scholarly journals Hubungan Durasi Paparan Gelombang Elektromagnetik Telepon Seluler Terhadap Kadar Melatonin Pada Tikus Putih (Rattus norvegicus) Galur Wistar

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Irrayanti Putri ◽  
Harliansyah Harliansyah
Keyword(s):  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Side Effect ◽  
Exposure Duration ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Albino Rats ◽  
Dark Control ◽  
Wistar Albino Rats

Background : Mobile Phone (MP) is a wireless communication tools that nowadays used by people with many features that can ease the user. Cellphone is releasing electromagnetic radiation that can causes side effect for the user itself, one example of the side effect is disturbing the melatonin hormone synthesis that can cause the abnormal sirkadian body rythm, so the sleep patterns are disrupted, causing insomnia, islam is teaching us to keep our health, for example is to keep the rythm of our bedtime regularly. Objective : Knowing the relation between exposure duration of mobile phone electromagnetic radiation to melatonin level of Wistar albino rats observed by medicine and islam perspectives. Methods : This study was experimental study, total sample was determined by frederer theory and analyzed using IBM SPSS Statistic 21 for Windows. Results : The results showed that melatonin levels in the positive control group (dark control group) 13,705 ± 0,500 were compared with the group which exposed for 3 hours 13,375 ± 0,654 with (p=0,299) and in the positive control group (dark control group) 13,705 ± 0,500 compared with the group which exposed for 6 hours 13,223 ± 0,529 with (p=0,116). Conclusions : There is no significant relation between exposure duration of mobile phone electromagnetic radiation to melatonin levels in Wistar albino rats.

Prevention of mobile phone induced skin tissue changes by melatonin in rat: an experimental study

2004 ◽  
Vol 20 (6-10) ◽  
pp. 133-139 ◽  
Author(s):  
Fehmi Ozguner ◽  
Gulsen Aydin ◽  
Hakan Mollaoglu ◽  
Osman Gökalp ◽  
Ahmet Koyu ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Mobile Phones ◽  
Tap Water ◽  
Granular Cell ◽  
Control Group ◽  
Albino Rats ◽  
Melatonin Treatment ◽  
Skin Changes ◽  
Histopathologic Changes ◽  
Wistar Albino Rats

Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of melatonin (Mel) on any of these changes. Thirty male Wistar-Albino rats were used in the study. The experimental groups were composed of: a nontreated control group, an irradiated group (IR) without Mel and an irradiated with Mel treatment group (IR + Mel). 900 MHz radiation was applied to IR group for 10 days (30 min/day). The IR + Mel group received 10 mg/kg per day melatonin in tap water for 10 days before irradiation. At the end of the tenth day, the skin graft was excized from the thoraco-abdominal area. Histopathologic changes in skin were analyzed. In the IR group, increased thickness of stratum corneum, atrophy of epidermis, papillamatosis, basal cell proliferation, increased granular cell layer (hypergranulosis) in epidermis and capillary proliferation, impairment in collagen tissue distribution and separation of collagen bundles in dermis were all observed compared to the control group. Most of these changes, except hypergranulosis, were prevented with melatonin treatment. In conclusion, exposure to 900 MHz radiation emitted by mobile phones caused mild skin changes. Furthermore, melatonin treatment can reduce these changes and may have a beneficial effect to prevent 900 MHz mobile phone-induced rat skin changes.

scholarly journals Effects of Aqueous Extract of Vigna unguiculata Seedlings Against Doxorubicin-Induced Cardiotoxicity and Kidney damage In Female Albino Rats

2016 ◽  
Vol 1 (04) ◽  
Author(s):  
Olatunde A. Oseni ◽  
Ademola S. K. Idowu ◽  
Aminat Isah
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Vigna Unguiculata ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Albino Rats ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Enzyme Markers

