scholarly journals AGE AND SEX FEATURES THE INDICATORS OF THE NATURAL NONSPECIFIC RESISTANCE OF GUTSUL BREED HORSES

2017 ◽  
Vol 53 ◽  
pp. 164-172
Author(s):  
M. V. Pasaylyuk ◽  
I. V. Stefurak ◽  
Yu. P. Stefurak
Keyword(s):  
Total Protein ◽  
Specific Resistance ◽  
Relative Content ◽  
The Body ◽  
Protein Fractions ◽  
Natural Resistance ◽  
Farm Animals ◽  
Eastern Carpathians ◽  
Γ Globulins ◽  
Age And Sex

Horses of Gutsul horse breed are native breed for Gutsul region of Eastern Carpathians. Skilled human using performance-keeping livestock of farm animals influence primarily on to the adaptive and protective properties of the body of farm animals. The study aimed to research the age and sex characteristics of natural resistance of Gutsul breed horses will promote the formation of measures to improve animal productivity, and will promote for all-round understanding of the unique breed postembryonic during ontogeny. The studies aim was to investigate age dynamics of non-specific resistance of the organism Gutsul breed horses of different sexes. The study was conducted during the 2013-2017 years. The blood samples (n = 96) of healthy horses (n = 28) Gutsul breed were analyzed. Material for the study was given from horses that were in proper diet and kept under the same conditions of Pre-Carpathians. The horses age and sex categories were formed as follows: foals 6 months (just weaned), 1 year, 1.5 years; mares and stallions aged 2 and 3 years; mares (blank), horses (before coupling period), geldings aged 6, 9, 12. To study the resistance of animals in whole blood such parameters were determined: protein fractions, amount of total protein of serum of blood, bactericidal activity of serum of blood (BASB), lysocym activity of serum of blood (LASB) index of completed phagocytosis (ICP). Analysis of non-specific resistance of the organism in the classic cluster for these studies (total protein, protein fractions, BASB, LASB, ICP) found that Gutsul breed horses are well adapted to living conditions in the territory Pre-Carpathians in all chosen by our time. The value of the studied parameters depended on the age and sex of the individual from whom the samples. To the onset of puberty horses the content of total protein increased its value. In all age categories the content of total protein was higher in stallions. Later, with age, although the total protein was increasing, but it was not significant when comparing the results for each gender in particular. Protein fractions of Gutsul breed horses recorded that the foals had the highest relative content of albumin, the lowest - γ-globulins. With age, albumin content changed in waves, but the albumin / globulin ratio remained high in the 12-year-old individuals with almost identical values for particles and geldings and mares, but indexes of ratio were significantly higher for stallions. The relative content of γ-globulin fraction of horses of different sexes increased with age, and in mares, starting year and a year and half of age, content γ-globulin was significantly higher than the rates the content of the fractions in the blood stallions appropriate age. Differences of γ-globulin fractions between mares and geldings were statistically unreliable. The dynamics of age changes BASB and LASB set like jump improving of these indicators from 6 months to a year and a year and half old and continue their stabilization occurred at 85-91-89% for BASB and 25-31-27% for LASB to mares, stallions, geldings, respectively. The indexes of ICP were already high at 6 months of age (0,84-0,9 st.un.). The level of adult the indexes of ICP out in the first year of life (for 0,87-0,93-0,89 st.un. for mare-stallions and geldings, according to). Thus, both humoral and cellular resistance performance is not constant. These indexes changed according to physiological status. In stallions, compared with mares, almost all ages favor and ICP indicators were higher. The content of γ-globulins were lower, while in females, respectively, recorded an opposite picture. Most indicators of natural resistance of the organism geldings were lower than stallions, showing the same trend, similar to the body of female horses.

scholarly journals The effectiveness of the use of a biologically active additive ekobentokorm in the diets of cattle

2021 ◽  
Vol 273 ◽  
pp. 02007
Author(s):  
Galina Zelenkova ◽  
Sergei Tresnitskii ◽  
Pavel Bykadorov ◽  
Anna Pecinovsky ◽  
Aleksandr Yenin ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Total Protein ◽  
Blood Cells ◽  
Physiological State ◽  
The Body ◽  
Biologically Active ◽  
Protein Fractions ◽  
Natural Resistance ◽  
Neutrophil Granulocytes ◽  
High Biological Activity

