scholarly journals INTOXICAÇÃO SUBAGUDA AO MANGANÊS EM RATOS WISTAR ADULTOS: AVALIAÇÃO DE PARÂMETROS OXIDATIVOS NO SNC E DEPOSIÇÃO DO METAL EM DIFERENTES TECIDOS

2018 ◽  
Vol 7 (2) ◽  
pp. 193-210
Author(s):  
Maria Victória Branco Flores ◽  
Tuany Eichwald ◽  
Analú Mantovani ◽  
Viviane Glaser ◽  
Carine Raquel Richter Schimitz ◽  
...  
Keyword(s):  
Body Weight ◽  
Mitochondrial Function ◽  
Complex I ◽  
Body Weight Gain ◽  
Thiobarbituric Acid ◽  
Significant Inhibition ◽  
The Body ◽  
Control Group ◽  
Peripheral Tissues ◽  
The Brain

O Manganês (Mn) é um metal essencial para o organismo. É distribuído no ambiente e utilizado em processos industriais. Apesar de essencial, é neurotóxico à exposições cumulativas, causando uma desordem neurológica, o Manganismo. O estudo avaliou o efeito da administração subaguda de Mn sob a forma de cloreto e acetato de Mn, sobre a função mitocondrial e parâmetros oxidativos no encéfalo, bem como o acúmulo deste metal no encéfalo e tecidos periféricos de ratos adultos. Os ratos receberam 6 mg/kg de Mn i.p. na forma de cloreto ou acetato de Mn, 5 dias/semana por 4 semanas. O grupo controle recebeu solução salina 0,9% pela mesma via de administração e mesmo período. Foi mensurada a concentração de substâncias reativas ao ácido tiobarbitúrico (TBARS) e grupamentos NPSH, a atividade dos complexos I e II da cadeia respiratória no encéfalo e/ou estruturas cerebrais, bem como o peso corporal e a concentração de Mn e Fe no soro, encéfalo, tecido renal e hepático. Foi observada uma diminuição no ganho de peso corporal dos animais que receberam o Mn, um aumento na concentração/depósito de Mn no soro, encéfalo e tecido renal, tanto na forma de cloreto e acetato de Mn, quando comparados com o grupo controle. Além disso, houve um aumento significativo no conteúdo de NPSH no encéfalo e, embora não significativo, uma tendência de aumento da concentração de TBARS, no grupo que recebeu cloreto de Mn. Ainda, foi verificada uma inibição na atividade do complexo I no estriado dos animais expostos ao cloreto de Mn. Não houve diferença entre os grupos nas atividades do complexo I e II no encéfalo e hipocampo. Em conjunto, os dados indicam que a exposição ao Mn em baixas doses contribui para o desenvolvimento de estresse oxidativo e disfunção mitocondrial no SNC, com aparente predileção de dano ao estriado.Palavras-chave: Manganês. Exposição subaguda. Parâmetros oxidativos. Função mitocondrial. MANGANESE SUBACUTE INTOXICATION IN ADULT WISTAR RATS: EVALUATION OF OXIDATIVE PARAMETERS IN CNS AND METAL DEPOSITION IN DIFFERENT TISSUES ABSTRACT: Mn is an essential metal to the organism. It is distributed in the environment and used in industrial processes. Although essential, it is neurotoxic to cumulative exposures, and can cause a neurological disorder, called Manganism. This study evaluated the effect of subacute Mn as chloride and acetate of Mn administration on mitochondrial function and oxidative parameters in adult rat brain, as well as the accumulation of this metal in the brain and peripheral tissues. The rats received 6 mg/kg of Mn i.p., as Mn chloride or Mn acetate, 5 days/week for 4 weeks. The control group received 0.9% of saline solution in the same way of administration and in the same period. It was measured the concentration of thiobarbituric acid reactive substances (TBARS) and NPSH groups, the activity of mitochondrial complex I and II in brain and/or in the brain structures, as well as the body weight and the concentration of Mn and Fe accumulation. It was observed a decrease on body weight gain in animals exposed to Mn and an increase of concentration/deposit of Mn in serum, brain and kidney, in the both Mn chloride and acetate form when compared to the control group. In addition, there was a significant increase in brain NPSH content and, although it was not significant, a trend of increasing on TBARS concentration in the group that received Mn. Besides that, a significant inhibition of complex I activity was observed in the striatum of the animals exposed to Mn. There was not difference between groups on complex I and II in the brain and hippocampus. Together, these data indicate that exposure to Mn at low doses contributes to the development of oxidative stress and mitochondrial dysfunction in the CNS, with apparent predilection of striatum damage.Keywords: Manganese. Subacute exposure. Oxidative parameters. Mitochondrial function.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

scholarly journals THE USE OF BIOSTIMULANT FOR INCREASING THE BODY WEIGHT GAIN OF CHICKENS

