scholarly journals Modern Algorithm for Diagnosis and Treatment of Diseases in Men That Lead to Infertility

Health of Man ◽  
2021 ◽  
pp. 8-14
Author(s):  
Oleh Nikitin ◽  
Mykola Yasynetsky
Keyword(s):  
Married Couple ◽  
Married Couples ◽  
Reproductive Technologies ◽  
Reproductive Age ◽  
Diagnosis And Treatment ◽  
Male Factor ◽  
Internal Organs ◽  
Child Treatment ◽  
Literary Sources ◽  
The World

The problem of sterile marriage provides great importance throughout the world. Infertility is a condition that is accompanied by a number of diseases of the genital organs and systemic diseases of the male or female organism. According to various literary sources, about 50–100 million people suffer from infertility in the world, that is, one out of 5–7 couples of reproductive age suffers from infertility. The problem of infertility in marriage is of particular importance in the context of the demographic crisis in Ukraine, where the frequency of infertile marriage among married couples of reproductive age is 10,0–15,0 %, and in some regions this indicator is close to 20,0 %. In Ukraine, there are more than 1 million infertile married couples, the male factor in the structure of infertility is about 40-50 % of cases. Most authors point to the polyetiology of male infertility. In its development, a significant role is assigned to such factors as neuropsychic, infectious toxic, congenital and genetic reasons, exogenous and habitual intoxications, ionizing radiation, dysfunctions of the endocrine glands and other internal organs, exposure to temperatures, vascular disorders, damage to the genital organs and their autoimmune lesions. Infertility is a complex and multifaceted problem, and there are a lot of different questions which need to solve. Particular difficulties arise in determining the treatment tactics in cases where there is a combination of various causes of infertility in a married couple. Opportune examination of partners with using modern hardware, laboratory and genetic methods is very important, and it allows to prescribe an effective treatment. The use of reproductive technologies significantly expands the possibilities for solving the problem of infertility. However, their main purpose is the birth of a child; treatment of diseases that have led to infertility requires additional efforts. In this regard, the development of modern methods of diagnosis and treatment of sterile marriage remains one of the actual problems.

scholarly journals Tachykinins and Kisspeptins in the Regulation of Human Male Fertility

2019 ◽  
Vol 9 (1) ◽  
pp. 113 ◽  
Author(s):  
Víctor Blasco ◽  
Francisco M. Pinto ◽  
Cristina González-Ravina ◽  
Esther Santamaría-López ◽  
Luz Candenas ◽  
...  
Keyword(s):  
Male Infertility ◽  
Male Fertility ◽  
Animal Species ◽  
Reproductive Age ◽  
Diagnosis And Treatment ◽  
Male Factor ◽  
Human Male ◽  
Human Fertility ◽  
The World

Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility.

scholarly journals THE USE OF THE PRP THERAPY TO ACTIVATE FOLLICULOGENESIS IN WOMEN OF THE LATE REPRODUCTIVE AGE IN PROGRAMS OF ASSISTED REPRODUCTIVE TECHNOLOGIES

World Science ◽  
2021 ◽  
Author(s):  
Uliana Dorofeieva ◽  
Oleksandra Boichuk
Keyword(s):  
Embryo Quality ◽  
Assisted Reproductive Technologies ◽  
Negative Impact ◽  
Platelet Rich Plasma ◽  
Married Couples ◽  
Treatment Method ◽  
Reproductive Technologies ◽  
Reproductive Age ◽  
Medical Problems ◽  
Fertilization Program

