scholarly journals Infant Iodine and Selenium Status in Relation to Maternal Status and Diet During Pregnancy and Lactation

2021 ◽  
Vol 8 ◽  
Author(s):  
Mia Stråvik ◽  
Klara Gustin ◽  
Malin Barman ◽  
Helena Skröder ◽  
Anna Sandin ◽  
...  
Keyword(s):  
Trace Elements ◽  
Breast Milk ◽  
Maternal Plasma ◽  
Selenium Status ◽  
Plasma Selenium ◽  
Median Plasma ◽  
Pregnancy And Lactation ◽  
Gestational Week ◽  
First Year Of Life ◽  
The Impact

Iodine and selenium are essential trace elements. Recent studies indicate that pregnant and lactating women often have insufficient intake of iodine and selenium, but the impact on fetal and infant status is unclear. Here, we assessed iodine and selenium status of infants in relation to maternal intake and status of these trace elements in the birth cohort NICE, conducted in northern Sweden (n = 604). Iodine was measured in urine (UIC) in gestational week 29, and in breast milk and infant urine 4 months postpartum, while selenium was measured in maternal plasma and erythrocytes in gestational week 29, and in breast milk and infant erythrocytes 4 months postpartum, in both cases using ICP-MS. Maternal intake was assessed with semi-quantitative food frequency questionnaires in gestational week 34 and at 4 months postpartum. The median intake of iodine and selenium during pregnancy (98 and 40 μg/d, respectively) and lactation (108 and 39 μg/d, respectively) was below recommended intakes, reflected in insufficient status (median UIC of 113 μg/L, median plasma selenium of 65 μg/L). Also, breast milk concentrations (median iodine 77 μg/L, median selenium 9 μg/L) were unlikely to meet infant requirements. Median UIC of the infants was 114 μg/L and median erythrocyte selenium 96 μg/kg, both similar to the maternal concentrations. Infant UIC correlated strongly with breast milk levels (rho = 0.64, p < 0.001). Their erythrocyte selenium correlated with maternal erythrocyte selenium in pregnancy (rho = 0.38, p < 0.001), but not with breast milk selenium, suggesting formation of prenatal reserves. Our results indicate that the transport of iodine and selenium to the fetus and infant is prioritized. Still, it is uncertain whether most infants had sufficient intakes. Further, the results might indicate an involvement of iodine in asthma development during the first year of life, which is essential to follow up. The low maternal and infant dietary intake of both iodine and selenium, especially when the mothers did not use supplements or iodized table salt, suggest a need for a general screening of women and young children.

scholarly journals Lutein concentration in human milk during early lactation and its relationship with dietary lutein intake

2009 ◽  
Vol 12 (10) ◽  
pp. 1878-1884 ◽  
Author(s):  
Hellas Cena ◽  
Anna Maria Castellazzi ◽  
Amedeo Pietri ◽  
Carla Roggi ◽  
Giovanna Turconi
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Maternal Plasma ◽  
Cross Sectional Study ◽  
Early Lactation ◽  
Dietary Recommendations ◽  
Mature Milk ◽  
Cross Sectional ◽  
Pregnancy And Lactation ◽  
Age Range