2020 ◽  
Vol 17 (35) ◽  
pp. 800-812
Author(s):  
Ilgiz DOLININ ◽  
George BAZEKIN ◽  
Evgeny SKOVORODIN ◽  
Almaz SHARIPOV ◽  
Ivan CHUDOV
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Live Weight ◽  
The Body ◽  
New Drugs ◽  
Natural Resistance ◽  
Control Group ◽  
Immunological Parameters

Poultry farming holds a special place in ensuring the products that the consumers demand, it provides the population with essential food products,such as eggs and meat,that contain vital micro and macronutrients, proteins, lipids, and vitamins. Therefore, the issues of rational, economically feasible feeding of meat poultry, namely broiler chickens, are an urgent task. It is also essential to find effective methods of their application in order to correct the natural resistance and immune and biological reactivity of birds. The purpose of this research is to study the effect of the biological stimulant-Nucleostim on the growth and development of chickens, hematological, and immunological parameters of the blood of birds.This Biostimulant is a purified bovine spleen extract containing at least 1 mg / ml of low molecular weight peptides (nucleotides and nucleosides) formed as a result of autolysis, using dry whey and diatomite as fillers. Onthe application ofNucleostim, the gain in live weight of chickens was increased by 9.7%. At the end of the experiment, the livability of the chicks of the experimental group treated with Nucleostimcame up to 88%, compared with the 72% of the control group. The use of biostimulant had a stimulating effect on the liver of chickens confirmed by the research results presented in the article, as well as contributed to the development of the thymus in the setting of general dystrophy. Thus, it improved chicklivability and increased body weight gain. The biological stimulant-Nucleostim as an adaptogenic, anabolic, and immunostimulatory agent is promising for finding new drugs that improve the health and productivity of poultry.

scholarly journals Effect of the dietary inclusion of the growth promoter avoparcin on the performance and carcass characteristics of growing goat kids

2018 ◽  
Vol 50 (1) ◽  
pp. 25
Author(s):  
V. A. BABIDIS (Β. Μ. ΜΠΑΜΠΙΔΗΣ) ◽  
P. FLOROU-PANERI (Π. ΦΛΩΡΟΥ-ΠΑΝΕΡΗ) ◽  
D. KUFIDIS (Δ. ΚΟΥΦΙΔΗΣ) ◽  
A. B. SPAIS (A.B. ΣΠΑΗΣ)
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
The Body ◽  
Feed Consumption ◽  
Control Group ◽  
Spleen Weight ◽  
Growth Promoter ◽  
Feed Conversion ◽  
Daily Consumption ◽  
Indigenous Goat

A trial was conducted with 32 indigenous goat kids (Capra prisca) 8,5 weeks old to examine the effectiveness of dietary avoparcin as growth promoting factor. The kids were randomly allocated into two groups (control- and avoparcin group with initial mean body weight of 11,61 ±1,16 kg and 11,57±1,47 kg, respectively) comprising of 16 kids (8 male and 8 female) each. For a period of 12 weeks, kids in the control group were given lucerne (alfalfa) hay (mean daily consumption 170 g/head) and an appropriate compound diet (given ad libitum), while kids in the avoparcin group were fed the same diet except that the compound diet was supplemented with avoparcin (20 mg/kg). Avoparcin supplementation significantly (P<0.05) improved final mean body weight by 10.57% (19.24 ± 2.33 kg vs. 17.40 ± 2.30 kg), body weight gain (BWG) by 32.30% (7.66 ± 1.42 kg vs. 5.79 ± 1.74 kg), mean daily feed consumption in dry matter basis (DM) by 14.24% (551.80 ± 31.60 g DM vs. 483.02 ± 28.94 g DM), feed conversion ratio by 13.62% (6.09 ± 0.47 kg DM consumption/kg BWG vs. 7.05 ± 0.56 kg DM consumption/kg BWG) and carcass weight by 14.86% (11.44 ± 1.48 kg vs. 9.96 ± 1.76 kg). Moreover, no significant differences (P>0.05) were noticed neither in carcass yield and carcass chemical composition nor in percentages of small intestine-, major omentum-, lung-,heart-, liver- and spleen weight in the body weight.

scholarly journals Evaluation of Carrot Pomace (Daucus carota L.) as Hypocholesterolemic and Hypolipidemic Agent on Albino Rats

