scholarly journals The Role of Maternal Progesterone and Estradiol Levels in Predicting the Success of Induction of Labour: A Preliminary Study

Author(s):  
Kanadi Sumapraja ◽  
Hilda R Badruddin

Objective: to evaluate whether maternal progesterone and estradiol levels could be used to predictthe success ofinduction of labour (IOL) Methods:This cross-sectional study was conducted at the Women’s Health Clinic as well as delivery suite of Dr. Cipto Mangunkusumo Hospital during the period of May 2016 to April 2017. Blood samples of term pregnant women who were indicated for IOL wereobtainedbefore birth. Results:A total 44 subject were recruited in this study.Of these, 24 subjects had successful IOL while the other 20 subjects had IOL failure. There was no significant difference of progesterone among both groups (66,7% vs 75%, p=0,55). The estradiol levels in subjects who successfully performed induction had an average of 16,916.28 ± 2,574.75 pg/mL which did not differ significantly from the failed of induction group with estradiol levels of 14,832.24 ± 2374.47 pg/mL (p = 0,65). Conclusion:We found no significant association between both maternal progesterone and estradiol levels and the success rate of IOL. Further studies with larger sample sizes are required to confirm whether progesterone and estradiol play pivotal roles in the success of IOL. Keywords: progesterone, estradiol, induction of labour   Tujuan: mengevaluasi kadar progesteron dan estradiol ibu sebagai prediktor kesuksesan induksi persalinan Metode: Penelitian ini menggunakan desain potong lintang yang berlangsung pada bulan Mei 2016 hingga April 2017 di Poliklinik dan IGD Kebidanan Rumah Sakit Umum Pusat Rujukan Nasional Cipto Mangunkusumo. Pasien hamil aterm yang dilakukan induksi persalinan dan memenuhi kriteria penelitian akan diambil sampel darah sebelum persalinan. Hasil: Dari 44 subjek yang mengikuti penelitian, 24 subjek berhasil dilakukan induksi persalinan dan 20 subjek gagal.Tidakterdapatperbedaanbermaknapadakadarprogesterone Antarakeduagrup(66,7% vs 75%, p=0,55). Kadar estradiol padapasien yang berhasildilakukaninduksimemiliki rata-rata 16.916,28 + 2.574,75pg/mL yang tidakberbedajauhdengankadar estradiol pasien yang gagalinduksiyaitu 14.832,24 + 2374,47pg/mL (p = 0,65). Kesimpulan: Tidakterdapat perbedaan bermakna antara kadar progesteron dan estradiol maternal terhadap keberhasilan induksi persalinan. Penelitian lebih lanjut dengan jumlah sampel yang lebih besar dibutuhkan untuk mengkonfirmasi hubungan ini dengan lebih baik. Kata kunci: progesteron, estradiol, induksi persalinan

2018 ◽  
Vol 8 (10) ◽  
pp. 183 ◽  
Author(s):  
Shervin Assari ◽  
Cleopatra Howard Caldwell

Background: Gender may alter African Americans’ vulnerability to discrimination. The type of outcomes that follow exposure to discrimination may also be gender-specific. Although teacher discrimination is known to deteriorate school performance, it is yet unknown whether male and female African American youth differ in the effect of teacher discrimination on school performance. Objective: This cross-sectional study explored the moderating role of gender on the effect of teacher discrimination on school performance in a national sample of African American youth. Methods: The National Survey of American Life-Adolescent Supplement (NSAL-A) enrolled a nationally representative sample (n = 810) of 13–17-year-old African American youth. Demographic factors, socioeconomic status, teacher discrimination, and school performance (grade point average, GPA) were measured. Linear multivariable regression models were applied for data analysis. Results: Males and females reported similar levels of perceived teacher discrimination. In the pooled sample, higher teacher discrimination was associated with lower school performance among African American youth (b = −0.35; 95% confidence interval (CI) = −0.49 to −0.22). Gender interacted with perceived teacher discrimination (b = 12; 95% CI = 0.24–2.02), suggesting a significant difference between males and females in the magnitude of the association between perceived teacher discrimination and GPA. In stratified models, perceived teacher discrimination was associated with worse school performance of females (b = −12; 95% CI = −0.03 to −2.78) but not males (b = 0.01; 95% CI = −0.07 to 0.08). Conclusion: In line with previous studies, gender was found to alter the vulnerability of African American youth to perceived discrimination. African American boys and girls may differ in their sensitivity to the effects of teacher discrimination on school performance.


