Anthropometric indices are associated with LDL cholesterol in postmenopausal Javanese women

Introduction: Lipid abnormalities are seen to be linked lack of physical activity, obesity, metabolic syndrome and diabetes mellitus. Postmenopausal women experience the changes of body composition by increasing the visceral fat. The study was aimed to explore relationship between anthropometric indices and lipid level in postmenopausal Javanese women. Methods: This cross sectional study included 34 healthy postmenopausal Javanese women, age range between 46-59 years, from Dusun Trukan, Karanggede dan Marangan Prambanan subdistrict, Sleman district. Anthropometric measurements were carried following standard procedure. Appropriate statistical tools were used to analyze data using SPSS Version 17. A p value <0.05 was taken as level of significance. Results: Abdominal circumference showed significant positive association with LDL level (r=0.289, p=0.049) but not with triglyceride, HDL level and total cholesterol level. BMI also showed significant positive association with LDL level (r=0.336, p=0.026) but not with other variables. Conclusion: The data concluded that abdominal circumference and BMI are positively association with LDL cholesterol but not with other components of the lipid profile in Javanese postmenopausal women. Further studies, however, needed to warranted to understand the causal relationship involving large number of subjects multiple centres. DOI: http://dx.doi.org/10.3329/bjms.v13i2.18293 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.124-127

Download Full-text

Lipid profiles and the risk of kidney cancer in the Swedish AMORIS study.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.7_suppl.342 ◽

2011 ◽

Vol 29 (7_suppl) ◽

pp. 342-342

Author(s):

M. Van Hemelrijck ◽

H. Garmo ◽

N. Hammar ◽

G. Walldius ◽

M. Lambe ◽

...

Keyword(s):

Kidney Cancer ◽

Proportional Hazards ◽

Positive Association ◽

Epidemiologic Studies ◽

Cox Proportional Hazards ◽

Lipid Profiles ◽

P Value ◽

Significant Positive Association ◽

Fourth Quartile ◽

Lipid Components

342 Background: Since multiple epidemiologic studies showed a link between obesity and kidney cancer (KCa), the lipid metabolism is thought to play a role in development of KCa. With the exception of cholesterol and total fat intake, the association between changes in lipid biomarkers and KCa has not often been researched. We assessed the link between lipid profiles and KCa risk in a large prospective cohort study. Methods: A cohort based on 85,261 persons (> 20 years old) with baseline measurements of glucose, triglycerides (TG), total cholesterol, HDL, LDL, apolipoprotein A-I and apoB was selected from the Swedish Apolipoprotein Mortality Risk (AMORIS) study. Multivariate Cox proportional hazards models were used to analyze associations between quartiles and dichotomized values of these lipid components and KCa risk. All models were adjusted for age, gender, socioeconomic status, fasting status, history of kidney disease prior to baseline (ICD9: 580-93), and glucose, cholesterol, and TG levels (depending on the covariate of interest). Results: During a mean follow-up of 12 years, 161 persons developed KCa (58% men). The mean age at baseline was 46 years. TG were the only lipid component for which a statistically significant association was found with risk of KCa (Hazard Ratio (HR): 1.05 (95%CI: 0.59-1.87), 1.77 (1.05-2.98), and 1.77 (1.04-3.02) for the second, third, and fourth quartile, compared to the first, with p-value for trend: 0.008). The lipid ratio of TG and HDL also showed a statistically significant positive association with risk of KCa (HR: 1.21 (0.71-2.08), 1.56 (0.94-2.58), and 1.92 (1.17-3.17) for the second, third, and fourth quartile, compared to the first, with p-value for trend: 0.004). No other associations were found between lipid components and KCa risk. Conclusions: This detailed analysis of lipid components and risk of KCa found a relation between levels of TG and KCa risk. In contrast to previous studies, we did not find an association between cholesterol levels and KCa risk. Lipid profiles based on the markers used in this study do not seem to reflect the etiological pathway that has previously been shown between obesity and KCa. Further mechanistic studies are required to assess the link between lipid deregulation and KCa. No significant financial relationships to disclose.