Doxorubicin is an anthracycline drug which is believed to cause immediate damage to myocardial cells by free radical generation in the cause of treatment of cancer. This study was however aimed to investigate the effects of the aqueous extract of the seedlings of Vigna unguiculata on heart, kidney as well as lipid profile disorders caused by this drug on female Wistar albino rats. Fifteen female Wistar albino rats were divided into three groups. Group 1 animals served as normal positive control; Group 2 animals served as negative control which were treated with 0.5mL of (20mg/kg body weight doxorubicin) while Group 3 animals were treated with 0.5mL each of 20mg/kg body weight doxorubicin and 10% aqueous extract of seedlings of Vigna unguiculata. Some enzyme markers and lipid contents were determined. The results of the study showed an increase in the activities of plasma ALP and AST after treatment with the drug except in the heart for AST which showed a significant reduction, while treatment with the extract brought about a decrease in the plasma and the organs except for kidney AST. The ALT on the other hand showed slight increase in the plasma with a decrease in the kidney and heart after treatment with the drug as the treatment with the extract tend to restore it to the control in both cases, there was increased plasma and kidney but reduced heart HDL-C after treatment with the drug which was observed to be restored to control after treatment with extract in both situations. The triglyceride and total cholesterol did not show similar trend in the plasma and the studied organs. The LDL-C was also observed to be increased in both plasma and organs after the treatment with the drug which later reduced significantly towards the control after the administration of the sprout extract. The present study has shown that the doxorubicin has damaging effects on both kidney and heart tissues while the sprouts extract produce a restoration to the normal in both organs.

scholarly journals Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5821
Author(s):  
Ali H. Abu Almaaty ◽  
Yasmin M. Abd El-Aziz ◽  
Nahed A. Omar ◽  
Ahmed M. Abdeen ◽  
Hala Afifi ◽  
...  
Keyword(s):  
Low Dose ◽  
Antioxidant Properties ◽  
Treated Group ◽  
Positive Control ◽  
Positive Control Group ◽  
Aluminum Silicate ◽  
Control Group ◽  
Albino Rats ◽  
High Dose ◽  
Propolis Extract

In this study, we evaluated the inflammatory responses induced by aluminum silicate (AS) cytotoxicity in rat lungs. The prophylactic effect of propolis extract was evaluated in 60 adult male albino rats. The rats were divided into six groups: (1) a normal, healthy control group; (2) a normal group fed with 200 mL of propolis extract/Kg; (3) a low-dose positive control group injected with 5 mg/kg of AS; (4) a treated group given propolis and a low dose of AS; (5) a high-dose positive control group injected with 20 mg/kg of AS; and (6) a treated group given propolis with a high-dose of AS. At the end of the two-month experiment, the rats’ lungs were removed. For each pair of lungs, one portion was subjected to biochemical analysis and the other underwent hematoxylin and eosin (H&E) staining in order to study its histology. The rats that received AS doses displayed significant disorders in their antioxidant contents as well as in their enzymatic activities and their histopathological structures revealed severe damage to their lung tissues. Upon the rats being treated with propolis, the enzymatic and antioxidant contents improved and partial improvements in the lung structures appeared, including minimized congestion, a reduced hemorrhage of blood vessels and preserved bronchioles, alveolar ducts, and alveoli. The prophylactic effectiveness of propolis extract on the cytotoxicity of AS, owing to the antioxidant properties of propolis, were studied.

HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS ESSENTIAL OILS AGAINST NEVIRAPINE-INDUCED HEPATIC DAMAGE IN WISTAR ALBINO RATS

2018 ◽  
Vol 15 (4) ◽  
pp. 64
Author(s):  
Marion Amujal ◽  
Kokas Ikwap ◽  
Andrew Tamale ◽  
Gabriel Tumwine ◽  
John Kateregga ◽  
...  
Keyword(s):  
Essential Oils ◽  
Scientific Evidence ◽  
Hiv Infections ◽  
Positive Control ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Albino Rats ◽  
Cymbopogon Citratus ◽  
Plant Materials ◽  
Wistar Albino Rats

