scholarly journals Integrated treatment of cattle in fasсiolosis

2019 ◽  
pp. 46-52
Author(s):  
N. Avramenko ◽  
N. Kozii ◽  
R. Shaganenko ◽  
V. Shaganenko
Keyword(s):  
Negative Impact ◽  
Integrated Treatment ◽  
The Body ◽  
Economic Damage ◽  
Control Group ◽  
St John’S Wort ◽  
Relevant Today ◽  
Treatment And Prevention ◽  
St John's Wort ◽  
Group 2

One of the reasons for the unprofi tability of dairy cattle breeding is fasciolose invasion. This disease can cause signifi cant economic damage in the form of a decrease in the milk production of cows, a decrease in the growth of young animals and a negative impact on the reproduction and renewal of the herd. The domestic veterinary market is saturated with a large number of various anti-trematode drugs of both foreign and domestic production, however, the price/eff ectiveness of anthelmintics remains a key aspect for animal owners. However, against parasitic drugs, they only destroy the parasite in the body of sick animals, without pouring in on the processes of recovery of the body after invasion. Longterm use of the same drugs, violation of the instructions for use of the latter leads to an increase in the number of reports of scientists from around the world about the increase in the number of cases of development of fasciol resistance in anthelmintics. That is why the search and testing of new therapeutic combinations that ensure the release of cattle from trematodes and helped restore disturbed physiological functions remain relevant today. The study presents the results of testing the use of a combination of rafenzene emulsion and infusion of St. John's wort on cattle fascioliasis in the conditions of the dairy industry of the Kyiv region. The purpose of the study was to study the therapeutic effi cacy of a combination of aetiotropic and pathogenetic therapies of calves for fasciulosis - rafenzol emulsion and infusion of herbs with St. John's wort. The young cattle of the black-bred breed, aged 12-18 months, were examined and their faeces sampled. The calves were monitored for 30 days during the experiment. They paid attention to the general condition. Heart rate, body temperature and respiratory rate were measured. Studies of individual organs and systems were performed according to conventional methods. Coprological studies were performed on the 10th and 30th day of observation. Used the method of sequential fl ushing faces. Calves, one of which was a control, was formed to study the eff ectiveness of antitrematodes measures. In each of them there were 5 animals, aff ected by fascioles, selected on the principle of analogues. The calves of the fi rst group were administered rafenzol emulsion at a dose of 0.75 ml of the preparation per 10 kg of body weight inside once, the animals of group 2 used the drug similar to the fi rst group. Previously they were fed with infusion of herbs St. John's wort. The control group was not treated.The results of the study indicate that the young is large aff ected with fascioles and the average invasion intensity is 48% and the intensity is 17 copies of eggs, respectively. Complex use of rafenzol emulsion with infusion of herbs with St. John's wort, according to the scheme, after 80 days revealed 80% of the extent and intensity. After 30 days, the indicator improved to 100%. Extensibility and intensifi cation of one rafenzol emulsion, after 10 days was 40%, for 30 days the effi ciency increased to 80%. St. John's wort improves the regeneration of tissue-damaged fasciolosis. It contributes to the absorption of feed and restore productivity. Therefore, treatment and prevention of fasciulosis in the farm is best done comprehensively. Key words: rafenzene emulsion, st. John's wort herb infusion, fasciolosis, disease intensity and intensity, effi cacy and drug intensity.

STUDYING SEDATIVE ACTIVITY OF COMBINED TINCTURE OF MOTHERWORT AND ST JOHN'S-WORT

2021 ◽  
Vol 92 (2) ◽  
pp. 59-64
Author(s):  
O. M. Khishova ◽  
◽  
V. D. Avdachenok ◽  
Keyword(s):  
Quality Indicators ◽  
Lateral Position ◽  
Control Group ◽  
Sodium Thiopental ◽  
Hypnotic Effect ◽  
St John’S Wort ◽  
Percolation Method ◽  
St John's Wort ◽  
Falling Asleep ◽  
Sedative Activity

The paper presents studying sedative activity of the combined tincture of motherwort and St. John's wort. The combined tincture of motherwort and St. John's wort was obtained by percolation method in a ratio 1:10. Standardization of the obtained tincture was carried out with quality indicators: description, content of active ingredients and ethanol, relative density, dry residue. According to all quality indicators, the tincture obtained met the requirements of the State Pharmacopoeia of the Republic of Belarus. Specific sedative activity of the combined tincture of motherwort and St. John's wort was assessed by barbiturates hypnotic effect prolongation (sodium thiopental), by the rate of falling asleep in animals and by animals staying in lateral position in relation to the control group to which sodium thiopental was injected. In the studies carried out it was found that injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml / kg increases sleep by 125,63% and also accelerates the process of falling asleep by 327,75% compared with the separate injection of motherwort and St. John's wort tincture at doses of 0,1 ml/kg. It was shown that the injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml/kg exhibits a potentiated effect and enhances the hypnotic effect of sodium thiopental administered at a dose of 10 mg/kg.

