scholarly journals Language input to infants of different socioeconomic statuses: A quantitative meta-analysis

2021 ◽  
Author(s):  
Shannon Dailey ◽  
Elika Bergelson
Keyword(s):  
Meta Analysis ◽  
Developmental Science ◽  
Language Input ◽  
Stage 1

This Registered Report has been granted Stage 1 in-principle acceptance at Developmental Science and the Stage 2 manuscript is currently under revision.

Genome-Wide Association Studies Identify Two Novel Loci Conferring Susceptibility to Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes

2021 ◽  
Author(s):  
Minako Imamura ◽  
Atsushi Takahashi ◽  
Masatoshi Matsunami ◽  
Momoko Horikoshi ◽  
Minoru Iwata ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Association Studies ◽  
Meta Analysis ◽  
Japanese Patients ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Stage 1

Abstract Several reports have suggested that genetic susceptibility contributes to the development and progression of diabetic retinopathy. We aimed to identify genetic loci that confer susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes. We analysed 5 790 508 single nucleotide polymorphisms (SNPs) in 8880 Japanese patients with type 2 diabetes, 4839 retinopathy cases and 4041 controls, as well as 2217 independent Japanese patients with type 2 diabetes, 693 retinopathy cases, and 1524 controls. The results of these two genome-wide association studies (GWAS) were combined with an inverse variance meta-analysis (Stage-1), followed by de novo genotyping for the candidate SNP loci (p < 1.0 × 10−4) in an independent case–control study (Stage-2, 2260 cases and 723 controls). After combining the association data (Stage-1 and -2) using meta-analysis, the associations of two loci reached a genome-wide significance level: rs12630354 near STT3B on chromosome 3, p = 1.62 × 10−9, odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.11–1.23, and rs140508424 within PALM2 on chromosome 9, p = 4.19 × 10−8, OR = 1.61, 95% CI 1.36–1.91. However, the association of these two loci were not replicated in Korean, European, or African American populations. Gene-based analysis using Stage-1 GWAS data identified a gene-level association of EHD3 with susceptibility to diabetic retinopathy (p = 2.17 × 10−6). In conclusion, we identified two novel SNP loci, STT3B and PALM2, and a novel gene, EHD3, that confers susceptibility to diabetic retinopathy; however, further replication studies are required to validate these associations.

Stage 1 Registered Report: Stress regulation via being in nature and social support in adults - a meta-analysis

2021 ◽  
Author(s):  
Alessandro Sparacio ◽  
Ivan Ropovik ◽  
Gabriela M. Jiga-Boy ◽  
Hans IJzerman
Keyword(s):  
Social Support ◽  
Publication Bias ◽  
Effect Size ◽  
Meta Analysis ◽  
Multilevel Regression ◽  
Stress Regulation ◽  
Analysis Workflow ◽  
Affective Consequences ◽  
Emotional Social Support ◽  
Stage 1

This meta-analysis explored whether being in nature and emotional social support are effective in reducing levels of stress through a Registered Report. We retrieved all the relevant articles that investigated a connection between one of these two strategies and various components of stress (physiological, affective and cognitive) as well as affective consequences of stress. We followed a stringent analysis workflow (including permutation-based selection models and multilevel regression-based models) to provide publication bias-corrected estimates. We found [no evidence for the efficacy of either strategy/evidence for one of the two strategies/evidence for both strategies] with an estimated mean effect size of [xx/xx] and we recommend [recommendation will be provided if necessary].

Lobar versus Sublobar Resection in the Elderly for Early Lung Cancer: A Meta-Analysis

2021 ◽  
Author(s):  
Josiah Ng ◽  
Yoshio Masuda ◽  
Jun Jie Ng ◽  
Lowell Leow ◽  
Andrew M. T. L. Choong ◽  
...  
Keyword(s):  
Overall Survival ◽  
Elderly Patients ◽  
Meta Analysis ◽  
Cancer Recurrence ◽  
Disease Free Survival ◽  
The Elderly ◽  
Sublobar Resection ◽  
Cell Lung Carcinoma ◽  
Risk Of Death ◽  
Stage 1