2020 ◽  
Vol 10 (3) ◽  
pp. 21-26
Author(s):  
Bashu Dev Pant ◽  
Anjana Rajbhandari ◽  
Resina Pradhan ◽  
Manju Bajracharya ◽  
Surendra Maharjan ◽  
...  

Introduction: Crowding in mandibular arch increases with increasing age and etiology of crowding is multifactorial in nature. Role of mandibular third molar in lower anterior crowding remains a topic of controvery over a period of century. The objective of this study was to assess whether there is any correlation between presence of mandibular third molar position and lower anterior crowding. Materials and Method: On the basis of third molar position one hundred and six sample of pretreatment orthodontic patients aged between 17 to 38 years were divided into erupted, erupting and agenesis group. The study was conducted in Peoples Dental College and Hospital from January 2020 to March 2020 after obtaining ethical approval from the institutional review committee. This cross-sectional study was done on dental casts and orthopantomogram; brass wire was used for measuring arch length and digital vernier caliper for measuring tooth material with modified segmental arch analysis method. Result: Among 106 samples collected 55 (51.88%) were female and 51(48.11%) were male and the mean age was 21.53 ± 3.91 years, Chi square and ANOVA test was used for Statistical analysis. This study showed no statistically significant differences between third molar position and lower anterior crowding on right (P= 0.68) and left side (P = 0.45). The study also showed that association between the third molar position and lower anterior crowding is more on left side compared to right side. Conclusion: Mandibular third molars have not statistically significant difference in lower anterior crowding so, extraction of third molars for relieving the anterior crowding is not justifiable


2020 ◽  
Vol 40 (2) ◽  
pp. 103-112
Author(s):  
Jerry Indra Setiawan ◽  
Suradi Suradi ◽  
Yusup Subagio Sutanto

Backgrounds: Professional divers have a greater lung volume than non-professional divers in higher force vital capacity (FVC) and force expiratory flow in 1 second (FEV1) values. The purpose of this study is to analyse the effect of pressure and duration of diving on changes in lung physiology in professional divers and non-professional divers. Methods: This is a cross sectional study on the personnel of the Indonesian Navy Dislambair Koarmada II Surabaya and RSAL personnel of dr. Ramelan Navy Hospital in Lakesla Surabaya in March-April 2019. Samples was collected with purposive sampling. This study used unpaired subjects with the independent t-test statistic analysis if the data is normally distributed and the Mann-Whitney U test if the data is not normally distributed Results: There was a significant difference in the professional divers group compared to non-professional divers group in the values of FVC (P=0.042) and FEV1 (P=0.040) at 1.3 ATA for 10 minutes and the FEV1 (P=0.049) for 20 minutes. No significant differences in FVC (P=0.092) at 1.3 ATA pressure for 20 minutes. There were no significant differences in FVC (P=0.865), FEV1 (P=0.659) at 1.5 ATA pressure for 10 minutes and FVC (P=0.858) and FEV1 (P=0.857) for 20 minutes. Conclusions: The different pressure in non-professional group could reduce the FEV1 value. There was a difference in the FVC value of the professional diver group and non-professional divers at a pressure of 1.5 ATA for 10 minutes. (J Respir Indo. 2020; 40(2): 103-12)


2021 ◽  
Vol 8 (04) ◽  
pp. 204-207
Author(s):  
Shreyansh Talera ◽  
Saurabh Singhal ◽  
Nishant Wadhera ◽  
Mayank Arora ◽  
Ravi Pratap