The rate of infertility in married couples of reproductive age in this country makes up from 10 to 15%, in some regions this value is close to 20% - acritical level that has a negative impact on demographic figures. The rate of pregnancy depends directly on the women’s age and decreases by 3.3times starting from the age of 19 and by the age of 48. The decrease in the ability to conceive is accounted for by subtle mechanisms related to thedeterioration of the quality of oocytes. The patients who are prepared for an extracorporeal fertilization program (ECF) and do not respond tocontrolled ovarian hyperstimulation protocols are considered to be poor respondents. Many studies focused on the development of an optimaltreatment method. However, none of the approaches seems to be effective enough to guarantee a successful use. Platelet-rich plasma is a new andpromising method that is successfully used in the reproductive science to solve a number of medical problems. All the patients whose commonfeatures were low oocyte output and poor embryo quality as well as failed ECF attempts were offered a treatment method of autologous PRP therapyafter their written consent. Three months later, one obtained astonishing results, which by the markers of biochemical infertility alone could beclassified as a complete biological phenomenon and are also characterized by improved embryo quality. The results of hormonal homeostasis show adecrease in the level of the follicle-stimulating hormone by 67.33% while the level of the anti-muellerian hormone is 75.18% higher.Thus, the use of the PRP therapy in poor respondents helps them to overcome their problematic reproductive barrier.

scholarly journals Correlation analysis of clinical and medical history records of married couples receiving infertility treatment

2021 ◽  
pp. 84-93
Author(s):  
I. S. Fedorov ◽  
Ju. S. Drapkina ◽  
N. N. Lobanova ◽  
N. P. Makarova ◽  
A. V. Timofeeva
Keyword(s):  
Medical History ◽  
Ovarian Stimulation ◽  
Married Couple ◽  
Married Couples ◽  
Surgical Removal ◽  
Fallopian Tubes ◽  
High Concentration ◽  
Male Factor ◽  
Art Programs ◽  
Art Program

Introduction. Despite the availability of general principles and regimens for ovarian stimulation on the assisted reproductive technology (ART) programs, an individual situational modification is required in each specific case.Objective. To optimize the ovarian stimulation protocols on the ART program based on the clinical and medical history records of the married couple.Materials and methods.The clinical and medical history records, as well as the stimulation cycle parameters of 60 married couples were analysed. The married couples enrolled in this study were diagnosed with infertility caused by tubo-peritoneal (44 married couples), male (5 married couples), combined factor (6 married couples), as well as external genital endometriosis combined with a male factor (3 married couples), and tubo-peritoneal factor (2 married couples). All married couples underwent IVF/ICSI procedures under the gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and ovarian stimulation on day 2 or 3 of the menstrual cycle.Results. All married couples were divided into two groups: 38 couples with a negative implantation result and 20 married couples with positive implantation results. The surgical removal of fallopian tubes has been shown to be inversely correlated with the duration of infertility. The use of hCG positively correlates to the ratio of mature oocytes and oocyte-cumulus complexes (OCC) and the onset of pregnancy. A reduced percentage of morphologically healthy sperm with an overall high concentration of sperm in the ejaculate can be interpreted as fertile sperm.Conclusions. During ovarian stimulation on the ART program, special attention should be paid to the duration of stimulation, the types of interventions for triggering final oocyte maturation and the total gonadotropin dose. A differentiated approach to conducting the surgical removal of fallopian tubes is required. The reduced percentage of morphologically healthy sperm with an overall high concentration of sperm in the ejaculate serves as a favourable prognostic factor for the outcome of ART programs.

scholarly journals Institute of surrogacy in modern society. Part 1

2020 ◽  
pp. 5-11
Author(s):  
E. V. Chechenkova ◽  
A. I. Zaryankina
Keyword(s):  
Assisted Reproductive Technologies ◽  
Modern Society ◽  
Reproductive Technologies ◽  
Single Women ◽  
Single Woman ◽  
Literary Sources ◽  
The World ◽  
History Of ◽  
Ancient Times ◽  
Medical University

Objective: to define the concept and essence of surrogacy, to study the history of its origin and approaches to solution of fertility problems with its help in different countries of the world, to analyze the attitude of modern generation to surrogacy. Material and methods. To achieve the above objective, various literary sources were analyzed. Also, a sociological survey of 60 students of Gomel State Medical University was conducted. Results. The performed analysis has found historical regularities of the use of surrogacy aimed at procreation since ancient times up till now. The retrospective statistical data of primary and secondary infertility in the world have been given. The modern possibilities of assisted reproductive technologies making it possible for childless families to have their own children have been described. The sociological survey has revealed that most boys and girls - 90 % are «for» using assisted reproductive technologies, and also the majority of the respondents think that it is acceptable to bring up a surrogate child by a single woman (85 %) or man (73 %). However, only 47 % of the respondents agree with the fact that a surrogate child may be raised by homosexual parents. Conclusion. Female and male infertility is a problem that is topical worldwide. Surrogacy is an assisted reproductive technology which in many cases is the only option for people to have their genetic children. In modern society, surrogacy is used by single women and men, including homosexuals. The attitude of modern generation to this fact is positive in most cases.

