scholarly journals Porcine Trypsin in the Manufacture of Biological Medicinal Products. Risks and Safety Requirements

2018 ◽  
Vol 18 (3) ◽  
pp. 161-167
Author(s):  
S. M. Sukhanov ◽  
E. M. Petruchuk
Keyword(s):  
High Resistance ◽  
Potential Risk ◽  
Chemical Treatment ◽  
Raw Materials ◽  
Animal Origin ◽  
Spongiform Encephalopathy ◽  
Quality And Safety ◽  
Medicinal Products ◽  
Safety Requirements ◽  
Physical And Chemical

Trypsin is a reagent widely used in the manufacture of biological medicinal products (BMPs). Until recently, pancreata of cattle, pigs and poultry were the main sources of trypsin preparations. The discovery of the disease called «transmissive spongiform encephalopathy» or «cow rabies» (TSE) in cattle in the late 1980s showed a clear need for limiting the use of this source. Given the potential risk of using trypsin obtained from cattle, porcine trypsin became more commonly used in the production of biological medicinal products. Enzymes obtained from raw materials of animal origin can be contaminated with circoviruses, parvo- and pestiviruses, and mycoplasmas that are common to pigs. Due to high resistance to physical and chemical treatment, these contaminants pose a potential risk to recipients of vaccines, as well as to other biological medicinal products. Prevention of contamination requires measures aimed at detection, reduction and inactivation of foreign agents, both in raw materials and during BMP production. The article considers the most common types of porcine trypsin contamination, methods of its detection, reduction and elimination. The article also contains information on the Russian and international requirements for the quality and safety of porcine trypsin used in the production of biological medicinal products.

scholarly journals Prion infections of animals: safety of food and medicinal raw materials of animal origin. Up-to-date data

2021 ◽  
Author(s):  
G.A. Nadtochey ◽  
S.W. Vangeli
Keyword(s):  
Raw Materials ◽  
Cellular Prion Protein ◽  
Animal Origin ◽  
Spongiform Encephalopathy ◽  
Natural Conditions ◽  
Muscle Tissues ◽  
Chemical Factors ◽  
Physical And Chemical ◽  
Sheep Scrapie

Prion infections of humans and animals are absolutely fatal. The cellular prion protein retains its antigenicity during the transition to the prion isoform; therefore, animals affected by prions do not respond to them with defensive reactions in the form of inflammation and the production of antibodies, which makes it difficult to diagnose the disease in vivo. In affected animals, prions accumulate in the nervous, lymphoreticular and muscle tissues and are released into the environment, in which they remain for many years. The resistance of prions to physical and chemical factors does not allow them to be inactivated in food by heat or radiation. Zoonoticity has been proven only for the causative agent of bovine spongiform encephalopathy, to which sheep, goats and pigs are susceptible. Sheep scrapie and chronic wasting deer disease occur widely in natural conditions in the form of enzootics and are similar in many characteristics. The zoonotic nature of their pathogens has not been proven.

Compound feed from different producers for piglets and their comparative assessment

2021 ◽  
pp. 3-12
Author(s):  
N. I. Kulmakova ◽  
T. A. Magomadov ◽  
N. M. Kostomakhin ◽  
M. N. Dmitrieva ◽  
H. Saleh
Keyword(s):  
Raw Materials ◽  
Comparative Assessment ◽  
Feed Additives ◽  
The Body ◽  
Animal Origin ◽  
Quality And Safety ◽  
Processing Technologies ◽  
Starting Compound ◽  
Federal Standard

