scholarly journals The Effect of Consanguinity on Reproductive Fitness and Selection Intensity in the Muslim Population of Western Uttar Pradesh, India

2021 ◽  
Vol 74 (1-3) ◽  
Author(s):  
Mohammad Afzal
Keyword(s):  
Public Awareness ◽  
Uttar Pradesh ◽  
Accurate Method ◽  
Selection Intensity ◽  
Runs Of Homozygosity ◽  
Negative Effects ◽  
Muslim Population ◽  
Secondary Sex Ratio ◽  
Genomic Basis ◽  
Generation Sequencing

ABSTRACT The study sought to ascertain the adverse effects of consanguinity among Muslim parents of Aligarh city located in western Uttar Pradesh in India. More than 478 families were visited and data were collected from only 100 of them being inbred to varying degrees of consanguinity. It was found that increasing degree of consanguinity decreases fertility (R2 = 0.2671, r = -0.1568), but increases mortality (R2 = 0.3161, r = 0.5622). Selection intensity (R2 = 0.1734, r = 0.4164) and secondary sex ratio (R2 = 0.3757, r = 0.6129) also go up as the degree of consanguinity increases. However, the genomic basis of Runs of Homozygosity (ROH) is a more accurate method of calculating homozygosity. Next Generation Sequencing may help better understand ROH and their utility as a tool for inbreeding detection. To avoid the inbreeding load, there is a need to raise public awareness of reproductive health and the potential negative effects of consanguinity.

The Influence of Memory-Aware Computation on Distributed BLAST

2019 ◽  
Vol 14 (2) ◽  
pp. 157-163
Author(s):  
Majid Hajibaba ◽  
Mohsen Sharifi ◽  
Saeid Gorgin
Keyword(s):  
Search Time ◽  
Genomic Research ◽  
Local Alignment ◽  
Negative Effects ◽  
Sequencing Technologies ◽  
Percent Improvement ◽  
Fast Processing ◽  
Search Tool ◽  
Memory Awareness ◽  
Generation Sequencing

Background: One of the pivotal challenges in nowadays genomic research domain is the fast processing of voluminous data such as the ones engendered by high-throughput Next-Generation Sequencing technologies. On the other hand, BLAST (Basic Local Alignment Search Tool), a longestablished and renowned tool in Bioinformatics, has shown to be incredibly slow in this regard. Objective: To improve the performance of BLAST in the processing of voluminous data, we have applied a novel memory-aware technique to BLAST for faster parallel processing of voluminous data. Method: We have used a master-worker model for the processing of voluminous data alongside a memory-aware technique in which the master partitions the whole data in equal chunks, one chunk for each worker, and consequently each worker further splits and formats its allocated data chunk according to the size of its memory. Each worker searches every split data one-by-one through a list of queries. Results: We have chosen a list of queries with different lengths to run insensitive searches in a huge database called UniProtKB/TrEMBL. Our experiments show 20 percent improvement in performance when workers used our proposed memory-aware technique compared to when they were not memory aware. Comparatively, experiments show even higher performance improvement, approximately 50 percent, when we applied our memory-aware technique to mpiBLAST. Conclusion: We have shown that memory-awareness in formatting bulky database, when running BLAST, can improve performance significantly, while preventing unexpected crashes in low-memory environments. Even though distributed computing attempts to mitigate search time by partitioning and distributing database portions, our memory-aware technique alleviates negative effects of page-faults on performance.