The value of risk factors in infertile men in the aspect of choice of assisted reproductive technologies to renew fertility in married couples

2016 ◽  
pp. 136-139
Author(s):  
Yu. N. Gurzhenko ◽  
◽  
A. O. Kutsenko ◽  
Keyword(s):  
Risk Factors ◽  
Male Infertility ◽  
Assisted Reproductive Technologies ◽  
Married Couples ◽  
Risk Groups ◽  
Reproductive Technologies ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Key Words Male Infertility ◽  
Personalized Approach

The objective: the rationalization of a personalized approach to the selection of the program art on the basis of the allocation of risk. Patients and methods. Were analyzed 180 couples with male factor infertility, which in 2012-2015, in the Institute of reproductive medicine (IRM) (Kiev) was held the program of intracytoplasmic sperm injection (ICSI) with the aim of restoring fertility. Examination and ICSI procedure is carried out in accordance with clinical protocols. Results. According to the results of analytical and synthetic analysis of primary documents (enhanced, adapted to the purpose of the work of the medical record) were identified risk factors (and their signs) for the development of male infertility and grouped by direction of impact. As a result, 25 of the 51 factors and their basis formed three groups: social (behavioral), biological/clinical and special medical. With the help of mathematical analysis it was determined the boundary values of the minimum and maximum of reliability of the negative result of the application of ART. Conclusion. It was proposed the predictive map for the determination of the probability of pregnancy in couples with male infertility problems with the application of ART. Was justified the separation of three risk groups to restore fertility in couples with male factor infertility using ART. Was based the principle of personalized approach to choosing the best program of art-based stratification of men at risk groups. Key words: male infertility, assisted reproductive technologies, risk factors, prognostic chart.

scholarly journals Comparing Selected Levels of Communication Between Fiancée, Fiancé and Spouses

2015 ◽  
Vol 5 (1) ◽  
pp. 137-153
Author(s):  
Barbara Lulek
Keyword(s):  
Communication Skills ◽  
Family Of Origin ◽  
Married Couple ◽  
Married Couples ◽  
Engaged Couples ◽  
The Family ◽  
The World ◽  
Convergence And Divergence ◽  
High Dynamics ◽  
Flow Of Information

Abstract A man, coming to the world in a family community, reaches maturity and in most cases sets a family of his own. Traditional transition from the family of origin to family of procreation combines with engagement followed by marriage as a family subsystem. These periods characterize with high dynamics of changes taking place within the marital subsystem. Bride and groom, and later married couple face the need to discuss family matters, negotiate marital roles, develop compliance and their identity, regulate marriage intimacy, solve conflicts, as well as, run their household. Undoubtedly, planning and organizing life requires developed communication skills. The author, guided by these premises, has sought to present some aspects of communication for engaged couples and spouses with many years of experience. Isolated groups were not accidental. Main reason was the ability to analyze the results in terms of convergence and divergence of views and assessments shown by brides and married couples at different stages of marriage - family life. Therefore, structure of this text was built by the following variables’ categories: frequency of conversations in the family and their themes, communication barriers between spouses and fiancés, ways of improving the flow of information between partners.

scholarly journals Comparative analysis of the subjective perception of oneself as a future parent among married couples with different reproductive history

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
V. A. Moshkivskaya
Keyword(s):  
Assisted Reproductive Technologies ◽  
Married Couple ◽  
Married Couples ◽  
Subjective Assessment ◽  
Reproductive Technologies ◽  
Structured Interview ◽  
Subjective Perception ◽  
Physiological Factors ◽  
Newborn Child ◽  
Female Version

