Decreased Expression of Metastasis Suppressor 1 Correlates with Poor Prognosis of Patients with Rectal Adenocarcinoma

Background: Venous thromboembolic events (VTE) are common causes of morbidity and mortality in glioblastoma patients. Mutation in the isocitrate dehydrogenase 1 enzyme (IDH1) is frequent in secondary glioblastoma and results in altered metabolomics. Objectives: This study evaluates whether IDH-1 status correlates with incidence of VTE in glioblastoma patients. Methods: Observational study of 398 cases of patients with glioblastoma, who all underwent surgery in a regional Neurosurgical centre between April 2012 and December 2014. IDH -1 status and Tissue factor (F3) protein expression were assessed by immunohistochemistry. Deep venous thrombosis (DVT) and pulmonary embolism (PE) were diagnosed by Doppler ultrasound and pulmonary CT angiogram respectively. Results: 336 cases were wild type (WT) IDH-1 (94.1%) and 21 cases were IDH-1 mutated (R132H) (5.9%). 51 patients had a thromboembolic event (15.3%), with all cases of VTE in WT IDH-1 tumors, a rate of 21.8% within this group. IDH-1 status had a significant correlation with VTE (p=0.033 Fisher exact test). As expected, mutant IDH was associated with prolonged patient survival (p=0.024 Log rank). The mean expression in IDH-1 wild type GBM was 7.14 and in R132h mutant GBM was 4.87 (log2 scale). This was highly statistically significant with a corrected P value of less than 0.0001. Conclusion: A significant association exists between IDH1 status in glioblastoma patients and the risk of VTE. Patients with wild type IDH-1 appear at high risk of VTE and appropriate precautions should be considered.

Download Full-text

Idh-1 Status and Venous Thromboembolism in Glioma Patients

Journal of Surgical Oncology ◽

10.31487/j.jso.2019.04.04 ◽

2019 ◽

pp. 1-5

Author(s):

Ahmed Aly ◽

Fiona Smith ◽

Laurence J Glancz ◽

Alistair Mccabe ◽

Julie Coventry ◽

...

Keyword(s):

P Value ◽

Fisher Exact Test ◽

Wild Type ◽

Isocitrate Dehydrogenase 1 ◽

Secondary Glioblastoma ◽

Exact Test ◽

Ct Angiogram ◽

Venous Thromboembolic Events ◽

Common Causes ◽

Venous Thromboembolic

Background: Venous thromboembolic events (VTE) are common causes of morbidity and mortality in glioblastoma patients. Mutation in the isocitrate dehydrogenase 1 enzyme (IDH1) is frequent in secondary glioblastoma and results in altered metabolomics. Objectives: This study evaluates whether IDH-1 status correlates with incidence of VTE in glioblastoma patients. Methods: Observational study of 398 cases of patients with glioblastoma, who all underwent surgery in a regional Neurosurgical centre between April 2012 and December 2014. IDH -1 status and Tissue factor (F3) protein expression were assessed by immunohistochemistry. Deep venous thrombosis (DVT) and pulmonary embolism (PE) were diagnosed by Doppler ultrasound and pulmonary CT angiogram respectively. Results: 336 cases were wild type (WT) IDH-1 (94.1%) and 21 cases were IDH-1 mutated (R132H) (5.9%). 51 patients had a thromboembolic event (15.3%), with all cases of VTE in WT IDH-1 tumours, a rate of 21.8% within this group. IDH-1 status had a significant correlation with VTE (p=0.033 Fisher exact test). As expected, mutant IDH was associated with prolonged patient survival (p=0.024 Log rank). The mean expression in IDH-1 wild type GBM was 7.14 and in R132h mutant GBM was 4.87 (log2 scale). This was highly statistically significant with a corrected P value of less than 0.0001. Conclusion: A significant association exists between IDH1 status in glioblastoma patients and the risk of VTE. Patients with wild type IDH-1 appear at high risk of VTE and appropriate precautions should be considered

Download Full-text

Erythropoietic Agents and Venous Thromboembolic Events in Multiple Myeloma Patients Treated with Anthracycline Based Chemotherapy and Immunomodulators.