Background: The use of nevirapine in the management of Human Immunodeficiency Virus (HIV) infections is greatly limited by its fatal hepatotoxicity. In sub-Saharan African, traditional medicine involving use of plant materials has been proposed to counteract liver damage, albeit with no scientific evidence. The aim of the present study was to determine the hepatoprotective effect of Cymbopogon citratus essential oils against nevirapine induced hepatic oxidative damage in Wistar albino rats. Materials and Methods: Five groups of rats received a daily oral dose of 36mg/kg nevirapine for 4 consecutive weeks. After 15 minutes, rats in three of the groups were given 200mg/kg, 400mg/kg and 800mg/kg of Cymbopogon citratus essential oil extract. The positive control group received nevirapine and 200mg/kg of silymarin while the normal control group received only 2ml of distilled water. Blood was used to determine the levels of liver function parameters and liver sections were used for histological studies. Results: The results revealed that oral administration of nevirapine (36mg/kg b.w. p.o) for 4 weeks significantly (P

Effects of Rosemary and husk on hemogram and some biochemical parameters during treatment of ulcerative colitis in rats

2019 ◽  
Vol 20 (1) ◽  
pp. 57-61
Author(s):  
Magdy Amer
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Biochemical Parameters ◽  
Blood Platelets ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Albino Rats ◽  
Serum Samples

Objective: The effects of rosemary (10 mg/kg B.W) and husk (5 mg/kg B.W) on hemogram, GSH , CAT , NO, IL-1β and IL-10 of rats (40 albino rats) were investigated Design:Experimental study Animals: 40 albino rats Procedures: The 1st group was served as negative control, while the remaening groups (2nd, 3rd and 4th) were given acetic acid (4%) to induce ulcerative colitis (UC). Then the 2nd group was used as positive control, the 3rd group was orally given rosemary daily for 7 days, while the 4th group was orally administerated husk daily for 7 days. Blood and serum samples were collected from all groups at one week post dosing Results: The obtained results revealed that, both the tested plants induced a significant increase in RBCs, Hb, PCV% and lymphocyte counts and a significant decrease in WBC, neutrophil, monocyte and blood platelets of treated rats compared with the positive control group. Conclusion and clinical relevance: In addition rosemary and husk evoked a significant increase in GSH, CAT and IL-10 and a significant decrease in NO and IL-1β in serum of treated rats in comparions with the positive control group.

scholarly journals Evaluation of Protective Properties of Elaeis oleifera Fruit Extract on Renal Parameters of Dichlorvos-Induced Nephrotoxocity in Albino Rats

2020 ◽  
pp. 1-13
Author(s):  
Edna Ogechi Nwachuku ◽  
Fedelis Beega ◽  
Adline Erinma Ben- Chioma ◽  
Ngozi Brisibe ◽  
Ibioku Elekima
Keyword(s):  
Treatment Group ◽  
Palm Oil ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Albino Rats ◽  
Study Group ◽  
Acute Study