Studies have established the effect of ekobentokorm (TU 9283-199-10514645-13-2013) on the metabolism of cows and the natural resistance of young black-and-white breed. The physiological state of cows was assessed by morphological and biochemical studies of blood, in which changes in the body’s metabolic processes were tracked in dynamics according to the following indicators: the number of red blood cells and hemoglobin level, total protein and protein fractions, glucose, urea, aminotransferases (AST, ALT), total calcium and inorganic phosphorus, trace elements (Mg, Zn, Fe, Cu) and carotene. The indicators characterizing the natural resistance of young animals were studied: red blood cells, white blood cells, hemoglobin, color index, total protein and protein fractions, phagocytic activity of neutrophil granulocytes, bactericidal and lysozyme activity of blood serum, the content and concentration of T-and B-lymphocytes, the level of circulating immune complexes (CIC). As a result of the conducted research, it was found that ekobentokorm has high biological activity, improves morphological and biochemical parameters of cows blood, and also increases milk productivity. It has a pronounced stimulating effect on the immunocompetent systems of the body of young animals, as a result of which the level of non-specific protection of the animal increases.

scholarly journals Dynamics of individual indicators of protein metabolism in the body of broiler chickens on the background of combined stress when included in the diet “Reasil Humic Vet” + “Laktin” and “Reasil Humic Health”

2020 ◽  
Vol 3 (2) ◽  
pp. 42-46
Author(s):  
V. G. Stoyanovskyy ◽  
M. O. Shevchuk ◽  
I. A. Kolomiiets ◽  
V. A. Kolotnytskyy
Keyword(s):  
Total Protein ◽  
Protein Metabolism ◽  
Broiler Chickens ◽  
Stress Factor ◽  
The Body ◽  
Control Group ◽  
Total Protein Content ◽  
Combined Stress ◽  
Stages Of Development ◽  
Γ Globulins

The body of  broiler chickens is characterized by a high metabolism, which promotes rapid growth and development, but their performance indicators are largely related to housing conditions, which are known to include a number of technological stressors. With the development of stress in the body of poultry changes the course of metabolic processes, which causes changes in all types of metabolism, including protein. The aim of the study was to determine the changes in individual indicators of protein metabolism in the body of broiler chickens against the background of combined stress when included in the diet “Reasil Humic Vet” + “Laktin” and “Reasil Humic Health”. At 13th day of life, all clinically healthy poultry were exposed to combined stress – revaccination (intranasal Newcastle disease) plus cold stress (for 60 minutes by air conditioning and 5 °C in the vivarium). Material for research was selected for 3 days after the action of the stress factor (stage of anxiety), 13, 20 and 26 days after the action of the stress factor (the resistance stage). The material for the study was blood plasma, which determined the concentration of total protein, as well as the content of albumin, globulin fraction (α1, α2, β, γ). It was found that 3 days after the action of stress in chickens of Control group the development of adaptive reactions is manifested by the stability of the total protein content and redistribution of the fractional composition of plasma globulins in the form of increased albumin and α2-globulins. At different stages of development of the stage of resistance in birds of Control group, the content of total protein decreases by an average of 14.6 % due to the content of albumin by 6.9 % and α2-globulins – by 15.9 %, against the background of increasing α1- and γ-globulins by 23.1 and 33.5 % with the stabilization of individual studied indicators at the final stages of development of the resistance stage. The use in the diet of broilers feed “Reasil Humic Vet”, probiotic feed supplement “Laktin”, feed “Reasil Humic Health” under the influence of complex stress helps to increase the intensity of protein metabolism in poultry with the development of adaptation syndrome, as evidenced by the growth of total protein on average by 37.8 % (P < 0.05) and albumin – by 17.0 % (P < 0.05), which indicates an increase in the intensity of protein-synthesizing properties of the organism. In different periods of stress in the blood of broiler chickens Research groups there is an increase in the ratio of individual protein fractions, especially the content of γ-globulins - an average of 21.3 % (P < 0.05), which indicates an increase in the immune status of their body with a predominance of numerical values in the Research 1 group of poultry.

scholarly journals The effect of cysticercosis invasion on the protein metabolism and cellular immunity of rabbits

2021 ◽  
Vol 23 (1) ◽  
pp. 7-11
Author(s):  
Y. V. Duda ◽  
Keyword(s):  
Cellular Immunity ◽  
Total Protein ◽  
Protein Metabolism ◽  
The Body ◽  
Total Protein Content ◽  
Blood Proteins ◽  
Visual Identification ◽  
Γ Globulins ◽  
Inflammatory Processes ◽  
Healthy Control