AbstractObjectiveThe present study aimed to estimate the lutein concentration in human milk during early lactation and its relationship with dietary lutein intake measured through the administration of a short FFQ.DesignA cross-sectional study in which an FFQ was administered twice: on day 3 (T0) and day 30 (T1) postpartum; meanwhile two breast milk samples were collected. Maternal plasma samples were obtained at T0. The comparison of dietary lutein intakes and likewise lutein concentrations in breast milk at T0 and T1 were analysed with Student’sttest. Pearson’s correlation coefficient was used to determine the association between dietary lutein intake and lutein concentration in milk and plasma, respectively, as well as the correlation between breast milk and plasma lutein concentrations at T0.SettingPavia, northern Italy.SubjectsTwenty-one pregnant women, age range 24–42 years, were recruited during their last trimester on a voluntary basis.ResultsBoth breast milk and plasma lutein concentrations were significantly correlated with dietary lutein intake (r= 0·86,P= 0·0001 andr= 0·94,P= 0·0001, respectively). There was a clear significant correlation between milk and plasma lutein concentrations (r= 0·87,P= 0·0001). Mature milk lutein concentration, although significantly reduced at T1 (P< 0·01), maintained a fairly high correlation with dietary lutein intake (r= 0·82,P= 0·0001).ConclusionsEven though milk lutein concentration decreased during early lactation, it remained significantly correlated with daily lutein intake. Therefore, while awaiting further research, dietary recommendations advising intake of fresh fruit and vegetables rich in lutein, throughout the whole duration of pregnancy and lactation, are extremely useful.

scholarly journals NUTRITIONAL PROBLEMS AND FACTORS FORMING HEALTH STATUS OF CHILDREN OVER THEIR FIRST YEAR

2021 ◽  
Vol 21 (3) ◽  
pp. 104-110
Author(s):  
S. N. Rustamova
Keyword(s):  
Weight Gain ◽  
Breast Milk ◽  
Physical Development ◽  
Main Group ◽  
First Year ◽  
Mixed Feeding ◽  
Feeding Methods ◽  
Functional Digestive Disorders ◽  
First Year Of Life ◽  
The Impact

Purpose: to investigate the impact of the type of feeding on the incidence and physical development of infants. Material and methods. During a year, 250 children of the first year of life under control received different types of feeding (breast milk and milk formulas, differing in composition). Physical development was assessed according to the generally accepted measurement technique in terms of absolute values, monthly increases in anthropometric indicators and mass-growth indices. Outpatient records of children, protocols of examination of a 1-year-old child were studied. The inclusion criteria for the main group of infants were: breastfeeding for at least 9 months; the age of children up to 1 year. The second comparison group included children who received mixed feeding, which includes probiotics. Results. In the girls of the second group, who received mixed feeding with probiotics (7100.0±95.9 g), the weight gain in the first year was significantly higher than the weight gain in the girls who received breast milk and standard formula - 6671 , 0±72.6 g. and 6733.3±91.8 g, respectively. Despite the fact that there were no significant differences in the medians of body weight and height in children of the main group and the comparison groups, it was found that children in the main group were overweight / obese at the age of 2 months had twice as less indicators than children who received mixed feeding. Breastfed children began to sit without support much earlier, on average at 7.6±0.05 months after birth, and children of the other two groups who are bottle-fed, on average, at 8.0±0.13 and 8,1±0.12 months, respectively (p <0.05). When studying the most common diseases of children over their first year of life, depending on the type of feeding, the following results were found out: acute intestinal infections made up the largest share in both groups, 7.7±2.34% of children in the I group, and 11.7±2.93% of children in the II group (p = 0.3905). Conclusion. The study has demonstrated that breastfeeding in the first year of life reduces the risk of overweight and ensures harmonious physical development, neuropsychic development, cuts down the frequency of infectious diseases, alimentary disorders, functional digestive disorders, and contributes to the normalization of intestinal microflora. It is also important to introduce optimal combinations of feeding methods for young children and adding probiotics.

scholarly journals The Impact of Maternal Diet during Pregnancy and Lactation on the Fatty Acid Composition of Erythrocytes and Breast Milk of Chilean Women

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 839 ◽  
Author(s):  
Cynthia Barrera ◽  
Rodrigo Valenzuela ◽  
Rodrigo Chamorro ◽  
Karla Bascuñán ◽  
Jorge Sandoval ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Breast Milk ◽  
Acid Composition ◽  
Maternal Diet ◽  
Pregnancy And Lactation ◽  
The Impact ◽  
Chilean Women

Gastric electrical activity in normal neonates during the first year of life. Effect of lactation with breast milk and formula

