Immune properties of lactoferrin and its protective role in new coronavirus infection COVID-19

2021 ◽  
pp. 22-26
Author(s):  
S. V. Orlova ◽  
E. A. Nikitina ◽  
E. V. Prokopenko ◽  
L. Yu. Volkova ◽  
A. N. Vodolazkaya
Keyword(s):  
Humoral Immunity ◽  
Acute Phase Protein ◽  
Clinical Manifestations ◽  
Protective Role ◽  
Viral Diseases ◽  
The Novel ◽  
Phase Protein ◽  
Nasal Secretions ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Thousands of studies have been conducted to study the new SARS-CoV-2 coronavirus, its infectious properties, transmission routes and all associated with the clinical manifestations and severity of COVID-19, especially with potential treatments. Lactoferrin is a member of the transferrin family, which is synthesized by epithelial cells of mammalian internal glands and is widely present in various secretory fluids such as milk, saliva, tears, and nasal secretions. Lactoferrin is one of the components of the innate humoral immunity, regulates the functions of immunocompetent cells and is a acute phase protein. Lactoferrin has strong antioxidant and anti-inflammatory properties. This review assesses the possibility of using lactoferrin as a supplement in immunocorrective therapy programs for viral diseases, including the novel coronavirus infection COVID-19.

FEATURES OF THE COURSE AND TACTICS OF MANAGING CHILDREN WITH KIDNEYS AND URINARY TRACT DISEASES DURING THE PANDEMIC OF NEW CORONAVIRUS INFECTION COVID-19

2021 ◽  
Vol 100 (4) ◽  
pp. 74-79
Author(s):  
I.M. Kagantsov ◽  
◽  
V.V. Sizonov ◽  
V.G. Svarich ◽  
K.P. Piskunov ◽  
...  
Keyword(s):  
Age Groups ◽  
Clinical Manifestations ◽  
Routine Care ◽  
The Novel ◽  
Urinary System ◽  
Death Rates ◽  
Global Pandemic ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Significant Health

The novel coronavirus infection (SARS-CoV-2), which first appeared in Wuhan, China in December 2019, has been declared a global pandemic by WHO. COVID-19 affects people of all age groups. The disease in children is usually asymptomatic or mild compared to adults, and with a significantly lower death rates. Data on kidney damage in children with COVID-19, as well as the effect of coronavirus infection on the course of diseases of the genitourinary system, are limited, the risks of contracting a new coronavirus infection in children with significant health problems, including those with chronic kidney disease, remain uncertain. The pandemic has affected the activities of surgeons treating diseases of the urinary system in children. Since the prospects for the end of the pandemic are vague, it is necessary to formulate criteria for selecting patients who can and should be provided with routine care in the pandemic. The purpose of this review is to highlight the features of the clinical manifestations and treatment of children with COVID-19, occurring against the background of previous renal pathology or complicating its course.

scholarly journals Diagnosis and treatment of acute coronary syndrome during the novel coronavirus infection COVID-19 pandemic

2020 ◽  
Vol 25 (4) ◽  
pp. 3854
Author(s):  
A. M. Namitokov ◽  
O. P. Ishevskaya ◽  
V. I. Fetisova ◽  
E. D. Kosmacheva ◽  
V. A. Porkhanov
Keyword(s):  
Acute Coronary Syndrome ◽  
Clinical Manifestations ◽  
The Novel ◽  
Therapeutic Approaches ◽  
Susceptible Population ◽  
Coronary Syndrome ◽  
Cardiovascular Patients ◽  
Coronavirus Infection ◽  
Artery Disease ◽  
Novel Coronavirus

The novel coronavirus infection COVID-19 pandemic has spread to more than 180 countries. Cardiovascular patients belong to one of the susceptible population cohorts. There is a peculiar pathogenesis and variety of clinical manifestations of COVID-19, as well as difficulties with early diagnosis. Other unresolved issues are routing, surgery and therapy of such patients and comorbidities. Due to absence of well-defined algorithms and guidelines, the treatment of patients with acute coronary syndrome (ACS) in different countries is carried out differently. Interactions between antiviral and coronary artery disease medications are also not completely clear. Based on the available data, the main organizational and therapeutic approaches for ACS during the COVID-19 pandemic are reflected.

