scholarly journals Status of Thyroid Hormone Parameters in Hypertensive Disorders of Pregnancy

2020 ◽  
Vol 3 (1) ◽  
pp. 302-305
Author(s):  
Amit Singh ◽  
Samir Singh
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Mean Value ◽  
Reproductive Age ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Difference ◽  
The Status ◽  
The Mean ◽  
One Year

Introduction: Hypertensive disorders of pregnancy (HDP) are the most common complications observed during pregnancy and are a leading cause of maternal and perinatal morbidity and mortality. Thyroid hormone abnormalities are prevalent in females of reproductive age group. However, the relation between thyroid hormones and hypertensive pregnant women remains unclear. This study aims to assess the status of thyroid hormone abnormalities in patients with HDP. Materials and Methods: This is a case-control study conducted for one year in Karnali Province Hospital and Deuti Hospital, Surkhet, Nepal. Thirty hypertensive patients with singleton pregnancies in the third trimester were taken as case and 30 healthy normotensive singleton pregnant women as control and their thyroid hormone parameters were compared. Statistical analysis was done using SPSS version 21. Results: The mean gestational age of recruited study subjects and control were 37.00 ± 3.04 weeks and 35.70±3.83 weeks (p>0.05). The mean value of TSH was significantly higher (p<0.05) in hypertensive subjects (4.19±2.95) μIU/L when compared with the control (2.67±1.71) μIU/L. There was no significant difference when the serum level of FT3 and FT4 were compared between hypertensive and normotensive pregnant women (p>0.05). Subclinical hypothyroidism was found in 16.66% of hypertensive subjects. Conclusions: HDP is associated with thyroid hormone abnormalities. An increase in TSH levels with normal FT3 and FT4 levels were found to be the most common form of thyroid dysfunction during pregnancy.

Activated Macrophages in Preeclampsia

Pteridines ◽  
1993 ◽  
Vol 4 (3) ◽  
pp. 144-148
Author(s):  
H. Schröcksnadel ◽  
D. Fuchs ◽  
M. Herold ◽  
H. Wachter ◽  
O. Dapunt
Keyword(s):  
Pregnant Women ◽  
Macrophage Activation ◽  
Tnf Alpha ◽  
Activated Macrophages ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Difference

SummaryNeopterin (serum. urine) and other markers of macrophage activation (lL-1 IL-6, TNF alpha) were compared in preeclamptic patients and healthy pregnant controls. The prepartal urine neopterin median in preeclampsia (337 μmol/mol creat.) was 33% higher than that of healthy pregnant controls (253 μmol/mol creat.). There was no statistically significant difference between the groups (p = 0.08). In plasma there were no statistically significant differences in cytokine concentrations between healthy pregnant and nonpregnant controls with the exception of neopterin. that showed higher values in pregnant women (p = O.OO4). Elevated levels of IL-6. TNF-alpha and neopterin were observed in hypertensive women. Differences to healthy pregnant controls were statistically significant for IL-6 (p = 0.008). TNF-alpha (p = 0.009) and neopterin (p=0.04) and were more pronounced in severe forms of the disease. These three parameters of monocytic origin showed positive significant correlations amongst each other. A participation of macrophages in the pathomechanism of hypertensive disorders of pregnancy can thus be assumed.

scholarly journals Association between maternal serum beta human chorionic gonadotropin levels and hypertensive disorders of pregnancy

2020 ◽  
Vol 9 (8) ◽  
pp. 3157
Author(s):  
Archana Kumari ◽  
Vahini M.
Keyword(s):  
Pregnant Women ◽  
Late Onset ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Study Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Difference ◽  
Β Hcg

Background: A major challenge in obstetrics is early identification of hypertensive disorders of pregnancy (HDP). This study was performed to determine the association between elevated maternal serum β-hCG levels and HDP, the correlation between serum β-hCG level and severity of preeclampsia and to determine the value of serum β-hCG level as a diagnostic marker for early diagnosis of HDP.Methods: This was a hospital based observational study conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi on 375 pregnant women with period of gestation more than 20 weeks, including 250 pregnant women with HDP as study group and 125 normotensive pregnant women as controls. Serum β-hCG concentration was measured and its level was compared between two groups.Results: The maternal mean serum β-hCG levels (51161.08±30038.21 IU/L) of study group of HDP were higher than the normotensive control group (17603.23±16748.21 IU/L). In non-severe preeclampsia, the mean serum levels were 36417.32±23876.74 IU/L while in severe preeclampsia, 60030.34±28771.31 IU/L. There was statistically significant difference (p<0.001) with higher levels in early onset preeclamptic mothers than late onset preeclampsia. The cut-off point of β-hCG for predicting HDP was 32077 IU/L with sensitivity of 65% and specificity of 86%.Conclusions: Serum β-hCG level is higher in HDP when compared to normotensive women. Higher levels of β-hCG are associated with increasing severity of hypertensive disorders of pregnancy. The utility of serum β-hCG as a diagnostic test is limited because of low sensitivity and difficulty in deciding the cut-off value.