2001 ◽  
Vol 120 (5) ◽  
pp. A209-A209
Author(s):  
G RIEZZO ◽  
R CASTELLANA ◽  
T DEBELLIS ◽  
F LAFORGIA ◽  
F INDRIO ◽  
...  
Keyword(s):  
Breast Milk ◽  
Electrical Activity ◽  
First Year ◽  
Gastric Electrical Activity ◽  
First Year Of Life ◽  
Normal Neonates

Pharmacokinetics, Placental and Breast Milk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV

2019 ◽  
Vol 25 (5) ◽  
pp. 556-576 ◽  
Author(s):  
E.M. Hodel ◽  
C. Marzolini ◽  
C. Waitt ◽  
N. Rakhmanina
Keyword(s):  
Breast Milk ◽  
Protease Inhibitors ◽  
Drug Class ◽  
Drug Transporters ◽  
Maternal Plasma ◽  
Antiretroviral Drugs ◽  
Physiological Changes ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
In Pregnancy

Background:Remarkable progress has been achieved in the identification of HIV infection in pregnant women and in the prevention of vertical HIV transmission through maternal antiretroviral treatment (ART) and neonatal antiretroviral drug (ARV) prophylaxis in the last two decades. Millions of women globally are receiving combination ART throughout pregnancy and breastfeeding, periods associated with significant biological and physiological changes affecting the pharmacokinetics (PK) and pharmacodynamics (PD) of ARVs. The objective of this review was to summarize currently available knowledge on the PK of ARVs during pregnancy and transport of maternal ARVs through the placenta and into the breast milk. We also summarized main safety considerations for in utero and breast milk ARVs exposures in infants.Methods:We conducted a review of the pharmacological profiles of ARVs in pregnancy and during breastfeeding obtained from published clinical studies. Selected maternal PK studies used a relatively rich sampling approach at each ante- and postnatal sampling time point. For placental and breast milk transport of ARVs, we selected the studies that provided ratios of maternal to the cord (M:C) plasma and breast milk to maternal plasma (M:P) concentrations, respectively.Results:We provide an overview of the physiological changes during pregnancy and their effect on the PK parameters of ARVs by drug class in pregnancy, which were gathered from 45 published studies. The PK changes during pregnancy affect the dosing of several protease inhibitors during pregnancy and limit the use of several ARVs, including three single tablet regimens with integrase inhibitors or protease inhibitors co-formulated with cobicistat due to suboptimal exposures. We further analysed the currently available data on the mechanism of the transport of ARVs from maternal plasma across the placenta and into the breast milk and summarized the effect of pregnancy on placental and of breastfeeding on mammal gland drug transporters, as well as physicochemical properties, C:M and M:P ratios of individual ARVs by drug class. Finally, we discussed the major safety issues of fetal and infant exposure to maternal ARVs.Conclusions:Available pharmacological data provide evidence that physiological changes during pregnancy affect maternal, and consequently, fetal ARV exposure. Limited available data suggest that the expression of drug transporters may vary throughout pregnancy and breastfeeding thereby possibly impacting the amount of ARV crossing the placenta and secreted into the breast milk. The drug transporter’s role in the fetal/child exposure to maternal ARVs needs to be better understood. Our analysis underscores the need for more pharmacological studies with innovative study design, sparse PK sampling, improved study data reporting and PK modelling in pregnant and breastfeeding women living with HIV to optimize their treatment choices and maternal and child health outcomes.