The quality of raw materials and goods of animal origin depends first of all on the safety of feed, their balance in terms of the main nutrients and digestibility by the body. As a rule, the lower the quality and safety of feed, the lower the productivity of all types of animals and poultry. The quality of feed is influenced by all stages of their production: growing conditions, harvesting and storage, processing technologies, canning and preparation for feeding. Where high-quality feed is used in diets, maximum productivity and high realization of the genetic potential of animals are obtained. During the storage and processing of plant and animal raw materials its physic and mechanical, biochemical, sanitary and microbiological properties change. This can be avoided only by observing the sanitary and hygienic requirements for bagging, harvesting, and storing feed. The quality of feed is confirmed by its physical, chemical, organoleptic, microbiological and other indicators, which determines the variety of feed control methods at all stages of their turnover. In this connection, the development and strengthening of control over the quality and safety of feed and feed additives is one of the important tasks of modern animal feeding science. The purpose of the work was to carried out a comparative assessment of four samples of the starting compound feed SK-3 for piglets of different producers. The experimental part of the work has been carried out in the laboratory of veterinary expertise at the compound feed plant LLC “Athens-Volga”. For the study of compound feed an average sample was taken from each sample, separating from the combined sample using a hand scoop according to Federal standard 13496.0-2016. Methods of sampling. Quality and safety control was carried out according to organoleptic, physic and chemical, microbiological indicators and the content of mycotoxins in compound feed. Monitoring of compound feed of the compared samples of the starting compound feed for piglets SK-3 according to the studied indicators has shown that all samples meet the sanitary and hygienic requirements of Federal standard of our country.

scholarly journals ANALISIS JAMINAN MUTU DAN KEAMANAN PANGAN SEPANJANG RANTAI PASOK UDANG BUDIDAYA (ANALYSIS OF QUALITY AND SAFETY ASSURANCE ALONG THE SUPPLY CHAIN OF CULTURED SHRIMP)

2020 ◽  
Vol 12 (1) ◽  
pp. 23
Author(s):  
Rizki Dewi Kristikareni ◽  
Abdul Rokhman ◽  
Achmad Poernomo
Keyword(s):  
Quality Assurance ◽  
Supply Chain ◽  
Gap Analysis ◽  
Raw Materials ◽  
Global Market ◽  
Raw Material ◽  
Quality And Safety ◽  
Shrimp Culture ◽  
Safety Requirements ◽  
Fishery Products

 Udang merupakan komoditas unggulan ekspor Indonesia yang memerlukan bahan baku yang berkualitas dan aman. Untuk mendapatkan bahan baku udang yang sesuai, seluruh anggota rantai pasok harus menerapkan persyaratan jaminan mutu dan keamanan hasil perikanan sesuai Kepmen KP Nomor: 52A/KEPMEN-KP/2013. Tujuan penelitian ini adalah mengevaluasi penerapan persyaratan jaminan mutu dan keamanan hasil perikanan sepanjang rantai pasok bahan baku udang untuk unit pengolahan ikan (UPI) di Jakarta Utara. Dua UPI telah dipilih menjadi responden untuk dirunut ke hulu mengenai pemenuhan persyaratan dimaksud. Pengumpulan data dilakukan melalui survei, observasi dan wawancara kepada UPI, pengumpul/pemasok, pembudidaya dan pembenih. Analisis kesenjangan dan uji korelasi berganda digunakan untuk menilai kesesuaian penerapan persyaratan jaminan mutu dan keamanan hasil perikanan. Hasil identifikasi menunjukkan masih terdapat kesenjangan penerapan yang dilakukan oleh pembudidaya dan pengumpul/pemasok dengan standar yang ada. Tingkat kesesuaian pada pembudidaya 58% (kurang sesuai) dan pemasok 48% (tidak sesuai). Apresiasi UPI terhadap mutu dan keamanan hasil perikanan masih belum memadai, diduga karena permintaan di pasar global sangat tinggi sedangkan pasokannya tidak sesuai. Penerbitan sertifikat yang terpisah-pisah di antara rantai pasok diduga menjadi salah satu penyebab. Diperlukan perubahan strategi kebijakan dalam pelaksanaan sistem sertifikasi udang budidaya untuk ekspor yang terintegrasi dalam satu sertifikat.Shrimp is Indonesia's leading export commodity that requires quality and safe raw materials. To get appropriate shrimp raw materials, all members of the supply chain must apply the quality assurance and safety requirements of fishery products in accordance with Ministerial Decree KP Number: 52A/KEPMEN-KP/2013. This study aimed to evaluate the implementation of quality assurance and safety requirements for fishery products along the supply chain of cultured shrimp raw material suppliers for fish processing units (UPI) in North Jakarta. Two UPIs have been selected as respondents whose suppliers were evaluated regarding the fulfillment of the specified requirements. Data collection was carried out through surveys, observations, and interviews with UPI, collectors/suppliers, farmers, and breeders. Gap analysis and multiple correlation tests were used to assess the appropriateness of the implementation of quality assurance and fishery product safety requirements. The results show that gaps existed between the implementation of the requirement by farmers and suppliers compared with existing standards. The implementation level for farmers is 58% (less according) and the supplier 48% (not according). It was observed that UPI's appreciation of the quality and safety of fishery products was inadequate, allegedly because demand in the global market is very high while the supply does not meet the demand. Issuance of separate quality and safety certificates along the supply chain are believed to be one of the causes. There is a need to change the policy strategy in implementing the shrimp culture certification system for export which can be integrated into one certificate.