Abstract Objectives We performed a systematic review and meta-analysis of outcomes of lobectomy versus sublobar resection in elderly patients (≥65) with stage 1 nonsmall cell lung carcinoma (NSCLC). Methods We searched for relevant articles using a set of inclusion and exclusion criteria. Meta-analytic techniques were applied. Results Twelve studies (n = 5834) were chosen. Our results indicate that in the elderly, lobectomy for stage 1 NSCLC confers a survival advantage over sublobar resection. Lobectomy patients had a lower risk of death within 5 years and lower odds of local cancer recurrence. Our results show that lobectomy had a better 5-year cancer-specific survival and 5-year disease-free survival that trended toward significance. The sublobar resection group showed better 30-day operative mortality that trended toward significance. Subgroup analysis of stage 1A cancer demonstrated no difference in 5-year overall survival rates. However, for stage 1B tumors 5-year overall survival favored lobectomy. Conclusion Lobectomy for stage 1 NSCLC in elderly patients is superior to sublobar resection in terms of survival and cancer recurrence and should be afforded where possible. For stage 1A tumors, sublobar resection is noninferior and may be considered. Further randomized controlled trials in this topic is required.

scholarly journals Stage 1 Registered Report: Anomalous perception in a Ganzfeld condition - A meta-analysis of more than 40 years investigation

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 826
Author(s):  
Patrizio E. Tressoldi ◽  
Lance Storm
Keyword(s):  
Trend Analysis ◽  
Publication Bias ◽  
Effect Size ◽  
Meta Analysis ◽  
Random Model ◽  
Moderator Analysis ◽  
Level Of Experience ◽  
Stage 1

This meta-analysis is an investigation into anomalous perception (i.e., conscious identification of information without any conventional sensorial means). The technique used for eliciting an effect is the ganzfeld condition (a form of sensory homogenization that eliminates distracting peripheral noise). The database consists of peer-reviewed studies published between January 1974 and June 2020 inclusive. The overall effect size will be estimated using a frequentist model and a Bayesian random model. Moderator analysis will be used to examine the influence of level of experience of participants and the type of task. Publication bias will be estimated by using three different tests. Trend analysis will be conducted on the cumulative database.

scholarly journals Personal factors and group creativity characteristics: A correlational meta-analysis [stage 1]

2021 ◽  
Author(s):  
Adrien Alejandro Fillon ◽  
Fabien Girandola ◽  
Nathalie Bonnardel ◽  
Jared Kenworthy ◽  
Lionel Souchet
Keyword(s):  
Individual Differences ◽  
Meta Analysis ◽  
Strong Support ◽  
Personal Factors ◽  
Creative Activity ◽  
Group Creativity ◽  
Team Creativity ◽  
Stage 1 ◽  
Different Characteristics ◽  
The Relationship

Previous research has investigated the relationship between personal factors and group creativity characteristics. On one side, they showed that individual differences play a role in group and team creativity. On the other side, they showed that group creativity activities have different characteristics, leading to numerous ways to assess effectiveness of creative activity. Nonetheless, no meta-analysis was performed on the relationship between the characteristics of the creative activity and individual differences. In this Registered Report, we conducted a meta-analysis (k = [XXX; number of studies/datasets]) on the relationship between personal factors and group creative activities characteristics (N = [XXXX]). We found [weak-to-no / weak / weak-to-medium / medium / medium-to-strong / strong] support for a [positive / negative] correlation between personal factors and creativity activities characteristics, r = X.XX, 95% CI [X.XX, X.XX]. We tested several moderators of the relationship, including [moderators]. Our analysis indicated that the relationship is [stronger / weaker] [moderators, e.g., in males than in females]. Data and analysis can be found in: https://osf.io/xwph9/?view_only=335369af22dc425096b1149cea66426a

scholarly journals Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort

2021 ◽  
Author(s):  
Antônio José Inda-Filho ◽  
Heitor Siqueira Ribeiro ◽  
Edilene Almeida Vieira ◽  
Aparecido Pimentel Ferreira
Keyword(s):  
Acute Kidney Injury ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Federal District ◽  
Incidence And Mortality ◽  
Epidemiological Profile ◽  
Stage 1 ◽  
Disease Stages

