scholarly journals ANÁLISIS LOCACIONAL DEL YACIMIENTO PALEOLÍTICO DE COVA EIRÓS (TRIACASTELA, LUGO)

Author(s):  
MIKEL DÍAZ-RODRÍGUEZ ◽  
RAMÓN FÁBREGAS-VALCARCE ◽  
ARTURO DE LOMBERA-HERMIDA ◽  
XOSÉ PEDRO RODRÍGUEZ-ÁLVAREZ

In this paper, we deal with the locational analysis of the Cova Eirós site (Triacastela, Lugo), occupied from the Middle Palaeolithic to the present. From GIS and statistics, we intend to approach those environmental factors that define its importance as a place of occupation over time and on a recurring basis. Once we have analysed the variables that characterize the site’s patterns of use, we have verified that Cova Eirós is an important, prominent and strategic point. The place is very close to the potential transit routes and has great visibility. It is also protected and set on a steep slope. Moreover, the site has hunting resources and raw materials sources nearby. So it is a settlement that presents ideal living conditions for hunter-gatherer groups.

1986 ◽  
Vol 67 (1) ◽  
pp. 8-11
Author(s):  
M. R. Rokitsky ◽  
A. V. Akinfiev ◽  
P. N. Grebnev ◽  
N. N. Molchanov ◽  
V. N. Poryvaeva ◽  
...  

Pathomorphosis should be understood as a general change in morbidity, a series of shifts in the general characteristics of a disease occurring over time under the influence of environmental factors, mass prevention and treatment measures, changes in social and living conditions, etc. This report presents the results of a 25-year retrospective review of experience in paediatric pulmonary surgery.


2010 ◽  
Vol 72 (08/09) ◽  
Author(s):  
D Penner ◽  
F Alaze ◽  
E Berens ◽  
A Ruhe ◽  
L Wolf ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yisong Huang ◽  
Shaoyong Su ◽  
Harold Snieder ◽  
Frank Treiber ◽  
Gaston Kapuku ◽  
...  

AbstractIncreased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability might be driven by genetic factors that are expressed consistently over time. We aimed to illustrate the relative contributions of genetic and environmental factors to the stability of carotid-distal PWV from youth to young adulthood. We also examined potential ethnic differences. For this purpose, carotid-distal PWV was measured twice in 497 European American (EA) and African American (AA) twins, with an average interval time of 3 years. Twin modelling on PWV showed that heritability decreased over time (62–35%), with the nonshared environmental influences becoming larger. There was no correlation between the nonshared environmental factors on PWV measured at visit 1 and visit 2, with the phenotypic tracking correlation (r = 0.32) completely explained by shared genetic factors over time. Novel genetic influences were identified accounting for a significant part of the variance (19%) at the second measurement occasion. There was no evidence for ethnic differences. In summary, novel genetic effects appear during development into young adulthood and account for a considerable part of the variation in PWV. Environmental influences become larger with age for PWV.


2020 ◽  
Author(s):  
Tatyana Dobreva ◽  
David Brown ◽  
Jong Hwee Park ◽  
Matt Thomson

AbstractAn individual’s immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic capillary blood extraction to enable simplified, cost-effective profiling of the human immune system across people and time at single-cell resolution. Using the platform, we detect widespread differences in cell type-specific gene expression between subjects that are stable over multiple days.SummaryIncreasing evidence implicates the immune system in an overwhelming number of diseases, and distinct cell types play specific roles in their pathogenesis.1,2 Studies of peripheral blood have uncovered a wealth of associations between gene expression, environmental factors, disease risk, and therapeutic efficacy.4 For example, in rheumatoid arthritis, multiple mechanistic paths have been found that lead to disease, and gene expression of specific immune cell types can be used as a predictor of therapeutic non-response.12 Furthermore, vaccines, drugs, and chemotherapy have been shown to yield different efficacy based on time of administration, and such findings have been linked to the time-dependence of gene expression in downstream pathways.21,22,23 However, human immune studies of gene expression between individuals and across time remain limited to a few cell types or time points per subject, constraining our understanding of how networks of heterogeneous cells making up each individual’s immune system respond to adverse events and change over time.


2017 ◽  
pp. 1-27
Author(s):  
Erika Jasionytė-Mikučionienė ◽  
Jolanta Šinkūnienė

The focus of the paper is on the frequency, distribution patterns and semantic profile of the necessitive impersonal reik(ė)ti ‘need’ in old and contemporary Lithuanian texts. The study employs corpus based quantitative and qualitative analysis to investigate the patterns of use of reik(ė)ti ‘need’ in the Database of Old Writings (16th-17th centuries) as well as the fiction sub-corpus of the Corpus of the Contemporary Lithuanian Language and the humanities and biomedical sciences sub-corpora of the Corpus of Academic Lithuanian (CorALit). The study follows van der Auwera and Plungian’s (1998) modality framework. The quantitative analysis shows that the present tense form reikia ‘need.PRS.3’ is the dominating one across all the sub-corpora analysed. The results of the qualitative study indicate that the deontic sub-type of participant external modality is prevailing in the old Lithuanian texts as well as in the fiction sub-corpus and in the biomedical sciences texts of the contemporary Lithuanian. The discourse of the humanities displays a fairly frequent employment of reik(ė)ti ‘need’ for discourse organising functions alongside the deontic uses. Although the usage patterns of reik(ė)ti ‘need’ in the biomedical sciences and the humanities share certain common features, they also point to discipline specific trends of argumentation. It is also important to observe that the objective deontic reik(ė)ti ‘need’ seems to gradually acquire the features of subjective deontic modality over time, which corresponds to the typical subjectification cline (cf. Traugott 1989).


