scholarly journals Potensi Ekstrak Curcuma Xanthorrhiza Sebagai Terapi Pendamping Tuberkulosis

2021 ◽  
Author(s):  
Hamzah Haryo Prakoso ◽  
Andre Setiawan ◽  
daffa sadewa
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Abdominal Pain ◽  
Side Effects ◽  
Clinical Manifestations ◽  
World Health ◽  
Exclusion Criteria ◽  
Anti Oxidant ◽  
Curcuma Xanthorrhiza ◽  
Anti Inflammatory ◽  
Tuberculosis Activity

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Most of it attacks the lungs and is still a world health problem. Therapy with a combination of drugs called Anti-Tuberculosis Drugs (OAT) has become a standard and effective cure for TB sufferers as long as it is regular and complete. However, the drawback of OAT is that it has several side effects that allow temporary drug interruption and worsening of clinical manifestations. For that we need companion therapy to overcome this. The purpose of this paper is to search and analyze literature regarding the potential of Curcuma xanthorrhizol extract as a companion therapy for tuberculosis. The method used is by searching the pubmed and google scholar databases with the keywords curcuma xanthorrhiza, curcumin, xanthorrhizol, flavonoids, Mycobacterium tuberculosis, anti-inflammatory, anti-oxidant, gastroprotective and anti-bacterial. Then the literature is selected based on inclusion and exclusion criteria. The results and discussion obtained were that curcuma xanthorrhiza has various active compounds that are useful for preventing side effects of OAT such as curcumin, xanthorrhizol, and flavonoids. Curcuma xanthorrhiza can be used as anti-inflammatory, anti-oxidant, gastroprotective so that side effects such as skin rashes, nausea, vomiting, abdominal pain and others can be prevented. Besides that, curcumin content in Curcuma xanthorrhiza has anti-tuberculosis activity. The conclusion is that curcuma xanthorrhiza extract can be considered as a companion drug for TB patients. It can be done further research on the potential of ginger

scholarly journals A Case of Polyneuropathy Following a Single Dose of Diethylcarbamazine and Albendazole During Mass Administration of Drug - A Case Report

1970 ◽  
Vol 1 (1) ◽  
pp. 56-58
Author(s):  
SC Kohli ◽  
UK Shrestha ◽  
VM Alurkar ◽  
A Maskey ◽  
M Parajuli ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Single Dose ◽  
Case Report ◽  
Side Effects ◽  
World Health Organization ◽  
Mass Drug Administration ◽  
World Health ◽  
Medical Sciences ◽  
The World ◽  
Health Organization

The global program to eliminate Lymphatic Filariasis created by The World Health organization in 1997 is based on mass administration of single annual doses of diethylcarbamazine ( DEC) plus albendazole in non African regions and of albendazole plus ivermectin in Africa. The usual side effects of DEC treatment include fever, chills, arthralgia, headaches, nausea, and vomiting. Albendazole is associated with relatively few side effects consisting of occasional nausea, vomiting, abdominal pain, headache, reversible alopecia, elevated aminotransferases and rarely leucopenia and rash. We report a case of polyneuropathy in a young individual following DEC and albendazole during mass drug administration. Keywords: Albendazole; DEC; Polyneuropathy. DOI: http://dx.doi.org/10.3126/njms.v1i1.5800   Nepal Journal of Medical Sciences. 2012; 1(1): 56-58

scholarly journals Ovarian Torsion Presentation, Treatment and Iatrogenic Surgical Management

2021 ◽  
pp. 70-76
Author(s):  
Sheema Sabahath ◽  
Hussain Salah AL Sinan ◽  
Asalah Tariq Alsaigh ◽  
Rawan AlSalamah AlFadhli ◽  
Tahani Salman Al Mansour ◽  
...  
Keyword(s):  
Blood Flow ◽  
Abdominal Pain ◽  
Side Effects ◽  
Adverse Events ◽  
Surgical Intervention ◽  
Clinical Manifestations ◽  
Ovarian Torsion ◽  
Adult Females ◽  
Uterine Ligaments ◽  
Life Threatening

Ovarian torsion is among the gynecological life-threatening conditions that may require urgent surgical intervention among the appearance of clinical manifestations. The most common clinical manifestations include severe abdominal pain, nausea extending to vomiting. The ovarian torsion is not limited to children only. However, it can also occur in adult females, either pregnant or non-pregnant. The etiology of the disease tends to be related to the weakness of the uterine ligaments or malpositioning of it due to known and unknown causes. Despite that, the surgical intervention is needed to release the torsion. Sometimes, it can lead to adverse events or side effects such as decreased blood flow to the surrounding structures. Which by role may lead to unpleasant complications and clinical manifestations of hemorrhage and shock. In this article, we reviewed the topic of ovarian torsion from different aspects, including the definition, causes, clinical evaluation, and clinical management and its common complications.