scholarly journals Comparison of Laboratory and Radiological Findings of Pregnant and Non-Pregnant Women with Covid-19

2021 ◽  
Vol 43 (03) ◽  
pp. 200-206
Author(s):  
Kadir Burak Ozer ◽  
Onder Sakin ◽  
Kazibe Koyuncu ◽  
Berk Cimenoglu ◽  
Recep Demirhan
Keyword(s):  
Pregnant Women ◽  
Health Care Professionals ◽  
Treatment Algorithm ◽  
Reproductive Age ◽  
Radiological Findings ◽  
Laboratory Findings ◽  
Number Of Patients ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Abstract Objective Covid-19 became a pandemic, and researchers have not been able to establish a treatment algorithm. The pregnant population is also another concern for health care professionals. There are physiological changes related to pregnancy that result in different laboratory levels, radiological findings and disease progression. The goal of the present article is to determine whether the laboratory results and radiological findings were different in non-pregnant women (NPWs) of reproductive age and pregnant women (PWs) diagnosed with the Covid-19 infection. Methods Out of 34 patients, 15 (44.11%) PWs and 19 (55.8%) NPWs were included in the study. Age, comorbidities, complaints, vitals, respiratory rates, computed tomography (CT) findings and stages, as well as laboratory parameters, were recorded from the hospital database. Results The mean age of the PWs was of 27.6 ±  0.99 years, and that of the NPWs was of 37.63 ±  2.00; when age was compared between the groups, a statistically significant difference (p = 0.001) was found. The mean systolic blood pressure of the PWs was of 116.53 ±  11.35, and that of the NPWs was of 125.53 ±  13.00, and their difference was statistically significant (p = 0.05). The difference in the minimum respiratory rates of the patients was also statistically significant (p = 0.05). The platelet levels observed among the PWs with Covid-19 were lower than those of the NPWs (185.40 ±  39.09 × 109/mcL and 232.00 ±  71.04 × 109/mcL respectively; p = 0.05). The mean D-dimer value of the PWs was lower in comparison to that of the NPWs (p < 0.05). Conclusion The laboratory findings and imaging studies may differ between pregnant and non-pregnant populations. It is important to properly interpret these studies. Future studies with a higher number of patients are required to confirm these preliminary data.

scholarly journals The effect of vitamin D3 supplements on the 25(OH)D levels in the II and III trimester of pregnant women in Sleman, Indonesia: randomized controlled trial

2020 ◽  
Vol 9 (1) ◽  
pp. 22
Author(s):  
Amalina T. Susilani ◽  
Hertanto W. Subagio ◽  
Noor Pramono ◽  
Martha I. Kartasurya
Keyword(s):  
Pregnant Women ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference ◽  
The Mean ◽  
Vitamin D3 Deficiency

Background: Pregnant women are among the groups at high risk of vitamin D3 deficiency due to the increased need for micro and macro nutrients during pregnancy. Vitamin D3 deficiency is associated with pregnancy complications, namely preterm birth, pre-eclampsia, gestational diabetes, and babies born small according to their gestational age.Methods: The study involved a randomized pretest-posttest control group design. Subjects selected include 80 pregnant women in second trimester. Data were collected in June 2020 to September 2020. The respondents were then randomly divided into 2 groups, comprising 40 each, where the first received 400 IU/day vitamin D3 supplementation for 12 weeks, and the second served as a control. Furthermore, 25 (OH) D were measured by using the ELISA method.Results: The mean value of the 25(OH)D levels after D3 supplementation and statistically showed a significant difference with a significance value of p<0.05 (0.01), compared to the control group.  Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00, compared to the control group. Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00.Conclusions: Vitamin D3 supplement of 400 IU per day can increase the levels of 25(OH)D in the II and III trimester of pregnant women in antenatal care (ANC), Sleman Regency, Yogyakarta.

scholarly journals Serum Galectin-3 in Women With Gestational Hypertension and Preeclampsia and Its Association With Preterm Birth