Download Full-text

Adherence to the low carbohydrate diet and the risk of breast Cancer in Iran

Nutrition Journal ◽

10.1186/s12937-019-0511-x ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 1

Author(s):

Bahareh Sasanfar ◽

Fatemeh Toorang ◽

Ahmad Esmaillzadeh ◽

Kazem Zendehdel

Keyword(s):

Breast Cancer ◽

Postmenopausal Women ◽

Premenopausal Women ◽

Positive Association ◽

Carbohydrate Diet ◽

Significant Positive Association ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Study Population ◽

Study Participants

Abstract Background Previous studies on the link between macronutrients and breast cancer have mostly focused on individual macronutrients rather than their combination. This study investigates the association between adherence to a low carbohydrate diet and odds of breast cancer among women. Methods This hospital-based case-control study was carried out on 412 women with pathologically confirmed breast cancer within the past year and 456 apparently healthy controls that were matched in terms of age and residential place. Dietary data was collected using a 168-item validated FFQ. Participants were classified in terms of quintiles of percentages of energy intake from carbohydrates, proteins, and fats. Then, individuals in the highest quintile of fat and protein intake were given a score of 5 and those in the lowest quintile of these macronutrients were given a score of 1. Participants in the other quintiles of these macronutrients were given the corresponding score. In terms of carbohydrate intake, those in the highest quintile received a score of 1 and those in the lowest quintile received 5. The scores were then summed up to calculate the total low carbohydrate diet (LCD) score, which varied from 3 to 15. A higher score meant greater adherence to a low carbohydrate diet. Results The mean age of study participants was 45.2 y and mean BMI was 28.4 kg/m2. Mean LCD score of participants was 8.9 ± 2.5 (8.9 ± 2.6 in cases and 9.0 ± 2.5 in controls). Although no significant association was observed between adherence to the LCD score and odds of breast cancer in the study population, a trend toward significant positive association was seen between consumption of LCD and odds of breast cancer in postmenopausal women; after controlling for several potential confounders, individuals in the third quartile of LCD score were 1.94 times more likely to have breast cancer than those in the lowest quartile (95% CI: 1.00, 3.76). This association strengthened after controlling for dietary variables (2.50; 1.18–5.32). Even after further adjustment for BMI, this association remained significant (2.64, 1.23–5.67). No significant relationship was observed in premenopausal women, either before or after controlling for confounders. Conclusion Adherence to LCD may be associated with increased odds of breast cancer in postmenopausal women. Prospective cohort studies are needed to confirm these findings.

Download Full-text

Hypertension as a prognostic factor in the prediction of mortality in patients with COVID-19: a systematic review and meta-analysis

European Heart Journal ◽

10.1093/eurheartj/ehab724.2393 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

C D P Pagdanganan ◽

J Juangco ◽

Keyword(s):