scholarly journals Assessment of quality and safety indicators of beverages made from vegetable raw materials

2020 ◽  
Vol 193 ◽  
pp. 01006
Author(s):  
Аnna I. Belousova ◽  
Lyudmila V. Donchenko
Keyword(s):  
Raw Materials ◽  
Customs Union ◽  
Quality And Safety ◽  
Chemical Parameters ◽  
Physical And Chemical Parameters ◽  
Vegetable Raw Materials ◽  
Physical And Chemical ◽  
Technical Regulations

Organoleptic and physical and chemical parameters of new pectin-containing beverages based on vegetable juices are given. Their compliance with the requirements of the technical regulations of the Customs Union in terms of safety indicators was confirmed. The conclusion about the feasibility of setting up new types of beverages for production was made.

scholarly journals FEATURES MERCHANDISING RESEARCH OF FUR PRODUCTS

2021 ◽  
Author(s):  
Жиленко ◽  
Новицька
Keyword(s):  
Quality Indicators ◽  
Raw Materials ◽  
Market Value ◽  
Production Method ◽  
Quality And Safety ◽  
Safety Requirements ◽  
Regulatory Documents ◽  
Retail Chains ◽  
Definition Of

Today, the range of fur products on the market is formed mainly due to the products of foreign manufacturers. Every year it is more and more difficult for a consumer to find a product of appropriate quality, since retail chains include in their assortment low-quality goods, the manufacturers of which do not fulfill the quality and safety requirements according to domestic regulatory documents. The purpose of this article is to study features that affect the quality and grade of fur and finished fur products, study defects and its impact on products, draw up a consistent scheme for researching fur products, analyze consumer properties and evaluate the quality of fur products using mink coats as an example. A merchandising expert examination of fur goods when determining its market value consists in classifying the goods as one of the classification categories, determining the characteristics of the goods and changing its quality indicators, and establishing the production method. The variety of semi-finished fur products is determined in accordance with the quality of the fur, depending on the maturity of the hairline, the presence of defects, the definition of ridge, size and other characteristics that significantly affect the quality and price of fur raw materials. The use of the proposed scheme for the study of fur products will allow determining quickly the type, quality and grade of fur and finished fur products, to prevent errors in determining the market value of fake, artificial, dyed and low-quality fur.

scholarly journals METHODOLOGICAL ASPECTS OF IDENTIFICATION OF TISSUE-SPECIFIC PROTEINS AND PEPTIDES FORMING THE CORRECTIVE PROPERTIES OF INNOVATIVE MEAT PRODUCTS

2018 ◽  
Vol 3 (3) ◽  
pp. 36-55 ◽  
Author(s):  
Natal’ya L. Vostrikova ◽  
Irina M. Chernukha ◽  
Daniil V. Khvostov
Keyword(s):  
Food Quality ◽  
New Technologies ◽  
Raw Materials ◽  
Muscle Protein ◽  
Food Additives ◽  
Meat Products ◽  
Food Products ◽  
Modern Technology ◽  
Animal Origin ◽  
Quality And Safety

One of the ways to address the food quality issues facing the industry is the development of standardized and certified methods related to the conduct of in-depth studies of biochemical indicators of quality and safety of meat and meat products. The world laboratory practice in the field of food quality and safety shows a constant expansion of the list of controlled indicators of food raw materials and products. An important feature of the modern period in the development of biomedical and biotechnological research is the introduction of a whole complex of postgenomic technologies, which are based on a systematic approach to the study of the functioning of the mammalian proteome in various physiological and pathological conditions, including the formation and development of alimentary-dependent pathologies. In this regard, the problem of multilateral study of food products, in particular their identification, is the most relevant, because the modern technology of their production has undergone significant changes and requires the development of “gentle “ processing modes. They concern raw materials and auxiliary materials used at all stages of production. This and new technologies of production of protein products from plant raw materials, as well as the introduction of food raw materials and food additives of artificial origin and the excess introduction of additives of plant and animal origin can cause falsification of products, as well as affect the health of the consumer. Food quality assessment includes the control of components of finished products. It is most difficult to determine the proportion of muscle protein in multi-component meat products that have undergone heat treatment. Therefore, in practice, when assessing the quality of food products, there is a need to identify its real composition in accordance with the declared normative documents. Currently, a promising area of research in the field of determining the composition of finished food is the selection of biomarkers of various components. Therefore, it is important to develop a methodology for the identification of biochemical changes in food raw materials under the influence of technological factors using modern research methods. This paper provides an overview of the protein and peptide analysis methodology, including the latest technologies that are becoming increasingly important.