2021 ◽  
Author(s):  
Dolina Gencheva ◽  
Fedya Nikolov ◽  
Ekaterina Uchikova ◽  
Rosen Mihaylov ◽  
Blagovesta Pencheva ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Premature Birth ◽  
Gestational Hypertension ◽  
Serum Levels ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Difference ◽  
Galectin 3

Hypertensive disorders of pregnancy are one of the leading causes of fetal and maternal mortality worldwide. Aside from the immediate risk they pose for the pregnant woman, there is significant evidence that women after such a pregnancy have a long-term risk for the development of cardiovascular diseases. On the other hand, Galectin-3 is a biomarker that has proven its role in cardiac remodeling, fibrosis, and heart failure. To determine the levels of Galectin-3 in women with gestational hypertension, preeclampsia, and in healthy pregnant women and test for association with premature birth. A prospective single-center clinical, epidemiological study was performed, and data were analyzed for 123 pregnant women-36 with gestational hypertension, 37 with preeclampsia, and 50 controls. ELISA method was used to determine the serum levels of Galectin-3. Mean Galectin-3 level was 6,53 ng/ml in the controls, 7.30 ng/ml in the gestational hypertension group, and 7,59 ng/ml in the preeclampsia group. There was a significant difference in the levels between the controls and each of the pathological groups (P<0,05), while the two pathological groups were not statistically different from each other. Additionally, higher Galectin-3 levels were associated with an OR~2.5 for even preterm birth after adjustment for the presence of the two hypertensive disorders of pregnancy. Gestational hypertension and preeclampsia were associated with significantly higher levels of Galectin-3, which could be indicative of cardiovascular dysfunction in those women, and were also related to premature birth.

scholarly journals Chicory Aroma Water for Neonatal Jaundice: A Randomized Clinical Trial

2017 ◽  
Vol 6 (4) ◽  
pp. 312-318
Author(s):  
Mohsen Manouchehrian ◽  
Mehrdad Shakiba ◽  
Mamak Shariat ◽  
Mohammad Kamalinejad ◽  
Mehdi Pasalar ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Neonatal Jaundice ◽  
Controlled Trial ◽  
Mean Value ◽  
Control Group ◽  
Term Infants ◽  
Randomized Controlled ◽  
Significant Difference ◽  
The Mean ◽  
Single Blind

Background: Although neonatal jaundice occurs in 60% of term infants, very little evidence is available on how to prevent it. Given the ethno-medical use of chicory aroma water (CAW) for the management of jaundice by Iranian pregnant women, the aim of this study was to evaluate whether the frequent CAW consumption was associated with fewer jaundice symptoms after 40 days. Materials and Methods: A single blind randomized controlled trial was designed to enroll participants from Lolagar Hospital, Tehran, Iran. Pregnant women (n=80) were randomly divided into two groups. The trial group was provided with common diet and an instruction to consume CAW. The control group was maintained on common diet. The proportion of phototherapy and mean value of bilirubin were measured and compared between the two groups. (IRCT registry number: IRCT2017041633475N1) Results: There was no statistically significant difference in the mean value of bilirubin between the women with frequent CAW consumption compared with the control. Also, the intake of CAW was not associated with a marked improvement in the need for phototherapy (P > 0.05). Conclusion: The findings of this study highlighted that the intake of CAW by pregnant women failed to ameliorate neonatal jaundice.[GMJ.2017;6(4):312-8] DOI: 10.22086/gmj.v6i4.973

scholarly journals Prevalence, Risk Factors and Management of Hypertensive Disorders of Pregnancy Among Pregnant Women in University of Benin Teaching Hospital, Benin City, Nigeria

2021 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Teaching Hospital ◽  
Screening Tools ◽  
Hypertensive Disorders Of Pregnancy ◽  
Multinomial Regression ◽  
Cross Sectional ◽  
Benin City ◽  
Hypertensive Disorders ◽  
The Mean

Background: This facility-based retrospective cross sectional design study examined the prevalence, risk factors and management of hypertensive disorders of pregnancy among pregnant women attending antenatal clinic in the University of Benin Teaching Hospital, Benin City Materials and Methods: A stratified proportionate sampling technique were adopted to review a total of 358 secondary data of patients who were managed for hypertensive disorders of pregnancy from June 2015 – June 2020 in the study institution. Data were analyzed using descriptive statistics, multinomial regression analysis at 0.05 the level of significance for all measured variables. Results: The mean ± SD = 31.15 ± 5.954 years. More than half 60.3% of them were multigravida. 60.1% were in second trimester. Mean BP at booking was 146/95 mmHg. 56.1% were overweight while 17.6% were obese. The mean ± SD ANC visits was 10.71 ± 5.411 times. The five-year prevalence rate of hypertensive disorders of pregnancy among pregnant women in the study setting is 10.9%. Conclusion: There is high prevalence of HDP in the study institution with preeclampsia most prevalent. Therefore, we strongly recommend the utilization of screening tools for the prediction, early diagnoses as well as timely intervention HDP

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

Risk Factors in Diabetes and Pregnant Women with Urinary Tract Infections Compared to Younger Aged Female.