The composition of blood proteins depends on the functional state of animals, as well as on various pathologies. The goal of the work was to establish the effect of cysticercosis invasion on the protein metabolism and cellular immunity of rabbits. Rabbits were divided into two groups after visual identification of the larval cysts presence: healthy (control) and diseased (experimental). Biochemical blood tests were performed using reagent sets produced by “Filisit-Diagnostika” (Ukraine). Spontaneous cysticercosis invasion of male rabbits caused changes in protein metabolism. The content of total protein in infected animals was higher by 8.79% (P<0.05) than in control. The increase in the total protein content was due to the globulin fraction, which was 1.50 times (P<0.05) higher in affected animals than in healthy rabbits. This rise occurred as a result of a high content of γ-globulins, both in absolute value by 1.69 times (P<0.05), and in percentage by 1.51 times (P<0.05). The albumins, which are completely synthesized by liver, were lower by 10.08% (P<0.05) in rabbits with cysticercosis. The protein coefficient of experimental animals was lower by 43.89% (P<0.05) compared with the control. The concentration of uric acid in diseased rabbits was lower by 34.09% (P<0.05) than in healthy ones. We have observed a high number of T-, B-lymphocytes and T-helper cells, especially the last two indicators, which increased respectively 1.54 times (P<0.01) and 1.36 times (P<0.05) against the background of a low number of T-suppressors and O-lymphocytes — almost 5 times (P<0.001) in affected animals than in healthy rabbits. In our opinion, such changes in the proteinogram and cellular immunity indicate the intensification of immune reactions in the body of rabbits infected with the Cysticercus pisiformis as a result of inflammatory processes that occur in the liver under the action of a mechanical, toxic effect of the helminths.

scholarly journals Feed additives to enhance productivity and natural agricultural resistance of animals

2019 ◽  
Vol 80 (4) ◽  
pp. 292-297
Author(s):  
I. V. Cheryomushkina ◽  
A. E. Chernitsky ◽  
N. N. Manilevich
Keyword(s):  
Clinical Status ◽  
Adaptive Immune Response ◽  
Stress Sensitivity ◽  
Feed Additives ◽  
The Body ◽  
Natural Resistance ◽  
Farm Animals ◽  
Feed Additive ◽  
Control Drug ◽  
Gastrointestinal Pathology

The use of intensive technologies in industrial livestock leads to an increase in the stress sensitivity of animals, a decrease in their immune status and the development of pathological conditions. To increase the safety of young stock, including by reducing its incidence and death from diseases, feed additives are being developed, including probiotics, prebiotics and (or) other components that stimulate the immunological resistance of animals, their growth and productivity. This article examines the effectiveness of the use of a complex feed additive containing a multienzyme enzyme preparation, the probiotic preparation Prolam and amaranth oilcake to increase the efficiency of growing calves. The studies were performed on calves of the red-motley breed from 10 days of age in Voronezhpishcheprodukt LLC. The study of the effect of the feed additive on the immune and clinical status was carried out on 40 calves, which were divided into 4 groups. The calves of the three experimental groups used the feed additive at a dosage of 5, 10 and 15 g per day from day 10, the control drug was not used. The use of a complex feed additive to calves in the neonatal period helps to optimize the process of formation of intestinal microbiocenosis, increase the body's natural resistance and adaptive immune response to antigenic effects, accompanied by a decrease in the incidence of animals, the duration and severity of gastrointestinal pathology. The use of the feed additive in the dosage of 10–15 g / head per day favorably affected the growth rate and the natural resistance of the body of calves. The data obtained are the basis for the inclusion of feed additives in the diet of young farm animals.

ОСОБЕННОСТИ БЕЛКОВОГО ОБМЕНА У БЫКОВ-ПРОИЗВОДИТЕЛЕЙ РАЗНЫХ ВОЗРАСТОВ

2019 ◽  
Author(s):  
N.V. BOGOLYUBOVA ◽  
I.V. GUSEV ◽  
R.A. RYKOV ◽  
N.A. KOMBAROVA
Keyword(s):  
Reference Values ◽  
Total Protein ◽  
Metabolic Profile ◽  
The Body ◽  
Farm Animals ◽  
Blood Levels ◽  
Serum Samples ◽  
Health And Nutrition ◽  
Relationship Of ◽  
The Relationship