Aim: Evaluate the protective effects of palm oil on renal parameters after dichlorvos toxicity in albino rats. Study Design and Methodology: The study consisted of 3 phases: The acute study which lasted for 24 hours, the sub-acute study which lasted for 14 days and the sub chronic study which lasted for 30 days. The design and treatment pattern is shown below. Phase 1: Acute Study. Group 1: No DDVP, No palm oil for 24 hours (Negative control), Group 2: 30 mg/kg of DDVP without palm oil (positive control), Group 3: 30 mg/kg of DDVP and 100 mg/kg palm oil for 24 hours (treatment group). Phase 2: Sub-Acute (14 days) Study. Group 4: No DDVP, No palm oil for 14 days (Negative control), Group 5: 10 mg/kg of DDVP without palm oil daily for 14 days (positive control), Group 6: 10 mg/kg of DDVP and 100 mg/kg of palm oil daily for 14 days (positive control). Phase 3: Sub-Chronic (30 days) Study. Group 7: No DDVP, No palm oil for 30 days (Negative control), Group 8: 10 mg/kg of DDVP without palm oil daily for 30 days (positive control), Group 9: 10 mg/kg of DDVP and 100 mg/kg palm oil daily for 30 days (treatment group). All administration was done orally. After the period of treatments, the rats were sacrificed after 18 hours of fast. Whole blood samples (5 mls) were collected into lithium heparin bottle and spun at 3500 rpm for 5 minutes to obtain plasma samples. Samples obtained were used for the determination of Na+, K+, HCO3, urea, and creatinine while renal tissues obtained were used for histopathological examinations. Results: Significantly higher values were seen in urea in the dichlorvos treated rats over a period of 24 hours, 14 days, and 30 days as compared to rats co-treated with palm oil and the control. Creatinine indicated significantly higher over a period of 24 hours while non-significant increases were observed in the dichlorvos treated rats over a period of 14 days and 30 days. More so, significantly higher values were seen in potassium in the dichlorvos treated rats over a period of 24 hours and 14 days, while significantly higher values in potassium were seen after period of 30 days as compared to rats co-treated with palm oil and the control. Sodium and chloride did not indicate significant difference over the period of 24 hours, 14 days, and 30 days. Histological examination of the renal tissue indicated structural distortions dichlorvos treated rats over a period of 24 hours, 14 days and 30 days while significant improvements in the structural integrity of the kidney were observed in rats co-treated with palm oil. Conclusion: Results obtained indicated that palm oil showed a protective effect in ameliorating the nephrotoxicity induced by dichlorvos as shown by the histological examination and decreased values of creatinine and urea as well as potassium in palm oil treated rats.

Effect of Propolis-Supplemented Diet on Body Composition and Endocrine Function of Adipose Tissue

2020 ◽  
Vol 19 (2) ◽  
pp. 217-221
Author(s):  
Maria Jesús Lisbona-González ◽  
Candela Reyes-Botella ◽  
Esther Muñoz-Soto ◽  
Maria Victoria Olmedo-Gaya, ◽  
Jorge Moreno-Fernandez ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Adipose Tissue ◽  
Endocrine Function ◽  
Control Group ◽  
Albino Rats ◽  
Standard Diet ◽  
Reduced Body ◽  
Esterified Fatty Acids ◽  
Wistar Albino Rats

Adipose tissue is an endocrine organ and has central role in interaction with other organs or tissues while propolis can induce lipolysis. Therefore, the aim of this study is to provide detailed information about adipose tissue homeostasis modifications and body composition during propolis supplement consumption. Twenty male Wistar albino rats (8 weeks) were divided into two groups of 10 animals each and fed for 90 days with two different types of diets: standard for the control group (diet C) and standard diet + 2% propolis (diet P). Thyroid hormones did not show differences, while ghrelin and adiponectin decreased in the group that was fed propolis. Insulin, leptin, and non-esterified fatty acids also increased along with reduced body weight and fat, in addition to increased lean mass when propolis was in the diet. We conclude that propolis could decrease ghrelin and adiponectin but increase non-esterified fatty acids and insulin secretion, which improves body composition.

scholarly journals Resistance to Fracture of Dental Roots Obturated with Different Materials

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Berkan Celikten ◽  
Ceren Feriha Uzuntas ◽  
Kamran Gulsahi
Keyword(s):  
Fracture Resistance ◽  
Testing Machine ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Root Canal Filling ◽  
Filling Materials ◽  
Group 2