Blood ◽

10.1182/blood.v108.11.5119.5119 ◽

2006 ◽

Vol 108 (11) ◽

pp. 5119-5119

Author(s):

Rachid Baz ◽

Steven M. Fruchtman ◽

Jerome B. Zeldis ◽

Esteban Walker ◽

Mohamad A. Hussein

Keyword(s):

Multiple Myeloma ◽

Pegylated Liposomal Doxorubicin ◽

Causative Factor ◽

Fisher Exact Test ◽

Thromboembolic Events ◽

Exact Test ◽

Venous Thromboembolic Events ◽

Venous Thromboembolic ◽

The Mean ◽

Aspirin Prophylaxis

Abstract Background: Erythropoietic agents (EPO) have recently been implicated with higher rates of thromboembolic events (VTE) in multiple myeloma (MM) patients receiving lenalidomide (R) and dexamethasone (Knight et al. NEJM 2006). Uncontrolled erythrocytosis, a recognized risk factor for VTE, may complicate therapy with EPO, but was not evaluated as a causative factor for VTE in the above report. We sought to evaluate the putative interactions between erythrocytosis, immunomodulator therapy, EPO and VTE. Patients and Methods: We retrospectively reviewed patients’ records from 2 studies of anthracycline-based chemotherapy with immunomodulators: pegylated liposomal doxorubicin, vincristine, dexamethasone and thalidomide (T) (study A) or lenalidomide (study B) in MM. Demographic variables, aspirin therapy, EPO therapy, immunomodulator therapy (T vs R), as well as laboratory variables (which included all hemoglobin values while on study) were reviewed. Results: From August 2001 to December 2005, 184 multiple myeloma patients with active disease were treated on study A (105) and B (79). The median age for patients was 63 and 62 years on study A and B respectively. Aspirin prophylaxis (81mg daily) was administered for all patients on study B and for all but 19 patients on study A. Among all patients, 113 patients (61%) received EPO. Twenty-six patients on study A and 7 patients on study B developed a VTE. Treatment with EPO was not associated with a higher rate of VTE compared to no treatment with EPO (19% versus 22%, Fisher exact test, p=0.8). The mean peak hemoglobin for patients with a VTE was not statistically different from patients without a VTE (14.2 vs. 13.8 g/dL, p=0.3). Similarly, the mean on study hemoglobin was not different among patients with a VTE and those without a VTE (11.7 vs. 11.6 g/dL, p=0.8). The mean hemoglobin at the time of the VTE was 12.0 g/dL (S.D. 1.5g/dL). Conclusion: Our results do not indicate an association between EPO and VTE in MM patients receiving anthracycline-based chemotherapy with an immunomodulator and aspirin prophylaxis. Uncontrolled erythrocytosis does not appear to be associated with VTE in this patient population. Of note, target hemoglobins were not commonly exceeded. Low dose Aspirin (81mg) is an effective prophylaxis for VTE in multiple myeloma patients receiving anthracycline based therapy with thalidomide or lenalidomide in conjunction with the use of erythropoietin therapy.

Download Full-text

Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population

Innate Immunity ◽

10.1177/17534259211029996 ◽

2021 ◽

pp. 175342592110299

Author(s):

Alexander Varzari ◽

Igor V. Deyneko ◽

Elena Tudor ◽

Harald Grallert ◽

Thomas Illig

Keyword(s):

Pulmonary Tuberculosis ◽

Interaction Analysis ◽

P Value ◽

Fisher Exact Test ◽

Snp Analysis ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Exact Test ◽

Pulmonary Tb ◽

The Republic

Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response ( VDR, MR1, TLR1, TLR2, TLR10, SLC11A1, IL1B, IL10, IFNG, TNF, IRAK1, and FOXP3) were tested for their association with pulmonary TB in 271 patients with TB and 251 community-matched controls from the Republic of Moldova. In addition, gene–gene interactions involved in TB susceptibility were analyzed for a total of 43 genetic loci. Single nucleotide polymorphism (SNP) analysis revealed a nominal association between TNF rs1800629 and pulmonary TB (Fisher exact test P = 0.01843). In the pairwise interaction analysis, the combination of the genotypes TLR6 rs5743810 GA and TLR10 rs11096957 GT was significantly associated with an increased genetic risk of pulmonary TB (OR = 2.48, 95% CI = 1.62–3.85; Fisher exact test P value = 1.5 × 10−5, significant after Bonferroni correction). In conclusion, the TLR6 rs5743810 and TLR10 rs11096957 two-locus interaction confers a significantly higher risk for pulmonary TB; due to its high frequency in the population, this SNP combination may serve as a novel biomarker for predicting TB susceptibility.