Для разработки референтных значений биохимических показателей, характеризующих нормальное течение обменных процессов, исследованы пробы сыворотки крови быков-производителей голштинской породы (n=102), разделенных на 4 группы по возрасту и содержащихся в условиях племпредприятия Московской области. В сыворотке крови определяли концентрацию общего белка, альбумина, мочевины, креатинина, активность аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (АСТ). Установлено, что с возрастом быков достоверно увеличивается содержание в крови общего белка. У животных 2—4 лет этот показатель увеличился на 11% (P<0,01), 4—6 лет — на 19,1% (P<0,01), более 6 лет — на 21,5% (P<0,001) по сравнению с быками до 2-летнего возраста. Это связано с повышением глобулиновой фракции. С возрастом быков в связи с увеличением их живой массы отмечалось повышение концентрации креатинина в крови, а также мочевины. У производителей 4—6-летнего возраста содержание мочевины в крови увеличивалось на 47,9% (P<0,001) по сравнению с быками до 2 лет. Повышение активности АСТ у быков-производителей с возрастом можно связать с повышенной нагрузкой на печень и сердечно-сосудистую систему в связи с их производственным использованием. Полученные данные о метаболическом профиле производителей разных возрастов помогут на практике проводить мониторинг и корректировку состояния животных, а также в разработке эталонных значений для оценки здоровья и уровня питания.Questions of the relationship of indicators of protein metabolism in the body of bulls with age can serve as accumulative material for the development of reference values of biochemical indicators characterizing the normal course of metabolic processes. The serum samples of the Holstein breeding bulls (n=102), divided into 4 groups by age and contained in the conditions of the “Head Center for the Reproduction of Farm Animals”, were investigated. The following parameters were determined in blood serum: concentration of total protein, albumin, urea, creatinine, activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST). As a result of research, it has been established that with age, bulls reliably increase blood levels of total protein. In the 2—4 year old bulls, this indicator increased by 11% (P<0.01), 4-6 years old — by 19.1% (P<0.01), and over 6 years old — by 21.5% (P<0,001) compared with animals under 2 years. This was associated with an increase in the globulin fraction. With increasing age of the bulls, an increase in the concentration of creatinine in the blood was observed, which is associated with an increase in body weight of animals. Noted the increase in urea in the blood of the bulls with age. Thus, in the blood of bulls of 4—6 years of age, this indicator increased by 47.9% (P<0.001) as compared with analogues up to 2 years. An increase in AST activity in bulls with age can be associated with an increased load on the liver and the cardiovascular system due to their production use. The obtained data on the metabolic profile of the bulls of different ages will help in practice to monitor and adjust the condition of the animals and to develop reference values for assessing health and nutrition levels. Key

scholarly journals Levels of protein fractions in blood serum of periparturient goats

2011 ◽  
Vol 80 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Lenka Janků ◽  
Leoš Pavlata ◽  
Ľubica Mišurová ◽  
Jaroslav Filípek ◽  
Alena Pechová ◽  
...  
Keyword(s):  
Blood Serum ◽  
Total Protein ◽  
Serum Proteins ◽  
Experimental Studies ◽  
Electrophoretic Analysis ◽  
Protein Fractions ◽  
Pathological Findings ◽  
Individual Protein ◽  
Diagnostic Interpretation ◽  
Γ Globulins

The aim of the study was to compare contents of individual protein fractions determined by electrophoresis in blood serum of healthy periparturient goats. Eight clinically healthy white shorthaired goats were examined. Blood samples of these goats were taken from v. jugularis three weeks and two weeks before the anticipated parturition, on the parturition day, 7 days after the parturition, and 28 days after the parturition. Individual protein fractions, albumins, α1-, α2-, β1-, β2- and γ-globulins were identified by electrophoretic analysis of blood serum. Percentage shares of individual protein fractions were converted from total protein values to g·l-1 values. The results indicated that individual serum protein fractions in periparturient goats showed significant dynamics of change. There were no significant differences between samples taken before the parturition and on the parturition day (except for the increase of β2 from 2.5 ± 0.3 g·l-1 observed 3 weeks before the parturition to 3.2 ± 0.4 g·l-1 measured 2 weeks before the parturition, and the decrease of γG levels from 9.5 ± 2.6 g·l-1 observed three weeks before the parturition to 8.1 ± 1.7 g·l-1 found on the parturition day), yet most indicators measured after the parturition were significantly higher (p < 0.05) than on the parturition day (values in g·l-1 observed on the parturition day versus values measured 28 days after the parturition: total protein 60.6 ± 4.3 vs. 71.3 ± 2.4, albumins 37.4 ± 2.9 vs. 42.7 ± 1.0, α2 3.4 ± 0.5 vs. 4.1 ± 0.8, β1 5.6 ± 0.5 vs. 6.3 ± 0.9, γG 8.1 ± 1.7 vs. 12.3 ± 1.9). The results bring new knowledge on the values of individual fractions of serum proteins in healthy goats, which is necessary for diagnostic interpretation of pathological findings in animals and also for experimental studies.

