scholarly journals A Differential Signature of Circulating miRNAs and Cytokines Between COVID-19 and Community-Acquired Pneumonia Uncovers Novel Physiopathological Mechanisms of COVID-19

2022 ◽  
Vol 12 ◽  
Author(s):  
Pedro Martínez-Fleta ◽  
Paula Vera-Tomé ◽  
María Jiménez-Fernández ◽  
Silvia Requena ◽  
Emilia Roy-Vallejo ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Multivariate Analysis ◽  
Elderly Patients ◽  
Plasma Protein ◽  
Plasma Levels ◽  
Community Acquired Pneumonia ◽  
Circulating Mirnas ◽  
Life Threatening ◽  
Plasma Mirnas ◽  
Independent Cohort

Coronavirus Disease 2019 (COVID-19) pneumonia is a life-threatening infectious disease, especially for elderly patients with multiple comorbidities. Despite enormous efforts to understand its underlying etiopathogenic mechanisms, most of them remain elusive. In this study, we compared differential plasma miRNAs and cytokines profiles between COVID-19 and other community-acquired pneumonias (CAP). A first screening and subsequent validation assays in an independent cohort of patients revealed a signature of 15 dysregulated miRNAs between COVID-19 and CAP patients. Additionally, multivariate analysis displayed a combination of 4 miRNAs (miR-106b-5p, miR-221-3p, miR-25-3p and miR-30a-5p) that significantly discriminated between both pathologies. Search for targets of these miRNAs, combined with plasma protein measurements, identified a differential cytokine signature between COVID-19 and CAP that included EGFR, CXCL12 and IL-10. Significant differences were also detected in plasma levels of CXCL12, IL-17, TIMP-2 and IL-21R between mild and severe COVID-19 patients. These findings provide new insights into the etiopathological mechanisms underlying COVID-19.

scholarly journals Circulating miRNAs and Cytokines Uncover Novel Physiopathological Mechanisms of COVID-19

2021 ◽  
Author(s):  
Pedro Martínez-Fleta ◽  
Paula Vera-Tomé ◽  
María Jiménez-Fernández ◽  
Silvia Requena ◽  
Emilia Roy-Vallejo ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Multivariate Analysis ◽  
Elderly Patients ◽  
Plasma Protein ◽  
Plasma Levels ◽  
Circulating Mirnas ◽  
Life Threatening ◽  
Plasma Mirnas ◽  
Independent Cohort

Abstract Coronavirus Disease 2019 (COVID-19) pneumonia is a life-threatening infectious disease, especially for elderly patients with multiple comorbidities. Despite enormous efforts to understand its underlying etiopathogenic mechanisms, most of them remain elusive. In this study, we compared differential plasma miRNAs and cytokines profiles between COVID-19 and other community-acquired pneumonias (CAP). A first screening and subsequent validation assays in an independent cohort of patients revealed a signature of 15 dysregulated miRNAs between COVID-19 and CAP patients. Additionally, multivariate analysis displayed a combination of 4 miRNAs (miR-106b-5p, miR-221-3p, miR-25-3p and miR-30a-5p) that significantly discriminated between both pathologies. Search for targets of these miRNAs, combined with plasma protein measurements, identified a differential cytokine signature between COVID-19 and CAP that included EGFR, CXCL12 and IL-10. Significant differences were also detected in plasma levels of CXCL12, IL-17, TIMP-2 and IL-21R between mild and severe COVID-19 patients. These findings provide new insights into the etiopathological mechanisms underlying COVID-19.

Monitoring of tricyclic antidepressant plasma levels and clinical response: a review of the literature. Part II

1989 ◽  
Vol 4 (2) ◽  
pp. 81-90 ◽  
Author(s):  
I.R. De Oliveira ◽  
P.A.S. Do Prado-Lima ◽  
B. Samuel-Lajeunesse
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Elderly Patients ◽  
Plasma Levels ◽  
Tricyclic Antidepressant ◽  
Review Of The Literature ◽  
Central Nervous System Toxicity ◽  
Routine Measurement ◽  
System Toxicity

SummaryPart II of this paper contains some general considerations on tricyclic antidepressant (TCA) monitoring. Long-term assessment of TCA plasma levels is advised by the few existent studies, although each of these focusses on different aspects. Cardiovascular and central nervous system toxicity is reviewed as well as pharmacokinetics and the importance of protein binding. Some consideration is also given to their use in elderly patients. The authors conclude that although available data support its usefulness in many situations, routine measurement of TCA levels is not warranted.