Active head movements facilitate compensation for effects of prism displacement on dynamic gait12

2006 ◽  
Vol 16 (1-2) ◽  
pp. 29-33
Author(s):  
Kim R. Gottshall ◽  
Michael E. Hoffer ◽  
Helen S. Cohen ◽  
Robert J. Moore
Keyword(s):  
Head Movement ◽  
Sensory Modality ◽  
Normal Subjects ◽  
The Body ◽  
Head Movements ◽  
Head Motion ◽  
Control Group ◽  
Entire Body ◽  
Group 3 ◽  
Group 2

Study design: Four groups, between-subjects study. Objectives: To investigate the effects of exercise on adaptation of normal subjects who had been artificially spatially disoriented. Background: Many patients referred for rehabilitation experience sensory changes, due to age or disease processes, and these changes affect motor skill. The best way to train patients to adapt to these changes and to improve their sensorimotor skills is unclear. Using normal subjects, we tested the hypothesis that active, planned head movement is needed to adapt to modified visual input. Methods and measures: Eighty male and female subjects who had normal balance on computerized dynamic posturography (CDP) and the dynamic gait index (DGI), were randomly assigned to four groups. All groups donned diagonally shift lenses and were again assessed with CDP and DGI. The four groups were then treated for 20 min. Group 1 (control group) viewed a video, Group 2 performed exercise that involved translating the entire body through space, but without separate, volitional head movement, Group 3 performed exercises which all incorporated volitional, planned head rotations, and Group 4 performed exercises that involved translating the body (as in Group 2) and incorporated volitional, planned head motion (as in Group 3). All subjects were post-tested with CDP and DGI, lenses were removed, and subjects were retested again with CDP and DGI. Results: The groups did not differ significantly on CDP scores but Groups 3 and 4 had significantly better DGI scores than Groups 1 and 2. Conclusions: Active head movement that is specifically planned as part of the exercise is more effective than passive attention or head movements that are not consciously planned, for adapting to sensorimotor change when it incorporates active use of the changed sensory modality, in this case head motion.

scholarly journals Effectiveness of medical treatment in overcoming the ureteral double-J stent related symptoms

2012 ◽  
Vol 6 (6) ◽  
pp. 234 ◽  
Author(s):  
Ugur Kuyumcuoglu ◽  
Bilal Eryildirim ◽  
Murat Tuncer ◽  
Gokhan Faydaci ◽  
Fatih Tarhan ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Group 4 ◽  
Double J Stent ◽  
Urinary Tract Symptoms ◽  
Stone Treatment ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Background: We investigated whether the frequency of lower urinary tract symptoms (LUTS) increased in patients in whom double-J stents were applied. We also evaluated several medical therapy protocols to treat symptoms related with ureteral stents.Materials and Methods: A total of 108 patients, in whom unilateral double-j stent was applied during ureteral stone treatment, were included. Before the double-J stent was applied, all patients completed storage components of the “International Prostate Symptom Score” (IPSSs), quality of life components of the IPSS (IPSS-QOL) and “Overactive Bladder Questionnaire” (OABq) forms and scores were calculated. After the procedure, cases were randomized into 5 groups, an antiinflammatory was given to Group 1, spasmolytic to Group 2, anticholinergic to Group 3 and α-blocker to Group 4. No additional drug was given to Group 5 as this control group. During the fourth week of the procedure, IPSSs, IPSS-QOL and OABq forms were again completed and scores were compared with the previous ones.Results: When all the cases were evaluated, the IPSSs, IPSS-QOLand OABq scores of patients in whom the double-J stent was applied were statistically significantly higher the procedure. Compared to the control group, the cases where the double-J stent was applied showed a higher IPSSs, IPSS-QOL and OABq scores and none of the medical therapies could prevent this increase.Interpretation: The frequency of LUTS increased in cases where the ureteral stent was applied and discomfort continued as long as the stent stayed in the body.