Prognostic Factor ◽

Odds Ratio ◽

Positive Association ◽

Hazard Ratio ◽

P Value ◽

Comorbid Condition ◽

Significant Positive Association ◽

Prediction Of Mortality ◽

Risk Of Mortality ◽

Increased Risk

Abstract Background The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) brought the majority of the world into a halt when it started to spread outside the virus epicenter in Wuhan, China. With the alarming increase in the number of cases and deaths worldwide, the possible risk factors should be determined in order to have a general idea on those who are more susceptible to have this disease. Hypertension, being one of the world's leading causes of noncommunicable diseases, was identified by the CDC to be one of underlying medical conditions that might pose an increased risk for severe illness from COVID-19. Objective The aim of this study is to determine the predictive value of hypertension as a comorbidity in COVID-19 mortality. Materials and methods Participants included all patients clinically diagnosed with COVID-19, and have hypertension as their pre-existing medical condition. Studies were selected based on study design, participants, exposure, outcome, timing, setting and language. The following databases were searched from June to August 2020 for case control and cohort studies on MEDLINE and CINAHL, ScienceDirect, Clinical Key, OVID database, Wiley Online library, and UpToDate. The criteria for evaluation of risk of bias were based on the selection bias, comparability bias and outcome bias. All information gathered were collated and evaluated using the Newcastle-Ottawa Quality Assessment Scale and CEBM. Results Individual studies all showed a significant relationship between hypertension and mortality in COVID-19 patients. Odds ratio ranging from 1.75 to 28.88, and hazard ratio ranging from 1.49 to 3.32 are present in the studies. For the data analysis, Mantel Haenszel method and random effects model was used for case control studies with odds ratio as effect measure; while Inverse variance method and fixed model was used for cohort studies with hazard ratio as effect measure. Both groups showed significant positive association between mortality and hypertension as a prognostic factor. Overall odds ratio is 5.25 (2.42–11.40) with a p value of <0.ehab724.23931, and the pooled hazard ratio is 2.21 (1.75–2.80) with a p value of <0.ehab724.23931. This shows that there is an increased risk of mortality among COVID-19 patients with hypertension as a comorbid condition. Conclusions Hypertension as a comorbid condition is a prognostic factor in the prediction of mortality in hospitalized COVID-19 patients. The ten included studies showed that there is a significant positive association suggesting an increased risk of mortality in COVID-19 patients with hypertension. FUNDunding Acknowledgement Type of funding sources: Other. Main funding source(s): University of the East Ramon Magsaysay Memorial Medical Center College of Medicine Forest Plot HR Hypertension COVID

Download Full-text

Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol

Nutrients ◽

10.3390/nu13082883 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2883

Author(s):

Inés Domínguez-López ◽

Isabella Parilli-Moser ◽

Camila Arancibia-Riveros ◽

Anna Tresserra-Rimbau ◽

Miguel Angel Martínez-González ◽

...

Keyword(s):

Lipid Profile ◽

Postmenopausal Women ◽

Tartaric Acid ◽

Cardiovascular Health ◽

Ldl Cholesterol ◽

Smoking Status ◽

Strong Association ◽

Density Lipoprotein ◽

P Value ◽

Wine Consumption

Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60–80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (−3.13 μg/mg (−5.54, −0.71), p-value = 0.016 and −3.03 μg/mg (−5.62, −0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.

Download Full-text

Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients

Biomolecular and Health Science Journal ◽

10.20473/bhsj.v2i2.14965 ◽

2019 ◽

Vol 2 (2) ◽

pp. 102

Author(s):

Lydia Juanita ◽

Usman Hadi ◽

Vitanata Arfijanto

Keyword(s):

Function Analysis ◽

Positive Association ◽

Prognostic Indicator ◽

Living Condition ◽

Enzyme Linked Immunosorbent Assay ◽

P Value ◽

Significant Positive Association ◽

Serum Neopterin ◽

Prospective Longitudinal ◽

Hiv Aids

Introduction: HIV/AIDS is still a major problem throughout the world even in Indonesia. Some markers can provide information regarding the description of immune activity in HIV/AIDS. Neopterin produced by macrophages as a catabolic result of Guanosine Triphosphate (GTP) is one of them. Neopterin has been widely studied as a prognostic indicator of the course in HIV/AIDS. Until now there have been no studies examine the association between neopterin levels and outcomes in 30 days of HIV/AIDS patients.Methods: A prospective longitudinal analytic study involved 56 samples of HIV/AIDS naive patients from January to April 2019. Serum neopterin levels were measured by the Enzyme Linked Immunosorbent Assay (ELISA) method. Outcome is a living condition or death within the first 30 days of the patient being treated. Discriminant function analysis was used to determine the association between variable and controlling confounding factors using the "R" program. Outputs of p value was significant if <0.05.Results: The average age of the study subjects was 39.7 ± 11 years old with predominantly male gender (71.4%). The median serum neopterin level of the study subjects was 168.13 nmol/L with the lowest levels of 11.78 nmol/L and the highest level of 196.95 nmol/L. Outcomes were grouped live and died, each group at 50%. There was a significant positive association between serum neopterin levels and outcomes in 30 days (p=0.02)Conclusion: Role of neopterin levels still need to be proven as a prognostic factor by evaluating other factors that influence the outcome of HIV/AIDS patients.