2013 ◽  
Vol 5 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Abd El-Moneim M.R. AFIFY ◽  
Ramy R.M ROMEILAH ◽  
Mahmoud M.H. OSFOR ◽  
Amir S.M. ELBAHNASAWY
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Obese People ◽  
Daucus Carota L ◽  
Hypercholesterolemic Diet

The current study examined the attenuating influence of dietary carrot pomace powder (CaPP) on hypercholesterolemia and various oxidative stress-associated with biochemical parameters in hypercholesterolemic rats. Thirty two male albino rats weighing 110±10 g were divided into four groups, the first group received the basal diet only and served as (negative control), the second group received the hypercholesterolemic diet and served as positive control, the other groups received hypercholesterolemic diet supplemented with 10%, 20% CaPP for six weeks. The obtained results revealed that groups supplemented with 10% and 20% CaPP significantly decrease total lipid, total cholesterol, triglycerides, low density lipoprotein cholesterol, liver enzymes: alanine aminotransferase, aspartate aminotransferase compared to positive and negative groups. Organs weight, body weight gain significantly decreased compared with positive control. Moreover dietary carrot pomace powder can used to reduce the body weight and reducing hypercholesterolemic complications. In addition, dietary carrot pomace powder serves to improve the blood picture and to reduce the blood glucose level in hypercholesterolemic rats and could use in obese people for body loss. Data of kidney function (Urea) record an increase in CaPP 20% level (26.9±2.96) but this increase was non significant with the negative control group (26.6±3.1).

scholarly journals The Effect of Ag Nanoparticles and Multimicrobial Preparation as Factors Stabilizing the Microbiological Homeostasis of Feed Tables for Cornu aspersum (Müller) Snails on Snail Growth and Quality Parameters of Carcasses and Shells

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2260
Author(s):  
Andrzej Łozicki ◽  
Tomasz Niemiec ◽  
Robert Pietrasik ◽  
Sylwester Pawęta ◽  
Anna Rygało-Galewska ◽  
...  
Keyword(s):  
Body Weight ◽  
Ag Nanoparticles ◽  
Thiobarbituric Acid ◽  
Quality Parameters ◽  
The Body ◽  
Control Group ◽  
Shell Size ◽  
Effective Microorganisms ◽  
Cornu Aspersum

The aim of this research was to evaluate the effect of Ag nanoparticles (nano-Ag) used in the paint covering feed tables or a multimicrobial preparation applied to feed tables on the microbiological composition of the feed table environment, the growth and mortality of snails, and selected parameters for assessing the quality of carcasses and snail shells. The research was carried out in a farm of Cornu aspersum (Müller) snails. In the control (K) group, paint without nano-Ag was used. In two other groups (N-Ag and N-Ag + effective microorganisms (EM)), the feed tables were covered with the same paint as in the control group but with the addition of 100 mg/L of nano-Ag it (N-Ag group). Additionally, multimicrobial preparation (EM Bokashi®) at a concentration of 10% was spread on the tables in the N-Ag + EM group. In the last group (EM), the feed tables were covered with paint without nano-Ag, and only multimicrobial preparation was applied at a concentration of 10%. During the tests, the body weight of snails was measured three times, and swab samples were taken from the feed tables for the examination of microbiological composition. At the end of the experiment, the snails were killed, and the weight of the carcass and the size of the shell were measured. The content of Ag and the degree of lipid oxidation (thiobarbituric acid reactive substances (TBARS)) in the carcasses were analyzed, and the content of Ca and the crushing strength of the shells were determined. In the N-Ag and N-Ag + EM groups, a significant reduction in the total number of bacteria, fecal streptococci, and Escherichia coli was found, while there was also a reduction in mold and fungi in the N-Ag + EM and EM groups. In the K and EM groups, the mortality of animals was higher than in the nano-Ag groups. In subsequent weight checks, the highest body weight was found in the EM group and the lowest in the N-Ag and N-Ag + EM groups. In addition, the carcass weight and shell size in the N-Ag group was significantly lower compared to the K and EM groups. In the N-Ag and N-Ag + EM groups, a higher Ag content in the carcasses and a greater degree of lipid peroxidation were found. The Ca content of the shells was the highest in the N-Ag group, and the hardness of shells was the highest in the N-Ag and N-Ag + EM groups.

scholarly journals Pengaruh Pemijatan terhadap Pertumbuhan dan Perkembangan Bayi Umur 3 – 4 Bulan di Wilayah Kerja Puskesmas Kanjilo Kecamatan Barombong Kabupaten Gowa

2019 ◽  
Vol 1 (1) ◽  
pp. 1-14
Author(s):  
Anna Sari Dewi
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Research Result ◽  
The Body ◽  
Rank Test ◽  
Control Group ◽  
Significance Level ◽  
Development Indicator ◽  
And Control