Download Full-text

Analisis faktor kejadian wasting pada anak balita 12-59 bulan di Puskesmas Bulili Kota Palu: Studi cross sectional

AcTion Aceh Nutrition Journal ◽

10.30867/action.v6i2.345 ◽

2021 ◽

Vol 6 (2) ◽

pp. 111

Author(s):

Hepti Muliyati ◽

Menis Mbali ◽

Hadidja Bando ◽

Riana Pangestu Utami ◽

Opyn Mananta

Keyword(s):

Public Health ◽

Birth Weight ◽

Low Birth Weight ◽

Public Health Problem ◽

Sampling Technique ◽

P Value ◽

Fisher Exact Test ◽

Important Public Health Problem ◽

Cross Sectional ◽

Exact Test

Wasting on children is an important public health problem because of its considerable impact on their health and growth. This problem could lead to iron deficiency which could induce infection disease and probably lower a child’s intelligence as a long-term effect. This study aimed to analyze factors related to wasting on 12-59 months children in Bulili Public Health Center (PHC), Palu City. The analytical descriptive study designed with a cross-sectional approach was applied in this study. One hundred and twenty-one subject was selected from 283 children with purposive sampling technique. Data were analyzed with chi-square and Fisher exact test with significant (p < 0,05). The result showed that most children with low birth weight experienced wasting with a p-value = 0,000. Most of the children from higher-income families did not experience wasting with a p-value = 0,004. Most children who didn’t receive breastfeeding milk did not experience wasting with a p-value = 0,958. This study concluded a correlation between low birth weight and income to wasting, but breastfeeding practice was not related.

Download Full-text

Analisis Perbedaan Posisi Meneran Miring Kiri dan Setengah Duduk Pada Ibu Bersalin Dengan Lama Kala II Di RSUD Dr. H. Moch Anshari Saleh Banjarmasin

Proceeding Of Sari Mulia University Midwifery National Seminars ◽

10.33859/psmumns.v0i1.22 ◽

2019 ◽

pp. 39-46

Author(s):

Dewi Pusparani Sinambela ◽

St. Hateriah

Keyword(s):