scholarly journals Quantitative assessment of erector spinae muscles and prognosis in elderly patients with pneumonia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroki Yoshikawa ◽  
Kosaku Komiya ◽  
Takashi Yamamoto ◽  
Naoko Fujita ◽  
Hiroaki Oka ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Hospital Mortality ◽  
Regression Models ◽  
Proportional Hazards ◽  
Community Acquired Pneumonia ◽  
Cox Proportional Hazards ◽  
Erector Spinae ◽  
Cross Sectional ◽  
Proportional Hazards Regression ◽  
Survivor Group

AbstractErector spinae muscle (ESM) size has been reported as a predictor of prognosis in patients with some respiratory diseases. This study aimed to assess the association of ESM size on all-cause in-hospital mortality among elderly patients with pneumonia. We retrospectively included patients (age: ≥ 65 years) admitted to hospital from January 2015 to December 2017 for community-acquired pneumonia who underwent chest computed tomography (CT) on admission. The cross-sectional area of the ESM (ESMcsa) was measured on a single-slice CT image at the end of the 12th thoracic vertebra and adjusted by body surface area (BSA). Cox proportional hazards regression models were used to assess the influence of ESMcsa/BSA on in-hospital mortality. Among 736 patients who were admitted for pneumonia, 702 patients (95%) underwent chest CT. Of those, 689 patients (98%) for whom height and weight were measured to calculate BSA were included in this study. Patients in the non-survivor group were significantly older, had a greater frequency of respiratory failure, loss of consciousness, lower body mass index, hemoglobin, albumin, and ESMcsa/BSA. Multivariate analysis showed that a lower ESMcsa/BSA independently predicted in-hospital mortality after adjusting for these variables. In elderly patients with pneumonia, quantification of ESMcsa/BSA may be associated with in-hospital mortality.

scholarly journals Drug Induced Pneumonitis Secondary to Treatment with Paritaprevir/Ritonavir/Ombitasvir and Dasabuvir (VIEKIRA PAK®) for Chronic Hepatitis C: Case Report of an Unexpected Life-Threatening Adverse Reaction

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Shih Yea Sylvia Wu ◽  
Bridget Faire ◽  
Edward Gane
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Kidney Injury ◽  
Complete Recovery ◽  
Final Diagnosis ◽  
Community Acquired Pneumonia ◽  
Drug Induced ◽  
First Case ◽  
Life Threatening

VIEKIRA PAK (ritonavir-boosted paritaprevir/ombitasvir and dasabuvir) is an approved treatment for compensated patients with genotype 1 (GT1) chronic hepatitis C virus (HCV) infection. This oral regimen has minimal adverse effects and is well tolerated. Cure rates are 97% in patients infected with HCV GT 1a and 99% in those with HCV GT 1b. We report the first case of life-threatening allergic pneumonitis associated with VIEKIRA PAK. This unexpected serious adverse event occurred in a 68-year-old Chinese female with genotype 1b chronic hepatitis C and Child-Pugh A cirrhosis. One week into treatment with VIEKIRA PAK without ribavirin, she was admitted to hospital with respiratory distress and acute kidney injury requiring intensive care input. She was initially diagnosed with community acquired pneumonia and improved promptly with intravenous antibiotics and supported care. No bacterial or viral pathogens were cultured. Following complete recovery, she recommenced VIEKIRA PAK but represented 5 days later with more rapidly progressive respiratory failure, requiring intubation and ventilation, inotropic support, and haemodialysis. The final diagnosis was drug induced pneumonitis.

Effect of Multiple Doses of Clarithromycin and Amoxicillin on IL-6, IFNγ and IL-10 Plasma Levels in Patients with Community Acquired Pneumonia

2004 ◽  
Vol 16 (1) ◽  
pp. 82-85 ◽  
Author(s):  
G. Demartini ◽  
D. Esposti ◽  
P. Marthyn ◽  
A. Lapidari ◽  
F. Fraschini ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Community Acquired Pneumonia ◽  
Multiple Doses

scholarly journals Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

2021 ◽  
Author(s):  
Fengmei Wang ◽  
Jirong Yu ◽  
Lei zhang ◽  
Yan Zhang ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Lupus Nephritis ◽  
Serum Creatinine ◽  
Plasma Levels ◽  
Clinical Relevance ◽  
Alternative Pathway ◽  
Clinicopathological Parameters ◽  
Low Density ◽  
Lower Plasma ◽  
Low Levels