2018 ◽  
Vol 1 (3) ◽  
pp. 26-38
Author(s):  
Abdulghani Mohamed Alsamarai ◽  
Shler Ali Khorshed
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Female Student ◽  
Mean Value ◽  
Infected Female ◽  
Significant Difference ◽  
Tract Infections

Background: Urinary tract infection is common with health impact in women and characterised by failure to treatment and recurrent episodes. Aim: This study was conducted to determine the risk factors for the development of urinary tract infection in diabetic and pregnant women in comparison to student female. Materials and methods: A prospective cross-sectional study conducted during the period from 1st of June 2015 to the end of January 2016. The population included in the study are 563 women, of them 425 were outpatients, and 138 were inpatients. Their age range between 18 and 80 years, with a mean age of 33.59±15.29 years. Urine samples collected and cultured on blood agar and MacConkey agar by spread plate technique. Bacterial colonies with different morphology were selected, purified and identified according to their biochemical characteristics using conventional standard methods. Results: In diabetic women, there were no significant difference in mean age and BMI values between culture positive and culture negative groups. However, pus cell mean scale was significantly higher [P=0.000] in women with urinary tract infection [1.76±1.25] than in those with negative culture [0.69±1.00]. In pregnant women, BMI mean value was significantly [P=0.013] lower in pregnant women with UTI [26.14] as compared to those without infection [26.99]. Pus cell scale mean value was significantly [P=0.000] higher in pregnant women with UTI [1.55] than women with negative UTI [0.85]. While there was no significant difference in mean age between UTI positive and negative pregnant women. In female student, there was a significant difference between UTI infected and non-infected in mean age [P=0.041] and pus cell scale [P=0.000]. However, BMI was not significantly different between infected and non-infected female student. Other risk factors association are variables in the 3 groups when analysed using X2, while AUC and OR show different trends of association between risk factors and UTI. Conclusion: BMI, pus cell scale, child number, delivery method, operation history and hospital setting were significantly associated with culture positivity in the 3 studied groups as determined by AUC. While OR confirmed association with pus sale scale in the 3 groups.

A new simpler approach to measure the strength of toe plantar flexion requiring no mechanical restraint with a light-weight device

2021 ◽  
pp. 095441192110029
Author(s):  
Yuko Komuro ◽  
Yuji Ohta
Keyword(s):  
Plantar Flexion ◽  
Mean Value ◽  
Simple Approach ◽  
Light Weight ◽  
New Approach ◽  
Mean Values ◽  
Mechanical Restraint ◽  
Significant Difference ◽  
Ankle Joints ◽  
The Mean

Conventionally, the strength of toe plantar flexion (STPF) is measured in a seated position, in which not only the target toe joints but also the knee and particularly ankle joints, are usually restrained. We have developed an approach for the measurement of STPF which does not involve restraint and considers the interactions of adjacent joints of the lower extremities. This study aimed to evaluate this new approach and comparing with the seated approach. A thin, light-weight, rigid plate was attached to the sole of the foot in order to immobilize the toe area. Participants were 13 healthy young women (mean age: 24 ± 4 years). For measurement of STPF with the new approach, participants were instructed to stand, raise the device-wearing leg slightly, plantar flex the ankle, and push the sensor sheet with the toes to exert STPF. The sensor sheet of the F-scan II system was inserted between the foot sole and the plate. For measurement with the seated approach, participants were instructed to sit and push the sensor with the toes. They were required to maintain the hip, knee, and ankle joints at 90°. The mean values of maximum STPF of the 13 participants obtained with each approach were compared. There was no significant difference in mean value of maximum STPF when the two approaches were compared (new: 59 ± 23 N, seated: 47 ± 33 N). The coefficient of variation of maximum STPF was smaller for data obtained with the new approach (new: 39%, seated: 70%). Our simple approach enables measurement of STPF without the need for the restraints that are required for the conventional seated approach. These results suggest that the new approach is a valid method for measurement of STPF.

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