scholarly journals Prolonged Medical Cannabis Treatment is Associated With Quality of Life Improvement and Reduction of Analgesic Medication Consumption in Chronic Pain Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Joshua Aviram ◽  
Gil M. Lewitus ◽  
Yelena Vysotski ◽  
Ben Yellin ◽  
Paula Berman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Dose ◽  
Medical Cannabis ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Treatment Regimens ◽  
Dose Comparison ◽  
Medication Consumption ◽  
Analgesic Medication

Introduction: Chronic non-cancer pain (CNCP) is one of the most prevalent indications for medical cannabis (MC) treatment globally. In this study, we investigated CNCP parameters in patients during prolonged MC treatment, and assessed the interrelation between CNCP parameters and the chemical composition of MC chemovar used.Methods: A cross-sectional questionnaire-based study was performed in one-month intervals for the duration of six months. Subjects were adult patients licensed for MC treatment who also reported a diagnosis of CNCP by a physician. Data included self-reported questionnaires. MC treatment features included administration route, cultivator, cultivar name and monthly dose. Comparison statistics were used to evaluate differences between the abovementioned parameters and the monthly MC chemovar doses at each time point.Results: 429, 150, 98, 71, 77 and 82 patients reported fully on their MC treatment regimens at six one-month intervals, respectively. Although pain intensities did not change during the study period, analgesic medication consumption rates decreased from 46 to 28% (p < 0.005) and good Quality of Life (QoL) rates increased from 49 to 62% (p < 0.05). These changes overlapped with increase in rates of (-)-Δ9-trans-tetrahydrocannabinol (THC) and α-pinene high dose consumption.Conclusion: Even though we observed that pain intensities did not improve during the study, QoL did improve and the rate of analgesic medication consumption decreased alongside with increasing rates of high dose THC and α-pinene consumption. Understanding MC treatment composition may shed light on its long-term effects.

3-D conformal treatment of prostate cancer to 74 Gy vs. high-dose-rate brachytherapy boost: A cross-sectional quality-of-life survey

2006 ◽  
Vol 45 (6) ◽  
pp. 708-716 ◽  
Author(s):  
Dirk Vordermark ◽  
Jörn Wulf ◽  
Klaus Markert ◽  
Kurt Baier ◽  
Oliver Kölbl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Cross Sectional ◽  
High Dose Rate Brachytherapy ◽  
Brachytherapy Boost ◽  
Conformal Treatment

scholarly journals Study protocol: The Dutch 20|30 Postmeningitis study: a cross-sectional follow-up of two historical childhood bacterial meningitis cohorts on long-term outcomes

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
O. El Tahir ◽  
R. C. J. de Jonge ◽  
S. Ouburg ◽  
S. A. Morré ◽  
A. M. van Furth
Keyword(s):  
Quality Of Life ◽  
Bacterial Meningitis ◽  
Prediction Models ◽  
Adverse Outcomes ◽  
Long Term Effects ◽  
Long Term Outcomes ◽  
Cross Sectional

Abstract Background Bacterial meningitis (BM) is a serious, life-threatening infectious disease of the central nervous system that often occurs in young children. The most common severe to moderate sequelae following BM are sensorineural hearing loss, neuromotor disabilities and mental retardation, while subtle sequelae include academic and behavioral disabilities. It is largely unknown whether these more subtle sequelae persist into adolescence and adulthood. Therefore, this study will investigate the very long-term effects of childhood BM in later life. Better understanding of long-term effects and early identification of adverse outcomes after BM are essential for more timely interventions. Additionally, certain single nucleotide polymorphisms (SNPs) are associated with disease severity and might predict adverse sequelae. These include SNPs in genes encoding for pathogen recognition and immune response upon infection. Accordingly, a secondary objective of this study is to investigate the role of genetic variation in BM and use any insights to predict short- and long-term outcomes. Methods In the Dutch 20|30 Postmeningitis study, adolescents and young adults (n = 947) from two historical cohorts with a prior episode of BM during childhood will be enrolled into a cross-sectional follow-up investigation using mainly questionnaires that examine executive and behavioral functioning, health-related quality of life, subjective hearing, mood and sleeping disorders, academic performance, and economic self-sufficiency. The results will be compared to normative data by one-sample t-tests. Multivariable regression analysis will be used to assess for any associations with causative pathogens and severity of BM. Participants that complete the questionnaires will be approached to provide a swab for buccal DNA and subsequent sequencing analyses. Logistic regression models will be used to predict sequelae. Discussion The unique follow-up duration of this cohort will enable us to gain insights into the possible very long-term adverse effects of childhood BM and how these might impact on quality of life. The investigation of host genetic factors will contribute to the development of prediction models which will serve as prognostic tools to identify children who are at high risk of adverse outcome after BM. Trial Registration Dutch Trial Register NTR-6891. Retrospectively registered 28 December 2017.