BACKGROUND WHO has declared Coronavirus disease 2019 (Covid-19) as a pandemic. Covid-19 leads to sickness and death. Human serum albumin (HSA) is the most common circulating protein in the body having oncotic as well as non-oncotic properties. The role of albumin in death among Covid-19 subjects, especially in this part of the country has not been frequently reported. The aim of the study was to analyse the role of serum albumin level as prognostic marker for Covid-19 positive patients. METHODS The present study was conducted in the department of Medicine at Chhatrapati Shivaji Subharti Hospital, Subharti Medical College, Meerut, UP. The study comprised of 100 subjects who were Covid positive from May 2020 to July 2020. A detailed explanation was given to all the participating respondents regarding the study and their contribution to it. Covid-19 was diagnosed on the basis of the WHO interim guidelines. A questionnaire was prepared to collect the patients’ demographic profile. Patients date of admission and discharge was recorded along with the outcome i.e., whether patient expired or survived. Patients’ diagnosis was identified along with the comorbidity (if present). Laboratory investigations comprised of CBC and serum albumin detection. Data so collected was tabulated in an excel sheet, under the guidance of statistician. Collected data was analysed using Statistical Package for the Social Sciences (SPSS) software version 24 and the tests used were t test and Fisher’s exact test and the level of significance was set at p < 0.05. RESULTS The study comprised of 100 subjects, out of which 45 were males and 55 were females. The overall mean age of the study subjects was 37.52 years. In our study, mortality was 35.29 %, 9.33 % and 85.7 % of the subjects having Covid-19+ type 2 diabetes (T2DM), only Covid-19 and Covid-19+ hypertension respectively with statistically significant difference as p < 0.05. Albumin level was significantly lower in expired patients (2.99) as compared to survivors (3.85) as p < 0.05. Hospital stay was also higher in expired patients. CONCLUSIONS Covid-19 patients had low serum albumin levels and that might play a role in the survival of patient. KEYWORDS Covid-19, Mortality, Albumin


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Branko Denona ◽  
Michael Foley ◽  
Rhona Mahony ◽  
Michael Robson

Abstract Background To demonstrate that studies on induction of labour should be analyzed by parity as there is a significant difference in the labour outcome among induced nulliparous and multiparous women. Methods Obstetric outcome, specifically caesarean section rates, among induced term nulliparous and multiparous women without a previous caesarean section were analyzed in this cross-sectional study using the Robson 10 group classification for the year 2016. Results In the total number of 8851 women delivered in 2016, the caesarean section rates among nulliparous women in spontaneous and induced labour, Robson groups 1 and 2A, were 7.84% (151/1925) and 32.63% (437/1339) respectively and among multiparous (excluding those women with a previous caesarean section), Robson group 3 and 4A were 1%(24/2389) and 4.37% (44/1005), respectively. Pre labour caesarean rates for nulliparous and multiparous women, Robson groups 2B and 4B (Robson M, Fetal Matern Med Rev, 12; 23–39, 2001) were 3.91% (133/3397) and 2.86% (100/3494), of the respective single cephalic cohort at term. Conclusion The data suggests that studies on induction of labour should be analyzed by parity as there is a significant difference between nulliparous and multiparous women.


Author(s):  
Nurelilasari Siregar ◽  
Rauza Sukma Rita ◽  
Yusrawati Yusrawati

Objective: The purpose of this research is to determine the effect of depot medroxyprogesterone acetate (DMPA) on the levels of follicle-stimulating hormone (FSH), progesterone, estradiol, and calcium.Methods: This was a cross-sectional study, this study was conducted in the region of Lubuk Buaya Health Care and Andalas Health Care on September– November 2017. Examination of FSH, progesterone, and estradiol levels was performed in the Laboratory Biomedicine, Faculty of Medicine, Andalas University by ELISA method, and the examination of calcium level was performed in Laboratory Biochemistry, Faculty of Medicine, Andalas University by calcium Arsenazo method. Then, the data were analyzed by Kolmogorov–Smirnov and independent t-test.Results: This study showed that there was a significant difference of FSH, progesterone, estradiol, and calcium levels on KB DMPA acceptors and non-acceptors with p<0.05.Conclusion: The use of contraception DMPA has the effect on the levels of FSH, progesterone, estradiol, and calcium in the blood.


2021 ◽  
Vol 10 (40) ◽  
pp. 3520-3525
Author(s):  
Pichaachari Rathika ◽  
Kaliyan Veeramuthu ◽  
Arumugam Subramanian Senthilkumar