Anti-inflammatory, antioxidant and anti- Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk.

2016 ◽  
Vol 192 ◽  
pp. 510-515 ◽  
Author(s):  
Lucas Noboru Fatori Trevizan ◽  
Kamilla Felipe do Nascimento ◽  
Joyce Alencar Santos ◽  
Candida Aparecida Leite Kassuya ◽  
Claudia Andrea Lima Cardoso ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Major Constituent ◽  
Anti Inflammatory ◽  
Tuberculosis Activity

Non-steroidal anti-inflammatory drugs and their effect on the nervous system: neurotoxicity, types, mechanism of occurrence

2021 ◽  
pp. 459-464
Author(s):  
Elmira Erfanovna Alimova ◽  
Elena Evgenievna Al-Rabadi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hearing Loss ◽  
Side Effects ◽  
World Health ◽  
The World ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Health Organization

Currently, according to the World Health Organization, about 20% of the world's population takes non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are lipophilic substances that easily penetrate the blood-brain barrier and can cause side effects from the central nervous system. Neurotoxicity (headache, dizziness, insomnia, depression, depersonalization, psychosis, and tremor occur during the treatment with indomethacin; visual impairment, drowsiness - during the treatment with meloxicam; hearing loss - when taking salicylates) ranks second after gastrotoxicity. The article describes the mechanisms of neurotoxicity that occur when taking NSAIDs.

scholarly journals Stroke in a patient with tuberculous meningitis and HIV infection

2013 ◽  
Vol 5 (1) ◽  
pp. e2013017 ◽  
Author(s):  
Maria Bruna Pasticci ◽  
Maurizio Paciaroni ◽  
Piero Floridi ◽  
Enisia Cecchini ◽  
Franco Baldelli
Keyword(s):  
Risk Factors ◽  
Differential Diagnosis ◽  
Mycobacterium Tuberculosis ◽  
Side Effects ◽  
Hiv Infection ◽  
Tuberculous Meningitis ◽  
Clinical Manifestations ◽  
Treatment Needs ◽  
Caucasian Female ◽  
Meningeal Tuberculosis

Abstract. Tuberculous meningitis (TBM) is a devastating disease. TBM occurs more commonly in HIV infected patients. The influence of HIV co-infection on clinical manifestations and outcome of TBM is not well defined. Yet, some differences have been observed and stroke has been recorded to occur more frequently. This study reports on an HIV infected Caucasian female with lung, meningeal tuberculosis and stroke due to a cortical sub-cortical ischemic lesion.TBM was documented in the absence of neurologic symptoms. At the same time, miliary lung TB caused by multi-susceptible Mycobacterium tuberculosis was diagnosed. Anti-TB therapy consisting of a combination of four drugs was administered. The patient improved and was discharged five weeks later. In conclusion, TBM and multiple underling pathologies including HIV infection, as well as other risk factors can lead to a greater risk of stroke. Moreover, drug interactions and their side effects add levels of complexity. TBM must be included in the differential diagnosis of HIV infected patients with stroke and TBM treatment needs be started as soon as possible before the onset of vasculopathy.

scholarly journals Hepatic fascioliasis: case report and review

1996 ◽  
Vol 38 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Salha Abdul-Hadi ◽  
Rosa Contretas ◽  
Claudio Tombazzi ◽  
Marta Alvarez ◽  
Maribel Melendez
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Side Effects ◽  
Clinical Manifestations ◽  
Documented Case ◽  
Human Fascioliasis ◽  
Oral Doses

A well documented case of hepatic fascioliasis (HF), successfully treated with triclabendazole, is reported. Predominant clinical manifestations were fever, marked eosinophilia and abdominal pain. Triclabendazole was given as two single oral doses of 10 mg/kg each. Neither side effects nor clinical or parasitological relapses were seen after three months of follow up Based on this experience and few other similar reports in the literature, triclabendazole might be a valid therapeutical alternative in the treatment of human fascioliasis.

scholarly journals Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of TransΔ9-Tetrahydrocannabinol/Sesame Oil on Adjuvant-Induced Arthritis in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Morouj Ismail ◽  
Hiba Hasan ◽  
Youmna El-Orfali ◽  
Hanan Ismail ◽  
Ghada Khawaja
Keyword(s):  
Side Effects ◽  
Interleukin 1 ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Antioxidant Defense System ◽  
Sesame Oil ◽  
Necrosis Factor Alpha ◽  
Adjuvant Induced Arthritis ◽  
First Line Therapy ◽  
Anti Inflammatory