Download Full-text

Interaction Between Dietary Acid Load and IL6 -572 G/C Polymorphism on Blood Pressure Among Postmenopausal Women in Malaysia

Current Developments in Nutrition ◽

10.1093/cdn/nzaa058_022 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1264-1264

Author(s):

Sook Yee Lim ◽

Yoke Mun Chan ◽

Ramachandran Vasudevan ◽

Mohd Shariff Zalilah ◽

Yit Siew Chin

Keyword(s):

Blood Pressure ◽

Postmenopausal Women ◽

Positive Association ◽

Gene Interaction ◽

Community Dwelling ◽

Dietary Intakes ◽

Significant Positive Association ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Abstract Objectives We examined whether IL6 single nucleotide genetic polymorphism modified the association between dietary acid load (DAL) and blood pressure among postmenopausal women in Malaysia. Methods A total of 211 community-dwelling postmenopausal women were recruited. Dietary intakes of participants were assessed using a validated interview-administered semi-quantitative food frequency questionnaire while DAL was estimated using potential renal acid load (PRAL). Agena® MassARRAY genotyping analysis was used to identify the IL6 genotype and blood pressure was measured using a Digital Automatic BP monitor (OMRON HEM-907, Japan). Interaction between DAL and IL6 -572 G/C polymorphism was assessed using linear regression test. Results There was a significant interaction between DAL and IL6 -572 G/C polymorphism on systolic blood pressure (SBP) (Pinteraction = 0.041). A significant positive association between DAL and SBP with stronger relationship in CG and GG genotype carriers compare to CC carriers were observed. On the other hand, there was no significant diet-gene interaction effect on diastolic blood pressure. Conclusions Our findings suggest that the association between DAL and SBP might be influenced by IL6 -572 G/C polymorphism among postmenopausal women. Further work on how IL6 -572 G/C polymorphism influences the association with DAL on hypertension are warranted. Funding Sources Supported by Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education Malaysia, and Putra Grant UPM.

Download Full-text

The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study

Nutrients ◽

10.3390/nu12010048 ◽

2019 ◽

Vol 12 (1) ◽

pp. 48

Author(s):

José Carlos Flores ◽

Esther Gracia-Lavedan ◽

Yolanda Benavente ◽

Pilar Amiano ◽

Dora Romaguera ◽

...

Keyword(s):

Chronic Lymphocytic Leukaemia ◽

Chronic Inflammation ◽

Lymphocytic Leukaemia ◽

Positive Association ◽

Future Research ◽

P Value ◽

Dietary Inflammatory Index ◽

Significant Positive Association ◽

Logistic Regression Models ◽

Inflammatory Index

Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.

Download Full-text

Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial

European Journal of Cardiovascular Nursing ◽

10.1177/1474515119831511 ◽

2019 ◽

Vol 18 (5) ◽

pp. 366-374

Author(s):

Sonia Ruiz-Bustillo ◽

Consol Ivern ◽

Neus Badosa ◽

Nuria Farre ◽

Esther Marco ◽

...

Keyword(s):

Heart Disease ◽

Ischaemic Heart Disease ◽

Ldl Cholesterol ◽

Controlled Trial ◽

Lipid Level ◽

Standard Of Care ◽

Lipid Lowering ◽

P Value ◽

Cholesterol Levels

Background and aims: Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an intensive lipid-lowering intervention, coordinated by nurses and implemented after hospital discharge, in patients hospitalized for an ischaemic heart disease event. Methods: Randomized controlled trial, in which a nurse-led intervention including periodic follow-up, serial lipid level controls, and subsequent optimization of lipid-lowering therapy, if appropriate, was compared with standard of care alone in terms of serum lipid-level control at six months after discharge. Results: The nurse-led intervention was associated with an improved management of low-density lipoprotein (LDL) cholesterol levels compared with standard of care alone: LDL cholesterol levels ⩽100 mg/dL were achieved in 97% participants in the intervention arm as compared with 67% in the usual care arm ( p value <0.001), the LDL cholesterol ⩽70 mg/dL target recommended by the 2016 European Society of Cardiology guidelines was achieved in 62% vs. 37% participants ( p value 0.047) and the LDL cholesterol reduction of ⩾50% recommended by the American College of Cardiology/American Heart Association in 2013 was achieved in 25.6% of participants in the intervention arm as compared with 2.6% in the usual care arm ( p value 0.007). The intervention was also associated with improved blood pressure control among individuals with hypertension. Conclusions: Our findings highlight the opportunity that nurse-led, intensive, post-discharge follow-up plans may represent for achieving LDL cholesterol guideline-recommended management objectives in patients with ischaemic heart disease. These findings should be replicated in larger cohorts.