Review of the impact Covid-19 has on the Psychosocial factors affecting Well-Being

2021 ◽  
pp. 3404-3408
Author(s):  
Sheila Menon FBSCH ◽  
Vidya Bhagat
Keyword(s):  
Psychosocial Factors ◽  
Health Workers ◽  
Public Awareness ◽  
Cost Effective ◽  
Well Being ◽  
Security Measures ◽  
Post Traumatic Stress ◽  
Negative Effects ◽  
Factors Affecting ◽  
The Impact

The COVID-19 pandemic has had a significant impact on the psychosocial factors that effect people globally. Particularly affected are children, students and health workers and the common symptoms identified are stress, anxiety disorders, depression and post-traumatic stress disorder. In addition, the various security measures implemented to ensure public safety have adversely affected relationships between people. This study directs public awareness to the value of psychotherapeutic support. Tele-therapy can be offered easily to people both at home or in the workplace, providing both cost effective and time sensitive solutions during times of crisis. The current review article provides an overview of the importance of maintaining psychological well-being during a pandemic and the identifies the role that empathetic communication has on wellbeing. The literature review was completed using electronic databases such as PubMed, Medline, and Scopus databases using the keywords covid-19, affected groups, affected relationships, psychology and its technological interventions, negative effects of pandemic so on.

scholarly journals Language and Madrasa in India, Uttar Pradesh.

2019 ◽  
Vol 4 (1) ◽  
pp. 12
Author(s):  
Arina Rohmatika
Keyword(s):  
Qualitative Analysis ◽  
Educational System ◽  
English Language ◽  
Language Teaching ◽  
Uttar Pradesh ◽  
Muslim Population ◽  
Arabic And English ◽  
Made In ◽  
Language Mastery ◽  
Descriptive Qualitative

Data India shows that  Muslim population in India, at the census 2001, was in second place after Hindus. It reached 138 million (13.4%) after Hindus which is little over 827 million (80.5%). This number implies how Islam has been well-received in India and entered into various areas of life including education. Muslim Educational System in India has developed over decades through its Islamic institution and madrasas. This study aims to see the language teaching in Darul Uloom, Deoband as it is reflected through its educational system and curriculum. This is a library based research in which extensive reviews of literature has been made in attempt to produce a descriptive qualitative analysis. This study shows that in Darul Uloom Deoband, stylized writing mastery has become the ultimate skills to acquire.here,  Language is not only merely targeted as a means of communication but also as a means to study Islamic textbooks. Moreover, it is expected that through the language mastery its students and alumni can be author of many books in Arabic and English. Language is learned comprehensively started from grammar, syntax, to Literature. Keywords: Language, Madrasa, Darul Uloom Deoband

scholarly journals A Review of Cases of Marijuana and Violence

2020 ◽  
Vol 17 (5) ◽  
pp. 1578
Author(s):  
Norman S. Miller ◽  
Redon Ipeku ◽  
Thersilla Oberbarnscheidt
Keyword(s):  
Public Health ◽  
Illicit Drug ◽  
Public Awareness ◽  
The United States ◽  
Personality Change ◽  
Health Policies ◽  
Negative Effects ◽  
Public Health Perspective ◽  
Public Health Policies ◽  
Loss Of Contact

Marijuana is the most consumed illicit drug in the world, with over 192 million users. Due to the current legalization push of marijuana in the United States, there has been a lack of oversight regarding its public health policies, as marijuana advocates downplay the drug’s negative effects. This paper’s approach is from a public health perspective, focusing specifically on the cases of violence amongst some marijuana users. Here, we present 14 cases of violence with chronic marijuana users that highlight reoccurring consequences of: marijuana induced paranoia (exaggerated, unfounded distrust) and marijuana induced psychosis (radical personality change, loss of contact with reality). When individuals suffering from pre-existing medical conditions use marijuana in an attempt to alleviate their symptoms, ultimately this worsens their conditions over time. Although marijuana effects depend on the individual’s endocannabinoid receptors (which control behavioral functions, like aggression) and the potency level of tetrahydrocannabinol (THC) in the drug, scientifically documented links between certain marijuana users and violence do exist. Wider public awareness of the risks and side effects of marijuana, as well as a more prudent health policy, and government agency monitoring of the drug’s composition, creation, and distribution, are needed and recommended.