2019 ◽  
Vol 46 ◽  
pp. 424-433
Author(s):  
Saeid Bahramiyan

There is a considerable body of studies regarding the activities of the Pleistocene human population in the Zagros and Alborz regions of Iran, as well as significant progress in the Palaeolithic studies in other regions, such as the foothills, plains and deserts’ margins. However, some of these peripheral regions and foothills are still neglected, and the information about the Palaeolithic period in these areas is limited. Khuzestan province, especially its northern regions, is one of these unstudied regions, yet the limited information about this region seems very interesting. Khervali, located on the western foothills of the Zagros Mountains and on the northern heights of Susa, nearby the western bank of the Karkheh River, is one of the few Palaeolithic sites identified in recent years. The site was identified in 2012 and was systemically surveyed. Due to the extension of the site and the distribution of the artefacts, sampling all the site was not feasible, therefore, four sections of the site were chosen for taking the samples and a total of 330 stone artefacts were collected. The results of the techno-typology analyses, as well as the frequency of the flakes, the Levallois samples and different types of scrapers, revealed that the artefacts date to the middle Palaeolithic period, with considerable access to the local raw materials.


Author(s):  
E. Krukovich ◽  
N. Tumanova ◽  
G. Bondar

Physical development (RF) is one of the main indicators of health status, largely due to hereditary factors, depends on the living conditions and upbringing, social and environmental factors [1,2,3,4]. This is especially important for children and adolescents in the process of growth and development. At the present stage of scientific research of RF in pediatrics, there is a transition from the analysis of average RF indicators to a personalized assessment [5,6].


2019 ◽  
Vol 9 (6) ◽  
pp. 146 ◽  
Author(s):  
Sheerin ◽  
Kovalchick ◽  
Overstreet ◽  
Rappaport ◽  
Williamson ◽  
...  

: Genes, environmental factors, and their interplay affect posttrauma symptoms. Although environmental predictors of the longitudinal course of posttraumatic stress disorder (PTSD) symptoms are documented, there remains a need to incorporate genetic risk into these models, especially in youth who are underrepresented in genetic studies. In an epidemiologic sample tornado-exposed adolescents (n = 707, 51% female, Mage = 14.54 years), trajectories of PTSD symptoms were examined at baseline and at 4-months and 12-months following baseline. This study aimed to determine if rare genetic variation in genes previously found in the sample to be related to PTSD diagnosis at baseline (MPHOSPH9, LGALS13, SLC2A2), environmental factors (disaster severity, social support), or their interplay were associated with symptom trajectories. A series of mixed effects models were conducted. Symptoms decreased over the three time points. Elevated tornado severity was associated with elevated baseline symptoms. Elevated recreational support was associated with lower baseline symptoms and attenuated improvement over time. Greater LGLAS13 variants attenuated symptom improvement over time. An interaction between MPHOSPH9 variants and tornado severity was associated with elevated baseline symptoms, but not change over time. Findings suggest the importance of rare genetic variation and environmental factors on the longitudinal course of PTSD symptoms following natural disaster trauma exposure.


2019 ◽  
Vol 26 ◽  
pp. 101882
Author(s):  
Sara Daffara ◽  
Gabriele L.F. Berruti ◽  
Giulia Berruto ◽  
Negar Eftekhari ◽  
Carmela Vaccaro ◽  
...  

2014 ◽  
Vol 25 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Shiona K Glass-Kaastra ◽  
Rita Finley ◽  
Jim Hutchinson ◽  
David M Patrick ◽  
Karl Weiss ◽  
...  

INTRODUCTION: Because antimicrobial use is commonly associated with the development of antimicrobial resistance, monitoring the volume and patterns of use of these agents is very important.OBJECTIVE: To assess the use of macrolide and lincosamide (ML) antimicrobials within Canadian provinces over time, and to compare use rates with those reported by European countries.METHODS: Antimicrobial prescribing data were used to develop two yearly metrics: prescriptions per 1000 inhabitant-days (PrIDs) and the mean defined daily doses (DDDs) per prescription, which were then used to build linear mixed models to assess differences among provinces over time.RESULTS: After accounting for repeated measures over time, prescribing rates (PrIDs) varied significantly according to province and year (P<0.001). However, little change occurred within each province over the time frame studied; from 1995 to 2010, each province had a PrID change <0.01. Quebec and British Columbia had significantly lower prescribing rates than all other provinces. No overall secular trend was apparent. In contrast, the DDDs per prescription did not vary significantly according to province, but showed a significant year-to-year increase.DISCUSSION: ML prescribing varied among provinces in Canada between 1995 and 2010, but remained relatively stable within each province. The average DDDs per ML prescription did not vary according to province, but increased linearly over time. These increases are likely to indicate that fewer prescriptions are being written for children over time, a practice supported by good antimicrobial stewardship principles.


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