Introduction. The problem of infertility is widely known around the world. According to WHO, 3% of the world's population suffers from infertility. In Russia, the problem of infertility is extremely urgent, the number of couples applying for assisted reproductive technologies is growing every year. However, the number of positive IVF protocols, successful pregnancy outcomes, and the quality of life of children born prematurely is still not high. There are more than 700 factors that affect the outcome of pregnancy, most of which are poorly understood, and research in various fields continues. In addition to the proven physiological factors that affect the outcome of pregnancy, there are a number of poorly understood factors that cause idiopathic infertility.Materials and Methods. Author's semi-structured interview for a married couple during pregnancy. Male and female version of the interview. Repeated author's interview for a woman in the early postpartum period. Content analysis.Results. The main results obtained during the interview were analyzed. Such as the subjective assessment of the perception of pregnancy (physical, emotional experiences), the motive of pregnancy, the assessment of one's own parental readiness to raise a child, parental competencies, changes in marital roles, studying the lifestyle before and during pregnancy, contact with one's own parents, behavior during childbirth, primary contact with a newborn child.Discussion and Conclusions. According to the results of the study, conclusions were obtained indicating the importance of timely provision of psychological assistance to pregnant women as a result of the use of ART. Women who are pregnant with ART are more anxious, less self-oriented, more likely to have obstetric and neonatal complications, difficulties with primary psychological contact with a newborn child, difficulties with breastfeeding.

scholarly journals Pathogenetic significance of the male factor in an uncompleted pregnancy

2021 ◽  
Vol 20 (3) ◽  
pp. 27-32
Author(s):  
E. V. Kudryavtseva ◽  
N. N. Potapov ◽  
V. V. Kovalev
Keyword(s):  
Chronic Diseases ◽  
Chromosomal Abnormalities ◽  
Married Couple ◽  
Married Couples ◽  
Control Group ◽  
Male Factor ◽  
Pregnancy Failure ◽  
History Of ◽  
Group 2 ◽  
Group 1

Introduction. When pregnancy failure occurs, not only the woman should be examined, but also her partner. Purpose of the study — to evaluate the significance of spermogram values in the partners of patients with an uncompleted pregnancy. Materials and methods. A retrospective comparative cohort study was conducted. A total of 197 married couples were ncluded in the study. Group 1 consisted of 71 couples with a history of miscarriag. Chromosomal abnormalities (CA) were detected during embryo cytogenetic examination in 45 cases; these patients were included in subgroup 1a; the rest constituted subgroup 1b. The control group (group 2) consisted of 126 couples without a history of pregnancy loss. A detailed anamnesis and general clinical examinations were performed in all the couples. Spouses of the patients underwent spermogram analysis. Results. The proportion of men who abused alcohol was higher in group 1 than in group 2 — 40.8% vs. 19% (p<0.01). In subgroup 1b chronic diseases were noted in 61.5% of men, in group 2 — only 28.6% (p<0.001). Differences in the number of men with normal spermogram were found between group 2 and subgroup 1b, 65.1% and 35.3%, respectively (p=0.036). In group 1, 45% of men had teratozospermia (43.5% in subgroup 1a, 47.1 in subgroup 1b) and in group 2, only 16.3% (p=0.004). Discussion. In most cases, the leading etiological factor in pregnancy failure is a chromosomal abnormality n the embryo (fetus). The role of the "male" factor is increasing in the genesis of pregnancy failure. Examination of thspouse should be an integral component of pre-conceptional preparation. Conclusion. Spousal alcohol abusrisk factor for CA in the embryo and for pregnancy failure. The presence of chronic diseases in the spouse is also a risk factor for pregnancy failure. Among the spermogram parameters, the number of spermatozoa with normal morphology is the most significant in assessing the ririsk of pregnancy failure in a married couple, teratozoospermia significantly increases the risk of non-pregnancy.