scholarly journals Influence of Religiosity on the Behavior of Buying Sports Apparel: A Study of the Muslim Market Segment in India

2019 ◽  
Vol 10 (2) ◽  
pp. 212-226
Author(s):  
Hasnan Baber
Keyword(s):  
New Products ◽  
Uttar Pradesh ◽  
Market Segment ◽  
Muslim Population ◽  
Religious Influences ◽  
Religious Person ◽  
Shopping Enjoyment ◽  
Apparel Manufacturers ◽  
Religious Obligation

The paper is aimed to study the influence of religiosity on the behavior of buying sports apparel in the Muslim market segment of India. The data was collected from 1000 Muslim respondents from four states: Uttar Pradesh, Delhi, Uttarakhand, and Jammu & Kashmir. The paper has found that religion plays no role when Muslims buy sports apparel. They shop as any other religious person does. No other factor, even fashion and religious obligation, is influenced by religion, except for shopping enjoyment responsiveness, which is influenced by intrapersonal Islamic religiosity. The paper’s perspective in studying the religious influences will assist sporting apparel manufacturers to design new products that will meet the requirements of the large Muslim segment in India, which is neglected so far. It will help marketers to save their effort and energy which would be utilized for Muslim Population.

scholarly journals SLR-superscaffolder: a de novo scaffolding tool for synthetic long reads using a top-to-bottom scheme

2019 ◽  
Author(s):  
Lidong Guo ◽  
Mengyang Xu ◽  
Wenchao Wang ◽  
Shengqiang Gu ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Next Generation Sequencing ◽  
Long Range ◽  
De Novo ◽  
Next Generation ◽  
Negative Effects ◽  
Complementary Information ◽  
Screening Algorithm ◽  
Long Reads ◽  
Generation Sequencing

AbstractSynthetic long reads (SLR) with long-range co-barcoding information have been recently developed and widely applied in genomics researches. We proposed a scaffolding model of the co-barcoding information and developed a scaffolding tool with adopting a top-to-bottom scheme to make full use of the complementary information in SLR datasets and a screening algorithm to reduce negative effects from misassembled contigs in an input assembly. In comparison with other available SLR scaffolding tools, our tool obtained the best quality improvement for different input assemblies, especially for those assembled by the next-generation sequencing reads, where the improvement of contiguity is about several hundred-folds.

scholarly journals Corruption in Lebanon: An Exploratory Study About Lebanese Managers’ and Employees’ Perceptions

2021 ◽  
Vol 6 (1) ◽  
pp. 38
Author(s):  
Chirine Khalil Nassar ◽  
Hussin Jose Hejase
Keyword(s):  
High Performance ◽  
Public Awareness ◽  
Business Sector ◽  
Negative Effects ◽  
Web Based ◽  
Organizational Goals ◽  
Awareness Campaigns ◽  
Business Operations ◽  
Business Practitioners ◽  
Major Factors

Corruption is one of the major factors which affects the development of the economic sector in Lebanon. The purpose of the present study was to investigate the ways in which the perceptions on corruption differed among managers and employees in Lebanese businesses. The study focused on the underlying assumptions made about corruption, the ways in which corruption affects business operations, and the preference for certain strategies to deal with corruption in the business sector. The study followed a quantitative approach relying on a web-based survey. The final valid sample consisted of 50 Lebanese managers and employees. The results showed a positive inclination toward the corrupt behaviour either due to social norms which tolerate corruption or as a result of high-performance expectations from superiors. In addition, findings showed large discrepancies in regard to the contribution of organizational norms to the proliferation of corruption in the business sector. In fact employees considered that managers often overlook and sometimes even encourage corrupt behaviours that allow the attainment of organizational goals.  The study highlights that corruption is engrained in Lebanon and has become prevalent to high extent that business actors use corrupt practices to be able to perform their activities and maintain their competitiveness. The findings of the study stress the urgency for business practitioners to take immediate action to mitigate corrupted actions by introducing changes in the organizational culture. Stressing and encouraging ethical values to combat corruption is a priority for all business actors as well as for public policy makers. Mediation of corruption necessitates more public awareness campaigns disclosing the negative effects of corruption on the health of sound business and the economy of the country at large.