Rheumatoid arthritis (RA) is a painful chronic autoimmune disease affecting the joints. Its first-line therapy, Methotrexate (MTX), although effective in ameliorating the progress of the disease, induces hepatotoxicity over long-term usage. Thus, seeking natural compounds with fewer side effects could be an alternative therapeutic approach. This study aimed to investigate the anti-inflammatory, antiarthritic, and antioxidative effects of synthetictrans-Δ9-tetrahydrocannabinol (Δ9-THC) dissolved in sesame oil (Dronabinol) against MTX in adjuvant-induced arthritis (AIA) rat model. Daily oral administration of Δ9-THC/sesame oil, over a period of 21 days, was well tolerated in arthritic rats with no particular psychoactive side effects. It markedly attenuated the severity of clinical manifestations, recovered the histopathological changes in tibiotarsal joints, and repressed the splenomegaly in arthritic rats. Δ9-THC/sesame oil therapy showed similar effects to MTX in neutralizing the inflammatory process of AIA, through attenuating erythrocyte sedimentation rate (ESR) scores and proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), and interleukin-6 (IL-6) levels, to normal values. As opposed to MTX, this natural combination markedly protected the liver of arthritic rats and downregulated the induced oxidative stress by increasing the antioxidant defense system such as activities of catalase and superoxide dismutase (SOD) and levels of glutathione (GSH). These results suggest promising effects for the clinical use of Δ9-THC/sesame oil therapy in alleviating arthritic clinical signs as well as arthritis-induced liver injury.

scholarly journals Acute Hepatitis Induced by Lyprinol, the Lipid Extract of the Green-Lipped Mussel (Perna canaliculus), in a Patient with Polyarthrosis

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Amr Abdulazim ◽  
Marion Hädrich ◽  
Matteo Montani ◽  
Nasser Semmo
Keyword(s):  
Rheumatoid Arthritis ◽  
Abdominal Pain ◽  
Side Effects ◽  
Acute Hepatitis ◽  
Lipid Extract ◽  
Complementary Treatment ◽  
Perna Canaliculus ◽  
Liver Transaminases ◽  
Supplementary Treatment ◽  
Anti Inflammatory

Lyprinol, the lipid extract of the green-lipped mussel (Perna canaliculus), is a readily and freely available agent with a putative anti-inflammatory impact. It has already found application as a complementary and supplementary treatment of osteoarthritis, rheumatoid arthritis, asthma, and cancer. So far no major side effects for Lyprinol have been reported, yet. Here, we present the case of a 76-year-old woman with acutely exacerbating abdominal pain and highly elevated liver transaminases while taking Lyprinol as a complementary treatment of polyarthrosis.

scholarly journals The Immune Escape Mechanisms of Mycobacterium Tuberculosis

2019 ◽  
Vol 20 (2) ◽  
pp. 340 ◽  
Author(s):  
Weijie Zhai ◽  
Fengjuan Wu ◽  
Yiyuan Zhang ◽  
Yurong Fu ◽  
Zhijun Liu
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immune Escape ◽  
Clinical Manifestations ◽  
Adaptive Immune Response ◽  
Epidemiological Data ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Immune Escape Mechanisms

Epidemiological data from the Center of Disease Control (CDC) and the World Health Organization (WHO) statistics in 2017 show that 10.0 million people around the world became sick with tuberculosis. Mycobacterium tuberculosis (MTB) is an intracellular parasite that mainly attacks macrophages and inhibits their apoptosis. It can become a long-term infection in humans, causing a series of pathological changes and clinical manifestations. In this review, we summarize innate immunity including the inhibition of antioxidants, the maturation and acidification of phagolysosomes and especially the apoptosis and autophagy of macrophages. Besides, we also elaborate on the adaptive immune response and the formation of granulomas. A thorough understanding of these escape mechanisms is of major importance for the prevention, diagnosis and treatment of tuberculosis.

COVID 19: REALS AND CHALLENGES AGAINST DOCTORS

2020 ◽  
Vol 2 (1) ◽  
pp. 65-87
Author(s):  
Zen Ahmad
Keyword(s):  
Virus Disease ◽  
Clinical Manifestations ◽  
World Health ◽  
Unknown Etiology ◽  
Wuhan City ◽  
Traditional Markets ◽  
Pneumonia Case ◽  
The World ◽  
New Type ◽  
Health Organization

Corona Virus Disease (Covid-19) is a contagious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was discovered in December 2019 in China. This disease can cause clinical manifestations in the airway, lung and systemic. The World Health Organization (WHO) representative of China reported a pneumonia case with unknown etiology in Wuhan City, Hubei Province, China on December 31, 2019. The cause was identified as a new type of coronavirus on January 7, 2020 with an estimated source of the virus from traditional markets (seafood market). ) Wuhan city

Sign in / Sign up

Export Citation Format

Share Document