Univariate Analysis ◽

Data Retrieval ◽

Bivariate Analysis ◽

P Value ◽

Fisher Exact Test ◽

Exact Test ◽

Second Stage Of Labor ◽

Second Stage ◽

Long Time ◽

Second Stage Labor

Latar Belakang: Lama Kala II dalam persalinan yaitu jangka waktu mulai dari serviks berdilatasi penuh sampai dengan kelahiran bayi tidak boleh melebihi 2 jam pada primigravidan dan 1 jam pada multigravida. Pemilihan posisi melahirkan sangat dianjurkan untuk memberikan rasa nyaman pada ibu, posisi dapat membantu penurunan janin ke dasar panggul dan mempercepat proses persalinan. Dari data yang diperoleh bulan Januari 2018 jumlah persalinan kala II lama sebanyak 0,30% dari 240 persalinan normal.Tujuan: Menganalisis Perbedaan Posisi Meneran Miring Kiri dan Setengah Duduk Pada Ibu Bersalin Dengan Lama Kala II.Metode: Jenis penelitian ini adalah Analisis kuantitatif. Rancangan penelitian menggunakan quasi eksperiment. Populasi penelitian semua ibu bersalin di RSUD Dr. H. Moch Anshari Saleh Banjarmasin. Pengambilan sebanyak 30 responden. Pengambilan data dilakukan dengan menggunakan ceklist. Analisa data yang dilakukan adalah Analisa Univariat dan Analisa Bivariat dengan uji Fisher Exact Test.Hasil: Responden yang menggunakan posisi meneran miring kiri 15 orang (50%) dan setengah duduk sebanyak 15 orang (50%). Jumlah responden primipara yang mengalami persalinan kala II 60 menit sebanyak 12 orang (40,0%), primipara yang mengalami kala II 60 menit sebanyak 2 orang (6,7%) dan responden multipara yang mengalami kala II 30 menit sebanyak 16 orang (53,3%), multipara yang mengalami kala II 30 menit sebanyak 0 orang (0%) dari hasil uji Fisher Exact Test dengan nilai p sebesar 0,483.Simpulan: Tidak ada perbedaan posisi miring kiri dengan posisi setengah duduk terhadap kemajuan persalinan kala II di RSUD Dr. H. Moch. Anshari Saleh Banjarmasin. Kata Kunci: Lama Kala II, Persalinan, Posisi Meneran. Analysis of Different Left and Half Posisition Straining on Mother with Second Duration of Labour In RSUD Dr. H. Moch Anshari Saleh BanjarmasinABSTRACT Background: The duration of second stage of labor is the period from the full dilated cervix to the birth of the baby should not exceed 2 hours in primigravida and 1 hour in multigravida. Position selection is very beneficial for giving comfort to the mother, the position can help lower the fetus to the pelvic floor and improve labor. From the data obtained in January 2018 the number of prolonged second stage deliveries was 0.30% of 240 normal deliveries.Objective: Analyze the Differences in Position Meniring Left and Half Seated at the Maternity with Long Time II.Method: This type of research is quantitative analysis. The study design used quasi experiment. The study population of all mothers giving birth at Dr. RSUD H. Moch Anshari Saleh Banjarmasin. Taking as many as 30 respondents. Data retrieval is done using a checklist. Data analysis performed was Univariate Analysis and Bivariate Analysis with Fisher Exact Test.Results: Respondents who used the left oblique piercing position were 15 people (50%) and half sat as many as 15 people (50%). The number of primiparous respondents who increased labor at second time 60 minutes was 12 people (40.0%), primipara who added second stage 60 minutes as many as 2 people (6.7%) and multiparous respondents who used second time 30 minutes as many as 16 people (53.3%), multiparas who replaced time II 30 minutes as many as 0 people (0%) from the results of the Fisher Exact Test with a p value of 0.483.Conclusion: There was no difference in left oblique position with sitting position towards the progress of second stage labor in Dr. Hospital. H. Moch. Ansari Saleh Banjarmasin. Keywords : Second Duration, Labour, Straining Position

Download Full-text

Hubungan Tingkat Pengetahuan Ibu Tentang Pemberian MP-ASI dengan Kejadian Diare pada Anak Usia 6-24 Bulan

HEALTH CARE : JURNAL KESEHATAN ◽

10.36763/healthcare.v9i1.74 ◽

2020 ◽

Vol 9 (1) ◽

pp. 34-42

Author(s):

Alvian Merza Radi Putra ◽

Melania Wahyuningsih ◽

Fajarina Lathu

Keyword(s):

P Value ◽

Fisher Exact Test ◽

Cross Sectional ◽

Exact Test

Diare lebih dominan menyerang anak-anak karena daya tahan tubuh anak-anak yang masih lemah. Faktor penyebab diare pada anak salah satunya pemberian MP-ASI oleh ibu. Dalam praktiknya pengetahuan ibu tentang pemberian MP-ASI masih minim. Tujuan dari penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan ibu tentang pemberian MP-ASI dengan kejadian diare pada anak usia 6-24 bulan Di Posyandu Padukuhan Pugeran Maguwoharjo Depok Sleman Yogyakarta. Jenis penelitian yaitu kuantitatif observasional analitik dengan rancangan penelitian Cross Sectional. Populasi penelitian ini ibu yang memiliki anak usia 6-24 bulan berjumlah 41 bulan Juli 2019 di Padukuhan Pugeran Maguwoharjo Depok Sleman Yogyakarta. Teknik Sampling menggunakan total sampling. Instrumen pengambilan data berupa kuisioner. Analisa data menggunakan Fisher Exact Test. Hasil menunjukkan ibu yang memiliki pengetahuan baik 28 orang (68,3%) sedangkan yang berpengetahuan cukup sebanyak 13 orang (31,7%). Anak yang tidak pernah mengalami diare dalam kurun waktu 3 bulan terakhir sebanyak 29 anak (70,7%) dan yang pernah mengalami diare dalam kurun waktu 3 bulan terakhir sebanyak 12 anak (29,3%). Didapatkan hasil nilai p value sebesar 0,419. Tidak ada hubungan antara tingkat pengetahuan ibu tentang MP- ASI dengan kejadian diare pada anak usia 6-24 bulan di Padukuhan Pugeran Maguwoharjo Depok Sleman Yogyakarta.