scholarly journals Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 687 ◽  
Author(s):  
Eun Seong Hwang ◽  
Seon Beom Song
Keyword(s):  
Adverse Effects ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Public Awareness ◽  
High Dose ◽  
Negative Effects ◽  
Methylation Of Dna ◽  
Multiple Routes ◽  
Underlying Mechanisms ◽  
High Level

Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be effective against a wide spectrum of diseases and conditions, including neurological dysfunctions, depression and other psychological disorders, and inflammatory diseases. Recent increases in public awareness on possible pro-longevity effects of nicotinamide adenine dinucleotide (NAD+) precursors have caused further growth of NAM consumption not only for clinical treatments, but also as a dietary supplement, raising concerns on the safety of its long-term use. However, possible adverse effects and their mechanisms are poorly understood. High-level NAM administration can exert negative effects through multiple routes. For example, NAM by itself inhibits poly(ADP-ribose) polymerases (PARPs), which protect genome integrity. Elevation of the NAD+ pool alters cellular energy metabolism. Meanwhile, high-level NAM alters cellular methyl metabolism and affects methylation of DNA and proteins, leading to changes in cellular transcriptome and proteome. Also, methyl metabolites of NAM, namely methylnicotinamide, are predicted to play roles in certain diseases and conditions. In this review, a collective literature search was performed to provide a comprehensive list of possible adverse effects of NAM and to provide understanding of their underlying mechanisms and assessment of the raised safety concerns. Our review assures safety in current usage level of NAM, but also finds potential risks for epigenetic alterations associated with chronic use of NAM at high doses. It also suggests directions of the future studies to ensure safer application of NAM.

Association between hypertension and adiposity indicators: A study among the Muslim population of Uttar Pradesh

2019 ◽  
Vol 13 (4) ◽  
pp. 2335-2338
Author(s):  
Ngawang Tselha ◽  
Chonsing Shimrah ◽  
Monika Kulshreshtha ◽  
Naorem Kiranmala Devi
Keyword(s):  
Uttar Pradesh ◽  
Muslim Population

Somatotype Characteristics of Sunni Muslim Population: A Cross-sectional Study

2020 ◽  
Vol 20 (1) ◽  
pp. 113-124
Author(s):  
Chonsing Shimrah ◽  
Sukhmani Kaur ◽  
Gurjinder Kaur ◽  
Shivani Chandel
Keyword(s):  
Uttar Pradesh ◽  
Cross Sectional Study ◽  
The Body ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Muslim Population ◽  
Opposite Trend ◽  
Study Population ◽  
Males And Females

The aim of this study was to understand the distribution of various somatotype components and determine the age- and sex-related variations of the somatotype among Sunni Muslim population of Uttar Pradesh, India. The study population consisted of 214 individuals (100 males and 114 females), belonging to the age group of 18–73 years. All somatometric measurements were taken according to the protocol of the International Society for the Advancement of Kinanthropometry (ISAK). Anthropometric somatotyping was done using Heath and Carter method. Somatotype dispersion distances (SDD), mean somatotype dispersion (SDM), and standard deviation of somatotype dispersion distance (DSD) were calculated. Somatochart was also plotted for the body physique of the studied population. The results showed that mean somatotype of males is balanced endomorph (4.2–3.2–3.1), while that of females is mesomorphic endomorph (6.6–3.7–1.2). Endomorphy and mesomorphy increased with age up to 55 years and then decreased thereafter; however, ectomorphy showed the opposite trend in both the sexes. The findings of the study indicate that males and females of Sunni Muslim population are predominantly endomorphic.

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