Analysis of the clinical manifestations of cerebral stroke in patients with the novel coronavirus infection (COVID-19)

2020 ◽  
pp. 30-45
Author(s):  
Vladislav V. Andreev ◽  
Alexander Y. Podunov ◽  
Daniil S. Lapin ◽  
Zarema L. Gilyaeva ◽  
Ekaterina N. Nikiforova ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Hemorrhagic Stroke ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Cerebral Stroke ◽  
The Novel ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Objective: To improve the diagnosis and treatment of acute cerebrovascular accident in patients with community-acquired pneumonia caused by the novel coronavirus infection (COVID-19). Materials and methods: For the first time, clinical manifestations of strokes in patients with diagnosed new coronavirus infection (COVID-19) were analyzed in 130 patients. The study was conducted in two groups. The main group consisted of 69,2 % (n = 90) with a clinical and instrumental diagnosis: novel coronavirus infection in combination with stroke. The control group (30,8 %; n = 40) included the cases of ischemic and hemorrhagic stroke without signs of SARS-CoV-2. In both groups, the severity of the disease and pathogenetic subtypes were compared, and the features of the laboratory biochemical data were studied. Statistical analysis of the outcomes was carried out taking into account the severity of brain and lung tissue damage. Results: In patients with cerebral stroke against the background of the new coronavirus infection (COVID-19), the prevalence of ischemic stroke cases (86,4 %) was noted for undetermined (41,4 %) and cardioembolic (35,7 %) pathogenetic subtypes (according to TOAST) with localization in the carotid basin (89,7 %). In hemorrhagic stroke, parenchymal hemorrhage was observed with a greater frequency (54,5 %). The severity of the diagnosed strokes according to the NIHSS scale was up to 13,16 (8,80) points with less severe brain damage — Glasgow coma scale (14,0 (12,0 15,0). In the group of the patients, a widespread lesion of the lung tissue was diagnosed in 82,2 % of cases. No significant increase in the incidence of clinically significant manifestations of systemic and organ hypercoagulation was established. Conclusions: In stroke patients with COVID-19, ischemic manifestations with undetermined and cardioembolic subtypes without age and gender features prevail, with no differences in the severity of the course and a large number of favorable outcomes. A high activity of inflammatory and infectious changes was established by clinical laboratory.

scholarly journals The Coronavirus Disease 2019 (COVID-19): A Review

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Sheikh Salahuddin Ahmed
Keyword(s):  
Clinical Manifestations ◽  
Severe Illness ◽  
The Novel ◽  
Full Spectrum ◽  
Pcr Method ◽  
Coronavirus Infection ◽  
Novel Virus ◽  
Clinical Illness ◽  
Novel Coronavirus ◽  
Supportive Management

Many details of the emergence of 2019 novel coronavirus infection such as its origin, spread, epidemiology, full spectrum of clinical illness, treatment and mortality rate has not been clearly defined. This review focuses the epidemiological evidences, clinical manifestations, investigations and treatment provided to the admitted cases of the 2019 novel coronavirus pneumonia in various hospitals of Wuhan city and other regions in China. Information have been gathered mainly from relevant researches and papers that were published recently. Clinical manifestations included fever, non-productive cough, dyspnoea, myalgia, fatigue, radiographic manifestations of pneumonia and detection of the novel virus by RT-PCR method. Some patients rapidly developed acute respiratory distress syndrome, acute respiratory failure, and other serious complications with fatal outcomes. There are neither vaccines nor effective treatments for the disease caused by the virus, but efforts are typically confined to symptomatic and supportive management. Antivirals and corticosteroids were used in severe illness but had no effective outcome.

scholarly journals Поражение пищеварительного тракта как проявление COVID-19 у ребенка 4 лет