Download Full-text

Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women

10.20944/preprints201906.0163.v1 ◽

2019 ◽

Author(s):

Hong-li Dong ◽

Feng Xiong ◽

Qing-wei Zhong ◽

Yi-hong Li ◽

Meng Liu ◽

...

Keyword(s):

Postmenopausal Women ◽

Menopausal Status ◽

Premenopausal Women ◽

Positive Association ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Total Testosterone ◽

Significant Positive Association ◽

Cross Sectional ◽

Bioavailable Testosterone

Little is known about the association between equol and bioavailable testosterone (BT) in adults. We examined the associations of urinary equol concentrations with serum total, bioavailable and free testosterone (FT), dehydroepiandrosterone sulfide (DHEAS), free androgen index (FAI) and sex hormone-binding globulin (SHBG) concentrations. This cross-sectional study included 1904 women aged 59.7 years. Urinary equol and serum sex hormone concentrations were measured. Overall, urinary equol tended to be inversely associated with bioactive forms of androgenic indices (BT, FT or FAI) but not with total testosterone (TT) or DHEAS. Urinary equol was also positively associated with SHBG. In multi-covariate-adjusted analyses stratified by menopausal status, graded and inverse associations between urinary equol and bioactive forms of androgenic indices (BT, FT and FAI) were observed in postmenopausal women (all p-trends <0.05), but not in premenopausal women. A significant positive association between urinary equol and SHBG was observed only in postmenopausal women. No significant associations were observed between urinary equol and TT or DHEAS in either group. A path analysis indicated that these associations of equol with androgens in postmenopausal women might be mediated by SHBG. Our findings indicated urinary equol exhibited graded and inverse associations with BT or FT but not TT in women.

Download Full-text

Maternal plasma lipids are involved in the pathogenesis of preterm birth

10.1101/2021.07.04.21259965 ◽

2021 ◽

Author(s):

Yile Chen ◽

Bing He ◽

Yu Liu ◽

Max Aung ◽

Zaira Rosario-Pabon ◽

...

Keyword(s):

Fatty Acids ◽

Puerto Rico ◽

Preterm Birth ◽

Plasma Lipids ◽

Preterm Births ◽

Positive Association ◽

Maternal Plasma ◽

P Value ◽

Causality Analysis ◽

Significant Positive Association

Background: Preterm birth is defined by the onset of labor at a gestational age shorter than 37 weeks and it can lead to premature birth and impose a threat to newborns health. The Puerto Rico PROTECT cohort is a well-characterized prospective birth cohort that was designed to investigate environmental and social contributors to preterm birth in Puerto Rico, where preterm birth rates have been elevated in recent decades. To elucidate possible relationships between metabolites and preterm birth in this cohort, we conducted a nested case-control study to conduct untargeted metabolomic characterization of maternal plasma of 31 preterm birth women and 69 full-term labor controls at 24-28 gestational weeks. Results: A total of 333 metabolites were identified and annotated with liquid chromatography/mass spectrometry. Subsequent weighted gene correlation network analysis shows the fatty acid and carene enriched module has a significant positive association (p-value=8e-04) with preterm birth. After controlling for potential clinical confounders, a total of 38 metabolites demonstrated significant changes uniquely associated with preterm birth, where 17 of them were preterm biomarkers. Among seven machine-learning classifiers, application of random forest achieved the highly accurate and specific prediction (AUC = 0.92) for preterm birth in testing data, demonstrating their strong potential as biomarkers for preterm births. The 17 preterm biomarkers are involved in cell signaling, lipid metabolism, and lipid peroxidation functions. Further causality analysis infers that suberic acid upregulates several fatty acids to promote preterm birth. Conclusions: Altogether, this study demonstrates the involvement of lipids, particularly fatty acids, in the pathogenesis of preterm birth.

Download Full-text