The aim of this study was to compare the vertical fracture resistance of roots obturated with different root canal filling materials and sealers. Crowns of 55 extracted mandibular premolar teeth were removed to provide root lengths of 13 mm. Five roots were saved as negative control group (canals unprepared and unfilled). Fifty root canals were instrumented and then five roots were saved as positive control group (canals prepared but unfilled). The remaining 45 roots were randomly divided into three experimental groups (n=15root/group) and obturated with the following procedures: in group 1, glass ionomer-based sealer and cone (ActiV GP obturation system); in group 2, bioceramic sealer and cone (EndoSequence BC obturation system); and in group 3, roots were filled with bioceramic sealer and cone (Smartpaste bio obturation system). All specimens were tested in a universal testing machine for measuring fracture resistance. For each root, the force at the time of fracture was recorded in Newtons. The statistical analysis was performed by using Kruskal-Wallis and post hoc test. There were no significant differences between the three experimental groups. The fracture values of three experimental and negative control groups were significantly higher than the positive control group. Within the limitations of this study, all materials increased the fracture resistance of instrumented roots.

scholarly journals Antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Arvind Kumar Srivastava ◽  
Alok Mukerjee ◽  
Abhishek Tripathi
Keyword(s):  
Blood Glucose ◽  
Cucumis Melo ◽  
Biological Properties ◽  
Positive Control ◽  
Positive Control Group ◽  
Public Health Issue ◽  
Control Group ◽  
Fruit Extract ◽  
Experimental Animals ◽  
Glucose Levels

Abstract Background Diabetes mellitus is a major public health issue related to the irregular metabolism of carbohydrates, protein, and fat. It occurs due to insufficient insulin production and insulin action. Cucumis melo possesses several biological properties including antioxidant, anti-inflammatory, antibacterial, antihypothyroidism, and antiangiogenic activities. The objective of the present study was to determine the antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals. Result Results show that treatment with C. melo fruit extract and fraction caused a reduction in blood glucose levels. Cucumis melo toluene fraction (CMTF) exhibited a significant (*P < 0.05) reduction of blood glucose level on the 28th day, i.e., 122 mg/dL, in comparison with the positive control group (streptozotocin (STZ)). However, the extract of C. melo showed less significant results in comparison with CMTF. Triglyceride, LDL, and VLDL levels were increased chronically due to STZ and were significantly (*P < 0.05) restored to 84.16, 86.97, and 19.73, respectively, by CMTF in comparison with the positive control group (STZ in the dose of 55 mg/kg). The extract-treated groups also showed similar results as CMTF, but their efficacy was lesser than CMTF. Conclusion It is can be concluded that C. melo fruits can be used as an effective antidiabetic and antihyperlipidemic drug. Graphical abstract

Protective effect of Saccharomyces cerevisiae in Rattus norvegicus Ischemic Stroke Model

2021 ◽  
pp. 5785-5789
Author(s):  
Dedy Budi Kurniawan ◽  
Mokhamad Fahmi Rizki Syaban ◽  
Arinal Mufidah ◽  
Muhammad Unzila Rafsi Zulfikri ◽  
Wibi Riawan
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ischemic Stroke ◽  
Brain Tissue ◽  
Tissue Injury ◽  
Intervention Group ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Hematopoietic Stem ◽  
The Brain

Stroke is one of the leading causes of morbidity and mortality in all ages. Ischemic stroke activates excitotoxic glutamate cascade leading to brain tissue injury. Saccharomyces cerevisiae is a unicellular yeast widely found in nature. S. cerevisiae is neuroprotective and able to increase the differentiation of hematopoietic stem cells (HSCs) into neuronal cells. it may increase levels of neuroprotectant BDNF in the brain tissue, therefore increase the protection of neurons. BDNF may prevent glutamate-driven excitotoxicity by reducing glutamate levels. This study uses a randomized post-test only controlled group design. In this in vivo study, rodent models of ischemic stroke were divided into five groups comprising of the negative control group, positive control group, intervention group 1 (18mg/kgBW), intervention group 2 (36mg/kgBW) and intervention group 3 (72 mg/kgBW). Groups treated with Saccharomyces cerevisiae extract showed significantly increased BDNF levels in the brain tissue, and the expression of the glutamate level was significantly reduced (P <0.05) compared to the positive control group. Thus Saccharomyces cerevisiae has a promising potential to become a therapy against ischemic stroke disease. however further research is needed regarding the efficacy and toxicity of Saccharomyces cerevisiae.

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