scholarly journals Long term treatment with omalizumab in adolescent with refractory solar urticaria

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Mauro Iannelli ◽  
Stefano Passanisi ◽  
Giuseppe Crisafulli ◽  
Stefania Arasi ◽  
Lucia Caminiti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Option ◽  
High Dose ◽  
Long Term Effects ◽  
Caucasian Girl ◽  
Chronic Inducible Urticaria ◽  
Solar Urticaria ◽  
Long Term Treatment

Abstract Background Solar urticaria represents an uncomfortable form of chronic inducible urticaria. First and second-line treatments are ineffective in some patients, leading to an impairment in their quality of life. Omalizumab represents a safe therapeutic option in case of refractory solar urticaria. Case presentation We update a case of a 21-year-old Caucasian girl affected by solar urticaria from the age of 14. Poor disease control was achieved with standard or high-dose of H1-antihistamines. Several omalizumab courses, including a 1-year-long course, were practiced resulting in clinical remission and significant improvement in patient’s quality of life. Conclusion Our experience confirms the effectiveness and safety of omalizumab for the management of refractory solar urticaria. Future studies are awaited in order to monitor long term effects and chronic doses of this treatment, particularly in patients who need concomitant therapy with antihistamines.

scholarly journals Long term effects of burn injury on health-related quality of life of adult burn survivors in Iceland: a descriptive cross-sectional study and validation of the Icelandic version of the Burn Specific Health Scale-Brief (BSHS-B)

2021 ◽  
Vol 107 (12) ◽  
pp. 581-588
Author(s):  
Lovísa Baldursdóttir ◽  
◽  
Sigríður Zoega ◽  
Gunnar Auðólfsson ◽  
Vigdís Friðriksdóttir ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Burn Injury ◽  
Health Related Quality ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Burn Survivors ◽  
Related Quality ◽  
Health Related ◽  
Specific Health

OBJECTIVES: The aim of the study was to assess the long-term effects of burn injury on the health-related quality of life of adult burn survivors in Iceland and to validate the translated Icelandic version of the Burn Specific Health Scale-Brief (BSHS-B). MATERIALS AND METHODS: The participants of this descriptive cross-sectional study were all burn survivors, 18 years or older, admitted to hospital for 24 hours or more because of skin burn during a 15 years period (N=196). They completed questionnaire about their health (BSHS-B), health related quality of life (EQ-5D-5) and additional questions on burn-related symptoms and their burn experience. RESULTS: Response rate was 34% (N=66). Men were 77%, mean age 45.7 years (sf=18.3 and range 18-82 years), mean age when burned was 34.0 (sf=20,1, range 1-75), median time from burn accident was 11.5 years (range 1-44 years) and 32% had been burned when under 18 years of age. Burn-specific health was 4.4-4.0 (median) and health on the EQ5D-5vas scale was 80 (median, range 10-100). Those who lost a body part or had skin transplantation had more negative body image and needed more selfcare than others (p<0.05). A significant proportion of participants reported physical and psychosocial symptoms such as itch (48%), persistent pain (37%), anxiety/depression (29%) and negative self-image (37%). Majority (67%) believed they did not get enough information, follow-up, or support after discharge from hospital. The Icelandic version of the Burn Specific Health Scale-Brief (BSHS-B) was reliable, but more research is needed to establish its validity. CONCLUSION: These findings suggest that most Icelandic burn survivors report acceptable health and health-related quality of life. The study identified a subgroup of survivors that experience persistent physical and psychosocial symptoms. Team approach with holistic support after discharge, for a prolonged period of time aiming at preventing physical and psychiatric morbidity, is recommended.

scholarly journals ­­The Combined Outcomes of the COVID-19 Pandemic and a Collapsing Economy on Quality of Life: A Cross-Sectional Study

2020 ◽  
Author(s):  
Hala Sacre ◽  
Aline Hajj ◽  
Danielle A Badro ◽  
Carla Abou Selwan ◽  
Randa Aoun ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sampling Technique ◽  
Family Satisfaction ◽  
Cross Sectional Study ◽  
University Education ◽  
Snowball Sampling ◽  
Sectional Study ◽  
Long Term Effects ◽  
Cross Sectional