scholarly journals Zingerone Ameliorates Hepatotoxicity

2020 ◽  
Vol 11 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Julietpoornamathy J ◽  
Parameswari C.S.
Keyword(s):  
The Body ◽  
Control Group ◽  
Medical Sciences ◽  
Toxic Compounds ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Insight Into ◽  
Group 1

In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats.  A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

scholarly journals Peculiarities of Evaluation of Biological Effects of the Influence of Electromagnetic Radiation in Conditions of Reduced Temperature (Experiment)

2021 ◽  
Vol 6 (2) ◽  
pp. 227-235
Author(s):  
O. Litovchenko ◽  
◽  
I. Perova ◽  
Keyword(s):  
Electromagnetic Radiation ◽  
Negative Impact ◽  
Biological Effects ◽  
The Body ◽  
Combined Effect ◽  
Male Rats ◽  
Control Group ◽  
Prevention Measures ◽  
Immunological Parameters ◽  
Reduced Temperature

In modern conditions there is a high need to improve methods for establishing the nature of the combined influence of factors using modern approaches for further development of prevention measures against the negative impact of factors on the body. The purpose of the study was to investigate the combined effect of electromagnetic radiation and low temperatures with subsequent determination of the level of contribution of each factor in the formation of biological effects within the experiment by mathematical analysis of data using the method of artificial intelligence. Materials and methods. The subchronic experiment (30 days) was performed on male rats. The animals were divided into groups: combined exposure to electromagnetic radiation (70 kHz, 600 V/m) and reduced temperature (40C), isolated exposure to reduced temperature, isolated exposure to electromagnetic radiation and a control group. The establishment of biological effects was performed at stages 5, 15 and 30 days of the experiment. Changes in the body were assessed by physiological, biochemical and immunological parameters of the blood (30 indicators). Data processing was performed using computational intelligence methods (Neuro-fuzzy system). Results and discussion. The combined effect of the factors was manifested by the following biological effects: intensification of peroxidation processes with simultaneous moderate suppression of antioxidant protection, intensification of lipid metabolism was characterized by dyslipoproteinemia, manifesting in: increase in triglycerides, cholesterol and its fractions. Changes of the immune system were decrease in the ability of neutrophils to phagocytosis at different stages of the experiment, imbalance of the activation of the system of reducing the concentration of C4 at the background of increased intensity of IgM and IgG synthesis. The method of determining the intensity of the factors, developed on the basis of factor and cluster analysis, allowed to determine that during the experiment the ratios between the factors changed, but the greatest contribution was made by reduced temperature by both biochemical parameters (63%) and immunological (53%) at the same time, the level of electromagnetic radiation contribution was 37% and 47%, respectively. Thus, the reduced temperature was the leading factor in the combined effect, which added 60% to the overall biological effect throughout the study, against the effect of electromagnetic radiation for which the level of contribution was only 40%. By means of the factor analysis informative indicators, making it possible to establish the characteristics of biological effects, and therefore leading indicators in formation of biological effects were the increase in concentration of DC with simultaneous decrease in concentration of SH-groups, increase in VLDL and suppression of oxygen-dependent metabolism of neutrophil-test. Conclusion. Thus, the tested mathematical approach allowed to determine the leading role of each of the studied factors under the conditions of their combined influence in different systems, which allows to predict probable appropriate reactions of the whole organism and gives a reasonable approach to the development of preventive measures

scholarly journals Secretory activity of cattle mammary gland tissues during lactation and duration of the interlactation period

2020 ◽  
Vol 10 (5) ◽  
pp. 278-286
Author(s):  
M.D. Kambur ◽  
A.Y. Lermontov ◽  
A.Y. Lermontov
Keyword(s):  
Acetic Acid ◽  
Mammary Gland ◽  
Milk Fat ◽  
Negative Impact ◽  
Secretory Activity ◽  
The Body ◽  
Control Group ◽  
Functional Regression ◽  
Dry Period ◽  
Mammary Gland Tissue