scholarly journals Application of native agarose gel electrophoresis of serum proteins in veterinary diagnostics

2016 ◽  
Vol 60 (4) ◽  
pp. 501-508 ◽  
Author(s):  
Bartosz Jania ◽  
Katarzyna Andraszek
Keyword(s):  
Total Protein ◽  
Serum Proteins ◽  
Protein Electrophoresis ◽  
The Body ◽  
Protein Fractions ◽  
Agarose Gel ◽  
Electrophoretic Separation ◽  
Electrophoretic Techniques ◽  
Cancer Multiple ◽  
Available Information

Abstract Electrophoretic techniques, used to separate mixtures of electrically charged particles, are widely used in science. One of these techniques, native protein electrophoresis in an agarose gel, is applied in human and veterinary medicine. Changes in the proportions of individual protein fractions correspond to significant changes in the physiology of the body. Although the pattern obtained by electrophoretic separation rarely indicates a specific disease, it provides valuable information for the differential diagnosis. Decades of research on the types of patterns obtained in the case of particular diseases have led to the accumulation of substantial knowledge. The paper presents the available information on this topic. Serum protein electrophoresis is recommended in cases of increased levels of total protein in order to reveal the nature of the process. The basic information which can be obtained from electrophoretic separation includes the immune status of the organism. Both increased antigenic stimulation and immunodeficiency are clearly visible in electropherograms. Moreover, the level of heterogeneity of the corresponding protein fractions can help to distinguish between infectious diseases and cancer - multiple myeloma - the latter producing a homogeneous immunoglobulin fraction. Analysis of other protein fractions helps to detect or confirm an ongoing inflammatory process and provides information regarding liver function. Even when the concentration of total protein is within the reference range, this analysis can be recommended as a basic laboratory test.

scholarly journals НЕСПЕЦІФІЧНА РЕЗИСТЕНТНІСТЬ КОЗЕНЯТ ЗА ДІЇ ПРОБІОТИКА «ЕВІТАЛІЯ» В УМОВАХ НЕ РЕГУЛЬОВАНОГО МІКРОКЛІМАТУ

2016 ◽  
Vol 18 (3(70)) ◽  
pp. 196-200
Author(s):  
A.N. Petrenko ◽  
L.L. Kushch
Keyword(s):  
Relative Humidity ◽  
Red Blood Cells ◽  
Total Protein ◽  
Blood Cells ◽  
White Blood Cells ◽  
The Body ◽  
Natural Resistance ◽  
Total Protein Content ◽  
Humoral Factors ◽  
Freeze Dried

Probiotic «Evitaliya» is freeze–dried, specific strains of lactic acid microorganisms (Lactococcus lactis, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus helveticus, Propionibacterium fredenreichii ssp shernanii), they contain vitamins B1, B2, B6, B12, A, E, C iron minerals, calcium, magnesium.The purpose of the study was to clarify the effect of the probiotic ferment «Evitaliya» on nonspecific resistance of kids zaanovskoy breed microclimate conditions according VNTP (for sheep and goat breeding enterprises): the room temperature 12–14 °C, relative humidity of 55 – 70%, the carbon dioxide content – 1.5 – 1.8 l/m3 and ammonia – 10 – 15mg/m3 air bacterial contamination 15 – 20 tys. KOE/m3. Implementation of this goal was decided to use hygienic (temperature, relative humidity, air velocity); hematological (red blood cells, white blood cells, hemoglobin), biochemical (total protein, albumin, globulin); immune (humoral factors – lysozyme and bactericidal activity of blood serum, cell – the neutrophil phagocytic activity), statisticsGetting results and their novelty: for the first time tested the new probiotic yeast «Evitaliya», with its goats orally at a dose of – 200 ml/head in the morning and evening, 100 ml.It was found that the use of «Evitaliya» promotes activation of redox processes in the body kids, stimulation of erythropoiesis: increase in hemoglobin concentration of 0.56% (P ≤ 0.05), the number of red blood cells to – 10.2% (P ≤ 0.05).Use of the drug is moderately activates metabolic processes in the body of kids: increases total protein content by 7.14% (P ≤ 0.05), globulin – by 1.76% (P ≤ 0.05). Use of the drug «Evitaliya» at the indicated doses helps stimulate natural resistance olrganіzmu kids: humoral protection indicators (BASK) rose by 1.52% (LASK) by 1.81%, the cell indices (FA) compared to the control were higher – 4.97%. 