Abstract BackgroundThis study aimed at examining the combined outcomes of the COVID-19 pandemic and a collapsing economy on the quality of life (QOL) of the general Lebanese population.MethodsA cross-sectional study was conducted from 10-18 May 2020, via an online-based questionnaire using the snowball sampling technique. It enrolled 502 adult participants.ResultsThe QOL had a mean of 14.80[14.37;15.24]. A lower QOL was associated with female gender (beta=-1.533[-2.324;-0.743]), university education (beta=-2.119[-3.353;-0.885]), fear of COVID-19 (beta=-0.131[-0.199;-0.063]), fear of poverty (beta=-0.232[-0.402;-0.063]), verbal violence at home (beta=-3.464[-5.137;-1.790]), and chronic disease (beta=-1.307[-2.283;-0.330]). Better family satisfaction (beta=0.380[0.235;0.525]) and better financial situation (beta=0.029[0.003;0.055]) were significantly correlated with better QOL. In the subsample of workers/looking for a job, additional factors affected QOL: physical exercise (beta=1.318[0.370;2.265]) was associated with better QOL, while previous waterpipe smoking, being self-employed before the crisis (beta=-1.22[-2.208;-0.231]), working from home since the economic crisis (-1.853[-3.692;-0.013]), closure of the institution (beta=-1.201[-2.607;0.204]), and worrying about long-term effects of the crisis on one's employment status (beta=-0.433[-0.650;-0.216]) were associated lower QOL; the fear of COVID-19 was not significantly associated with QOL (p>0.05).ConclusionThis study showed that during the pandemic, economic and other factors, directly or indirectly related to COVID-19, significantly affected quality of life. The fear of COVID-19 and fear of poverty mainly impacted the QOL of the general population; however, the fear of COVID-19 lost its significance among workers, who reported that factors negatively affecting their QOL are directly related to their employment and the already collapsing economy in Lebanon.

scholarly journals Comparative analysis: QOL in breast cancer patientsbefore and during the COVID-19 pandemic

Mastology ◽  
2021 ◽  
Vol 31 ◽  
Author(s):  
Letícia Araujo Pinholato ◽  
Maria Clara Santos Pupim ◽  
Ana Cristina da Silva do Amaral Herrera ◽  
Carlos Eduardo Coral de Oliveira
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Comparative Analysis ◽  
Psychological Health ◽  
Longitudinal Research ◽  
Cross Sectional Study ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Study Population

Introduction: The 2019 outbreak of coronavirus disease (COVID-19) posed unprecedented challenges of emotional matter for women diagnosed with breast cancer. This research aimed to compare the quality of life of patients who were diagnosed with breast cancer from 2014 to 2019, and patients who were diagnosed during the COVID-19 pandemic, from January to August 2020. Methods: A cross-sectional study was performed, including patients with breast cancer, associated or not with chronic pathologies, with no psychiatric disorders, aged over 18 years. The questionnaire developed by the European Organisation for Research and Treatment of Cancer (EORTC-C30) version 3.0 was used for the comparative analysis of quality of life. The study population consisted of 185 women, of which 43.2% (n = 80) were previously diagnosed and 56.7% (n = 105) were diagnosed during the pandemic, with a median age of 45 years (IQ = 15). Results: The EORTC-C30 quality of life score remained the same for both groups (33.33; 33.33). There was a decrease in the scores on the emotional (58; 50) and physical (60; 40) scales of patients diagnosed during the pandemic. Conclusions: Future longitudinal research should contribute to the understanding of the long-term effects of COVID-19 on the psychological health of patients with breast cancer.

Perceived Overprotection and Its Association With Quality of Life in Dementia

GeroPsych ◽  
2019 ◽  
Vol 32 (3) ◽  
pp. 125-134
Author(s):  
Mechthild Niemann-Mirmehdi ◽  
Andreas Häusler ◽  
Paul Gellert ◽  
Johanna Nordheim
Keyword(s):  
Quality Of Life ◽  
Patient Autonomy ◽  
Positive Association ◽  
Well Being ◽  
Negative Association ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
People With Dementia ◽  
Mental Well Being

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.