The research aimed at investigating whether there was the massage effect on the growth and development of the infants of 3 – 4 months old in the working area of PHC Kanjilo, Barombong District, Gowa Regency.  This was a quasy experiment research with the pretest-posttest method on the treatment and control groups. Sample consisted of 38 subjects who were selected by the purposive sampling technique. The samples were divided into 2 group, namely the treatment group ( n=19) and control group (n=19) by matching the same age and sex in the two groups. The variables measured were the body weight gain, height gain, development indicator change. The research used the statistic test of Wilcoxon signed rank test, Mann Whitney U test, McNemar test with the  significance level of 0.05. The research result indicates that after the massage has been carried out for 30 days, there is the significant change particularly on the body weight gain variable with the  value of p = 0,008 (<0.05) and the development indicator change variable with the value of p = 0.05.  While for the height, the change is not significant between the infants who are given the massage and are not given the massage with the value of p = 0,091 (> 0.05), likewise, the development indicator change is not significant on the infants who are not massaged (p=0,317).

scholarly journals Effect of dietary stevia-based sweetener on body weight and humoral immune response of broiler chickens

2021 ◽  
Vol 14 (4) ◽  
pp. 913-917
Author(s):  
Ramón Miguel Molina-Barrios ◽  
Cielo Rubí Avilés-Trejo ◽  
María Esthela Puentes-Mercado ◽  
Jesús Raymundo Cedillo-Cobián ◽  
Juan Francisco Hernández-Chavez
Keyword(s):  
Immune Response ◽  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Steviol Glycosides ◽  
Infectious Bronchitis

Background and Aim: Steviol glycosides extracted from the leaves of Stevia rebaudiana Bertoni have been of much consideration recently because of their beneficial effects on health, raising the possibilities for improving farm animals' health. Although some studies on stevia's dietary effect on body weight gain are available, few studies have been conducted to evaluate stevioside supplementation on immune response in broilers. This experiment aimed to analyze how a stevia-based sweetener can affect broiler chickens' growth performance and humoral response. Materials and Methods: In this experiment, one hundred and twenty 1-day-old Cobb-line broiler chicks fed with commercial starter/grower diets were included in three groups and supplemented with stevia-based sweetener at levels 0, 80, and 160 ppm, respectively. Chickens were weighed on day 0 and every 7 days for the next 6 weeks. Chicks were then immunized on days 10 and 24 with a Newcastle and infectious bronchitis vaccine and blood sampled on days 7, 24, and 35. Serologic assays were performed to detect specific antibody levels. Results: The body weight means and body weight gain on day 42 were found to be significantly higher in birds from the group fed with 80 ppm of stevia-based sweetener than those in the control group and slightly higher than those in the group supplemented with 160 ppm of stevia-based sweetener. Likewise, on day 35, antibodies against the Newcastle disease virus were higher in the treatment groups. Immune response to infectious bronchitis virus vaccination was not statistically different among the three groups through the experiment. Conclusion: Stevia-based sweetener at 80 ppm in commercial-based diets improved body weight gain and immune response in broiler chickens at the market age.

Selection, characterisation and evaluation of potential probiotic Lactobacillus spp. isolated from poultry droppings

2016 ◽  
Vol 7 (1) ◽  
pp. 35-44 ◽  
Author(s):  
S. Asghar ◽  
M. Arif ◽  
M. Nawaz ◽  
K. Muhammad ◽  
M.A. Ali ◽  
...  
Keyword(s):  
Immune Response ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Negative Control ◽  
The Body ◽  
Control Group ◽  
Rrna Gene ◽  
Poultry Droppings

Aim of the present study was to characterise and evaluate probiotic potential of lactobacilli isolated from indigenous poultry. Lactobacilli were isolated from poultry droppings and identified by genus specific polymerase chain reaction and 16S rRNA gene sequencing. Isolates were characterised in vitro by their ability to tolerate low pH and bile salts, phytase activity, antimicrobial activity, antibiotic susceptibility profile, and autoaggregation and coaggregation with poultry gut pathogens. In vivo evaluation of selected isolates was done by their effect on the body weight gain and immune response of broiler chicks. Total of 90, one-day old chicks, were randomly divided in 9 groups and given selected lactobacilli alone and in combinations (108 cfu/bird, daily) from day 7 to day 35. Body weight gain and humoral immune response to New Castle Disease Virus (NDV) vaccine were determined weekly. Three lactobacilli isolates (SMP52, SMP64 and SMP70) were selected as potentially probiotic bacteria on the basis of in vitro characterisation and identified as Lactobacillus crispatus, Lactobacillus casei and L. crispatus, respectively. Chicks supplemented with ‘SMP52’, ‘SMP64’, ‘SMP70’ and ‘SMP64+SMP70’ and a commercial probiotic product (Protexin) showed significantly higher mean weight gain per bird (1,584±35.2, 1,629±30.6, 1,668±34.7, 1,619±29.5 and 1,576±31.7 g/bird, respectively) as compared to negative control group (1,394±26.7 g/bird), on day 35. SMP 70 also showed significantly higher geometric mean titre against NDV vaccine at day 21 as compared to negative control. It is concluded that L. crispatus SMP52, L. casei SMP64 and L. crispatus SMP70 are potential probiotic candidates which alone or in different combinations may increase body weight of broilers.