Doctor Ru ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 56-59
Author(s):  
I.M. Osmanov ◽  
◽  
O.N. Solodovnikova ◽  
S.N. Borzakova ◽  
T.V. Sbrodova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Bacterial Infections ◽  
Clinical Manifestations ◽  
Enteric Infection ◽  
The Novel ◽  
Key Points ◽  
Enteric Infections ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Objective of the Paper: To represent a case of the novel coronavirus infection COVID-19 in a 4-year-old child with isolated bowel damage. Key Points. COVID-19 impacts several systems and organs. Usually, children have mild or asymptomatic disease. Clinical manifestations of COVID-19 in children can be damage not only of respiratory tract, but also of GIT, requiring differential diagnosis of enteric infections (both viral and bacterial). Prompt diagnosis of COVID-19 is essential for antiepidemic measures and suppression an infectious process. The case shows challenges faced by clinicians when diagnosing COVID-19 in patients with isolated GIT damages without catarrhal signs. Course of the disease in this patient was characterised by a number of features indicative of a bacterial enteric infection: abdominal pain, diarrhoea, increased CRP, colitis syndrome in stool test, warranting differential diagnosis of acute enteric bacterial infections. Negative bacterial culture, detection of SARS-CoV2 RNA in oropharynx and nasopharynx mucous, fast stool normalisation and dyspeptic events arrest allowed diagnosing that the diarrhoea was associated with COVID-19. One month of metabolic and probiotic therapy normalised stool, arrested abdominal pain, and improved exercise tolerance. Conclusion. GIT damage in paediatric COVID-19 patients is essential and unexplored. COVID-19 should be added to differential diagnosis in case of clinical manifestations of an acute enteric infection. Keywords: children, novel coronavirus infection, COVID-19, GIT.

A clinical case of the novel coronavirus (COVID-19) reinfection in a health care worker

2021 ◽  
Vol 27 (2) ◽  
pp. 195-200
Author(s):  
Irina V. Kovtyukh ◽  
Gennady E. Gendlin ◽  
Igor G. Nikitin ◽  
Ekaterina V. Kabirova ◽  
Olga Yu. Markina
Keyword(s):  
Health Care ◽  
Immune Responses ◽  
Health Care Worker ◽  
Humoral Immunity ◽  
Clinical Case ◽  
The Novel ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Care Worker

The peculiarities of immune responses to a novel coronavirus infection (COVID-19) and the possibility of reinfection due to the variability of humoral immunity are currently under discussion. This article presents a case of COVID-19 reinfection in a health care worker.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

High cytokine levels and cytokine storm in the novel coronavirus infection

2021 ◽  
pp. 38-47
Author(s):  
Maksim Leonidovich Maksimov ◽  
Albina Ayratovna Zvegintseva ◽  
Lyudmila Yurievna Kulagina ◽  
Albina Zainutdinovna Nigmedzyanova ◽  
Elvina Ramisovna Kadyseva
Keyword(s):  
Peripheral Blood ◽  
High Frequency ◽  
The Novel ◽  
Cytokine Storm ◽  
The Public ◽  
Systemic Inflammatory Reaction ◽  
Scientific World ◽  
Cytokine Levels ◽  
Coronavirus Infection ◽  
Novel Coronavirus

A review article is based on current foreign sources. The level of cytokines in the peripheral blood can be increased in many diseases, but in some cases there may be an excess of their normal concentration in tens, hundreds or more times with the development of a peculiar clinical picture, which is based on a systemic inflammatory reaction. In the literature this condition has received the figurative name «cytokine storm», which highlights an extremely violent reaction of the immune system with an unknown (often unfavorable) outcome. Close attention of the scientific world and the public to the problem of extremely high levels of cytokines in the peripheral blood (hypercytokinemia) was drawn due to the high frequency of the cytokine storm in the novel coronavirus infection.

The novel coronavirus infection (COVID-19) concurrent with pseudomembranous colitis in the early postpartum period: a clinical case

2021 ◽  
Vol 9_2021 ◽  
pp. 232-236
Author(s):  
Shklyaev A.E. Shklyaev A ◽  
Bessonov A.G. Bessonov A ◽  
Chushyalova D.A. Chushyalova D ◽  
Mikhailova M.D. Mikhailova M ◽  
Meleshkina M.V. Meleshkina M ◽  
...  
Keyword(s):  
Postpartum Period ◽  
Pseudomembranous Colitis ◽  
Clinical Case ◽  
The Novel ◽  
Early Postpartum Period ◽  
Early Postpartum ◽  
Coronavirus Infection ◽  
Novel Coronavirus
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