Levels of Trace Elements in Human Breast Milk in Jordan: a Comparison with Infant Formula Milk Powder

2021 ◽  
Author(s):  
Yahya R. Tahboub ◽  
Adnan M. Massadeh ◽  
Nihaya A. Al-sheyab ◽  
Diab El shrafat ◽  
Israa A. Nsserat
Keyword(s):  
Trace Elements ◽  
Breast Milk ◽  
Infant Formula ◽  
Milk Powder ◽  
Human Breast Milk ◽  
Human Breast ◽  
Formula Milk ◽  
Infant Formula Milk

scholarly journals Parental mental health conditions and use of healthcare services in children the first year of life– a register-based, nationwide study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Signe Heuckendorff ◽  
Martin Nygård Johansen ◽  
Søren Paaske Johnsen ◽  
Charlotte Overgaard ◽  
Kirsten Fonager
Keyword(s):  
Mental Health ◽  
Healthcare Services ◽  
Health Condition ◽  
Health Conditions ◽  
Mental Health Condition ◽  
Parental Mental Health ◽  
Mental Health Conditions ◽  
First Year Of Life ◽  
Paternal Mental Health ◽  
The Impact

Abstract Background Parental mental health conditions have been associated with increased morbidity and use of healthcare services in offspring. Existing studies have not examined different severities of parental mental health conditions, and the impact of paternal mental health has been overlooked. We examined the association between two severities of parental mental health conditions and use of healthcare services for children during the first year of life and explored the impact of both maternal and paternal mental health conditions. Methods This register-based cohort study included all live-born children born in Denmark from 2000 to 2016. Information on socioeconomics, diagnoses, drug prescriptions, and healthcare contacts was extracted from nationwide public registries. Parents were grouped according to severity of mental condition based on the place of treatment of the mental health condition. Negative binominal regression analyses were performed to estimate the incidence rate ratio (IRR) of contacts to general practice (GP), out-of-hour medical service, emergency room (ER), and out- and inpatient hospital contacts during the first 12 months of the child’s life. Results The analyses included 964,395 children. Twenty percent of the mothers and 12 % of the fathers were identified with mental health conditions. Paternal mental health conditions were independently associated with increased risk of infant healthcare contacts (GP IRR 1.05 (CI95% 1.04–1.06) and out-of-hour IRR 1.20 (CI95% 1.18–1.22)). Risks were higher for maternal mental health conditions (GP IRR 1.18 (CI95% 1.17–1.19) and out-of-hour IRR 1.39 (CI95% 1.37–1.41)). The risks were even higher if both parents were classified with a mental health condition (GP IRR 1.25 (CI95% 1.23–1.27) and out-of-hour contacts IRR 1.49 (CI95% 1.45–1.54)), including minor mental health condition (GP IRR 1.22 (CI95% 1.21–1.24) and out-of-hour IRR 1.37 (CI95% 1.34–1.41)). This pattern was the same for all types of healthcare contacts. Conclusions Both maternal and paternal mental health conditions, including minor mental health conditions, were associated with increased utilization of healthcare services. Focus on both parents’ mental health conditions (even if minor) may be warranted in service planning.

Eplerenone levels in maternal serum, cord blood, and breast milk during pregnancy and lactation

2021 ◽  
Author(s):  
Jumpei Saito ◽  
Asako Mito ◽  
Naho Yakuwa ◽  
Kayoko Kaneko ◽  
Hiroyo Kawasaki ◽  
...  
Keyword(s):  
Breast Milk ◽  
Cord Blood ◽  
Maternal Serum ◽  
Pregnancy And Lactation

scholarly journals Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women´s Weight: Possible Impact on Feto-Placental Vascular Function

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 506 ◽  
Author(s):  
Susana Contreras-Duarte ◽  
Lorena Carvajal ◽  
María Jesús Garchitorena ◽  
Mario Subiabre ◽  
Bárbara Fuenzalida ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vascular Function ◽  
Plasma Cholesterol ◽  
Umbilical Vein ◽  
Maternal Plasma ◽  
Maternal Weight ◽  
Cholesterol Levels ◽  
The Impact