Abstract Introduction Acute kidney injury (AKI) is a frequent syndrome affecting patients admitted to intensive care units (ICU), and it is associated with poor clinical outcomes. The aim of the present study was to understand the epidemiological profile of patients with AKI admitted to ICUs. Methods Prospective cohort study, carried out in three ICUs in the Federal District, Brazil. Between October/2017 and December/2018, 8,131 patients were included in the cohort. AKI was defined according to the KDIGO criteria. The main outcomes assessed were AKI development and mortality within 28 days of hospitalization. Results Of the 8,131 patients followed up, 1,728 developed AKI (21.3%). Of the 1,728 patients with AKI, 1,060 (61.3%) developed stage 1, while stages 2 and 3 represented 154 (8.9%) and 514 (29.7%), respectively. Of these, 459 (26.6%) underwent renal replacement therapy. The mortality was 25.7% for those with AKI, and 4.9% for those without AKI. Discussion Patients with AKI had higher mortality rates when compared to those without AKI. Likewise, among patients with AKI, higher disease stages were associated with higher death occurrences. AKI incidence (21.3%) and mortality (25.7%) in our study is in line with the largest meta-analysis ever conducted, in which incidence and mortality of 21.6 and 23.9% were observed, respectively. These findings confirm the importance of establishing the KDIGO guideline for the definition and management of AKI in Brazilian ICUs.

scholarly journals Stage 2 Registered Report: Anomalous perception in a Ganzfeld condition - A meta-analysis of more than 40 years investigation

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 234
Author(s):  
Patrizio E. Tressoldi ◽  
Lance Storm
Keyword(s):  
Regression Model ◽  
Effect Size ◽  
Close Agreement ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Questionable Research Practices ◽  
Effect Model ◽  
Meta Regression ◽  
Stage 1

This meta-analysis is an investigation into anomalous perception (i.e., conscious identification of information without any conventional sensorial means). The technique used for eliciting an effect is the ganzfeld condition (a form of sensory homogenization that eliminates distracting peripheral noise). The database consists of studies published between January 1974 and December 2020 inclusive. The overall effect size estimated both with a frequentist and a Bayesian random-effect model, were in close agreement yielding an effect size of .088 (.04-.13). This result passed four publication bias tests and seems not contaminated by questionable research practices. Trend analysis carried out with a cumulative meta-analysis and a meta-regression model with Year of publication as covariate, did not indicate sign of decline of this effect size. The moderators analyses show that selected participants outcomes were almost three-times those obtained by non-selected participants and that tasks that simulate telepathic communication show a two-fold effect size with respect to tasks requiring the participants to guess a target. The Stage 1 Registered Report can be accessed here: https://doi.org/10.12688/f1000research.24868.3

scholarly journals Evolution of Stage 1 Twin-to-Twin Transfusion Syndrome (TTTS): Systematic Review and Meta-Analysis

2016 ◽  
Vol 19 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Asma Khalil ◽  
Emily Cooper ◽  
Rosemary Townsend ◽  
Basky Thilaganathan
Keyword(s):  
Laser Surgery ◽  
Case Reports ◽  
Meta Analysis ◽  
Survival Rates ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Definitive Answer ◽  
Registration Number ◽  
The Cochrane Library ◽  
Stage 1

Objectives: The natural history of stage 1 Twin-to-twin transfusion syndrome (TTTS) remains unclear and its optimal management is yet to be established. The main aims of this meta-analysis were to quantify the incidence of progression in stage 1 TTTS and to ascertain survival in these pregnancies.Methods: MEDLINE, EMBASE, and The Cochrane Library were searched. Reference lists within each article were hand-searched for additional reports. The outcomes included incidence of progression and survival in stage 1 TTTS. Randomized controlled trials, cohort and case-control studies were included. Case reports, studies including three or fewer cases of stage 1 TTTS, and editorials were excluded. Proportion meta-analysis was used for analysis (Registration number: CRD42016036190).Results: The search yielded 3,085 citations; 18 studies were included in the review (172 pregnancies to assess progression and 433 pregnancies to assess the survival). The pooled incidence of progression in stage 1 TTTS was 27% [95% CI 16–39%]. The pooled overall survival, double survival and at least one survival in the pregnancies managed expectantly were 79% [95% CI 62–92%], 70% [95% CI 54–84%] and 87% [95% CI 69–98%], respectively. In those undergoing amnioreduction, the corresponding figures were 77% [95% CI 68–85%], 67% [95% CI 57–76%] and 86% [95% CI 76–94%], respectively. The survival rates were 68% [95% CI 54–81%], 54% [95% CI 36–72%], and 81% [95% CI 69–90%], when laser surgery was performed.Conclusions: The optimal initial management of stage 1 TTTS remains in equipoise. The ongoing randomized trial comparing immediate laser surgery versus conservative management should provide a definitive answer.

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