Changes in the secretory activity of mammary gland during the involution period are designed to create conditions for inexhaustible use of the mammary gland, ensure the normal course of structural and functional regression for the development for the next lactation. For animals in which the interlactation period lasted less than 45 days, the absorption of non-esterified fatty acids in the last week of the involution period was 2.8 times higher than in animals in which the interlactation period lasted at least 55 days, 1.48 times higher than the absorption of acetic acid, 1.24 times higher than β-oxybutyric acid, 1.28 times higher than glucose, 2.82 times the total amount of phospholipids and triacylglycerols. For acetic acid, β-oxybutyric acid and glucose, not only higher absorption rates were observed, but also a tendency to increase the absorption level in the last weeks of lactation in animals with an interlactation period of less than 45 days, indicating metabolic changes in mammary gland tissue during the involution period. The duration of the dry period affects the secretory activity of breast tissue during lactation and the quality of milk produced during this period, which is expressed by lower fat content in the product while reducing the duration of the dry period to less than 45 days and reducing milk fat by 10.42% during the next calving. At the same time, the body weight of newborn calves in animals, whose interlactation period was less than 45 days by 19.3%, was lower than the animals of the control group, i.e., those who were in the interlactation period for at least 55 days, which indicates the negative impact of reducing the duration of the dry period on the body of animals.

scholarly journals Impact of lead acetate and sodium and potassium stearates on lipid peroxidation processes in the body of experimental animals

2021 ◽  
Vol 100 (4) ◽  
pp. 406-410
Author(s):  
Olha Ye. Fedoriv ◽  
Alexandra Ye. Kopach ◽  
Nataliia A. Melnyk
Keyword(s):  
Lipid Peroxidation ◽  
Drinking Water ◽  
Lead Acetate ◽  
Sodium Stearate ◽  
The Body ◽  
Female Rats ◽  
White Female ◽  
Control Group ◽  
Diene Conjugates ◽  
Group 2

Introduction. Given the significant prevalence of lead in the environment, research in this area has significant social and economic importance. Lead compounds are characterized by high toxicity and increased ability to cumulate in ecosystems, humans, and animals. Lead enters the human body with food, drinking water, atmospheric air, and smoking. Lead causes pathological changes in the nervous system, blood-forming organs, kidneys, etc. Materials and methods. The experiments were carried out on four groups of white female rats, each included seven animals, weighing 150-200 g. The first group of animals was a control. The second group consumed dechlorinated water from the city water supply, followed by lead acetate. The animals from the third and fourth groups drank the same water with sodium stearate and potassium stearate content in a dose of 1/250 LD50. After the 40th-day of the use of these waters, the animals were orally administered lead acetate at a dose of 7 mg/kg. The levels of lipid peroxidation biomarkers were studied by studying the content of diene conjugates (DC) and malondialdehyde (MDA) in blood serum, liver, and kidney homogenates. Results. The administration of 1/2 acetate LD50 to lead in experimental rats drinking water with stearates was accompanied by a significant increase in the DCs concentration and (MDA) in animals. Higher concentrations of LPO products were observed in the group of animals that consumed water from potassium stearate. Conclusions. 1. With the oral administration of lead acetate against the background of drinking water containing stearates at a dose of 1/250 LD50, an increase in lipid peroxidation indices was noted compared with the control group. 2. Higher concentrations of LPO products were observed in the group of animals consuming water from potassium stearate.

scholarly journals THE INTEGRATED ASSESSMENT OF EFFECTIVITY OF MINERAL WATER "FATEEVSKAYA" IN PATIENTS WHO USE REMOVABLE DENTAL CONSTRUCTIONS

2018 ◽  
Vol 14 (2) ◽  
pp. 109-114
Author(s):  
Ольга Садыкова ◽  
Ol'ga Sadykova ◽  
Сергей Жолудев ◽  
Sergey Zholudev ◽  
Антон Еликов ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Salivary Glands ◽  
Mineral Water ◽  
Ph Value ◽  
Negative Impact ◽  
Secretory Activity ◽  
Salivary Secretion ◽  
The Body ◽  
Control Group ◽  
Before And After