scholarly journals Effects of Phytase Supplementation to Diets with or without Zinc Addition on Growth Performance and Zinc Utilization of White Pekin Ducks

Animals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 280 ◽  
Author(s):  
Youssef A. Attia ◽  
Nicola F. Addeo ◽  
Abd Al-Hamid E. Abd Al-Hamid ◽  
Fulvia Bovera
Keyword(s):  
Body Weight ◽  
Feed Intake ◽  
Raw Materials ◽  
Body Weight Gain ◽  
Basal Diet ◽  
The Body ◽  
Control Group ◽  
Feed Conversion ◽  
Pekin Ducks ◽  
Feed Digestibility

The effect of phytase and inorganic Zn supplementation was studied in 180 male White Pekin ducks (WPD) from 1 to 56 days of age. The birds were divided into four groups fed the same basal diet (containing 26 ppm of Zn from raw materials): the control group did not receive Zn supplementation; the second group was supplemented with 30 ppm of Zn oxide; and the third and fourth groups were fed the control and the 30 ppm diets, respectively, both supplemented with 500 U of E. coli phytase. Each group contained five replicates of nine ducks. The body weight and feed intake were recorded at 1, 28 and 56 days of age. At 56 days of age, five birds/group were used to measure feed digestibility and five other birds/group were slaughtered. Zn at 30 ppm increased the body weight gain (BWG, p < 0.01) and feed intake (p < 0.05) and improved the feed conversion (FCR, p < 0.05) of the growing ducks. The Zn retention and Zn level in the excreta increased (p < 0.01) due to Zn supplementation. The addition of phytase improved BWG (p < 0.01) and FCR (p < 0.05) of growing ducks. The use of phytase reduced (p < 0.01) the level of Zn in duck excreta. Phytase supplementation to the basal diet at 30 ppm seems to be adequate to meet Zn requirements for ducks without further Zn additions.

scholarly journals The Effects of Using Synthetic and Natural Color Foods on Lipid Profile and Liver Function in Rats

2019 ◽  
Vol 11 (4) ◽  
pp. 363-367
Author(s):  
Emam ABDEL-RAHIM ◽  
Hossam S. EL-BELTAGI ◽  
Rehab F.M. ALI ◽  
Abeer A. AMER ◽  
Somia M. MOUSA
Keyword(s):  
Body Weight ◽  
Feed Efficiency ◽  
Body Weight Gain ◽  
Total Cholesterol Level ◽  
The Body ◽  
Control Group ◽  
Average Weight ◽  
Natural Color ◽  
Acclimation Period ◽  
Food Dyes

Today synthetic food dyes are being used most commonly as food colorant in confectionaries for children. Present study was designed to evaluate effect of tartrazine and chocolate brown as a synthetic color and turmeric, cocoa as a natural color on Swiss albino mice. The rats have been fed on color biscuits and after the acclimation period, rats were divided into 7 groups (5 rats each one). Rats treated with dose level 7.5 mg/kg /day (ADI) in tartrazine and turmeric and 0.15 mg/kg /day (ADI) in chocolate brown and cocoa. The study revealed a highly noticeable decrease in the body weight gain, food intake and feed efficiency in synthetic color of mice compared to the control group, the mixture improvement this effects and non-significant with natural color. A significant increase in the average weight of the major organs liver, spleen, heart, pancreas and kidney of the mice has been increased significantly in synthetic color treated groups with tartrazine and chocolate brown. Total cholesterol level, T-lipid, LDL and vLDL were no significant change in all mice administration color foods, but significant increase in T.G with tartrazine and chocolate brown and has significant decrease in HDL-C with tartrazine and chocolate brown. There was a significant increase in the level of ALT, AST and ALP with tartrazine and chocolate brown while compared to control group. The mixture synthetic and natural color improved the results. Bilirubin levels were significantly increased with tartrazine and chocolate brown.

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