Glittre ADL test in eutrophic, overweight and obese elderly

2020 ◽  
Vol 21 (1) ◽  
pp. 49
Author(s):  
Augusto Baumhardt Guidoti ◽  
Ângelo Pereira Cattani ◽  
Cintia Laura De Araujo ◽  
Fernanda Beatriz Costa Delacoste ◽  
Guilherme Scotta Hentschke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Capacity ◽  
Elderly Women ◽  
Handgrip Strength ◽  
Exercise Intolerance ◽  
World Health ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
World Health Organization Quality

The Glittre ADL-test (TGlittre) has been designed and validated to measure functional capacity during daily living activities in patients with chronic obstructive pulmonary disease (COPD) but is now used in several other situations. The aim of this study was to evaluate the applicability of TGlittre in a sample of overweight and obese eutrophic elderly. This was an experimental and cross-sectional study, which included 21 elderly women, allocated by BMI, in eutrophic (n = 8), overweight (n = 6) and obese (n = 7) groups. They were assessed for functional capacity (TGlittre and 6MWT), quality of life (QOL) with the questionnaire World Health Organization Quality of Life for Older People (WHOQOL-OLD) and handgrip strength (HGS). TGlittre correlated with age (p = 0.0040) and with 6MWT (p = 0.0086), but no statistical difference was found in TGlittre's performance time and the distance covered in 6MWT between groups. TGlittre did not correlate with HGS (p = 0.1493) and WHOQOL-Old (p = 0.0905). The data obtained in the present study corroborate that TGlittre is used as a functional measurement variable in the elderly population.Keywords: aged, obesity, exercise intolerance.­­­

Kualitas Hidup Pasien Pascaintervensi Koroner Perkutan

1970 ◽  
Vol 2 (1) ◽  
Author(s):  
Remita Ully Hutagalung ◽  
F Sri Susilaningsih ◽  
Ai Mardiyah
Keyword(s):  
Quality Of Life ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
College Education ◽  
Coronary Intervention ◽  
Health Condition ◽  
Cross Sectional ◽  
Percutaneous Coronary ◽  
Environment Domain

Penyakit jantung koroner adalah penyakit yang dapat mengancam kehidupan seseorang. Pelaksanaan tindakan non bedah intervensi koroner perkutan pasien masih memiliki risiko terjadinya serangan berulang, stenosis dan ancaman kematian. Tujuan penelitian ini adalah mengidentifikasi kualitas hidup pasien pascatindakan intervensi koroner perkutan. Desain penelitian ini adalah potong lintang. Pengambilan sampel secara consecutive samplingdidapatkan 50 responden yaitu pasien yang sedang kontrol pascaintervensi coroner per kutan di Poliklinik Spesialis Jantung RSUP Dr. Hasan Sadikin Bandung, penelitian ini dilakukan pada 1-14 November 2013. Kualitas hidup diukur dengan instrumen WHOQOL-BREFdengan empat domain kualitas hidup yaitu domain fisik, psikologis, sosial, dan lingkungan. Analisis menggunakan statistik deskripsi. Hasil penelitian menunjukkan bahwa responden memiliki kualitas hidup baik sebesar 50%. Perawat memiliki peran dalam membantu pasien mencapai kualitas hidup yang optimal, diantaranya melalui peningkatan efikasi diri pasien melalui pendampingan dan pemberian informasi dalam usaha mencapai kualitas hidup.Kata kunci:Intervensi koroner perkutan, kualitas hidup, WHOQOL-BREF AbstractCoronary heart disease is a disease that can threaten person’s life, and can lead to the change of the quality of life. This coronary heart disease can be solved with non-surgical called percutaneous coronary intervention. This action will be normalized the quality of perfusion in the coronary arteries, which would certainly have an impact on the quality of life of patients. The research objective was to observe the patient of quality of life after treatment on intervention percutaneous coronary. The research design was cross sectional. There were 50 respondents taken by consecutive sampling. Data were collected in outpatient room in RSUP Dr. Hasan Sadikin Bandung, who have came with treatment routine schedule after percutaneous coronary intervention during November 1st–14th 2013. The questionnaire use WHOQOL-BREF format with 26 questions that consisting of 4 domains of quality of life: physical domain, psychological domain, social domain, and environment domain. Majority of patients were male (74 %), with the range of age mostly 56-66 years ( 34 % ), married ( 96 % ), college education was the highest ( 66 % ), the majority had not a primary job like as housewife , retired, student, etc. ( 26 % ). Data were collected using the questionnaire WHOQOL – BREF. The result have shown that rates of quality of life was good ( 50 % ) and health condition after percutaneous coronary intervention neither satisfied nor dissatisfied ( 44 % ). Nurses have a role in helping patients achieve optimal quality of life like giving information to patient correctlyKey words: Percutaneous coronary intervention, quality of life, WHOQOL – BREF

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