BACKGROUND Alcohol use disorder is one of the dangerous public health burden. The construct of impulsivity and its various dimensions in relation with aggression are relevant for understanding alcohol dependence and relapse. The goal of the study is to describe the role of impulsivity and aggression in the context of alcohol dependence. The purpose and implications of this study was to understand the human factors contributing to aggression and impulsivity and in providing advanced treatment programs. METHODS This cross-sectional study was discussed in detail and approved by the ethical committee of the Madras Medical College. The cases were selected consecutively from all the patients attending the outpatients as well as inpatient for the same after fulfilling the inclusion and exclusion criteria, within seven days of last intake of alcohol. The diagnosis was made according to International Classification of Diseases (ICD-10) criteria after ruling out psychotic disorder and other comorbid medical illnesses. Informed consent was obtained from all the patients and caregivers. Descriptive statistics used meticulously to measure the magnitude. RESULTS This study found significant positive correlation (P < 0.001) between impulsivity, aggression subtypes with alcohol dependence. Various subsets in Barrett impulsivity scale (BIS) and subsets of Buss Perry aggression scales (BPAS) had positive correlations. We found that as severity of dependence increases, impulsivity and aggression scores increases and vice versa. The comparison of means of illness variables within groups showed that there was no significant difference between groups in terms of age of onset of illness, last alcohol intake, number of hospital admissions, duration of abstinence and frequency of relapse. CONCLUSIONS This study describes the important role of behavioural model and disease model of alcoholism, 1,2 greatly stresses the inability to control the quantity and frequency of the drinking behaviour. There is higher level of connectivity between alcohol dependence with biological and behavioural indicators of impulsivity and aggression. 3 It supports that relapse is an acquired behaviour in which the individual is able to control his substance taking pattern through adequate cognitive behavioural techniques in addition to pharmacological treatment and also suggest more research needed in future to focus on causality and intervention. KEY WORDS Impulsivity, Aggression, Alcohol dependence, Relapse


Author(s):  
Lucia L Levita ◽  
Hadiprodjo Hadiprodjo ◽  
Nusratuddin Abdullah ◽  
Nugraha U Pelupessy

Objective : To determine the relationship between estradiol levels and psychosocial stress in the perimenopausal women. Methods : Sixty perimenopausal included in a cross-sectional study from July to December 2016. Blood samples obtained from the women to measure the estradiol and the cortisol levels. Stress level measured with visual. Data presented as the mean and standard deviation (mean±SD) with p-value <.05 was considered statistically significant.  Results : There was no significant difference between the estradiol levels and the stress level (p=0.27) during perimenopause period. The estradiol levels were higher compared with the cortisol levels. The non parametrik correlations analysis show the estradiol levels were not correlated with the cortisol levels (p=0.352). However, the cortisol levels were correlated with the stress levels (p<0.05). Conclusion : Estradiol does not cause psychosocial stress during perimenopause period in our study population Keywords : Estradiol, psychosocial stress, perimenopause


2021 ◽  
Vol 21 (1) ◽  
pp. 135-145
Author(s):  
Gabriel Lucas Morais Freire ◽  
Adson Alves Silva ◽  
José Fernando Vila Nova Moraes ◽  
Nathan Leonardo Gomes Costa ◽  
Daniel Vicentini Oliveira ◽  
...  