Gestational diabetes mellitus (GDM) associates with fetal endothelial dysfunction (ED), which occurs independently of adequate glycemic control. Scarce information exists about the impact of different GDM therapeutic schemes on maternal dyslipidemia and obesity and their contribution to the development of fetal-ED. The aim of this study was to evaluate the effect of GDM-treatments on lipid levels in nonobese (N) and obese (O) pregnant women and the effect of maternal cholesterol levels in GDM-associated ED in the umbilical vein (UV). O-GDM women treated with diet showed decreased total cholesterol (TC) and low-density lipoproteins (LDL) levels with respect to N-GDM ones. Moreover, O-GDM women treated with diet in addition to insulin showed higher TC and LDL levels than N-GDM women. The maximum relaxation to calcitonin gene-related peptide of the UV rings was lower in the N-GDM group compared to the N one, and increased maternal levels of TC were associated with even lower dilation in the N-GDM group. We conclude that GDM-treatments modulate the TC and LDL levels depending on maternal weight. Additionally, increased TC levels worsen the GDM-associated ED of UV rings. This study suggests that it could be relevant to consider a specific GDM-treatment according to weight in order to prevent fetal-ED, as well as to consider the possible effects of maternal lipids during pregnancy.

scholarly journals Impacts of Long- and Short-Term of Irrigation with Treated Wastewater and Synthetic Fertilizers on the Growth, Biomass, Heavy Metal Content, and Energy Traits of Three Potential Bioenergy Crops in Arid Regions

Energies ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3037
Author(s):  
Mahmoud F. Seleiman ◽  
Nasser Al-Suhaibani ◽  
Salah El-Hendawy ◽  
Kamel Abdella ◽  
Majed Alotaibi ◽  
...  
Keyword(s):  
Trace Elements ◽  
Arid Regions ◽  
Biomass Energy ◽  
Recommended Dose ◽  
Treated Wastewater ◽  
Bioenergy Crops ◽  
Virgin Soil ◽  
Field Crops ◽  
Synthetic Fertilizers ◽  
The Impact

The availability of suitable water is an important factor for increasing the cultivated areas and sustainability in arid (i.e., less than 200 mm precipitation per year) and semiarid regions (i.e., 200–700 mm precipitation per year). Therefore, this study aimed to analyze the impact of treated wastewater (TWW) and groundwater (GW) as well as synthetic fertilizers (50% and 100% of the recommended NPK dose; 150–150–60 kg N–P2O5–K2O ha−1) on the growth, biomass, energy traits, and macro and trace elements of maize (Zea mays L.), sorghum (Sorghum bicolor L.), and pearl millet (Pennisetum glaucum L) grown in old cultivated (first location; L1) and virgin soil (L2 and L3) as potential bioenergy crops. The soil in L1 has been irrigated with treated wastewater for the last 15 years and continued to be irrigated with treated wastewater in this investigation. The virgin soil was divided into two parts: the first part was irrigated with TWW, and the second part was irrigated with GW. The experiments were laid out in a split-plot with a randomized complete block design with water treatments (TWW in old and virgin soil, and GW in virgin soil) in main plots, and the two treatments of fertilization (50% and 100% of the recommended NPK dose) were distributed randomly in subplots. Compared with the crops irrigated with GW, the crops irrigated with TWW, whether grown on old or virgin soil, showed higher plant height, total chlorophyll content, leaf area per plant, total biomass, energy content, and gross energy with low ash. They also contained higher (but lower than permissible limits) concentrations of macro-elements (NPK) and trace elements (Fe, Mn, Cu, Zn, Cd, Pb, Ni, and Co). In addition, the application of a 50% recommended dose of NPK with TWW showed equivalent results to a 100% recommended dose of NPK on all measured parameters with few exceptions. In conclusion, the TWW can be used to irrigate field crops allocated for bioenergy production in arid regions because it does not harm the plants and environment. In addition, the 50% recommended dose of NPK fertilizer exerted no negative effects on the growth and energy production of field crops, thereby protecting the environment and reducing the leaching of excessive fertilizers into GW.

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