PHUBBING BEHAVIOR AND ROMANTIC RELATIONSHIP: MECHANISM OF MENTAL HEALTH AMONG MARRIED COUPLES

2020 ◽  
Vol 4 (1) ◽  
pp. 103-137
Author(s):  
Rabia Zonash Mir
Keyword(s):  
Mental Health ◽  
Romantic Relationship ◽  
Rating Scale ◽  
Short Form ◽  
Married Couple ◽  
Married Couples ◽  
Mental Health Issue ◽  
Health Issues ◽  
Arranged Marriage ◽  
Love Marriage

Does Phubbing Behavior and Romantic Relation leads to Mental Health issues among married couple? The present study intended to explore the effect of how phubbing behavior and romantic relationships are affecting mental health of married couples. For the study purpose a sample of 120 Married couples were taken between the age ranges 20-60 years of age. Partner Phubbing Rating Scale developed by Roberts and David (2015) was used to measure phubbing behavior among married couples. Romantic Partner Scale (RPS) developed by Zacchilli, Hendricks, and Hendricks, (2012) was applied to assess the romantic relationship between both partners and the third scale used was short form of Mental Health Continuum developed by Keyes (2005) in order to assess the mental health issue among married couples. Phubbing behavior positively predicted interactional activity and negatively predicts compromise, avoidance, separation, dominance and submission. Phubbing behavior negatively predicts mental health among married couples. Gender difference indicates that males are higher on romantic relationship as well as mental health as compared to females. As far as demographic variables are concerned, based on the findings of current research, it was concluded that there was no gender differences found in phubbing behavior, romantic relationship, and mental health of married couples. Phubbing behavior is significantly higher in love marriage couples in comparison with arranged marriage couples.

CLINICAL CASE OF SUCCESSFUL TREATMENT OF INFERTILITY IN A PATIENT WITH FAILURE IVF RESULTS IN ANAMNESIS

2020 ◽  
pp. 61-67
Author(s):  
Kalinkina O.B. ◽  
Tezikov Yu.V. ◽  
Lipatov I.S. ◽  
Aravina O.R.
Keyword(s):  
Assisted Reproductive Technologies ◽  
Transvaginal Ultrasound ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Abnormal Uterine Bleeding ◽  
Clinical Situation ◽  
Reproductive Technologies ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Number Of Publications

Genital endometriosis is a disease of women of reproductive age, accompanied by infertility in 50% [1]. Adenomyosis can be considered as an endometriosis of the uterus. Histologically, this process is represented by ectopic, non-tumor endometrial glands, and stroma surrounded by hypertrophic and hyperplastic myometrium [2]. Adenomyosis is accompanied by pelvic pain of varying intensity as well as menstrual disorders [1]. The disease is accompanied by significant violations of reproductive function (infertility, unsuccessful attempts at pregnancy and miscarriage, abnormal uterine bleeding). Adenomyosis can be accompanied by a violation of the function of adjacent organs (such as the bladder, rectum). Often, one of the clinical manifestations of adenomyosis is the development of sideropenic syndrome, which is also caused by the development of chronic post-hemorrhagic iron deficiency anemia. This is accompanied by a deterioration in the general condition of patients, a decrease in their ability to work. Despite a large number of publications in Russian and foreign scientific sources devoted to this problem, reproductive doctors and obstetricians-gynecologists often underestimate the role of adenomyosis in pregnancy planning using assisted reproductive technologies. Without interpreting the anamnesis data obtained through an active survey, doctors do not prescribe additional methods for diagnosing this pathology, which is not complex and expensive. To confirm the diagnosis, a transvaginal ultrasound examination of the pelvic organs during the premenstrual period is sufficient. In cases that are difficult to diagnose, the MRI method of the corresponding anatomical area can be used. Underestimation of the clinical picture and under-examination of the patient did not allow prescribing timely correction of the pathology and led to unsuccessful attempts to implement the generative function using assisted reproductive technologies. The conducted examination with clarification of the cause of IVF failures and the prescribed reasonable treatment made it possible to achieve regression of endometriosis foci in this clinical situation, followed by the patient's ability to realize generative function.

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