Abstract Background The aim of the study was to investigate the clinical relevance of IgM deposition in patients with LN in a large cohort. Results 217 patients with renal biopsy–proven lupus nephritis were enrolled. The associations between glomerular IgM deposition and clinicopathological parameters were further analyzed. IgM deposition was positively correlated with glomerular C1q and C3 deposition moderately (r = 0.436, P < 0.001; r = 0.408, P < 0.001, respectively), and inversely correlated with plasma levels of C3 and CFH mildly (r=-0.138, P = 0.043; r=-0.147, P = 0.037, respectively). By multivariate analysis, we found that glomerular IgM deposition independently contributes to glomerular C3 deposition in patients with lupus nephritis (OR = 2.002, 95% CI: 1.295–3.094, P = 0.002). In addition, we also found that patients with IgM 0+-2 + had similar plasma CFH levels, but in patients with IgM3+-4+, plasma CFH levels were significantly lower (300.4 ± 155.8µg/ml vs. 429.9 ± 187.5µg/ml, P < 0.001). Furthermore, patients with high density of glomerular IgM and low levels of CFH had heavier proteinuria, higher serum creatinine and lower plasma C3 levels (5.7 ± 3.1g/d vs. 4.7 ± 3.5g/d, P = 0.037;150.1 ± 121.0µmol/L vs. 105.6 ± 97.1µmol/L, P = 0.005; 0.3 ± 0.2µg/L vs. 0.4 ± 0.2µg/L, P = 0.04, respectively), comparing with those with low density of glomerular IgM and low levels of CFH. Conclusions Our results suggested IgM might bind to injury-associated epitopes and be involved in disease progression and provided a possible relevance of CFH and IgM in the process of alternative pathway (AP) activation.

scholarly journals Health, Food Consumption, Social Economy, and Stunting Incidency in Timor Leste

2017 ◽  
Vol 13 (2) ◽  
Author(s):  
Cipriano Do Rosario Pacheco ◽  
Intje Picauly ◽  
Mindo Sinaga
Keyword(s):  
Infectious Disease ◽  
Multivariate Analysis ◽  
Social Economy ◽  
Health Sector ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Bivariate Analysis ◽  
Health Food ◽  
Cross Sectional ◽  
Timor Leste

Stunting can affect the health of toddlers. The prevalence of stunting in Timor Leste in 2014 is 50.2%, whereas in Aileu District is 52.3%. Stunting can interfere intellectual growth and development. The purpose of this study was to analyze the relationship between stunting determinants. The research design was cross sectional. The population of this study was toddlers 24-59 months old, with a sample size of 102 people. Sampling technique used was simple random sampling. Data were analyzed bivariately using simple linear regression, while multivariate analysis was performed using multiple logistic regressions. Bivariate analysis revealed variables that have significant relationship with stunting: immunization (p=0.026), infectious disease (p=0.049), income (p=0.003), total family member (p=0.045). Multivariate analysis obtained two variables as determinant factor of stunting: infectious disease (p=0.025; OR=0.355; 95% CI=0.144-0.877), income (p=0.028; OR=0.332; 95% CI=0.124-0.887). The incidence of stunting in toddlers in Aileu District is very serious (54.9%). Toddlers with stunting demonstrated the adverse effects of stunting on growth, development, and the quality of human resources. Stunting is not only a health sector issue. It is necessary to have appropriate interventions with early and liable management through various related sectors.

scholarly journals PENGALAMAN CAREGIVER DALAM MERAWAT PASIEN PALIATIF DI PANTI WERDHA TULUS KASIH

2021 ◽  
Vol 5 (1) ◽  
pp. 19
Author(s):  
Putri Raissa Hamidah ◽  
Nurhayati Siagian
Keyword(s):  
Elderly Patients ◽  
Old Age ◽  
Sampling Technique ◽  
Development Stage ◽  
Daily Activities ◽  
Final Phase ◽  
Interview Methods ◽  
Life Threatening ◽  
Caregiver Experiences ◽  
Palliative Patients

Late adulthood or known as old age, is the final phase of the life development stage. Old age is often identified with a period of decline in various bodily functions and an impact on helplessness. Because of this, many elderly suffer from incurable and life-threatening diseases known as palliative diseases. Many families of elderly patients who have palliative diseases feel unable to care for their patients at home, and finally, choose to leave elderly palliative patients at the Wredha Home because patients depend on the help of others for care to fulfill their needs and to carry out their daily activities accompanied by a caregiver at the Wredha Home. This reasearch was to ascertain an expertises felt by caregivers in caring for palliative patients at the Tulus Kasih Home. This research uses qualitative methods, data collection using interview methods with structured guides, and a purposive sampling technique that includes four participants. The result of this study covered six themes: the caregiver's understanding of palliative patients, what the palliative patients needs, what difficulties the caregiver experiences when giving action to elderly palliative patients, the caregiver's response when having difficulty caring for palliative patients, what efforts are made by the caregiver when having difficulty caring for palliative patients, and the efforts made by the caregiver in increasing the action for palliative patients.

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