Download Full-text

Kontribusi Karakteristik Ibu Terhadap kejadian Stunting Pada Anak Usia 24-36 Bulan Di Sleman Yogyakarta

JURNAL KESEHATAN MASYARAKAT ◽

10.47317/jkm.v12i02.191 ◽

2019 ◽

Vol 12 (02) ◽

Author(s):

Prastiwi Putri Basuki ◽

Triana Uminingsih

Keyword(s):

P Value ◽

Fisher Exact Test ◽

Chi Square ◽

Cross Sectional ◽

Exact Test ◽

Purposive Sampling

Stunting pada masa balita perlu mendapat perhatian khusus termasuk pada anak usia 24-36 bulan. Usia 24-36 bulan merupakan usia anak yang mengalami perkembangan pesat dalam kemampuan kognitif dan motorik. Banyak faktor yang mempengaruhi terjadinya kejadian stunting pada anak, antara lain karakteristik ibu. Tujuan dari penelitian ini adalah mengetahui kontribusi karakteristik ibu terhadap kejadian stunting pada anak usia 24-36 bulan. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional yang dilakukan di Desa Sendang Mulyo Minggir Sleman Yogyakarta. Sampel yang diambil sebanyak 75 anak usia 24-36 bulan dengan teknik purposive sampling. Analisis data bivariat menggunakan Chi Square dan Fisher Exact Test dan analisis multivariat menggunakan regresi linier. Hasil penelitian menunjukkan bahwa pendidikan ibu (p value=0,000), pengetahuan ibu (p value=0,022) dan pemberian ASI Ekslusif (p value=0,011) yang artinya terdapat hubungan dengan kejadian stunting. Sedangkan status pekerjaan ibu (p value=0,217) tidak signifikan berhubungan dengan kejadian stunting. Berdasarkan analisis multivariat regresi linier menunjukkan hasil bahwa pendidikan ibu, status pekerjaan ibu, pengetahuan ibu tentang gizi, dan pemberian ASI Ekslusif bersama-sama mempunyai kontribusi terhadap kejadian stunting sebesar 88,2%. Perlu peningkatan program multisektoral dengan melibatkan semua lapisan masyarakat untuk mengurangi kejadian stunting.

Download Full-text

A profile and treatment outcome of seasonal hyper-acute panuveitis

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v2i1.3702 ◽

1970 ◽

Vol 2 (1) ◽

pp. 35-38 ◽

Cited By ~ 4

Author(s):

E Shrestha

Keyword(s):

Visual Acuity ◽

Medical Treatment ◽

Visual Outcome ◽

P Value ◽

Fisher Exact Test ◽

Mean Values ◽

Exact Test ◽

Pediatric Age Group ◽

Significant Difference ◽

The Mean

Introduction: Seasonal hyper-acute panuveitis (SHAPU) is a sight-threatening disease and its management is challenging. Objective: To study the profile and evaluate the visual outcome of the patients of clinicallydiagnosed cases of SHAPU after treatment. Subjects and methods: A retrospective interventional hospital-based study was carried out involving 21 subjects with clinically-diagnosed SHAPU. The data were retrieved from the record section of the hospital and analyzed. The variables studied were demographic pattern, clinical condition, duration of presentation and visual acuity before and after the treatment. Statistics: The data were analyzed using Epi Info version 2000. Percentage prevalence, mean values with standard deviation, relative risk, 95% CI and p value were calculated. P value of < 0.05 was considered to be significant. Results: Among the 21 cases, the numbers of male and female were 11 (52.4 %) and 10 (46.7 %) respectively. A comparative analysis of gender in children and adults did not show any significant difference (RR=0.47, 95% CI = 0.22 - 1.01, Fisher exact test: p = 0.14). The mean for all ages was 7 ± 12.68 years, while the mean age in pediatric cases was 4.5 ± 3.91 years. Thirteen (61.9%) cases occurred in children below fifteen years. Fifteen (71.4 %) cases reported during September and October. Presenting visual acuity of all cases was less than 3/60. All of them received medical treatment. By the end of the 4th week, seven (33.3 %) patients regained vision to 6/18. Conclusion: SHAPU is more prevalent in pediatric age group. It is equally prevalent among males and females. The visual acuity can improve with early medical treatment. Keywords: SHAPU; panuveitis; steroid; phthisis bulbi DOI: 10.3126/nepjoph.v2i1.3702 Nep J Oph 2010;2(1) 35-38

Download Full-text

An Evaluation of Snake Bites and Antivenin Use at a Regional Medical Center

The American Surgeon ◽

10.1177/000313481007600735 ◽

2010 ◽

Vol 76 (7) ◽

pp. 755-758

Author(s):

Larry I. Watson ◽

Christy Spivey ◽

Cen Rema Menon ◽

Cyrus A. Kotwall ◽

Thomas V. Clancy ◽

...