scholarly journals The effectiveness of mineral adaptogen in experimental immunosuppression

2021 ◽  
Vol 215 (12) ◽  
pp. 29-40
Author(s):  
M. Drozd
Keyword(s):  
Immune System ◽  
Research Methods ◽  
Experimental Studies ◽  
The Body ◽  
Natural Resistance ◽  
Farm Animals ◽  
Laboratory Animals ◽  
Control Group ◽  
Statistical Research ◽  
Experimental Animals

Abstract. Modern conditions of animal husbandry and poultry farming dictate a continuous search for effective means that increase the natural resistance of the organism of farm animals and poultry. The purpose of the study. In this regard, an experimental study was conducted on laboratory animals using a mineral adaptogen of domestic production in order to determine its effectiveness in conditions of artificially induced immunosuppression. The objectives of the study were to determine the immunobiochemical status, subcellular and intra-organ changes in the organs of the immune system at all levels. Research methods. Experimental studies were carried out using generally accepted zootechnical, pathomorphological, histological, immunobiochemical and statistical research methods. Results. Immunobiochemical changes in the body of experimental animals are described. Microscopic changes at the level of tissues and cells in the organs of the immune system at all levels are described. Changes in the organs of the immune system during immunosuppression and against the background of feeding mineral adaptogen are described. Morphological examination of the immune system organs in experimental animals revealed prolonged immunosuppressive changes for 14 days. At the same time, after induced immunosuppression, significant structural changes remain in the central and peripheral organs of the immune system in the form of lymphoid tissue atrophy (in the thymus, both in the organ of central immunogenesis and in the organs of the peripheral immune system – the spleen and lymph nodes and intra-organ lymph formations). During histological studies, the structure of cells and tissues, when using a mineral adaptogen, was more morphologically mature and was in a functionally active state, and dystrophic and necrotic processes were observed in the control group. The conducted studies convincingly prove the effect of mineral adaptogen on increasing natural resistance and its immunoprotective properties. Scientific novelty. For the first time in experimental conditions, a simultaneous assessment of the immunobiochemical parameters of the blood of laboratory animals and a microscopic examination of the organs of the immune system at all levels with morphometric analysis of the data obtained were given. As a result of the conducted studies, the immuno- and organoprotective effect of feeding the mineral adaptogen was proved and the immunomodulatory effect was morphometrically confirmed.

scholarly journals Prophylactic "Xymedon" in Abdominal Surgery

2021 ◽  
Vol 14 (2) ◽  
pp. 152-160
Author(s):  
Nikita A. Koloshein ◽  
Sergei G. Izmailov ◽  
Egor Е. Lukoianychev ◽  
Andrey Е. Leontev ◽  
Alexey А. Bodrov ◽  
...  
Keyword(s):  
Wound Healing ◽  
Defense Mechanisms ◽  
Specific Resistance ◽  
Effective Means ◽  
The Body ◽  
Natural Resistance ◽  
Surgical Patients ◽  
Wound Complications ◽  
Nonspecific Resistance ◽  
The Impact

Importance. Surgical procedures have a lot of stress, causing significant violation of the non specific defense mechanisms of the body and the immune system, which requires the use of different pharmacological agents in order to increase natural resistance to infection.Purpose. An analytical review of experimental and clinical research in the direction of studying the effectiveness of the impact of enteral xymedon on reparative process of surgical wounds and tissue non-specific resistance of the organism to infection for the prevention of inflammatory wound complications.Materials and methods. The analysis of experimental and clinical data, dealing with the question of studying the effect of enteral and topical xymedon to repair tissue in the area of the surgical wound and the non-specific resistance to infection.The criteria for the effectiveness of the drug were clinical and laboratory parameters, and statistic methods.Results and their discussion. The analysis of experimental and clinical studies have shown that enteral and topical use xymedon in surgical patients stimulates wound healing surgical site and increases nonspecific resistance to infection by increasing the functional activity of neutrophils, their backup potentials normalize the concentration of a bioactive and immunoreactive fibronectin in blood plasma, improve antimicrobial activity of wound.Conclusions. Xymedon is recommended as an effective means of pharmacological support of wound healing in surgical patients to prevent postoperative wound complications.

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