La práctica del deporte ha sido considerada una de las principales herramientas para el desarrollo de habilidades para la vida entre los jóvenes participantes en el deporte. Este estudio transversal investigó el papel predictivo de la edad y el tiempo de práctica en el desarrollo de habilidades para la vida entre 207 practicantes de futsal masculinos, con edades comprendidas entre 12 y 17 años, del estado de Pernambuco, Brasil. Los instrumentos utilizados fueron la Escala de habilidades para la vida deportiva y un cuestionario semiestructurado. El análisis de los datos se realizó a través del Análisis de varianza multivariante, la correlación de Spearman y la Regresión múltiple (p <.05). Los resultados mostraron una diferencia significativa (p <.05; rango η2 .036-.142) en todas las habilidades para la vida según el grupo de edad, evidenciando puntuaciones más altas para los adolescentes mayores. Además, los adolescentes más experimentados mostraron puntajes más altos en la meta sentada (p = .001, η2 = .074); resolución de problemas (p = .013, η2 = .042), comunicación (p = .003, η2 = .054) y habilidades para la vida total (p = .002, η2 = .057). Hubo una correlación significativa (p <.05) y positiva entre la edad y casi todas las subescalas de habilidades para la vida. La regresión múltiple reveló que solo la edad presentaba predicciones positivas hacia las habilidades para la vida. Se puede concluir que la edad es un predictor del desarrollo de habilidades para la vida entre los jóvenes practicantes de fútbol sala. The practice of sports has been considered one of the main tools for the life skills development among youth sport participants. This cross-sectional study investigated the predicting role of age and time of practice in the development of life skills among 207 male futsal practitioners, aged between 12 and 17 years, from the state of Pernambuco, Brazil. The instruments used were the Life Skills Scale for Sports and a semi-structured questionnaire. Data analysis was conducted through Multivariate Analysis of Variance, Spearman’s correlation and Multiple Regression (p<.05). The results showed significant difference (p<.05; η2 range .036-.142) in all life skills according to age group, evidencing higher scores for older adolescents. Further, more experienced adolescents showed higher scores at goal seating (p=.001, η2=.074); problems solving (p=.013, η2=.042), communication (p=.003, η2=.054) and total life skills (p=.002, η2=.057). There was significant (p<.05) and positive correlation between age and almost all life skills subscales. Multiple regression revealed only age presented positive prediction toward life skills. It can be concluded that age is a predictor of life skills development among youth futsal practitioners. A prática esportiva tem sido considerada uma das principais ferramentas para o desenvolvimento de habilidades para a vida entre jovens praticantes de esportes. Este estudo transversal investigou o papel preditivo da idade e do tempo de prática no desenvolvimento de habilidades para a vida em 207 praticantes de futsal do sexo masculino, com idades entre 12 e 17 anos, do estado de Pernambuco, Brasil. Os instrumentos utilizados foram a Escala de Habilidades para a Vida Esportiva e um questionário semiestruturado. A análise dos dados foi realizada por meio da Análise Multivariada de Variância, correlação de Spearman e Regressão Múltipla (p <0,05). Os resultados mostraram diferença significativa (p <0,05; η2 variando de 0,036 a 0,142) em todas as habilidades para a vida de acordo com a faixa etária, evidenciando escores mais altos nos adolescentes mais velhos. Além disso, os adolescentes mais experientes apresentaram pontuações mais altas nos assentos para as metas (p = 0,001; η2 = 0,074); resolução de problemas (p = 0,013, η2 = 0,042), comunicação (p = 0,003, η2 = 0,054) e habilidades totais para a vida (p = 0,002, η2 = 0,057). Houve correlação significativa (p <0,05) e positiva entre idade e quase todas as subescalas de habilidades para a vida. A regressão múltipla revelou que apenas a idade apresentou predição positiva em relação às habilidades para a vida. Pode-se concluir que a idade é um preditor do desenvolvimento de habilidades para a vida entre jovens praticantes de futsal.


2021 ◽  
Vol 11 (1) ◽  
pp. 081-090
Author(s):  
Arushi Mohan ◽  
Padmini SN ◽  
Brunda MS ◽  
Abhinaya Shekhar ◽  
Paul Matthew ◽  
...  

Background: COVID-19 is a novel disease triggered by the SARS-CoV-2 virus, a beta coronavirus similar to MERS-CoV and SARS CoV. Inflammatory markers have a vital role in the pathogenesis of nCOVID 19; understanding the importance of these inflammatory markers in determining disease status is essential given the impact of the disease on healthcare. Thus, being able to triage cases with minimal tests is momentous to capture, which we have investigated as per our study guidelines of the role of inflammatory markers such as D-dimer, CRP (C - reactive protein), Ferritin, LDH (Lactate Dehydrogenase) in patients with COVID 19. In addition, limited data is available comparing the utility of these inflammatory markers to predict the following parameters as the need for ICU, oxygen support requirement, and duration of in-hospital stay, which can help guide the management protocol. Aim: This study aims to determine markers associated with poor prognosis in patients with Coronavirus disease 2019 (COVID-19). Objectives: 1) To assess the inflammatory markers that are routinely investigated in COVID- 19 patients. 2) To determine the most probable factor to estimate severity in COVID- 19 and thus predict prognosis. Methods: This is a retrospective cross-sectional observational study of patients who tested SARS COV 2 positive by RT PCR. The laboratory inflammatory markers, namely Lactate Dehydrogenase, C reactive protein, D-dimer, Ferritin, were assessed in the selected patients, and their clinical data and demographic details were taken into account. The parameters considered for contributing to the severity included the number of days of stay in the hospital, oxygen requirement, and ICU needs. Analyses relied upon analysis of variance for cross-sectional study design and a P< 0.05 statistical significance criterion. Results: There was a statistically significant difference found between oxygen requirement and D dimer (p<0.001), LDH (p= 0.002), and CRP (p= 0.024). There was a statistically significant difference found between admission to ICU and D Dimer (p= 0.001). Conclusion: A statistically significant association between the increasing D-dimer levels and all the outcome measures considered was found. The D-dimer, LDH, and CRP help predict oxygen requirement, and all the inflammatory markers can predict the number of days of stay in the hospital.


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