Keyword(s):

Medical Center ◽

Length Of Hospital Stay ◽

Clinical Information ◽

P Value ◽

Fisher Exact Test ◽

Exact Test ◽

Snake Bites ◽

Regional Medical ◽

Regional Medical Center ◽

Physical Findings

Snake bites are a rare but challenging problem for surgeons. The purpose of our study was to evaluate our experience with snake bites at a regional medical center. We reviewed patients treated for snake bites from 2004 to July 2008. Demographics, clinical information, and outcomes were documented. Descriptive statistics were used, and χ2, t test, and Fisher exact test were used to compare patients based on antivenin use. A P value < 0.05 was considered significant. Over the study period, 126 patients presented to the emergency department with 44 (35%) requiring hospital admission. The average age was 38 years (range, 2 to 76 years); 66 per cent were male and 95 per cent white. Bites most commonly occurred in the summer and fall months with none from December through March. Copperhead bites accounted for 50 per cent of bites. An average of 4.8 vials of antivenin was given to 61 per cent of admitted patients with 93 per cent receiving the drug within 6 hours. Minor reactions to antivenin occurred in three patients (11%). Two patients required surgery (5%), and the readmission rate was 7 per cent. There was no known morbidity or mortality. When comparing patients who received antivenin with patients who did not, the only significant clinical variables were an increased prothrombin time (12.1 vs 11.7, respectively; P = 0.048) and a longer length of hospital stay (3 vs 1.8 days, P = 0.0006) in patients receiving antivenin. The majority of patients with snake bites can be treated with supportive care and antivenin when indicated. Antivenin use at our institution is largely based on physical findings and not related to laboratory values.

Download Full-text

A comparative study between endoscope assisted transtympanic pop-in tympanoplasty and permeatal underlay tympanoplasty

Journal of Kathmandu Medical College ◽

10.3126/jkmc.v6i2.19805 ◽

2018 ◽

Vol 6 (2) ◽

pp. 65-68 ◽

Cited By ~ 1

Author(s):

Meera Bista ◽

Toran KC

Keyword(s):

Success Rate ◽

College Teaching ◽

Control Group ◽

P Value ◽

Fisher Exact Test ◽

Taste Sensation ◽

Exact Test ◽

Medical College ◽

Prospective Longitudinal ◽

Made In

Background: Otoscopic procedure like tympanoplasty is one of the magic wands that an ear nose throat surgeon possesses to alleviate the suffering of a hearing impaired patient. Endoscopic trans-tympanic pop in technique is an alternative method where tympanic fascial graft is placed medial to tympanic membrane remnant through the perforation without elevation of tympanomeatal flap and angled endoscope is used to assess the ossicular chain.Objective: The study was done to compare the results of endoscope assisted trans-tympanic pop-in tympanoplasty with permeatal underlay tympanoplasty.Methods: The study is a prospective, longitudinal and experimental study conducted in Kathmandu Medical College Teaching Hospital from January 2016 to June 2016. A total of sixty-two patients, thirty-one in study and thirty-one in control group were present. The comparison was made in terms of success rate, decrease in taste sensation and time taken for the procedure. Data analysis was done by SPSS version 20. Categorical data were tested by Fisher Exact test and p-value of <0.005 was considered statistically significant.Result: Among 62 patients, 55 had successful graft uptake (88.7% success rate). Hearing improvement was seen in 51 patients (88.25%). Regarding taste sensation 5 out of 62 had decrease in taste sensation after surgery (8%). Time taken was approximately 30 to 45 minutes (mean =44.1min) in endoscopic transtympanic pop-in type and 60 to 90 minutes (mean =73.8 min) in permeatal underlay type.Conclusion: We can conclude that endoscopic trans-tympanic pop-in tympanoplasty gives similar hearing and graft uptake result but with less time and greater ease as compared to permeatal underlay technique.

Download Full-text