Subject. Removable dentures have a negative impact on supporting tissues, biochemical parameters and composition of the microflora of the oral cavity, secretory activity of the salivary glands and other processes of the maxillofacial region and the body as a whole. One of the methods that can be used in the treatment and prevention of prosthetic stomatitis is balneotherapy. In the article, using the clinical, biochemical, microbiological and histological methods, the effectiveness of the use of mineral water "Fateevskaya" in patients using removable orthopedic structures was studied. Objectives of the study was to evaluate the effectiveness of procedures for small balneotherapy with the use of mineral water "Fateevskaya" in patients with removable dentures. Methods.We examined 158 elderly and senile age patients with removable dentures. Correction of removable dentures was carried out to all patients at the initial stage. All examined patients are divided into two groups. The group received the treatment with the low balneotherapy with “Fateevskaya” mineral water (78 patients, and the clinical control group (80 patients). The clinical condition of oral cavity was assessed before and after the course of low balneotherapy. Were researched: changes of mucous membrane of prosthetic bed, salivation rates, disturbance of salivary secretion, oral microbiocenosis. Results.Of the research showed that in both groups were increase of pH value, appears lower values of total protein and glucose, decrease in activity of some enzymes. This explanation is due to a decrease in the stress response to using the removable dentures, normalization of salivary glands functioning, decrease in the intensity of the phlogiston process. The results of a histological research also confirm this. The results of microbiological crops before and after the low balneotherapy indicate the oral biocenosis normalization. The positive changes in the researched parameters had significantly larger statistically valid values in the group received the treatment with the low balneotherapy with “Fateevskaya” mineral water. The results of the complex research allow us to recommend the “Fateevskaya” mineral water to low balneotherapy in dental practice.

scholarly journals Influence of milk thistle, methifene and sylimevit on the morphological parameters of laying hens in experimental chronic cadmium toxicosis

2020 ◽  
Vol 3 (1) ◽  
pp. 42-46
Author(s):  
A. Y. Ostapyuk ◽  
B. V. Gutyj
Keyword(s):  
Body Weight ◽  
Laying Hens ◽  
Modern Science ◽  
The Body ◽  
Control Group ◽  
Milk Thistle ◽  
Morphological Parameters ◽  
Treatment And Prevention ◽  
Physiological Processes ◽  
Experimental Group

One of the most pressing problems of modern science is the systematic study of natural processes, forecasting and complex assessment of changes in the environment under the influence of anthropogenic load. Blood composition is a relatively constant indicator, which is at the same time one of the labile systems of laying hens. Physiological processes that occur in the body, largely affect the quality of blood. Hematological studies make it possible to study in more detail the effect of cadmium on the body of chickens, on the basis of which a more specific development of the scheme of treatment and prevention of cadmium toxicosis in poultry is possible. The aim of this study was to investigate the effect of milk thistle, methifene and silymevitis on the morphological indices of laying hens in the development of chronic cadmium toxicosis. 32 laying hens, 78 weeks of age, were selected for the study. Four experimental groups were formed: control and three experimental. The control group (C) chickens and the three experimental groups were cadmium sulfate 4 mg/kg body weight in water. The chickens of the experimental group E1 with feed were fed the fruits of milk thistle spotted at a dose of 2.0 g/kg of feed once a day for 30 days. The chickens of the E2 experimental group were fed methifene at a dose of 0.28 g/kg of feed once a day for 30 days with feed. The chickens of the E3 experimental group were fed a sylimevit at a dose of 0.36 g/kg of feed once a day for 30 days. Drinking cadmium sulphate to laying hens at a dose of 4 mg/kg body weight contributed to a decrease in red blood cell count, hemoglobin level and an increase in leukocyte counts. With cadmium load of laying hens, milk thistle, methifene and sylimevit have a positive effect on the morphological parameters of the blood. In chronic cadmium toxicosis in laying hens, the best normalizing effect on the morphological parameters of the blood of experimental chickens is sylimevit, compared with methifene and milk thistle.

scholarly journals FRACTURES OF THE MANDIBLE AT THE BODY AND ANGLE REGION: PATTERNS, EPIDEMIOLOGY, DIAGNOSTIC PRINCIPLES. PART I

2017 ◽  
Vol 21 (2) ◽  
pp. 100-103
Author(s):  
Sh. Chzhan ◽  
P. S Petruk ◽  
Yu. A Medvedev
Keyword(s):  
Successful Treatment ◽  
Imaging Techniques ◽  
Clinical Manifestations ◽  
Detailed Examination ◽  
Accurate Diagnosis ◽  
The Body ◽  
Mandibular Fractures ◽  
Relevant Today ◽  
Treatment And Prevention ◽  
Key Points

The article reflects the aspects of epidemiology and principles of diagnosis in mandibular fractures. The problem remains relevant today. Due to the complexity of the mechanisms of the injury and their acceptance, a variety of clinical manifestations, the limited knowledge of the patients about their injury, the diagnosis and treatment of these injuries sometimes are difficult. Detailed examination with modern imaging techniques and accurate diagnosis are the key points in successful treatment and prevention of complications in this category of patients.

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