Ensuring the quality and safety of canned meat for child nutrition

2021 ◽  
Author(s):  
A.A. Odintsova ◽  
Keyword(s):  
Child Nutrition ◽  
Food Products ◽  
Quality And Safety ◽  
Safety Requirements ◽  
Chemical Indicators ◽  
Canned Meat ◽  
Physical And Chemical

The paper represents physical and chemical indicators and indicators of the safety of canned meat for child nutrition. It is noted that food products for children must contain a strict amount of components that must meet safety requirements.

scholarly journals State control (supervision) over the quality and safety of agricultural products (on the example of the Sverdlovsk region)

2021 ◽  
Vol 128 ◽  
pp. 03010
Author(s):  
Dmitry Bagretsov ◽  
Boris Voronin ◽  
Elena Chebykina
Keyword(s):  
Russian Federation ◽  
Raw Materials ◽  
Legal Regulation ◽  
Agricultural Products ◽  
Animal Origin ◽  
Quality And Safety ◽  
Executive Authority ◽  
The Russian Federation ◽  
Federal Laws ◽  
The Government

The Federal Service for Veterinary and Phytosanitary Surveillance (Rosselkhoznadzor), located in the structure of the Ministry of Agriculture of the Russian Federation, implements control and supervisory activities by a specially authorized state authority in the field of quality and safety of agricultural products, raw materials and food, checks legal entities and individual entrepreneurs in the implementation of their activities, compliance with its requirements, established by federal laws and other regulatory legal acts of the state executive authority in this area. Structural divisions of the Rosselkhoznadzor, for example, the Rosselkhoznadzor Administration for the Sverdlovsk Region, exist in the constituent entities of the Russian Federation. Specialists of this structure carry out functional control and supervisory measures to ensure the quality and safety of agricultural products produced in the Sverdlovsk Region and imported from other regions of the Russian Federation and abroad. Legal regulation of relations in this area is carried out by federal laws, resolutions of the Government of the Russian Federation and other regulatory legal acts that differentially regulate certain areas in the field of quality and safety of agricultural raw materials of plant and animal origin.

scholarly journals Research of quality and safety indicators of organic raw materials for development of new cookie recipes

2021 ◽  
pp. 36-40
Author(s):  
Alina Tkachenko ◽  
Ivan Syrokhman ◽  
Lyudmyla Guba ◽  
Yulia Basova ◽  
Elena Goryachova
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Atomic Absorption ◽  
Acid Composition ◽  
Nutritional Value ◽  
Raw Materials ◽  
Quality And Safety ◽  
Drying Method ◽  
Safety Requirements

Studies of quality and safety of organic flour and oils for the development of cookies are considered. The objects of the study are samples of organic spelt, corn and coconut flour; and samples of organic oils (camelina and hemp). The purpose of the study is to substantiate the feasibility of using organic raw materials for the development of new cookie recipes. To determine the quality and safety of organic flour, the nutritional value, physicochemical parameters and safety indicators (content of salts of heavy metals) have been analyzed. To determine the quality of organic oils, the fatty acid composition has been analyzed. Standard methods have been used for the study. The moisture content of the flour has been determined by the drying method. Ash content – by the method of organic matter charring. Atomic absorption and flameless atomic absorption methods have been used to determine the safety indicators of the flour. The fatty acid composition of oils has been determined by gas chromatography. It has been proved, that organic raw materials meet the safety requirements of the Regulation of maximum levels of certain contaminants in food, approved by the Order of the Ministry of Health of Ukraine № 368 of 13.05.2013 and can be used as a promising enrichment for the nutritional value of cookies

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