM in the village of Tell subdistrict of Sidoarjo regency Sukodono ignorance alternative ways to control blood sugar levels. The purpose of this study was to analyze the influence of herbal therapy steeping Salam leaves against a decrease in blood glucose levels in the elderly. Methods:This study design pre Experiment (One-group pre-post test design). Samples were taken using purposive sampling and obtained as many as 28 elderly Tell Rural District of Sukodono Sidoarjo. The independent variable is the herbal therapy steeping Salam leaves and the dependent variable is blood glucose levels in the elderly. Test Gluchose research instruments used for the measurement of blood sugar levels. Test data analysis using Paired T-test ? ? 0.05. Results:The results showed that the steeping Salam leaves for lowering blood glucose levels in elderly people with diabetes mellitus is evidenced by the results of Test Paired t-test showed ? = 0.000 before and after the treatment groups. Conclution:Seeing the results of this study can be concluded that the steeping Salam leaves containing astringent compounds can affect insulin sensitivity thereby stimulating the parasympathetic autonomic nerve stimulation and stimulate the release of insulin from the pancreas gland. Furthermore, the public are advised to be used as an alternative way to control blood sugar levels.

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Relaksasi Benson untuk Mengontrol Kadar Gula Darah Penderita DM di Wilayah Kerja Puskesmas Pahandut Palangka Raya

PengabdianMu Jurnal Ilmiah Pengabdian kepada Masyarakat ◽

10.33084/pengabdianmu.v4i1.629 ◽

2019 ◽

Vol 4 (1) ◽

pp. 30-35

Author(s):

Aida Kusnaningsih

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Belief Systems ◽

Relaxation Techniques ◽

Glucose Levels ◽

Systems Research ◽

Blood Glucose Levels ◽

The Media ◽

Sugar Levels

Diabetes mellitus is a metabolic disease characterized by an increase in blood glucose levels. One way to manage it is with Benson Relaxation. Benson Relaxation is a relaxation technique that is a combination of relaxation techniques with individual belief systems. Research shows that Benson relaxation can reduce blood glucose levels in DM patients. Community service activities by applying the results of the study namely Benson Relaxation to control blood sugar levels were carried out in 32 DM patients. Activities include health education about DM and Benson Relaxation and the practice of carrying out Benson's Relation accompanied by the sounds of the Asmaul Husna. The media used during the activity were LCD projector and IM3 Asmaul Husna. The event went smoothly according to the plan; all participants followed the movement enthusiastically from beginning to end. During the event, the media used during the activity can function properly, and the environment is quite conducive. The evaluation results of the participants were able to mention again about DM and its management and were able to practice Benson Relaxation well. The activity provided benefits in the form of increasing knowledge about Diabetes Mellitus and its management and the ability to carry out Benson Relaxation to control blood sugar levels in DM patients in the Pahandut Community Health Center Palangka Raya Benson work area.

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PENGARUH JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA DAN 2 JAM PP(Post Prandial) PADA PENDERITA DIABETES MELITUS

Jurnal Kesehatan Medika Saintika ◽

10.30633/jkms.v10i1.311 ◽

2019 ◽

Vol 10 (1) ◽

pp. 77

Author(s):

Febria Syafyu Sari ◽

Ridhyalla Afnuhazi

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Fasting Blood Glucose ◽

Aloe Vera ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Patients With Diabetes ◽

Paired T Test ◽

Diabetes Melitus

ABSTRAK Diabetes Melitus merupakan penyakit yang paling menonjol yang disebabkan oleh gagalnya pengaturan gula darah. Lidah buaya berkhasiat untuk menurunkan kadar gula dalam darah bagi penderita diabetes dan dapat mengontrol tekanan darah. Tujuan penelitian untuk mengetahui pengaruh jus lidah buaya (AloeBarbadensis Miller) terhadap penurunan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Desain penelitian merupakan Quasi Eksperimental dengan pendekatan one group pretest – postest design. Sampel terbagi menjadi 14 responden. Data dianalisis dengan paired t-test. Hasil menunjukan rata-rata penurunan glukosa darah puasa pada intervensi (28,42 gr/dl) dan glukosa darah 2 jam pp pada intervensi (40,57 gr/dl). Untuk analisis bivariat terdapat perbedaan antara glukosa puasa dan 2 jam pp dengan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Kesimpulan didapatkanlidah buaya dapat menurunkan kadar glukosa darah.Berdasarkan hasil penelitian jus lidah buaya dapat menjadi salah satu alternatif keperawatan non farmakologi dalam penyakit diabetes melitus. Kata Kunci : Lidah Buaya ; Diabetes Mellitus THE EFFECT OF VEGETABLE VOCATIONAL JUICE ON FAST BLOOD GLUCOSE LEVELS AND 2 HOURS OF PP (Post Prandial) IN DIABETES MELLITUS ABSTRACT Diabetes mellitus is the most prominent disease caused by the failure of blood sugar regulation. Aloe vera is efficacious can to reduce blood sugar levels for diabetics and can control blood pressure. The purpose of this study was to determine the effect of Aloe Barbadensis Miller on the reduction of fasting blood glucose GDP and 2 hours of PP (post prendial) in patients with diabetes mellitus. The research design is Experimental Quasi with one group pretest - postest design approach. The sample is divided into 14 respondents. Data were analyzed by paired t-test. The results showed an average decrease in fasting blood glucose at intervention (28.42 gr / dl) and 2 hours pp blood glucose at intervention (40.57 gr / dl). For bivariate analysis there was a difference between fasting glucose and 2 hours pp with fasting blood glucose GDP) and 2 hours PP (Post Prendial) in patients with diabetes mellitus. The conclusion is that aloe vera can reduce blood glucose levels. Based on the results of research on aloe vera juice can be an alternative non-pharmacological nursing in diabetes mellitus. Keywords: Aloe Vera ; Diabetes Mellitus

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UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

Jurnal Insan Farmasi Indonesia ◽

10.36387/jifi.v4i1.602 ◽

2021 ◽

Vol 4 (1) ◽

pp. 44-53

Author(s):

Andri Priyoherianto ◽

◽

Panji Ratih Suci ◽

Putri Rizki Cahya Fatimah ◽

Atik Nur Wijayanti

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Water Hyacinth ◽

Leaf Extract ◽

Positive Control ◽

Negative Control ◽

Glucose Levels ◽

Normal Limits ◽

Blood Glucose Levels ◽

Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

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